Detailed information for compound 1085849

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.463 | Formula: C23H25N3O3
  • H donors: 1 H acceptors: 2 LogP: 1.99 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C(=O)c1cccc(c1)COc1ccc2c(c1)c(C)cc(=O)[nH]2
  • InChi: 1S/C23H25N3O3/c1-16-12-22(27)24-21-7-6-19(14-20(16)21)29-15-17-4-3-5-18(13-17)23(28)26-10-8-25(2)9-11-26/h3-7,12-14H,8-11,15H2,1-2H3,(H,24,27)
  • InChiKey: QNTFZQLJODAFJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 3B, cGMP-inhibited Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0064 0.014 0.058
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0243 0.0776 0.1012
Loa Loa (eye worm) Smad1 0.0092 0.024 0.0313
Leishmania major cathepsin L-like protease 0.005 0.0089 0.0368
Loa Loa (eye worm) hypothetical protein 0.0442 0.1489 0.1941
Loa Loa (eye worm) hypothetical protein 0.0034 0.003 0.0039
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0064 0.014 0.058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0089 0.0526
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.015 0.0196
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2173 0.7672 1
Plasmodium falciparum thioredoxin reductase 0.0243 0.0776 0.1012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0089 0.0526
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0002 0.0008
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0243 0.0776 0.1012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0064 0.014 0.0136
Schistosoma mansoni survival motor neuron protein 0.0048 0.008 0.0102
Echinococcus granulosus ferritin 0.0035 0.0036 0.0047
Toxoplasma gondii thioredoxin reductase 0.07 0.241 0.3141
Brugia malayi RNA binding protein 0.0454 0.1531 0.1995
Loa Loa (eye worm) MH2 domain-containing protein 0.0092 0.024 0.0313
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1531 0.1941
Loa Loa (eye worm) hypothetical protein 0.0442 0.1489 0.1941
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0027 0.0007 0.0029
Mycobacterium ulcerans hypothetical protein 0.0442 0.1489 0.1903
Echinococcus multilocularis cathepsin L 0.0026 0.0002 0.0003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Plasmodium falciparum ferrodoxin reductase-like protein 0.0064 0.014 0.0182
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0007 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0134 0.017
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0243 0.0776 0.3221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.005 0.009 0.0117
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1597 0.5613 0.5597
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0243 0.0776 0.3221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0134 0.0174
Brugia malayi Probable ClpP-like protease 0.2173 0.7672 1
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0243 0.0776 0.3221
Loa Loa (eye worm) TAR-binding protein 0.0454 0.1531 0.1995
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.0746 0.0972
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2173 0.7672 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0749 0.2584 0.3368
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.2173 0.7672 1
Onchocerca volvulus 0.0497 0.1687 1
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0002 0.0008
Schistosoma mansoni cellular tumor antigen P53 0.0204 0.0639 0.081
Plasmodium vivax vivapain-1 0.0026 0.0002 0.0003
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Schistosoma mansoni Smad4 0.0092 0.024 0.0304
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0193 0.0252
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0243 0.0776 0.3221
Loa Loa (eye worm) PDE1B protein 0.0027 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0091 0.0236 0.0308
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0125 0.0355 0.045
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0297 0.097 0.1264
Schistosoma mansoni hypothetical protein 0.0064 0.014 0.0177
Onchocerca volvulus 0.0048 0.008 0.0477
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0426 0.054
Schistosoma mansoni bromodomain containing protein 0.0071 0.0163 0.0207
Echinococcus multilocularis lamin dm0 0.0197 0.0613 0.0799
Loa Loa (eye worm) hypothetical protein 0.0442 0.1489 0.1941
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2173 0.7672 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0027 0.0007 0.0009
Echinococcus granulosus GPCR family 2 0.0079 0.019 0.0248
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0399 0.052
Brugia malayi MH2 domain containing protein 0.0041 0.0057 0.0075
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.1425 0.4998 0.498
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0002 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Leishmania major hypothetical protein, conserved 0.0064 0.014 0.058
Loa Loa (eye worm) beta-lactamase 0.0442 0.1489 0.1941
Mycobacterium tuberculosis Probable hydrolase 0.0442 0.1489 0.1459
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0007 0.0029
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Plasmodium falciparum phosphodiesterase gamma, putative 0.0027 0.0007 0.0009
Echinococcus multilocularis expressed conserved protein 0.009 0.0231 0.0302
Echinococcus granulosus geminin 0.017 0.0516 0.0673
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0029
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0064 0.014 0.0136
Schistosoma mansoni apoferritin-2 0.0035 0.0036 0.0046
Mycobacterium ulcerans lipase LipD 0.0442 0.1489 0.1903
Trypanosoma brucei NADH dehydrogenase 0.0064 0.014 0.058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0442 0.1489 0.1889
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0027 0.0007 0.0029
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0064 0.014 0.0182
Plasmodium vivax glutathione reductase, putative 0.07 0.241 0.3141
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0064 0.014 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Loa Loa (eye worm) hypothetical protein 0.0096 0.0252 0.0329
Loa Loa (eye worm) hypothetical protein 0.005 0.0089 0.0116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0089 0.0526
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0064 0.014 0.0182
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1597 0.5613 0.5597
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0334 0.1388
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0243 0.0776 0.1012
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0009
Giardia lamblia hypothetical protein 0.0027 0.0007 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Trichomonas vaginalis D-aminoacylase, putative 0.0442 0.1489 0.883
Loa Loa (eye worm) nuclear factor I 0.0051 0.0092 0.012
Echinococcus granulosus tumor protein p63 0.1395 0.489 0.6374
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0243 0.0776 0.3221
Echinococcus multilocularis glutamate synthase 0.0064 0.014 0.0182
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0027 0.0007 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1531 0.1941
Echinococcus multilocularis mothers against decapentaplegic 2 0.0041 0.0057 0.0075
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0243 0.0776 0.3221
Loa Loa (eye worm) hypothetical protein 0.0193 0.06 0.0782
Schistosoma mansoni ferritin 0.0035 0.0036 0.0046
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0064 0.014 0.0182
Trichomonas vaginalis set domain proteins, putative 0.0497 0.1687 1
Echinococcus multilocularis cysteine protease 0.005 0.0089 0.0116
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0243 0.0776 0.0984
Entamoeba histolytica cysteine protease, putative 0.005 0.0089 0.0343
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0064 0.014 0.0182
Schistosoma mansoni zinc finger protein 0.0027 0.0006 0.0008
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1597 0.5613 0.7303
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0057 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Echinococcus multilocularis lamin 0.0197 0.0613 0.0799
Brugia malayi hypothetical protein 0.0056 0.011 0.0144
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0105 0.0287 0.0374
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0002 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0442 0.1489 0.1941
Entamoeba histolytica hypothetical protein 0.0751 0.259 1
Echinococcus granulosus glutamate synthase 0.0064 0.014 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0007 0.0029
Echinococcus multilocularis zinc finger protein 0.0027 0.0006 0.0008
Brugia malayi Pre-SET motif family protein 0.0437 0.1471 0.1917
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.011 0.0144
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2173 0.7672 1
Brugia malayi beta-lactamase family protein 0.0442 0.1489 0.1941
Echinococcus multilocularis musashi 0.0197 0.0613 0.0799
Trypanosoma cruzi hypothetical protein, conserved 0.0442 0.1489 0.618
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0064 0.014 0.0182
Leishmania major hypothetical protein, conserved 0.0064 0.014 0.058
Schistosoma mansoni smad1 5 8 and 0.0092 0.024 0.0304
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0027 0.0007 0.0029
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0002 0.0008
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0095 0.0249 0.0325
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.2173 0.7672 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0064 0.014 0.058
Brugia malayi intermediate filament protein 0.0197 0.0613 0.0799
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0027 0.0007 0.0009
Giardia lamblia NADH oxidase lateral transfer candidate 0.0243 0.0776 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0092 0.024 0.0313
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0751 0.259 0.3376
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0243 0.0776 0.1012
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0007 0.0009
Onchocerca volvulus 0.005 0.0089 0.0526
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Schistosoma mansoni glutamate synthase 0.0064 0.014 0.0177
Echinococcus granulosus expressed conserved protein 0.009 0.0231 0.0302
Mycobacterium tuberculosis Conserved protein 0.0442 0.1489 0.1459
Brugia malayi Cathepsin L-like precursor 0.005 0.0089 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1531 0.1941
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0243 0.0776 0.1012
Schistosoma mansoni lamin 0.0197 0.0613 0.0778
Loa Loa (eye worm) RNA binding protein 0.0454 0.1531 0.1995
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0089 0.0343
Giardia lamblia Thioredoxin reductase 0.0064 0.014 0.1802
Leishmania major hypothetical protein, conserved 0.0027 0.0007 0.0029
Loa Loa (eye worm) MH1 domain-containing protein 0.0092 0.024 0.0313
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0089 0.0116
Schistosoma mansoni hypothetical protein 0.0079 0.019 0.0242
Plasmodium falciparum thioredoxin reductase 0.07 0.241 0.3141
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.003 0.0039
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0027 0.0007 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0442 0.1489 0.883
Loa Loa (eye worm) hypothetical protein 0.0071 0.0164 0.0214
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0064 0.014 0.054
Schistosoma mansoni hypothetical protein 0.0079 0.019 0.0242
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0064 0.014 0.0182
Schistosoma mansoni glutamate synthase 0.0064 0.014 0.0177
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0334 0.0391
Onchocerca volvulus 0.005 0.0089 0.0526
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0007 0.0041
Brugia malayi cytoplasmic intermediate filament protein 0.0105 0.0287 0.0374
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Echinococcus multilocularis tar DNA binding protein 0.0454 0.1531 0.1995
Echinococcus granulosus cathepsin L 0.0026 0.0002 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0751 0.259 0.3376
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0064 0.014 0.0182
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.07 0.241 0.2382
Trypanosoma cruzi hypothetical protein, conserved 0.0442 0.1489 0.618
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0252 0.0973
Toxoplasma gondii selenide, water dikinase 0.0064 0.014 0.0182
Schistosoma mansoni disulfide oxidoreductase 0.0064 0.014 0.0177
Loa Loa (eye worm) hypothetical protein 0.017 0.0516 0.0673
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0007 0.0029
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0442 0.1489 0.1459
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.019 0.0248
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0002 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Schistosoma mansoni transcription factor LCR-F1 0.0751 0.259 0.3285
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0074
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0064 0.014 0.0136
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.2173 0.7672 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0243 0.0776 0.0845
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0009
Echinococcus granulosus beta LACTamase domain containing family member 0.0442 0.1489 0.1941
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0064 0.014 0.0104
Brugia malayi Cathepsin L-like precursor 0.0034 0.003 0.0039
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0089 0.0116
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0027 0.0007 0.0009
Brugia malayi Thioredoxin reductase 0.07 0.241 0.3141
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0243 0.0776 0.1012
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.0007 0.0009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.0426 0.0555
Onchocerca volvulus 0.0197 0.0613 0.3635
Mycobacterium tuberculosis Probable oxidoreductase 0.1775 0.6249 0.6235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0089 0.0526
Loa Loa (eye worm) hypothetical protein 0.2173 0.7672 1
Leishmania major hypothetical protein, conserved 0.0064 0.014 0.058
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.014 0.0829
Plasmodium vivax phosphodiesterase gamma, putative 0.0027 0.0007 0.0009
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0027 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0248 0.0797 0.1038
Trypanosoma cruzi NADH dehydrogenase, putative 0.0064 0.014 0.058
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0027 0.0007 0.0041
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0334 0.0436
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0252 0.0329
Loa Loa (eye worm) hypothetical protein 0.0041 0.0057 0.0075
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0089 0.0368
Echinococcus granulosus mothers against decapentaplegic 2 0.0041 0.0057 0.0075
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0064 0.014 0.0182
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0027 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.017 0.0516 0.0655
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0193 0.0746
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.0195 0.0254
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0027 0.0007 0.0009
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0064 0.014 0.0829
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0007 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1531 0.1941
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0334 0.0391
Plasmodium vivax ferrodoxin reductase, putative 0.0064 0.014 0.0182
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0027 0.0007 0.0009
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0442 0.1489 0.1941
Schistosoma mansoni Smad4 0.0041 0.0057 0.0073
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0064 0.014 0.054
Plasmodium vivax vivapain-3 0.0026 0.0002 0.0003
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0064 0.014 0.0829
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0195 0.0248
Loa Loa (eye worm) transcription factor SMAD2 0.1356 0.4753 0.6195
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.014 0.0829
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0089 0.0526
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0064 0.014 0.0182
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1027 0.3578 0.4664
Trypanosoma cruzi trypanothione reductase, putative 0.0243 0.0776 0.3221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0039 0.0051
Schistosoma mansoni hypothetical protein 0.0079 0.019 0.0242
Echinococcus granulosus cysteine protease 0.0026 0.0002 0.0003
Brugia malayi Cathepsin L-like precursor 0.005 0.0089 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Brugia malayi Cathepsin L-like precursor 0.0034 0.003 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0002 0.0008
Onchocerca volvulus Cathepsin L homolog 0.005 0.0089 0.0526
Mycobacterium leprae Probable lipase LipE 0.0442 0.1489 0.1903
Trichomonas vaginalis mercuric reductase, putative 0.0243 0.0776 0.4602
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0027 0.0007 0.0009
Onchocerca volvulus 0.0197 0.0613 0.3635
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0002 0.0008
Leishmania major hypothetical protein, conserved 0.0056 0.011 0.0457
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0426 0.054
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0064 0.014 0.0182
Plasmodium vivax vivapain-2 0.005 0.0089 0.0116
Plasmodium vivax thioredoxin reductase, putative 0.07 0.241 0.3141
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0057 0.0074
Echinococcus granulosus intermediate filament protein 0.0197 0.0613 0.0799
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0007 0.0029
Brugia malayi glutathione reductase 0.07 0.241 0.3141
Brugia malayi Cathepsin L-like precursor 0.005 0.0089 0.0116
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0442 0.1489 0.1459
Mycobacterium ulcerans NADH dehydrogenase 0.0064 0.014 0.0136
Echinococcus granulosus cathepsin l1 0.005 0.0089 0.0116
Trichomonas vaginalis glutamate synthase, putative 0.0064 0.014 0.0829
Loa Loa (eye worm) hypothetical protein 0.0051 0.0092 0.012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.0228 0.0297
Loa Loa (eye worm) ctsf protein 0.005 0.0089 0.0116
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0007 0.0009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1597 0.5613 0.5597
Trichomonas vaginalis penicillin-binding protein, putative 0.0442 0.1489 0.883
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Brugia malayi Intermediate filament tail domain containing protein 0.0197 0.0613 0.0799
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Trypanosoma brucei trypanothione reductase 0.07 0.241 1
Schistosoma mansoni sulfide quinone reductase 0.0064 0.014 0.0177
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.0228 0.0297
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Schistosoma mansoni hypothetical protein 0.0048 0.008 0.0102
Schistosoma mansoni glutamate synthase 0.0064 0.014 0.0177
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0009
Echinococcus multilocularis mothers against decapentaplegic 6 0.0041 0.0057 0.0075
Onchocerca volvulus 0.005 0.0089 0.0526
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Onchocerca volvulus 0.0064 0.014 0.0829
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0009
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0089 0.0116
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0064 0.014 0.0136
Leishmania major cAMP-specific phosphodiesterase, putative 0.0027 0.0007 0.0029
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0002 0.0008
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0064 0.014 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0195 0.0248
Schistosoma mansoni ferritin light chain 0.0035 0.0036 0.0046
Brugia malayi hypothetical protein 0.0751 0.259 0.3376
Leishmania major trypanothione reductase 0.07 0.241 1
Giardia lamblia Glutamate synthase 0.0064 0.014 0.1802
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0057 0.0074
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0027 0.0007 0.0009
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0064 0.014 0.054
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1775 0.6249 0.6235
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0027 0.0007 0.0009
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0064 0.014 0.0182
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0454 0.1531 0.1995
Schistosoma mansoni ferritin 0.0035 0.0036 0.0046
Echinococcus multilocularis cysteine protease 0.005 0.0089 0.0116
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0064 0.014 0.058
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.011 0.0457
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0064 0.014 0.054
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0089 0.0113
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0064 0.014 0.0182
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0064 0.014 0.0182
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Schistosoma mansoni peptidase Clp (S14 family) 0.2173 0.7672 0.9731
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0442 0.1489 0.1903
Echinococcus granulosus lamin dm0 0.0197 0.0613 0.0799
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.005 0.0089 0.0116
Plasmodium falciparum cysteine proteinase falcipain 3 0.005 0.0089 0.0116
Schistosoma mansoni smad 0.0092 0.024 0.0304
Brugia malayi RNA recognition motif domain containing protein 0.0454 0.1531 0.1995
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0064 0.014 0.058
Leishmania major cysteine peptidase A (CPA) 0.005 0.0089 0.0368
Trichomonas vaginalis D-aminoacylase, putative 0.0442 0.1489 0.883
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0002 0.0003
Plasmodium falciparum glutathione reductase 0.0243 0.0776 0.1012
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0007 0.0029
Toxoplasma gondii hypothetical protein 0.0749 0.2584 0.3368
Leishmania major cathepsin L-like protease 0.0191 0.0591 0.2454
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0057 0.0075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0442 0.1489 0.1941
Toxoplasma gondii ABC1 family protein 0.0442 0.1489 0.1941
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.003 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Brugia malayi hypothetical protein 0.0036 0.0039 0.0051
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0442 0.1489 0.1941
Echinococcus granulosus tar DNA binding protein 0.0454 0.1531 0.1995
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0064 0.014 0.0104
Schistosoma mansoni smad1 5 8 and 0.0092 0.024 0.0304
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0027 0.0007 0.0009
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0027 0.0007 0.0009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0134 0.0174
Loa Loa (eye worm) hypothetical protein 0.0197 0.0613 0.0799
Echinococcus granulosus Smad4 0.0092 0.024 0.0313
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.0007 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.014 0.058
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Echinococcus multilocularis smad 0.0092 0.024 0.0313
Loa Loa (eye worm) hypothetical protein 0.0234 0.0746 0.0972
Loa Loa (eye worm) glutathione reductase 0.07 0.241 0.3141
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0064 0.014 0.0182
Brugia malayi mothers against decapentaplegic homolog 3 0.0041 0.0057 0.0075
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0002 0.0008
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0064 0.014 0.054
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0002 0.0008
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0064 0.014 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2173 0.7672 1
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.0746 0.0972
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0243 0.0776 0.3221
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0243 0.0776 0.3221
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0064 0.014 0.058
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.011 0.0457
Mycobacterium tuberculosis Conserved protein 0.0442 0.1489 0.1459
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Plasmodium falciparum glutathione reductase 0.07 0.241 0.3141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0243 0.0776 0.3221
Treponema pallidum thioredoxin reductase (trxB) 0.0064 0.014 0.0136
Brugia malayi beta-lactamase 0.0442 0.1489 0.1941
Echinococcus multilocularis geminin 0.017 0.0516 0.0673
Brugia malayi MH2 domain containing protein 0.1356 0.4753 0.6195
Trichomonas vaginalis penicillin-binding protein, putative 0.0442 0.1489 0.883
Echinococcus multilocularis tumor protein p63 0.1395 0.489 0.6374
Echinococcus multilocularis Smad4 0.0092 0.024 0.0313
Mycobacterium ulcerans glutamate synthase subunit beta 0.0064 0.014 0.0136
Loa Loa (eye worm) programmed cell death 8 0.0064 0.014 0.0182
Brugia malayi TAR-binding protein 0.0454 0.1531 0.1995
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0092 0.024 0.0313
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0442 0.1489 0.1889
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0007 0.0029
Leishmania major hypothetical protein, conserved 0.0442 0.1489 0.618
Schistosoma mansoni Smad4 0.0041 0.0057 0.0073
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.014 0.0829
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.0228 0.0297
Echinococcus granulosus peptidase Clp S14 family 0.1425 0.4998 0.6514
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Echinococcus multilocularis GPCR, family 2 0.0079 0.019 0.0248
Loa Loa (eye worm) hypothetical protein 0.0442 0.1489 0.1941
Onchocerca volvulus 0.0442 0.1489 0.883
Brugia malayi MH1 domain containing protein 0.0092 0.024 0.0313
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0064 0.014 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.003 0.0176
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.011 0.0144
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0243 0.0776 0.3221
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0257 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0002 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.014 0.058
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0591 0.2454
Plasmodium falciparum cysteine proteinase falcipain 1 0.0026 0.0002 0.0003
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0064 0.014 0.0104
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.1425 0.4998 0.6498
Schistosoma mansoni ferritin 0.0035 0.0036 0.0046
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0027 0.0007 0.0029
Schistosoma mansoni intermediate filament proteins 0.0197 0.0613 0.0778
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0064 0.014 0.0136
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.019 0.0248
Schistosoma mansoni apoferritin-2 0.0035 0.0036 0.0046
Brugia malayi Latrophilin receptor protein 2 0.0079 0.019 0.0248
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0007 0.0009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0197 0.0613 0.0799
Trypanosoma cruzi cruzipain precursor, putative 0.0191 0.0591 0.2454
Brugia malayi acetyltransferase, GNAT family protein 0.0297 0.097 0.1264
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.011 0.0457
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0442 0.1489 0.1941
Mycobacterium tuberculosis Conserved protein 0.0442 0.1489 0.1459
Brugia malayi Pre-SET motif family protein 0.0063 0.0134 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0089 0.0526
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0064 0.014 0.0136
Plasmodium vivax unspecified product 0.0026 0.0002 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0002 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0334 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0057 0.0337
Leishmania major hypothetical protein, conserved 0.0027 0.0007 0.0029
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1775 0.6249 0.6235
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Echinococcus multilocularis protein patched 0.0041 0.0057 0.0074
Echinococcus multilocularis beta LACTamase domain containing family member 0.0442 0.1489 0.1941
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0027 0.0007 0.0009
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0027 0.0007 0.0029
Onchocerca volvulus 0.0204 0.0639 0.3788
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1775 0.6249 0.8136
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0064 0.014 0.0182
Onchocerca volvulus 0.0063 0.0134 0.0793
Echinococcus granulosus cathepsin L cysteine proteinase 0.005 0.0089 0.0116
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0064 0.014 0.0136
Echinococcus multilocularis expressed protein 0.0035 0.0036 0.0047
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0027 0.0007 0.0009
Leishmania major cathepsin L-like protease 0.0191 0.0591 0.2454
Brugia malayi Smad1 0.0092 0.024 0.0313
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0002 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0334 0.0424
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0064 0.014 0.058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0009
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0243 0.0776 0.1012
Leishmania major cathepsin L-like protease 0.005 0.0089 0.0368
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.0228 0.0297
Plasmodium vivax SET domain protein, putative 0.0063 0.0134 0.0174
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0002 0.0008
Onchocerca volvulus 0.005 0.0089 0.0526
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Leishmania major cathepsin L-like protease 0.005 0.0089 0.0368
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0027 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0091 0.0236 0.0308
Trypanosoma cruzi trypanothione reductase, putative 0.07 0.241 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.019 0.0248
Leishmania major cathepsin L-like protease 0.005 0.0089 0.0368
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0243 0.0776 0.3221
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.011 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0007 0.0041
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0355 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0007 0.0041
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0089 0.0343
Trypanosoma cruzi NADH dehydrogenase, putative 0.0064 0.014 0.058
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0064 0.014 0.058
Loa Loa (eye worm) thioredoxin reductase 0.07 0.241 0.3141
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.2173 0.7672 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Brugia malayi Cathepsin L-like precursor 0.005 0.0089 0.0116
Brugia malayi Cathepsin L-like precursor 0.005 0.0089 0.0116
Trichomonas vaginalis glutathione reductase, putative 0.0243 0.0776 0.4602
Giardia lamblia Hypothetical protein 0.0027 0.0007 0.0089
Echinococcus multilocularis mothers against decapentaplegic 5 0.0092 0.024 0.0313
Trichomonas vaginalis apoptosis inducing factor, putative 0.0064 0.014 0.0829
Trichomonas vaginalis ferritin, putative 0.0035 0.0036 0.0213
Mycobacterium ulcerans ferredoxin reductase 0.0064 0.014 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0749 0.2584 0.3368
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0027 0.0007 0.0041
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0064 0.014 0.0136
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0065
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.014 0.0829
Trypanosoma cruzi major cysteine proteinase, putative 0.015 0.0446 0.1849
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.0797 0.1038
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0027 0.0007 0.0009
Echinococcus granulosus zinc finger protein 0.0027 0.0006 0.0008
Brugia malayi PHD-finger family protein 0.0032 0.0025 0.0033
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0243 0.0776 0.0969
Onchocerca volvulus 0.0034 0.003 0.0176
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0007 0.0009
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0064 0.014 0.0136
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0243 0.0776 0.1012
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0057 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0089 0.0526
Onchocerca volvulus 0.005 0.0089 0.0526
Schistosoma mansoni microtubule-associated protein tau 0.0723 0.2494 0.3163
Schistosoma mansoni patched 1 0.0041 0.0057 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0089 0.0526
Brugia malayi Cathepsin L-like precursor 0.005 0.0089 0.0116
Onchocerca volvulus 0.005 0.0089 0.0526
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0064 0.014 0.0136
Onchocerca volvulus Cathepsin F homolog 0.005 0.0089 0.0526
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1597 0.5613 0.5597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.014 0.0829
Mycobacterium ulcerans dehydrogenase 0.0064 0.014 0.0136
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0355 0.0463
Loa Loa (eye worm) hypothetical protein 0.1 0.3481 0.4538
Loa Loa (eye worm) acetyltransferase 0.0297 0.097 0.1264
Loa Loa (eye worm) MH2 domain-containing protein 0.1356 0.4753 0.6195
Loa Loa (eye worm) hypothetical protein 0.0064 0.014 0.0182
Echinococcus granulosus cathepsin l cysteine peptidase 0.005 0.0089 0.0116
Plasmodium falciparum phosphodiesterase delta, putative 0.0027 0.0007 0.0009
Onchocerca volvulus 0.0442 0.1489 0.883
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0064 0.014 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0064 0.014 0.0182
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0334 0.0436
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0243 0.0776 0.3221
Toxoplasma gondii cathepsin CPL 0.005 0.0089 0.0116
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.0797 0.1038
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0334 0.0436
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0007 0.0029
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0089 0.0116
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0007 0.0029
Entamoeba histolytica thioredoxin reductase, putative 0.0064 0.014 0.054
Toxoplasma gondii NADPH-glutathione reductase 0.0243 0.0776 0.1012
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0126 0.0164
Loa Loa (eye worm) hypothetical protein 0.005 0.0089 0.0116
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0243 0.0776 0.3221
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Brugia malayi glutamate synthase 0.0064 0.014 0.0182
Echinococcus multilocularis peptidase Clp (S14 family) 0.1425 0.4998 0.6514
Loa Loa (eye worm) hypothetical protein 0.0056 0.011 0.0144
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0027 0.0007 0.0041
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0749 0.2584 0.3337
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Echinococcus granulosus smad 0.0092 0.024 0.0313
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0027 0.0007 0.0089
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0027 0.0007 0.0009
Loa Loa (eye worm) fibroinase 0.005 0.0089 0.0116
Schistosoma mansoni ferritin 0.0035 0.0036 0.0046
Plasmodium falciparum cysteine proteinase falcipain 2a 0.005 0.0089 0.0116
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0027 0.0007 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0089 0.0116
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0064 0.014 0.0182
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.2173 0.7672 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Brugia malayi CHE-14 protein 0.0041 0.0057 0.0074
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.008 0.0105
Schistosoma mansoni smad1 5 8 and 0.0092 0.024 0.0304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.003 0.0176
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0065
Brugia malayi MH2 domain containing protein 0.0092 0.024 0.0313
Plasmodium vivax vivapain-2 0.005 0.0089 0.0116
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0064 0.014 0.0182
Echinococcus multilocularis microtubule associated protein 2 0.0723 0.2494 0.325
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.0007 0.0009
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0027 0.0007 0.0009
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.0228 0.135
Onchocerca volvulus 0.005 0.0089 0.0526
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.2173 0.7672 1
Echinococcus granulosus lamin 0.0197 0.0613 0.0799
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0027 0.0007 0.0009
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0243 0.0776 0.0743
Schistosoma mansoni hypothetical protein 0.0751 0.259 0.3285
Treponema pallidum oxidoreductase 0.0064 0.014 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0591 0.2454
Brugia malayi Bromodomain containing protein 0.0083 0.0205 0.0268
Echinococcus multilocularis protein dispatched 1 0.0047 0.0078 0.0101
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Echinococcus granulosus thioredoxin glutathione reductase 0.0701 0.2412 0.3144
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0252 0.0329
Entamoeba histolytica cysteine proteinase 2 0.0026 0.0002 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0442 0.1489 0.618
Echinococcus multilocularis ferritin 0.0035 0.0036 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0064 0.014 0.0136
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0252 0.0329
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0243 0.0776 0.3221
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.011 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0002 0.0012
Brugia malayi hypothetical protein 0.0234 0.0746 0.0972
Loa Loa (eye worm) hypothetical protein 0.0204 0.0639 0.0833
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.1425 0.4998 0.498
Brugia malayi cathepsin L-like precursor 0.0034 0.003 0.0039
Mycobacterium tuberculosis Probable reductase 0.1597 0.5613 0.5597
Schistosoma mansoni lamin 0.0197 0.0613 0.0778
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.014 0.058
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0064 0.014 0.0136
Loa Loa (eye worm) hypothetical protein 0.0048 0.0082 0.0107
Onchocerca volvulus 0.0442 0.1489 0.883
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0027 0.0007 0.0009
Treponema pallidum NADH oxidase 0.0243 0.0776 0.0969
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0089 0.0526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Schistosoma mansoni smad 0.0041 0.0057 0.0073
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0749 0.2584 0.3337
Trichomonas vaginalis glutamate synthase, putative 0.0064 0.014 0.0829
Loa Loa (eye worm) hypothetical protein 0.0034 0.003 0.0039
Entamoeba histolytica hypothetical protein 0.0751 0.259 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0178 0.0546 0.0712
Mycobacterium tuberculosis Probable lipase LipD 0.0442 0.1489 0.1459
Leishmania major NADH dehydrogenase, putative 0.0064 0.014 0.058
Trichomonas vaginalis esterase, putative 0.0442 0.1489 0.883
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0002 0.0003
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0178 0.0546 0.0712
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0243 0.0776 0.0969
Echinococcus granulosus cathepsin l1 0.0034 0.003 0.0039
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0079 0.019 0.0248
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0048 0.0062
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0039 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0095 0.0249 0.0325
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.014 0.0829
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0064 0.014 0.0182
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0516 0.0673
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0065
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0079 0.019 0.0242
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0027 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0034 0.003 0.0039
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.1471 0.1917
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0064 0.014 0.0182
Brugia malayi beta-lactamase family protein 0.0442 0.1489 0.1941
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.019 0.0248
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0092 0.024 0.0304
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0027 0.0007 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0442 0.1489 0.1459
Schistosoma mansoni hypothetical protein 0.017 0.0516 0.0655
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0064 0.014 0.0829
Mycobacterium tuberculosis Probable esterase LipL 0.0442 0.1489 0.1459
Loa Loa (eye worm) cysteine protease 0.005 0.0089 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0134 0.017
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.003 0.0114
Brugia malayi MH2 domain containing protein 0.0092 0.024 0.0313
Echinococcus granulosus mothers against decapentaplegic 6 0.0041 0.0057 0.0075
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0027 0.0007 0.0029
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.2173 0.7672 1
Schistosoma mansoni sulfide quinone reductase 0.0064 0.014 0.0177
Mycobacterium leprae conserved hypothetical protein 0.0442 0.1489 0.1903
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0007 0.0029
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0193 0.2491
Loa Loa (eye worm) hypothetical protein 0.1027 0.3578 0.4664
Brugia malayi MH1 domain containing protein 0.0051 0.0092 0.012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Echinococcus granulosus expressed protein 0.0035 0.0036 0.0047
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.0228 0.135
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0064 0.014 0.0136
Mycobacterium ulcerans monoxygenase 0.0064 0.014 0.0136
Mycobacterium tuberculosis Probable dehydrogenase 0.1597 0.5613 0.5597
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0089 0.0526
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0174 0.0532 0.2209
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0243 0.0776 0.0969
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0334 0.0391
Echinococcus granulosus TGF beta signal transducer SmadC 0.0092 0.024 0.0313
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0064 0.014 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0002 0.0003
Brugia malayi Bromodomain containing protein 0.0046 0.0073 0.0096
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0007 0.0041
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0243 0.0776 0.0969
Echinococcus granulosus histone acetyltransferase KAT2B 0.0286 0.0932 0.1215
Loa Loa (eye worm) intermediate filament protein 0.0197 0.0613 0.0799
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0089 0.0526
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0064 0.014 0.0182
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.017 0.0516 0.0655
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.0195 0.0254
Mycobacterium ulcerans hypothetical protein 0.0064 0.014 0.0136
Brugia malayi MH1 domain containing protein 0.0051 0.0092 0.012
Echinococcus multilocularis thioredoxin glutathione reductase 0.0701 0.2412 0.3144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0591 0.2454
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0041 0.0057 0.034
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0064 0.014 0.0104
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0027 0.0007 0.0041
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0089 0.0113
Plasmodium falciparum cysteine proteinase falcipain 2b 0.005 0.0089 0.0116
Leishmania major cathepsin L-like protease 0.005 0.0089 0.0368
Echinococcus granulosus microtubule associated protein 2 0.0723 0.2494 0.325
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0064 0.014 0.0104
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0057 0.0075
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0064 0.014 0.1802
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.019 0.0248
Mycobacterium ulcerans esterase/lipase LipP 0.0442 0.1489 0.1903
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0297 0.097 0.123
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0027 0.0007 0.0009
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0334 0.03
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0064 0.014 0.0104
Schistosoma mansoni ferritin light chain 0.0035 0.0036 0.0046
Entamoeba histolytica disulphide oxidoreductase, putative 0.0064 0.014 0.054
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0243 0.0776 0.3221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0243 0.0776 0.3221
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.015 0.0196
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0027 0.0007 0.0029
Mycobacterium ulcerans beta-lactamase 0.0442 0.1489 0.1903
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0064 0.014 0.0829
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2173 0.7672 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0089 0.0526
Entamoeba histolytica cysteine protease, putative 0.0026 0.0002 0.0008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.019 0.0248
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0089 0.0116
Onchocerca volvulus Cathepsin L homolog 0.005 0.0089 0.0526
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0027 0.0007 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0243 0.0776 0.0969
Loa Loa (eye worm) hypothetical protein 0.008 0.0195 0.0254
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0064 0.014 0.058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.0797 0.1038
Entamoeba histolytica cysteine proteinase 1, putative 0.0026 0.0002 0.0008
Entamoeba histolytica hypothetical protein 0.0751 0.259 1
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0591 0.2454
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0064 0.014 0.0182
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0442 0.1489 0.1459
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1531 0.1941
Leishmania major cathepsin L-like protease 0.0191 0.0591 0.2454
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0399 0.052
Brugia malayi MH1 domain containing protein 0.0092 0.024 0.0313
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0095 0.0249 0.0325
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0007 0.0029
Entamoeba histolytica hypothetical protein 0.0751 0.259 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.76 uM Inhibition of human PDE3A by fluorescence microplate reader ChEMBL. 20005117
IC50 (binding) = 3.51 uM Inhibition of human PDE3B by fluorescence microplate reader ChEMBL. 20005117
Ratio IC50 (binding) = 4 Ratio of IC50 for drug to IC50 for vesnarinone against human PDE3B by fluorescence microplate reader ChEMBL. 20005117
Ratio IC50 (binding) = 6 Ratio of IC50 for drug to IC50 for vesnarinone against human PDE3A by fluorescence microplate reader ChEMBL. 20005117

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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