Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0094 | 0.0094 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0432 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0094 | 0.0143 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0094 | 0.0298 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0094 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0094 | 0.0094 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0094 | 0.0094 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0094 | 0.0094 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0094 | 0.0094 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0094 | 0.0094 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0176 | 0.3148 | 0.4818 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0094 | 0.0143 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0094 | 0.0298 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0094 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0094 | 0.0094 |
Onchocerca volvulus | 0.0053 | 0.0867 | 0.1904 | |
Onchocerca volvulus | 0.0176 | 0.3148 | 0.7523 | |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.4153 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.3636 | 0.3636 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.3636 | 0.3636 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0176 | 0.3148 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0094 | 0.0094 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0094 | 0.0143 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0432 | 0.0661 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0432 | 0.0432 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0094 | 0.0298 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0094 | 0.0143 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0094 | 0.0094 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0094 | 0.0094 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0134 | 0.2368 | 0.3625 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0432 | 0.1372 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0094 | 0.0094 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0094 | 0.0143 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.2368 | 0.7524 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0094 | 0.0143 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0546 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0094 | 0.0143 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0094 | 0.0298 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0094 | 0.0094 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0867 | 0.2753 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0094 | 0.0094 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0134 | 0.2368 | 0.3625 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0094 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0094 | 0.0094 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0144 | 0.2567 | 0.3929 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0432 | 0.1372 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0094 | 0.0298 |
Onchocerca volvulus | 0.0175 | 0.3141 | 0.7506 | |
Echinococcus granulosus | tumor protein p63 | 0.0359 | 0.6533 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0432 | 0.1372 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0094 | 0.0094 |
Echinococcus multilocularis | rho associated protein kinase | 0.0176 | 0.3148 | 0.4818 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0432 | 0.1372 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0094 | 0.0094 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0094 | 0.0094 |
Onchocerca volvulus | 0.023 | 0.4153 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0094 | 0.0094 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0094 | 0.0094 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0094 | 0.0143 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0094 | 0.0094 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0094 | 0.0143 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0094 | 0.0094 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0094 | 0.0143 |
Echinococcus multilocularis | tumor protein p63 | 0.0359 | 0.6533 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0094 | 0.0094 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0094 | 0.0143 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0094 | 0.0143 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0094 | 0.0298 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0412 | 0.0631 |
Schistosoma mansoni | thyroid hormone receptor | 0.0144 | 0.2567 | 0.8154 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0432 | 0.0432 |
Onchocerca volvulus | 0.0029 | 0.0432 | 0.0833 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0094 | 0.0143 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0094 | 0.0143 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0867 | 0.0867 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0094 | 0.0298 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0094 | 0.0143 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0432 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0094 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0094 | 0.0094 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0094 | 0.0298 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0094 | 0.0094 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0432 | 0.0661 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0094 | 0.0298 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0094 | 0.0094 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0094 | 0.0094 |
Schistosoma mansoni | thyroid hormone receptor | 0.0144 | 0.2567 | 0.8154 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0094 | 0.0094 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0432 | 0.0661 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0094 | 0.0094 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0094 | 0.0094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.