Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.4231 | 0.913 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0207 | 0.0446 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0101 | 0.4448 | 0.8914 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.0515 | 0.1111 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.292 | 0.5853 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.01 | 0.0226 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.4448 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0207 | 0.0446 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.01 | 0.0226 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.1165 | 0.2513 |
Trypanosoma brucei | polo-like protein kinase | 0.0101 | 0.4448 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.1405 | 0.0938 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.1405 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.292 | 0.5853 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 0.4231 | 0.8481 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.2528 | 0.5455 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.2238 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.0515 | 0.1111 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1405 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.01 | 0.0226 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0515 | 0.1111 |
Onchocerca volvulus | 0.0028 | 0.1092 | 0.2454 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1405 | 0.2816 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0101 | 0.4448 | 0.9597 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0101 | 0.4448 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0515 | 0.1111 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.1449 | 0.2904 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1405 | 0.2263 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.1405 | 0.0938 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.335 | 0.7229 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.335 | 0.6715 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.1405 | 0.0938 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.1405 | 0.2263 |
Echinococcus multilocularis | GPCR, family 2 | 0.0036 | 0.1449 | 0.3126 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1405 | 0.2816 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.2106 | 0.4735 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.292 | 0.6301 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1165 | 0.2513 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.1405 | 0.2263 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1405 | 0.0938 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0113 | 0.4989 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1405 | 0.0938 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.01 | 0.0226 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0515 | 0.1111 |
Onchocerca volvulus | 0.0035 | 0.1405 | 0.3159 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.1405 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1405 | 0.2816 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1405 | 0.2816 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1405 | 0.3159 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1405 | 0.0938 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.1405 | 0.0938 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.4448 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0036 | 0.1449 | 0.3126 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.01 | 0.0226 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.4448 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1449 | 0.2904 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.4231 | 0.913 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0201 | 0.0404 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.1092 | 0.2188 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.292 | 0.6301 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4989 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1405 | 0.2816 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.1092 | 0.2355 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.1449 | 0.2904 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.4448 | 0.9597 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1405 | 0.3159 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.1405 | 0.2816 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.0515 | 0.1032 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0515 | 0.1111 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.1405 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.01 | 0.0226 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.292 | 0.6301 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.0515 | 0.1032 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.292 | 0.6301 |
Onchocerca volvulus | 0.0035 | 0.1405 | 0.3159 | |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.1405 | 0.0938 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0128 | 0.0277 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0096 | 0.4231 | 0.8481 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.292 | 0.5853 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.01 | 0.0226 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.1165 | 0.2513 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.01 | 0.0226 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.4634 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1405 | 0.3032 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0105 | 0.4634 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.01 | 0.0226 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.01 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.335 | 0.6715 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0128 | 0.0277 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.1405 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.01 | 0.0226 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1449 | 0.3126 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.1092 | 0.2188 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.292 | 0.5853 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.01 | 0.0226 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.1405 | 0.3159 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.1449 | 0.3126 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1449 | 0.3126 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.292 | 0.6301 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1405 | 0.3159 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.292 | 0.6301 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.4448 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.1405 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0101 | 0.4448 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.4231 | 0.913 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.4448 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.1449 | 0.3126 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.01 | 0.0226 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0101 | 0.4448 | 0.9597 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1405 | 0.3032 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1405 | 0.3159 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0105 | 0.4634 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0207 | 0.0414 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.4448 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.1449 | 0.3126 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.1405 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.4231 | 0.913 |
Schistosoma mansoni | kinase | 0.0051 | 0.2167 | 0.4676 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.1405 | 0.2816 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0113 | 0.4989 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0128 | 0.0277 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1405 | 0.2816 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0101 | 0.4448 | 0.9597 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.4634 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.4231 | 0.913 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.1405 | 0.5166 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.292 | 0.6301 |
Brugia malayi | hypothetical protein | 0.0105 | 0.4634 | 0.9289 |
Brugia malayi | RNA binding protein | 0.0068 | 0.292 | 0.5853 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.01 | 0.0226 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.292 | 0.5853 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.4231 | 0.913 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0101 | 0.4448 | 0.8914 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.01 | 0.0226 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0515 | 0.1032 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.4448 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.1449 | 0.2904 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.01 | 0.0226 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.01 | 0.0226 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.1405 | 0.0938 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1405 | 0.2263 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.1449 | 0.3126 |
Brugia malayi | beta-lactamase | 0.0035 | 0.1405 | 0.2816 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0515 | 0.1111 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0128 | 0.0277 |
Giardia lamblia | Kinase, PLK | 0.0101 | 0.4448 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.1405 | 0.3032 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.4448 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1405 | 0.3159 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.4231 | 0.913 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.01 | 0.0226 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.1405 | 0.2816 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1405 | 0.2816 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.2106 | 0.4735 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0128 | 0.0277 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.4634 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1449 | 0.3126 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1405 | 0.2816 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.1405 | 0.3032 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0015 | 0.0515 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1165 | 0.2513 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.4448 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.1405 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.1405 | 0.3159 | |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1449 | 0.3126 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.1405 | 0.0938 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.4634 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0113 | 0.4989 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0105 | 0.4634 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.4634 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 2 % | Inhibition of Candida albicans SAP2 at 10 uM by spectrophotometry | ChEMBL. | 20184325 |
Inhibition (binding) | = 6 % | Inhibition of Candida albicans SAP2 at 10 uM by spectrophotometry relative to pepstatin A | ChEMBL. | 20184325 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.