Detailed information for compound 1085846

Basic information

Technical information
  • TDR Targets ID: 1085846
  • Name: 6-methyl-N-(3-morpholin-4-ylpropyl)pyridine-3 -carboxamide
  • MW: 263.335 | Formula: C14H21N3O2
  • H donors: 1 H acceptors: 2 LogP: 0.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cn1)C(=O)NCCCN1CCOCC1
  • InChi: 1S/C14H21N3O2/c1-12-3-4-13(11-16-12)14(18)15-5-2-6-17-7-9-19-10-8-17/h3-4,11H,2,5-10H2,1H3,(H,15,18)
  • InChiKey: XCHQRSVSCLFOQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methyl-N-(3-morpholinopropyl)pyridine-3-carboxamide
  • 6-methyl-N-(3-morpholinopropyl)-3-pyridinecarboxamide
  • 6-methyl-N-(3-morpholinopropyl)nicotinamide
  • 6-Methyl-N-(3-morpholin-4-yl-propyl)-nicotinamide
  • BAS 00484135

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0012 0.0012
Echinococcus granulosus glutamate synthase 0.001 0.011 0.011
Schistosoma mansoni cpg binding protein 0.0031 0.0783 0.1147
Onchocerca volvulus 0.0017 0.0324 0.0522
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1791 0.2624
Schistosoma mansoni hypothetical protein 0.001 0.011 0.0161
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0012 0.0017
Schistosoma mansoni dishevelled 0.001 0.0091 0.0133
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0039 0.1039 0.2803
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1797 0.2633
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.011 0.0322
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0039 0.1039 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1791 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.001 0.011 0.0058
Plasmodium falciparum thioredoxin reductase 0.0039 0.1039 0.2803
Loa Loa (eye worm) hypothetical protein 0.001 0.0091 0.0091
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0066 0.0066
Mycobacterium leprae conserved hypothetical protein 0.004 0.1056 0.2183
Trypanosoma brucei hypothetical protein, conserved 0.004 0.1056 0.2855
Schistosoma mansoni disulfide oxidoreductase 0.001 0.011 0.0161
Mycobacterium tuberculosis Probable hydrolase 0.004 0.1056 0.1205
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.011 0.0058
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.1039 0.3035
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0091 0.0091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.1039 0.3035
Loa Loa (eye worm) matrixin family protein 0.0041 0.1102 0.1102
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0295 0.0614
Onchocerca volvulus 0.001 0.0091 0.0146
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0012 0.0012
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0039 0.1039 0.1039
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.1039 0.2803
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0295 0.0433
Trichomonas vaginalis glutamate synthase, putative 0.001 0.011 0.1044
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1581 0.4474
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.1039 0.3035
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0039 0.1039 0.2803
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0295 0.0433
Echinococcus granulosus muscleblind protein 0.0319 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.3513 0.4335
Brugia malayi CXXC zinc finger family protein 0.003 0.0728 0.0728
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1782 0.1782
Echinococcus granulosus phd:f box containing protein 0.0016 0.0295 0.0295
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0146 0.4441 0.5518
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.001 0.011 0.0058
Schistosoma mansoni sulfide quinone reductase 0.001 0.011 0.0161
Brugia malayi beta-lactamase family protein 0.004 0.1056 0.1056
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.1728 0.1728
Mycobacterium ulcerans beta-lactamase 0.004 0.1056 0.5626
Schistosoma mansoni cpg binding protein 0.0031 0.0783 0.1147
Brugia malayi DIX domain containing protein 0.001 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.001 0.0091 0.0091
Brugia malayi jmjC domain containing protein 0.0063 0.1782 0.1782
Mycobacterium tuberculosis Probable reductase 0.0117 0.3513 0.4335
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0091 0.0091
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0443 0.0424
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.011 0.1044
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0091 0.0091
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0039 0.1039 0.5525
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0295 0.0863
Brugia malayi jmjC domain containing protein 0.0061 0.1728 0.1728
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0091 0.0146
Mycobacterium leprae Probable lipase LipE 0.004 0.1056 0.2183
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0295 0.0295
Brugia malayi glutathione reductase 0.0114 0.3422 0.3422
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.1056 0.1056
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0016 0.0295 0.0295
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0114 0.3422 0.422
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.001 0.011 0.011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.011 0.1044
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.001 0.011 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0443 0.0443
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0091 0.0091
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0039 0.1039 0.1522
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.1056 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.011 0.1044
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0295 0.0863
Brugia malayi beta-lactamase 0.004 0.1056 0.1056
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0039 0.1039 0.2803
Onchocerca volvulus 0.001 0.011 0.0178
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.1056 0.1205
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0039 0.1039 0.2803
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.1728 0.1728
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.035 0.035
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0062 0.177 0.177
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.011 0.011
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.1056 0.1205
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.1039 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.011 0.1044
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.001 0.011 0.011
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0146 0.4441 0.5518
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1791 0.2624
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1791 0.1791
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.011 0.0058
Mycobacterium tuberculosis Conserved protein 0.004 0.1056 0.1205
Loa Loa (eye worm) hypothetical protein 0.004 0.1056 0.1056
Mycobacterium ulcerans hypothetical protein 0.004 0.1056 0.5626
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0091 0.0133
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.001 0.011 0.011
Schistosoma mansoni glutamate synthase 0.001 0.011 0.0161
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0091 0.0091
Brugia malayi Matrixin family protein 0.0017 0.0324 0.0324
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.1039 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.001 0.011 0.1044
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0295 0.0295
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.0992 0.1601
Echinococcus multilocularis cpg binding protein 0.0031 0.0783 0.0783
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.1056 0.1205
Loa Loa (eye worm) hypothetical protein 0.0201 0.6198 0.6198
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.007 0.007
Brugia malayi jmjC domain containing protein 0.0016 0.0295 0.0295
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.001 0.011 0.011
Echinococcus multilocularis glutamate synthase 0.001 0.011 0.011
Loa Loa (eye worm) matrixin family protein 0.0038 0.0992 0.0992
Schistosoma mansoni dishevelled 0.001 0.0091 0.0133
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0091 0.0091
Brugia malayi jmjC domain containing protein 0.0016 0.0295 0.0295
Loa Loa (eye worm) thioredoxin reductase 0.0114 0.3422 0.3422
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.011 0.0058
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.1056 0.5626
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1791 0.1791
Loa Loa (eye worm) hypothetical protein 0.001 0.0091 0.0091
Schistosoma mansoni sulfide quinone reductase 0.001 0.011 0.0161
Loa Loa (eye worm) hypothetical protein 0.004 0.1056 0.1056
Echinococcus granulosus thioredoxin glutathione reductase 0.0114 0.3422 0.3422
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0091 0.0133
Plasmodium falciparum glutathione reductase 0.0039 0.1039 0.2803
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0146 0.4441 1
Brugia malayi jmjC domain containing protein 0.0016 0.0295 0.0295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.1039 0.3035
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.1728 0.1728
Trypanosoma cruzi NADH dehydrogenase, putative 0.001 0.011 0.0322
Loa Loa (eye worm) hypothetical protein 0.0319 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.1056 1
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0295 0.0433
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.3513 0.4335
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.011 0.011
Onchocerca volvulus 0.004 0.1056 0.1703
Echinococcus granulosus sulfide:quinone oxidoreductase 0.001 0.011 0.011
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0295 0.0295
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0039 0.1039 0.1039
Plasmodium vivax JmjC domain containing protein 0.0016 0.0295 0.0559
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1791 0.5103
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.1056 0.1547
Brugia malayi glutamate synthase 0.001 0.011 0.011
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0295 0.0559
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.011 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.1039 0.3035
Plasmodium vivax thioredoxin reductase, putative 0.0114 0.3422 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0039 0.1039 0.5525
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.1056 0.3085
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.3513 0.4335
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0295 0.0295
Schistosoma mansoni regulator of G protein signaling 0.001 0.0091 0.0133
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0091 0.0091
Treponema pallidum NADH oxidase 0.0039 0.1039 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0295 0.0433
Trypanosoma cruzi NADH dehydrogenase, putative 0.001 0.011 0.0322
Echinococcus multilocularis muscleblind protein 0.0319 1 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0012 0.0012
Brugia malayi hypothetical protein 0.001 0.0091 0.0091
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.3513 0.4335
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.011 0.011
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.1039 1
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.1056 0.1205
Loa Loa (eye worm) histone methyltransferase 0.0009 0.007 0.007
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0295 0.0295
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0091 0.0091
Brugia malayi hypothetical protein 0.001 0.0091 0.0091
Toxoplasma gondii NADPH-glutathione reductase 0.0039 0.1039 0.2845
Trichomonas vaginalis mercuric reductase, putative 0.0039 0.1039 0.9839
Plasmodium falciparum thioredoxin reductase 0.0114 0.3422 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0324
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.001 0.011 0.0322
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.001 0.011 0.1044
Loa Loa (eye worm) hypothetical protein 0.001 0.011 0.011
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0324
Toxoplasma gondii thioredoxin reductase 0.0114 0.3422 1
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.0324 0.0324
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.1039 0.3035
Brugia malayi beta-lactamase family protein 0.004 0.1056 0.1056
Schistosoma mansoni dep domain containing protein 0.001 0.0091 0.0133
Mycobacterium ulcerans lipase LipD 0.004 0.1056 0.5626
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.001 0.011 0.0322
Loa Loa (eye worm) hypothetical protein 0.004 0.1056 0.1056
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.0443 0.0443
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.001 0.011 0.011
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.001 0.011 0.011
Brugia malayi Matrixin family protein 0.0041 0.1102 0.1102
Leishmania major hypothetical protein, conserved 0.004 0.1056 0.2855
Onchocerca volvulus 0.004 0.1056 0.1703
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.011 0.1044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.1039 0.3035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.1039 0.3035
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.1039 0.3035
Trypanosoma cruzi trypanothione reductase, putative 0.0114 0.3422 1
Schistosoma mansoni glutamate synthase 0.001 0.011 0.0161
Loa Loa (eye worm) hypothetical protein 0.004 0.1056 0.1056
Toxoplasma gondii selenide, water dikinase 0.001 0.011 0.0058
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0091 0.0091
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1791 0.2141
Trypanosoma brucei trypanothione reductase 0.0114 0.3422 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0039 0.1039 0.1039
Trichomonas vaginalis glutamate synthase, putative 0.001 0.011 0.1044
Onchocerca volvulus 0.004 0.1056 0.1703
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.1056 0.1205
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.035 0.035
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0039 0.1039 0.2803
Echinococcus multilocularis muscleblind protein 1 0.0319 1 1
Brugia malayi Matrixin family protein 0.0017 0.0324 0.0324
Plasmodium vivax hypothetical protein, conserved 0.004 0.1056 0.2855
Mycobacterium leprae PROBABLE HYDROLASE 0.0021 0.0443 0.0769
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0295 0.0295
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.0324 0.0474
Brugia malayi Hemopexin family protein 0.0024 0.0553 0.0553
Brugia malayi Matrixin family protein 0.0017 0.0324 0.0324
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0091 0.0091
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0295 0.0295
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.007 0.007
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.3513 0.7856
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0012 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1791 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0295 0.0295
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.011 0.011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.7959 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.1056 0.1056
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0039 0.1039 0.2845
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0295 0.0295
Brugia malayi Thioredoxin reductase 0.0114 0.3422 0.3422
Onchocerca volvulus 0.003 0.0728 0.1175
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.001 0.011 0.011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0114 0.3422 0.3422
Mycobacterium tuberculosis Probable oxidoreductase 0.0146 0.4441 0.5518
Schistosoma mansoni cpg binding protein 0.003 0.0728 0.1067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0295 0.0295
Toxoplasma gondii ABC1 family protein 0.004 0.1056 0.2896
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0039 0.1039 0.1183
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0728 0.0728
Entamoeba histolytica disulphide oxidoreductase, putative 0.001 0.011 1
Mycobacterium tuberculosis Conserved protein 0.004 0.1056 0.1205
Giardia lamblia NADH oxidase lateral transfer candidate 0.0039 0.1039 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.1056 0.1205
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.011 0.1044
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.011 0.0322
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0703 0.0703
Entamoeba histolytica thioredoxin reductase, putative 0.001 0.011 1
Mycobacterium ulcerans hydrolase 0.0021 0.0443 0.1982
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.1056 0.5626
Onchocerca volvulus Matrilysin homolog 0.0017 0.0324 0.0522
Loa Loa (eye worm) hypothetical protein 0.004 0.1056 0.1056
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0039 0.1039 0.2803
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.1056 1
Loa Loa (eye worm) hypothetical protein 0.004 0.1056 0.1056
Onchocerca volvulus Matrilysin homolog 0.0038 0.0992 0.1601
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0295 0.0295
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.001 0.011 0.0322
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1791 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0039 0.1039 0.2803
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0091 0.0091
Plasmodium falciparum glutathione reductase 0.0114 0.3422 1
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0091 0.0091
Loa Loa (eye worm) beta-lactamase 0.004 0.1056 0.1056
Loa Loa (eye worm) programmed cell death 8 0.001 0.011 0.011
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0091 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.1056 1
Schistosoma mansoni glutamate synthase 0.001 0.011 0.0161
Leishmania major hypothetical protein, conserved 0.0016 0.0295 0.0559
Loa Loa (eye worm) hypothetical protein 0.0319 1 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.001 0.011 0.0322
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.1056 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.1782 0.2611
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.1056 0.1547
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.1056 0.3085
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.001 0.011 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.001 0.011 0.011
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.1039 0.2803
Plasmodium vivax glutathione reductase, putative 0.0114 0.3422 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.1782 0.2611
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.011 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.001 0.011 0.011
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0062 0.177 0.177
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0295 0.0433
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.011 0.1044
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1791 0.5074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0039 0.1039 0.5525
Schistosoma mansoni hypothetical protein 0.0024 0.0553 0.081
Loa Loa (eye worm) glutathione reductase 0.0114 0.3422 0.3422
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.001 0.011 1
Brugia malayi jmjC domain containing protein 0.0016 0.0295 0.0295
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0041 0.1078 0.158
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.1056 0.1056
Brugia malayi N-terminal motif family protein 0.0201 0.6198 0.6198
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0324
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.001 0.011 0.0322
Trichomonas vaginalis esterase, putative 0.004 0.1056 1
Echinococcus granulosus cpg binding protein 0.0031 0.0783 0.0783
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0295 0.0614
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0703 0.0703
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.011 0.1044
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.1782 0.1782
Trichomonas vaginalis glutathione reductase, putative 0.0039 0.1039 0.9839
Schistosoma mansoni jumonji domain containing protein 0.0061 0.1728 0.2531
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0091 0.0091
Leishmania major trypanothione reductase 0.0114 0.3422 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0201 0.6198 1
Onchocerca volvulus 0.0024 0.0553 0.0892
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0295 0.0559
Mycobacterium tuberculosis Conserved protein 0.004 0.1056 0.1205
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.001 0.011 0.1044
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.011 0.011
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0039 0.1039 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.1039 0.2803
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.3513 0.4335
Brugia malayi Matrixin family protein 0.0017 0.0324 0.0324
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.1056 0.1056

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Inhibition of MAOA in Sprague-Dawley rat brain mitochondria using kynuramine substrate by fluorimetry ChEMBL. 20117937
IC50 (binding) > 100 uM Inhibition of MAOB in Sprague-Dawley rat brain mitochondria using kynuramine substrate by fluorimetry ChEMBL. 20117937

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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