Detailed information for compound 1085965

Basic information

Technical information
  • TDR Targets ID: 1085965
  • Name: 3-(5-bromo-1,3-thiazol-2-yl)-1-(3-methylpheny l)sulfonylurea
  • MW: 376.249 | Formula: C11H10BrN3O3S2
  • H donors: 2 H acceptors: 4 LogP: 3.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NS(=O)(=O)c1cccc(c1)C)Nc1ncc(s1)Br
  • InChi: 1S/C11H10BrN3O3S2/c1-7-3-2-4-8(5-7)20(17,18)15-10(16)14-11-13-6-9(12)19-11/h2-6H,1H3,(H2,13,14,15,16)
  • InChiKey: UGGXZOFPTPJQCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(5-bromothiazol-2-yl)-1-(3-methylphenyl)sulfonyl-urea
  • 3-(5-bromo-2-thiazolyl)-1-(3-methylphenyl)sulfonylurea
  • 3-(5-bromo-1,3-thiazol-2-yl)-1-(3-methylphenyl)sulfonyl-urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fructose-1,6-bisphosphatase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni fructose-16-bisphosphatase-related Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma japonicum ko:K03841 fructose-1,6-bisphosphatase I, putative Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus granulosus fructose 16 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei gambiense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania donovani fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania braziliensis fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania major Get druggable targets OG5_127400 All targets in OG5_127400
Toxoplasma gondii fructose-bisphospatase II Get druggable targets OG5_127400 All targets in OG5_127400
Loa Loa (eye worm) fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma congolense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Neospora caninum Fructose-1 6-biphosphatase, related Get druggable targets OG5_127400 All targets in OG5_127400
Candida albicans similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania mexicana fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania infantum fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii fructose-bisphospatase I fructose-1,6-bisphosphatase 1 338 aa 326 aa 31.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0189 0.2511 0.2511
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0933 0.1423
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.1122 0.1122
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0189 0.2511 0.2511
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0132 0.0201
Loa Loa (eye worm) hypothetical protein 0.005 0.0443 0.0675
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0618 0.0618
Plasmodium falciparum histone deacetylase 2 0.0253 0.3465 0.5285
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0189 0.2511 0.3829
Echinococcus granulosus histone deacetylase 1 0.0461 0.6556 0.6556
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0379 0.0579
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0142 0.0142
Schistosoma mansoni histone deacetylase 0.0461 0.6556 0.6556
Onchocerca volvulus 0.0026 0.0089 0.0276
Schistosoma mansoni histone deacetylase 4 5 0.0253 0.3465 0.3465
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0142 0.0142
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0089 0.0136
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0089 0.0136
Loa Loa (eye worm) hypothetical protein 0.0461 0.6556 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0132 0.0132
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.007 0.0743 0.1133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0379 0.0379
Echinococcus granulosus histone deacetylase 6 0.0253 0.3465 0.3465
Brugia malayi Histone deacetylase family protein 0.0253 0.3465 0.5285
Echinococcus granulosus histone deacetylase 8 0.016 0.2079 0.2079
Trypanosoma brucei histone deacetylase, putative 0.0253 0.3465 0.5285
Loa Loa (eye worm) hypothetical protein 0.0093 0.1082 0.1651
Plasmodium falciparum histone deacetylase 1 0.0461 0.6556 1
Schistosoma mansoni hypothetical protein 0.0083 0.0933 0.0933
Echinococcus granulosus histone deacetylase 0.0253 0.3465 0.3465
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0933 0.0933
Trichomonas vaginalis histone deacetylase, putative 0.0461 0.6556 1
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0189 0.2511 0.3829
Brugia malayi Histone deacetylase family protein 0.0253 0.3465 0.5285
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.0125
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0933 0.1423
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0223 0.0223
Trichomonas vaginalis histone deacetylase, putative 0.0461 0.6556 1
Schistosoma mansoni hypothetical protein 0.0033 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0201
Plasmodium vivax SET domain protein, putative 0.003 0.0142 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0379 0.0379
Echinococcus multilocularis histone deacetylase 3 0.0461 0.6556 0.6556
Plasmodium vivax histone deacetylase, putative 0.016 0.2079 0.3171
Echinococcus granulosus tar DNA binding protein 0.0062 0.0618 0.0618
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0223 0.0223
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0189 0.2511 0.3829
Loa Loa (eye worm) glutaminase 2 0.0274 0.3778 0.5762
Leishmania major histone deacetylase, putative 0.0253 0.3465 0.5285
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0217
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0422 0.0644
Trichomonas vaginalis histone deacetylase, putative 0.0461 0.6556 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0933 0.0933
Trypanosoma brucei histone deacetylase 3 0.0253 0.3465 0.5285
Schistosoma mansoni histone deacetylase hda2 0.016 0.2079 0.2079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0126 0.0126
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.007 0.0743 0.1133
Loa Loa (eye worm) RNA binding protein 0.0062 0.0618 0.0943
Schistosoma mansoni microtubule-associated protein tau 0.0692 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0192 0.0294
Trypanosoma cruzi histone deacetylase, putative 0.016 0.2079 0.3171
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0933 0.0933
Entamoeba histolytica hypothetical protein 0.0108 0.1311 0.1999
Echinococcus granulosus histone deacetylase 3 0.0461 0.6556 0.6556
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.007 0.0743 0.1133
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0132 0.0201
Echinococcus multilocularis peregrin 0.0029 0.0132 0.0132
Trypanosoma brucei histone deacetylase 4 0.0253 0.3465 0.5285
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0618 0.0618
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.007 0.0743 0.1133
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0132 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0379 0.0379
Echinococcus multilocularis histone deacetylase 7 0.0253 0.3465 0.3465
Loa Loa (eye worm) hypothetical protein 0.016 0.2079 0.3171
Mycobacterium ulcerans glutaminase 0.0274 0.3778 0.5
Schistosoma mansoni histone deacetylase 1 2 3 0.016 0.2079 0.2079
Loa Loa (eye worm) histone deacetylase 3 0.0461 0.6556 1
Schistosoma mansoni histone deacetylase 0.0461 0.6556 0.6556
Loa Loa (eye worm) histone deacetylase 1 0.0461 0.6556 1
Echinococcus multilocularis histone deacetylase 1 0.0461 0.6556 0.6556
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0595 0.0908
Schistosoma mansoni histone deacetylase hda2 0.0273 0.3768 0.3768
Brugia malayi Pre-SET motif family protein 0.003 0.0142 0.0217
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0132 0.0132
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0461 0.6556 1
Entamoeba histolytica hypothetical protein 0.0108 0.1311 0.1999
Giardia lamblia PHD finger protein 15 0.0029 0.0132 0.0201
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.0136
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0132 0.0132
Schistosoma mansoni intermediate filament proteins 0.0026 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0061 0.0611 0.0611
Schistosoma mansoni histone deacetylase 4 5 0.0253 0.3465 0.3465
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0089 0.0136
Brugia malayi jmjC domain containing protein 0.0035 0.0223 0.0341
Loa Loa (eye worm) histone deacetylase 11 0.016 0.2079 0.3171
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0142 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0379 0.0379
Schistosoma mansoni lamin 0.0026 0.0089 0.0089
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0618 0.0943
Entamoeba histolytica histone deacetylase, putative 0.0461 0.6556 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0618 0.0943
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.1311 0.1311
Echinococcus granulosus intermediate filament protein 0.0026 0.0089 0.0089
Toxoplasma gondii histone deacetylase HDAC5 0.016 0.2079 0.3171
Brugia malayi DnaJ domain containing protein 0.0061 0.0611 0.0932
Giardia lamblia Histone deacetylase 0.0461 0.6556 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0192 0.0294
Leishmania major histone deacetylase, putative 0.0253 0.3465 0.5285
Echinococcus multilocularis microtubule associated protein 2 0.0692 1 1
Trypanosoma brucei histone deacetylase 2 0.016 0.2079 0.3171
Schistosoma mansoni hypothetical protein 0.0108 0.1311 0.1311
Onchocerca volvulus Alhambra homolog 0.0029 0.0132 0.0407
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0461 0.6556 1
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0829 0.0829
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2804 0.4277
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0223 0.0223
Trypanosoma cruzi histone deacetylase 1, putative 0.0461 0.6556 1
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3233 0.4931
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0142 0.0142
Schistosoma mansoni glutaminase 0.0274 0.3778 0.3778
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0422 0.0644
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0422 0.0644
Brugia malayi PHD-finger family protein 0.0029 0.0132 0.0201
Plasmodium falciparum phd finger protein, putative 0.0029 0.0132 0.0201
Brugia malayi Histone deacetylase 1 0.0461 0.6556 1
Onchocerca volvulus 0.003 0.0142 0.044
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0189 0.2511 0.2511
Brugia malayi Pre-SET motif family protein 0.0209 0.2804 0.4277
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0379 0.0379
Trichomonas vaginalis histone deacetylase, putative 0.0461 0.6556 1
Echinococcus granulosus histone deacetylase 6 0.0253 0.3465 0.3465
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0132 0.0201
Trypanosoma cruzi histone deacetylase, putative 0.0253 0.3465 0.5285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0379 0.0379
Echinococcus multilocularis histone deacetylase 0.0253 0.3465 0.3465
Toxoplasma gondii histone deacetylase HDAC1 0.0253 0.3465 0.5285
Echinococcus granulosus histone deacetylase 7 0.0253 0.3465 0.3465
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.0611 0.0611
Loa Loa (eye worm) glutaminase 0.0274 0.3778 0.5762
Brugia malayi histone deacetylase 3 (HD3) 0.0461 0.6556 1
Brugia malayi Bromodomain containing protein 0.0029 0.0132 0.0201
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.0611 0.0932
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0618 0.0943
Entamoeba histolytica hypothetical protein 0.0108 0.1311 0.1999
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0302 0.0302
Plasmodium falciparum histone deacetylase, putative 0.0253 0.3465 0.5285
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0142 0.0142
Plasmodium vivax histone deacetylase, putative 0.0253 0.3465 0.5285
Loa Loa (eye worm) hypothetical protein 0.0113 0.1386 0.2114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0142 0.0142
Trichomonas vaginalis histone deacetylase, putative 0.0461 0.6556 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.1311 0.1311
Leishmania major histone deacetylase, putative 0.0461 0.6556 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0933 0.0933
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.1311 0.1311
Toxoplasma gondii fructose-bisphospatase II 0.0189 0.2511 0.3829
Loa Loa (eye worm) hypothetical protein 0.0049 0.0422 0.0644
Echinococcus multilocularis histone deacetylase 6 0.0253 0.3465 0.3465
Onchocerca volvulus Histone deacetylase 10 homolog 0.016 0.2079 0.643
Brugia malayi TAR-binding protein 0.0062 0.0618 0.0943
Schistosoma mansoni hypothetical protein 0.0083 0.0933 0.0933
Echinococcus granulosus histone deacetylase 6 0.0273 0.3768 0.3768
Plasmodium vivax histone deacetylase 2, putative 0.0253 0.3465 0.5285
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0189 0.2511 0.3829
Brugia malayi histone deacetylase 1 (HD1) 0.0461 0.6556 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0618 0.0618
Echinococcus granulosus peregrin 0.0029 0.0132 0.0132
Brugia malayi intermediate filament protein 0.0026 0.0089 0.0136
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0083 0.0933 0.1423
Loa Loa (eye worm) histone deacetylase 7A 0.0253 0.3465 0.5285
Trypanosoma cruzi histone deacetylase, putative 0.016 0.2079 0.3171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0379 0.0379
Echinococcus multilocularis musashi 0.0026 0.0089 0.0089
Onchocerca volvulus 0.0026 0.0089 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0618 0.0618
Trichomonas vaginalis histone deacetylase, putative 0.0461 0.6556 1
Echinococcus granulosus lamin 0.0026 0.0089 0.0089
Echinococcus multilocularis lamin dm0 0.0026 0.0089 0.0089
Schistosoma mansoni lamin 0.0026 0.0089 0.0089
Echinococcus granulosus lamin dm0 0.0026 0.0089 0.0089
Echinococcus multilocularis histone deacetylase 8 0.016 0.2079 0.2079
Brugia malayi glutaminase DH11.1 0.0274 0.3778 0.5762
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0933 0.0933
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0302 0.0302
Trypanosoma cruzi histone deacetylase, putative 0.0253 0.3465 0.5285
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0142 0.0217
Brugia malayi jmjC domain containing protein 0.0096 0.1122 0.1711
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0618 0.0618
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.1122 0.1122
Echinococcus multilocularis histone deacetylase 6 0.0273 0.3768 0.3768
Brugia malayi RNA binding protein 0.0062 0.0618 0.0943
Brugia malayi histone deacetylase 11 0.016 0.2079 0.3171
Toxoplasma gondii histone deacetylase HDAC2 0.0461 0.6556 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0379 0.0579
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.0611 0.0932
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0933 0.0933
Plasmodium vivax histone deacetylase 1, putative 0.0461 0.6556 1
Schistosoma mansoni hypothetical protein 0.0029 0.0132 0.0132
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0142 0.0142
Loa Loa (eye worm) histone deacetylase 0.0253 0.3465 0.5285
Brugia malayi fructose-1,6-bisphosphatase 0.0189 0.2511 0.3829
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0223 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0618 0.0618
Leishmania major 0.0189 0.2511 0.3829
Toxoplasma gondii histone deacetylase HDAC3 0.0461 0.6556 1
Entamoeba histolytica hypothetical protein 0.0108 0.1311 0.1999
Echinococcus multilocularis histone deacetylase 6 0.0253 0.3465 0.3465
Brugia malayi hypothetical protein 0.0108 0.1311 0.1999
Trypanosoma cruzi histone deacetylase 1, putative 0.0461 0.6556 1
Trypanosoma cruzi histone deacetylase, putative 0.0253 0.3465 0.5285
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0461 0.6556 1
Toxoplasma gondii histone deacetylase HDAC4 0.016 0.2079 0.3171
Toxoplasma gondii fructose-bisphospatase I 0.007 0.0743 0.1133
Trichomonas vaginalis glutaminase, putative 0.0274 0.3778 0.5762
Echinococcus multilocularis lamin 0.0026 0.0089 0.0089
Onchocerca volvulus 0.0238 0.3233 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0223 0.0341
Schistosoma mansoni hypothetical protein 0.0083 0.0933 0.0933
Leishmania major histone deacetylase, putative 0.0461 0.6556 1
Trypanosoma brucei histone deacetylase 1 0.0461 0.6556 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 23 uM Inhibition of FBPase in mouse liver ChEMBL. 19969452
IC50 (binding) = 0.17 uM Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate ChEMBL. 19969452
IC50 (binding) = 0.31 uM Inhibition of FBPase in human liver ChEMBL. 19969452

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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