Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3781 | 0.4428 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.7357 | 0.7328 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.7357 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.7357 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.7357 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.7357 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.7357 | 0.7328 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.7357 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.4678 | 0.6015 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4678 | 0.4619 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.3781 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.4393 | 0.5396 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.0453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4678 | 0.4619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.0453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.7357 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.7357 | 0.7328 |
Brugia malayi | hypothetical protein | 0.0018 | 0.2226 | 0.2029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.3781 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.4393 | 0.5 | |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.1361 | 0.108 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3781 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.3781 | 0.4445 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.4393 | 0.5381 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3781 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.3781 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4393 | 0.4331 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.006 | 0.8867 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.1361 | 0.1265 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.1361 | 0.108 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0531 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3781 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.4678 | 0.6015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3781 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 25 ug ml-1 | Antiproliferative activity against human LoVo cells | ChEMBL. | 20022253 |
IC50 (functional) | > 100 ug ml-1 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release | ChEMBL. | 20022253 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.