Detailed information for compound 108696

Basic information

Technical information
  • TDR Targets ID: 108696
  • Name: 2-chloro-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydrox ymethyl)-2-[6-(naphthalen-1-ylmethylamino)pur in-9-yl]oxolan-3-yl]benzamide
  • MW: 544.989 | Formula: C28H25ClN6O4
  • H donors: 4 H acceptors: 6 LogP: 3.79 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)NC(=O)c1ccccc1Cl)n1cnc2c1ncnc2NCc1cccc2c1cccc2
  • InChi: 1S/C28H25ClN6O4/c29-20-11-4-3-10-19(20)27(38)34-22-24(37)21(13-36)39-28(22)35-15-33-23-25(31-14-32-26(23)35)30-12-17-8-5-7-16-6-1-2-9-18(16)17/h1-11,14-15,21-22,24,28,36-37H,12-13H2,(H,34,38)(H,30,31,32)/t21-,22-,24-,28-/m1/s1
  • InChiKey: PVFFQHIQQXRQSO-XABBOIKWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-(1-naphthylmethylamino)purin-9-yl]tetrahydrofuran-3-yl]benzamide
  • 2-chloro-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-(1-naphthalenylmethylamino)-9-purinyl]-3-tetrahydrofuranyl]benzamide
  • 2-chloro-N-[(2R,3R,4S,5R)-4-hydroxy-5-methylol-2-[6-(1-naphthylmethylamino)purin-9-yl]tetrahydrofuran-3-yl]benzamide
  • 2-chloro-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-(1-naphthylmethylamino)-9-purinyl]-3-tetrahydrofuranyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dnaJ subfamily B 0.041 0.3235 0.5269
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0041 0.005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0088 0.0608 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0088 0.0608 0.0645
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Brugia malayi Cytochrome P450 family protein 0.0056 0.0341 0.0362
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0088 0.0608 0.0601
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.01 0.0106
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Leishmania major nucleoside phosphorylase-like protein 0.0026 0.0101 0.0208
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0087 0.0599 0.0965
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0068 0.0073
Echinococcus multilocularis Niemann Pick C1 protein 0.0231 0.1771 0.2704
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0035 0.0043
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0226 0.0334
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0088 0.0608 0.0921
Schistosoma mansoni nuclear receptor nhr-48 0.0042 0.0226 0.0218
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0101 0.0389
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.0956 0.5555
Schistosoma mansoni memapsin-2 (A01 family) 0.042 0.3317 0.3312
Brugia malayi steroid hormone receptor 0.0088 0.0608 0.0645
Toxoplasma gondii ABC1 family protein 0.0035 0.0171 0.1489
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0042
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0047 0.0267 0.0283
Brugia malayi hypothetical protein 0.0042 0.0226 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0231 0.1771 0.8692
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0023 0.0015
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0023 0.0024
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0026 0.0101 0.0333
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0041 0.0043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0288 0.0306
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0041 0.0032
Echinococcus multilocularis GPCR, family 2 0.0049 0.0288 0.043
Leishmania major methylthioadenosine phosphorylase, putative 0.0026 0.0101 0.0208
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0035 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0107 0.0757 0.0803
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0026 0.0101 0.0107
Brugia malayi Cation transporter family protein 0.0019 0.0041 0.0043
Toxoplasma gondii aspartyl protease 0.0017 0.0023 0.0134
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1714 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0384 0.0376
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0201 0.165
Brugia malayi bZIP transcription factor family protein 0.0087 0.0599 0.0636
Brugia malayi Bromodomain containing protein 0.0045 0.025 0.0265
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0026 0.0101 0.0333
Echinococcus granulosus intermediate filament protein 0.0026 0.01 0.0149
Schistosoma mansoni microtubule-associated protein tau 0.0764 0.6133 0.6129
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0263 0.2034 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0606 0.3506
Loa Loa (eye worm) hypothetical protein 0.0088 0.0608 0.0645
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0041 0.0053
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0687 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0171 0.2404
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0687 0.3978
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0041 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0226 0.0334
Brugia malayi glutathione reductase 0.0039 0.0201 0.0213
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0465 0.0493
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0041 0.0043
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0017 0.0023 0.0134
Brugia malayi hypothetical protein 0.0047 0.0267 0.0283
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0041 0.0053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0956 0.1943
Onchocerca volvulus 0.0069 0.0446 0.5207
Brugia malayi nuclear receptor NHR-88 0.0042 0.0226 0.024
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0465 0.07
Onchocerca volvulus 0.0116 0.0835 1
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0116 0.0835 0.1269
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0171 0.0266
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0041 0.005
Echinococcus granulosus Niemann Pick C1 protein 0.0231 0.1771 0.2878
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0465 0.3176
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0333 0.0325
Loa Loa (eye worm) uridine phosphorylase 0.0026 0.0101 0.0107
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0041 0.0043
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0041 0.0043
Echinococcus multilocularis nAChR subunit 0.0019 0.0041 0.005
Schistosoma mansoni coup transcription factor 0.0088 0.0608 0.0601
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0245 0.1104
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0445 0.0472
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0088 0.0608 0.0645
Brugia malayi uridine phosphorylase family protein 0.0026 0.0101 0.0107
Echinococcus granulosus lamin 0.0026 0.01 0.0149
Brugia malayi ecdysteroid receptor 0.0088 0.0608 0.0645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0088 0.0608 0.0645
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0171 0.0956
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0041 0.005
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0225 0.1724 0.1717
Schistosoma mansoni bromodomain containing protein 0.0073 0.0482 0.0474
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0221 0.0326
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0026 0.0101 0.0544
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0041 0.0043
Loa Loa (eye worm) hypothetical protein 0.0047 0.0267 0.0283
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Brugia malayi hypothetical protein 0.0042 0.0226 0.024
Echinococcus multilocularis tumor protein p63 0.0374 0.2944 0.4504
Mycobacterium tuberculosis Hypothetical protein 0.0026 0.0101 0.0544
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0035 0.0043
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.004 0.0049
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.056 0.4466 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0687 0.3978
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0171 0.025
Trichomonas vaginalis cdc25b, putative 0.0116 0.0835 0.4039
Schistosoma mansoni cpg binding protein 0.0032 0.015 0.0142
Echinococcus multilocularis uridine phosphorylase 1 0.0026 0.0101 0.0142
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0041 0.0043
Onchocerca volvulus 0.0019 0.0041 0.0218
Loa Loa (eye worm) hypothetical protein 0.0047 0.0267 0.0283
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.0608 0.0921
Brugia malayi Carboxylesterase family protein 0.0066 0.0424 0.045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0088 0.0608 0.098
Loa Loa (eye worm) hypothetical protein 0.0051 0.0301 0.0319
Loa Loa (eye worm) nuclear hormone receptor 0.0042 0.0226 0.024
Schistosoma mansoni thyroid hormone receptor 0.0474 0.3762 0.3757
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0101 0.0152
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0465 0.0457
Schistosoma mansoni nuclear receptor 0.0042 0.0226 0.0218
Plasmodium falciparum thioredoxin reductase 0.0039 0.0201 0.165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0088 0.0608 0.0645
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0245 0.2162
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0088 0.0608 0.0921
Mycobacterium ulcerans hypothetical protein 0.0035 0.0171 0.0335
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0226 0.0356
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0026 0.0101 0.0962
Schistosoma mansoni uridine phosphorylase 0.0026 0.0101 0.0093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.0608 0.0921
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0088 0.0608 0.0921
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0226 0.2502
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0041 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1025 0.156
Schistosoma mansoni hypothetical protein 0.0699 0.56 0.5597
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0026 0.0101 0.0208
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0226 0.0218
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0041 0.0032
Echinococcus granulosus Protein patched homolog 1 0.0231 0.1771 0.2878
Loa Loa (eye worm) hypothetical protein 0.0049 0.0288 0.0306
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0341 0.0362
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0465 0.0745
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0445 0.067
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.1938 0.2056
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0465 0.1024
Brugia malayi nuclear receptor NHR-67 0.0042 0.0226 0.024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.0956 0.2125
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0149 0.1103 0.7893
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0231 0.1771 0.1764
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0171 0.1374
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0026 0.0101 0.019
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0101 0.0093
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0101 0.0389
Toxoplasma gondii exonuclease III APE 0.0018 0.0035 0.0241
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0171 0.0182
Onchocerca volvulus 0.0019 0.0041 0.0218
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Brugia malayi TAR-binding protein 0.0068 0.0445 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0171 0.0366
Echinococcus granulosus nuclear receptor nhr 48 0.0042 0.0226 0.0356
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0956 0.0948
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Loa Loa (eye worm) hypothetical protein 0.0088 0.0608 0.0645
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0041 0.005
Plasmodium falciparum glutathione reductase 0.0039 0.0201 0.165
Loa Loa (eye worm) hypothetical protein 0.0088 0.0608 0.0645
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0424 0.0638
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0182
Schistosoma mansoni hypothetical protein 0.0049 0.0288 0.0281
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0041 0.0043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.012 0.0128
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Entamoeba histolytica rodhanase-like domain containing protein 0.0116 0.0835 0.5915
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1025 0.1661
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0606 0.3506
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0465 0.1024
Loa Loa (eye worm) hypothetical protein 0.0088 0.0608 0.0645
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0042 0.0226 0.024
Onchocerca volvulus 0.0035 0.0171 0.1826
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0041 0.0043
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0226 0.0334
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0411 0.325 0.3448
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0041 0.0053
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0041 0.005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0606 0.3506
Schistosoma mansoni zinc finger protein 0.0016 0.0019 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0171 0.0956
Schistosoma mansoni hypothetical protein 0.0071 0.0465 0.0458
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0182
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0757 0.0803
Entamoeba histolytica hypothetical protein 0.0184 0.1388 1
Brugia malayi hypothetical protein 0.0017 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0088 0.0608 0.0645
Loa Loa (eye worm) hypothetical protein 0.0041 0.0222 0.0235
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.016 0.017
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0023 0.0015
Brugia malayi CXXC zinc finger family protein 0.0029 0.012 0.0128
Schistosoma mansoni retinoic acid receptor RXR 0.0088 0.0608 0.0601
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0088 0.0608 0.0601
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0088 0.0608 0.0921
Loa Loa (eye worm) hypothetical protein 0.0107 0.0761 0.0807
Schistosoma mansoni nAChR subunit 0.0019 0.0041 0.0032
Entamoeba histolytica rodhanase-like domain containing protein 0.0116 0.0835 0.5915
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0041 0.0032
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0042 0.0226 0.0218
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0411 0.325 0.5294
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0047 0.0267 0.0397
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0288 0.0306
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0288 0.0458
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0042 0.0226 0.024
Brugia malayi nuclear hormone receptor family member odr-7 0.0042 0.0226 0.024
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0149 0.1103 0.5371
Onchocerca volvulus 0.0116 0.0835 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0451 0.0679
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0386 0.3039 0.4949
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0116 0.0835 0.1351
Schistosoma mansoni hypothetical protein 0.041 0.3235 0.3229
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.0108
Loa Loa (eye worm) hypothetical protein 0.0047 0.0267 0.0283
Schistosoma mansoni hypothetical protein 0.0184 0.1388 0.1381
Echinococcus granulosus methylthioadenosine phosphorylase 0.0026 0.0101 0.0152
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0101 0.0389
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0017 0.0023 0.0134
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0101 0.0093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0088 0.0608 0.098
Loa Loa (eye worm) hypothetical protein 0.0047 0.0267 0.0283
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.016 0.0341
Loa Loa (eye worm) hypothetical protein 0.0066 0.0424 0.045
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.016 0.017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.0608 0.0645
Echinococcus multilocularis cpg binding protein 0.0032 0.015 0.0218
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0101 0.0491
Schistosoma mansoni zinc finger protein 0.0042 0.0226 0.0218
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.056 0.4466 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0023 0.0015
Loa Loa (eye worm) glutathione reductase 0.0039 0.0201 0.0213
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0424 0.0417
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0041 0.005
Echinococcus granulosus cpg binding protein 0.0032 0.015 0.0232
Loa Loa (eye worm) hypothetical protein 0.0026 0.01 0.0106
Schistosoma mansoni hypothetical protein 0.0107 0.0757 0.0749
Onchocerca volvulus 0.0029 0.012 0.1199
Brugia malayi Rhodanese-like domain containing protein 0.0116 0.0835 0.0886
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0288 0.043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0087 0.0599 0.0907
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0041 0.0043
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0035 0.0027
Brugia malayi Nuclear hormone receptor-like 1 0.0088 0.0608 0.0645
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.056 0.4466 1
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0041 0.005
Mycobacterium tuberculosis Conserved protein 0.0035 0.0171 0.0956
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0171 0.0738
Onchocerca volvulus 0.0026 0.01 0.0944
Trypanosoma brucei cytochrome P450, putative 0.0034 0.016 0.0341
Loa Loa (eye worm) hypothetical protein 0.0107 0.0761 0.0807
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0066 0.007
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0101 0.0208
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0023 0.0015
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0101 0.0152
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0101 0.0208
Schistosoma mansoni purine nucleoside phosphorylase 0.0026 0.0101 0.0093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.0608 0.0645
Onchocerca volvulus 0.0019 0.0041 0.0218
Schistosoma mansoni nAChR subunit 0.0019 0.0041 0.0032
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0035 0.0041
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0041 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.0608 0.0645
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0041 0.0043
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0201 0.0213
Echinococcus granulosus tar DNA binding protein 0.0068 0.0445 0.0713
Loa Loa (eye worm) hypothetical protein 0.0088 0.0608 0.0645
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0226 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0101 0.0389
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0196 0.0807
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.056 0.4466 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0101 0.0142
Schistosoma mansoni hypothetical protein 0.0022 0.0066 0.0058
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0096 0.0135
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0231 0.1771 0.1879
Echinococcus multilocularis lamin dm0 0.0026 0.01 0.014
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0101 0.0152
Schistosoma mansoni hypothetical protein 0.0699 0.56 0.5597
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0023 0.0024
Brugia malayi beta-lactamase 0.0035 0.0171 0.0182
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0184 0.1388 0.2253
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0101 0.0152
Mycobacterium tuberculosis Conserved protein 0.0035 0.0171 0.0956
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0445 0.0437
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.0023 0.0023
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0023 0.0015
Onchocerca volvulus 0.0019 0.0041 0.0218
Brugia malayi nuclear receptor RXR 0.0042 0.0226 0.024
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0041 0.0043
Brugia malayi Cytochrome P450 family protein 0.0015 0.0008 0.0009
Brugia malayi nuclear hormone receptor 0.0042 0.0226 0.024
Brugia malayi CHE-14 protein 0.0231 0.1771 0.1879
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0035 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0288 0.0306
Loa Loa (eye worm) DR-78 0.0042 0.0226 0.024
Mycobacterium leprae probable uridine phosphorylase 0.0026 0.0101 0.1369
Echinococcus granulosus zinc finger protein 0.0026 0.0099 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0088 0.0608 0.0645
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0026 0.0101 0.1369
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0041 0.0043
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0035 0.0027
Echinococcus multilocularis lamin 0.0026 0.01 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0024
Schistosoma mansoni patched 1 0.0231 0.1771 0.1764
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0288 0.043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0171 0.0956
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0411 0.325 0.4974
Schistosoma mansoni lamin 0.0026 0.01 0.0091
Toxoplasma gondii thioredoxin reductase 0.0039 0.0201 0.1762
Echinococcus multilocularis microtubule associated protein 2 0.0764 0.6133 0.9396
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0023 0.0015
Onchocerca volvulus Putative nachr subunit 0.0019 0.0041 0.0218
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0101 0.0152
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0101 0.0142
Mycobacterium leprae Probable lipase LipE 0.0035 0.0171 0.2404
Loa Loa (eye worm) hypothetical protein 0.0066 0.0424 0.045
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.0058
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.0956 0.8652
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0101 0.0491
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0171 0.0163
Schistosoma mansoni hypothetical protein 0.0386 0.3039 0.3033
Trypanosoma brucei trypanothione reductase 0.0039 0.0201 0.0433
Brugia malayi RNA binding protein 0.0068 0.0445 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0088 0.0608 0.0645
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0263 0.2034 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0101 0.0142
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.0023 0.0024
Brugia malayi PHD-finger family protein 0.0032 0.0145 0.0154
Echinococcus multilocularis ecdysone induced protein 78C 0.0088 0.0608 0.0921
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0424 0.045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0035 0.0059
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0205 0.0322
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.0608 0.098
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0101 0.0142
Schistosoma mansoni nAChR subunit 0.0019 0.0041 0.0032
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0101 0.0152
Loa Loa (eye worm) cytochrome P450 0.0015 0.0008 0.0009
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0041 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0088 0.0608 0.098
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0088 0.0608 0.0601
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0096 0.0144
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0041 0.005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0424 0.068
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0026 0.0101 0.0333
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0023 0.0015
Echinococcus granulosus acetylcholinesterase 0.0066 0.0424 0.068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1025 0.156
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0041 0.0032
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0445 0.0472
Trichomonas vaginalis esterase, putative 0.0035 0.0171 0.0738
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0041 0.0053
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0245 0.1104
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0042 0.0226 0.0334
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0.0023 0.0024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.0108
Brugia malayi hypothetical protein 0.0069 0.0446 0.0473
Onchocerca volvulus 0.0042 0.0226 0.2502
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.116 0.1231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0088 0.0608 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0445 0.0437
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0041 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0956 0.0948
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0041 0.0043
Mycobacterium ulcerans beta-lactamase 0.0035 0.0171 0.0335
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0026 0.0101 0.0491
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.056 0.4466 0.9144
Brugia malayi cytochrome P450 0.0015 0.0008 0.0009
Echinococcus granulosus FTZ F1 alpha 0.0088 0.0608 0.098
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0041 0.0043
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0263 0.2034 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0041 0.005
Leishmania major hypothetical protein, conserved 0.0035 0.0171 0.0366
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Loa Loa (eye worm) steroid hormone receptor 0.0088 0.0608 0.0645
Loa Loa (eye worm) CYP4Cod1 0.0034 0.016 0.017
Trypanosoma cruzi ISWI complex protein 0.0016 0.0019 0.0025
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0171 0.0956
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.0608 0.0645
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.056 0.4466 0.6839
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0101 0.0389
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.056 0.4466 0.7279
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0026 0.0101 0.0389
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0184 0.1388 0.2117
Brugia malayi photoreceptor-specific nuclear receptor 0.0088 0.0608 0.0645
Schistosoma mansoni nAChR subunit 0.0019 0.0041 0.0032
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0041 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0106 0.0112
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0201 0.0295
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0445 0.0437
Trichomonas vaginalis cdc25c, putative 0.0116 0.0835 0.4039
Loa Loa (eye worm) hypothetical protein 0.0088 0.0608 0.0645
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0606 0.3506
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0101 0.0093
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0023 0.0015
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0101 0.0142
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0267 0.0259
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.01 0.0106
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.116 0.1231
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0096 0.0088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1025 0.1661
Echinococcus multilocularis nuclear receptor nhr 48 0.0042 0.0226 0.0334
Echinococcus granulosus tumor protein p63 0.0374 0.2944 0.4794
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0042 0.0226 0.0334
Echinococcus granulosus lamin dm0 0.0026 0.01 0.0149
Schistosoma mansoni nuclear receptor 0.0042 0.0226 0.0218
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0245 0.2162
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0201 0.0314
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0116 0.0835 0.4039
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0023 0.0015
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0101 0.0389
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0102
Brugia malayi MTAP 0.0026 0.0101 0.0107
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0041 0.0053
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0226 0.2502
Mycobacterium tuberculosis Probable reductase 0.0088 0.0606 0.3506
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0263 0.2034 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0465 0.1024
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0041 0.0043
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0041 0.0043
Brugia malayi nuclear hormone receptor family member nhr-6 0.0042 0.0226 0.024
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0149 0.1103 1
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.056 0.4466 0.4737
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0042 0.0226 0.0218
Schistosoma mansoni nAChR subunit 0.0019 0.0041 0.0032
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0041 0.0043
Echinococcus multilocularis sterol regulatory element binding protein 0.0231 0.1771 0.2704
Brugia malayi Thioredoxin reductase 0.0039 0.0201 0.0213
Schistosoma mansoni transcription factor LCR-F1 0.0184 0.1388 0.1381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1025 0.1018
Onchocerca volvulus Protein ultraspiracle homolog 0.0088 0.0608 0.7205
Loa Loa (eye worm) intermediate filament protein 0.0026 0.01 0.0106
Brugia malayi hypothetical protein 0.1167 0.9427 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0171 0.0956
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0023 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0171 0.0366
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0101 0.0208
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0182
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0041 0.0043
Brugia malayi ecdysone receptor 0.0042 0.0226 0.024
Schistosoma mansoni cpg binding protein 0.0029 0.012 0.0112
Toxoplasma gondii phosphorylase family protein 0.0026 0.0101 0.0848
Brugia malayi beta-lactamase family protein 0.0035 0.0171 0.0182
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0267 0.0283
Loa Loa (eye worm) hypothetical protein 0.0156 0.116 0.1231
Brugia malayi nuclear receptor NHR-88 0.0088 0.0608 0.0645
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0101 0.0152
Schistosoma mansoni thyroid hormone receptor 0.0474 0.3762 0.3757
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0059
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0116 0.0835 0.4039
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0035 0.004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0245 0.0387
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0041 0.0043
Toxoplasma gondii phosphorylase family protein 0.0026 0.0101 0.0848
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0023 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0171 0.0738
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0035 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0171 0.0366
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0465 0.1024
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0041 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0182
Schistosoma mansoni intermediate filament proteins 0.0026 0.01 0.0091
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0226 0.0218
Trypanosoma brucei ISWI complex protein 0.0016 0.0019 0.0025
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0026 0.0101 0.0544
Trypanosoma cruzi ISWI complex protein 0.0016 0.0019 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0088 0.0608 0.0645
Schistosoma mansoni hypothetical protein 0.0049 0.0288 0.0281
Brugia malayi nuclear receptor RXR 0.0047 0.0267 0.0283
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0171 0.0182
Schistosoma mansoni cpg binding protein 0.0032 0.015 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0088 0.0608 0.0645
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0041 0.0043
Trypanosoma brucei uridine phosphorylase 0.0026 0.0101 0.0208
Echinococcus granulosus geminin 0.0699 0.56 0.9131
Onchocerca volvulus 0.0035 0.0171 0.1826
Plasmodium vivax glutathione reductase, putative 0.0039 0.0201 0.165
Entamoeba histolytica hypothetical protein 0.0184 0.1388 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0041 0.005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0088 0.0608 0.0601
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0041 0.0053
Echinococcus multilocularis protein dispatched 1 0.0231 0.1771 0.2704
Treponema pallidum uridine phosphorylase (udp) 0.0149 0.1103 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0271 0.0287
Schistosoma mansoni lamin 0.0026 0.01 0.0091
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.016 0.0312
Schistosoma mansoni purine nucleoside phosphorylase 0.0026 0.0101 0.0093
Loa Loa (eye worm) hypothetical protein 0.0116 0.0835 0.0886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1025 0.1018
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0171 0.0335
Echinococcus granulosus GPCR family 2 0.0049 0.0288 0.0458
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0116 0.0835 0.0886
Toxoplasma gondii aspartyl protease ASP1 0.0017 0.0023 0.0134
Loa Loa (eye worm) hypothetical protein 0.0085 0.058 0.0615
Brugia malayi Cation transporter family protein 0.0019 0.0041 0.0043
Echinococcus multilocularis jun protein 0.0087 0.0599 0.0907
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.0956 0.1453
Schistosoma mansoni nAChR subunit 0.0019 0.0041 0.0032
Onchocerca volvulus 0.0116 0.0835 1
Echinococcus granulosus nAChR subunit 0.0019 0.0041 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Leishmania major cytochrome p450-like protein 0.0034 0.016 0.0341
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0088 0.0608 0.0601
Toxoplasma gondii aspartyl protease ASP3 0.0017 0.0023 0.0134
Onchocerca volvulus 0.0035 0.0171 0.1826
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0956 0.1943
Loa Loa (eye worm) hypothetical protein 0.0231 0.1771 0.1879
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0149 0.1103 0.5371
Echinococcus granulosus microtubule associated protein 2 0.0764 0.6133 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0606 0.3506
Onchocerca volvulus Bile acid receptor homolog 0.0088 0.0608 0.7205
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.056 0.4466 0.4461
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0011
Mycobacterium ulcerans hydrolase/amidase 0.0611 0.4883 1
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.016 0.0341
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0035 0.0037
Leishmania major hypothetical protein, conserved 0.0016 0.0019 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.0088 0.0608 0.0601
Toxoplasma gondii Purine nucleoside phosphorylase 0.0149 0.1103 1
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0026 0.0101 0.019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0474 0.3762 0.5759
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0088 0.0608 0.0601
Echinococcus granulosus uridine phosphorylase 1 0.0026 0.0101 0.0152
Echinococcus granulosus thyroid hormone receptor alpha 0.0042 0.0226 0.0356
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0101 0.0152
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0088 0.0608 0.098
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.6526 1
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0026 0.0101 0.0142
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0101 0.0491
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.0608 0.098
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.1025 0.1088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0171 0.0738
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0171 0.0956
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0047 0.0267 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.0608 0.0645
Chlamydia trachomatis AMP nucleosidase 0.0026 0.0101 0.5
Brugia malayi hypothetical protein 0.0184 0.1388 0.1473
Loa Loa (eye worm) hypothetical protein 0.0055 0.0333 0.0353
Plasmodium falciparum purine nucleoside phosphorylase 0.0149 0.1103 1
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1059 0.1123
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0023 0.0024
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0116 0.0835 0.0828
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0041 0.0043
Loa Loa (eye worm) hypothetical protein 0.0076 0.0506 0.0537
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0171 0.0163
Giardia lamblia UPL-1 0.0026 0.0101 0.0333
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0196 0.1602
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.116 0.1231
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0221 0.0347
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.004 0.0032
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0687 0.3978
Brugia malayi Cytochrome P450 family protein 0.0034 0.016 0.017
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0041 0.0043
Onchocerca volvulus 0.0116 0.0835 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0386 0.3039 0.465
Onchocerca volvulus 0.0026 0.01 0.0944
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0088 0.0608 0.098
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0101 0.0208
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0116 0.0835 0.4039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Echinococcus multilocularis zinc finger protein 0.0026 0.0099 0.0139
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0101 0.0544
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0411 0.325 0.3245
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0201 0.0433
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0424 0.0638
Echinococcus multilocularis FTZ F1 alpha 0.0088 0.0608 0.0921
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0465 0.0493
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.038 0.3393
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0445 0.0472
Onchocerca volvulus 0.0042 0.0226 0.2502
Schistosoma mansoni nAChR subunit 0.0019 0.0041 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0171 0.0738
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0101 0.0389
Brugia malayi conserved hypotetical protein 0.0042 0.0226 0.024
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0445 0.0437
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0116 0.0835 0.4039
Loa Loa (eye worm) hypothetical protein 0.1167 0.9427 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0606 0.8814
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0047 0.0267 0.0259
Brugia malayi hypothetical protein 0.0017 0.0023 0.0024
Loa Loa (eye worm) RNA binding protein 0.0068 0.0445 0.0472
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0088 0.0608 0.0645
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0267 0.0283
Brugia malayi Pepsin A precursor 0.0017 0.0023 0.0024
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0042 0.0226 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.0608 0.0645
Loa Loa (eye worm) nuclear receptor NHR-67 0.0042 0.0226 0.024
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0445 0.0437
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0041 0.0053
Brugia malayi hypothetical protein 0.0047 0.0267 0.0283
Echinococcus multilocularis dnaJ subfamily B 0.041 0.3235 0.495
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0171 0.0182
Echinococcus multilocularis musashi 0.0026 0.01 0.014
Trichomonas vaginalis cdc25b, putative 0.0116 0.0835 0.4039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Entamoeba histolytica rodhanase-like domain containing protein 0.0116 0.0835 0.5915
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.1025 0.1088
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0171 0.0738
Brugia malayi Cytochrome P450 family protein 0.0034 0.016 0.017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0288 0.0458
Brugia malayi nuclear hormone receptor 0.0088 0.0608 0.0645
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0041 0.0053
Loa Loa (eye worm) hypothetical protein 0.0088 0.0608 0.0645
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.0027 0.0106 0.0219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0956 0.1943
Loa Loa (eye worm) hypothetical protein 0.056 0.4466 0.4737
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0205 0.0303
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0026 0.0101 0.019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0088 0.0608 0.0601
Schistosoma mansoni hypothetical protein 0.0049 0.0288 0.0281
Echinococcus granulosus sterol regulatory element binding protein 0.0231 0.1771 0.2878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0088 0.0608 0.0645
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0088 0.0608 0.7205
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0041 0.0053
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0171 0.0956
Echinococcus multilocularis geminin 0.0699 0.56 0.8579
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0041 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Onchocerca volvulus 0.0055 0.0333 0.3815
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0149 0.1103 0.7893
Schistosoma mansoni zinc finger protein 0.0026 0.0099 0.009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0088 0.0608 0.0645
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0026 0.0101 0.0107
Onchocerca volvulus 0.0088 0.0608 0.7205
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0196 0.1192
Brugia malayi Cation transporter family protein 0.0019 0.0041 0.0043
Onchocerca volvulus 0.0019 0.0041 0.0218
Schistosoma mansoni nuclear hormone receptor 0.0088 0.0608 0.0601
Brugia malayi tailless protein 0.0042 0.0226 0.024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1059 0.1052
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0088 0.0608 0.0645
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0101 0.0142
Brugia malayi Carboxylesterase family protein 0.0066 0.0424 0.045
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0116 0.0835 0.4039
Echinococcus multilocularis protein patched 0.0231 0.1771 0.2704
Brugia malayi Bromodomain containing protein 0.0086 0.0585 0.0621
Onchocerca volvulus 0.0019 0.0041 0.0218
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.004 0.0052
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0411 0.325 0.3448
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0026
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0226 0.024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0171 0.0335
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0041 0.0043
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0424 0.0638
Schistosoma mansoni uridine phosphorylase 0.0026 0.0101 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0226 0.0356
Loa Loa (eye worm) beta-lactamase 0.0035 0.0171 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0043
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0041 0.0043
Brugia malayi Rhodanese-like domain containing protein 0.0116 0.0835 0.0886
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0226 0.0356
Brugia malayi orphan nuclear receptor NR2E1 0.0042 0.0226 0.024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0451 0.0723
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0041 0.0053
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0245 0.2056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1025 0.1018
Echinococcus granulosus jun protein 0.0087 0.0599 0.0965
Mycobacterium ulcerans lipase LipD 0.0035 0.0171 0.0335
Brugia malayi beta-lactamase family protein 0.0035 0.0171 0.0182
Brugia malayi follicle stimulating hormone receptor 0.0251 0.1938 0.2056
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0201 0.1132
Entamoeba histolytica hypothetical protein 0.0184 0.1388 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.0956 0.1547
Loa Loa (eye worm) carboxylesterase 0.0066 0.0424 0.045
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0035 0.5
Echinococcus granulosus acetylcholinesterase 0.0066 0.0424 0.068
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1059 0.1612
Brugia malayi Steroid receptor seven-up type 2 0.0088 0.0608 0.0645
Loa Loa (eye worm) acetyltransferase 0.0144 0.1059 0.1123
Echinococcus granulosus ecdysone induced protein 78C 0.0088 0.0608 0.098
Treponema pallidum pfs protein (pfs) 0.0026 0.0101 0.0622
Mycobacterium tuberculosis Conserved protein 0.0035 0.0171 0.0956
Schistosoma mansoni jun-related protein 0.0071 0.0465 0.0458
Loa Loa (eye worm) hypothetical protein 0.0047 0.0267 0.0283
Brugia malayi intermediate filament protein 0.0026 0.01 0.0106
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1006 0.1629
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0041 0.0043
Entamoeba histolytica hypothetical protein 0.0026 0.0101 0.0491
Loa Loa (eye worm) hypothetical protein 0.0042 0.0226 0.024
Entamoeba histolytica hypothetical protein 0.0184 0.1388 1
Schistosoma mansoni hypothetical protein 0.0049 0.0288 0.0281
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0149 0.1103 1
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0101 0.0208
Leishmania major trypanothione reductase 0.0039 0.0201 0.0433
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0059

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) NA 0 uM Inhibitory activity against Leishmania mexicana GAPDH; Inactive at 50 microM ChEMBL. 11405646

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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