Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1064 | 0.1064 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.1064 | 0.1064 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.7465 | 0.7465 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.7465 | 0.7465 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.1064 | 0.1064 |
Brugia malayi | TAR-binding protein | 0.0075 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.7465 | 0.7465 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.1064 | 0.1064 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.4503 | 0.4503 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.4503 | 0.4503 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.1064 | 0.1064 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4503 | 0.4503 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1064 | 0.1064 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.7465 | 0.7465 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1064 | 0.1064 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1064 | 0.1064 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.1064 | 0.1064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 1.6228 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | 1.7452 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.