Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.5463 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.7045 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.7045 | 0.6972 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.5463 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.5463 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.5463 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0029 | 0.7045 | 0.6972 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.7045 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.5463 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.5463 | 0.7754 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 1 | 0.5 |
Echinococcus multilocularis | musashi | 0.0029 | 0.7045 | 0.6972 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.7045 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0939 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.6804 | 0.9658 |
Echinococcus multilocularis | lamin | 0.0029 | 0.7045 | 0.6972 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0241 | 0.0342 |
Onchocerca volvulus | 0.0029 | 0.7045 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.7045 | 0.6738 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.7045 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.1363 | 0.0468 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.7045 | 0.6972 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.7045 | 0.6972 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.5463 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.5463 | 0.4992 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.7045 | 0.6738 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.5463 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.5463 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IP (functional) | = 150 nM | Allosteric modulation of human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced calcium mobilization by FLIPR assay | ChEMBL. | 19962304 |
PPB (ADMET) | = 98.1 % | Plasma protein binding in human serum | ChEMBL. | 19962304 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.