TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 496.602 | Formula: C26H36N6O4
H donors: 1 H acceptors: 4 LogP: 1.45 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCOCCn1c2cc(ncc2nc(c1=O)N1CCN(CC1)[C@@H]([C@H](O)C)C)c1ccc(nc1)OC
InChi: 1S/C26H36N6O4/c1-5-13-36-14-12-32-23-15-21(20-6-7-24(35-4)28-16-20)27-17-22(23)29-25(26(32)34)31-10-8-30(9-11-31)18(2)19(3)33/h6-7,15-19,33H,5,8-14H2,1-4H3/t18-,19-/m1/s1
InChiKey: ZZHCAPMRVHYZMC-RTBURBONSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.0419	0.5432
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0208	0.0246
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0592	0.8237
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0113	0.0032
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0024	0.0105	0.0124
Schistosoma mansoni	metabotropic glutamate receptor	0.0045	0.0362	0.0429
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0086	0.5
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0074	0.07	0.0829
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0208	0.1992
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0113	0.0441
Brugia malayi	hexokinase type II	0.0229	0.2561	0.3033
Onchocerca volvulus	Hexokinase homolog	0.0453	0.5229	0.6194
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0592	0.8237
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0074	0.07	1
Plasmodium falciparum	GAF domain-related protein, putative	0.0023	0.01	0.0017
Brugia malayi	RNA, U transporter 1	0.0086	0.0849	0.1005
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0115	0.1191	0.141
Brugia malayi	Hexokinase family protein	0.0223	0.2487	0.2946
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Loa Loa (eye worm)	hexokinase	0.0223	0.2487	0.2946
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.07	0.0735
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.07	0.0735
Trypanosoma brucei	hexokinase, putative	0.0722	0.8443	1
Echinococcus granulosus	hexokinase	0.0722	0.8443	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1695	0.2007
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0033	0.0208	0.0246
Toxoplasma gondii	hypothetical protein	0.0023	0.01	0.0017
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0023	0.01	0.5
Plasmodium falciparum	hexokinase	0.0722	0.8443	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Echinococcus granulosus	hexokinase	0.0722	0.8443	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1695	0.2007
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0105	0.0124
Schistosoma mansoni	ran	0.0022	0.0086	0.0101
Echinococcus multilocularis	hexokinase	0.0722	0.8443	0.8443
Trypanosoma cruzi	hexokinase, putative	0.0722	0.8443	1
Plasmodium vivax	hypothetical protein, conserved	0.0023	0.01	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1191	0.141
Brugia malayi	Muscleblind-like protein	0.0157	0.1695	0.2007
Loa Loa (eye worm)	glutamate receptor	0.0037	0.0257	0.0305
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.04	0.0474
Trypanosoma brucei	hexokinase	0.0722	0.8443	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0033	0.0208	0.0246
Toxoplasma gondii	hypothetical protein	0.0023	0.01	0.0017
Loa Loa (eye worm)	hexokinase	0.0722	0.8443	1
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0181	0.0181
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Schistosoma mansoni	hypothetical protein	0.0323	0.3684	0.4363
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0078	0.0752	0.0891
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.07	1
Brugia malayi	Hexokinase family protein	0.0722	0.8443	1
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0093	0.0933	0.1105
Echinococcus multilocularis	hexokinase	0.0722	0.8443	0.8443
Echinococcus granulosus	hexokinase type 2	0.0722	0.8443	1
Entamoeba histolytica	hexokinase 2	0.0722	0.8443	1
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0084	0.0828	0.0981
Schistosoma mansoni	ran	0.0022	0.0086	0.0101
Echinococcus multilocularis	muscleblind protein	0.0157	0.1695	0.1695
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.07	0.0735
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0023	0.01	0.5
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0113	0.0032
Echinococcus granulosus	muscleblind protein	0.0157	0.1695	0.2007
Brugia malayi	Receptor family ligand binding region containing protein	0.0024	0.0105	0.0124
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0113	0.0441
Toxoplasma gondii	hexokinase	0.0722	0.8443	1
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0592	0.8237
Echinococcus multilocularis	hexokinase type 2	0.0722	0.8443	0.8443
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0086	0.0086
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.07	1
Schistosoma mansoni	importin beta-1	0.003	0.0181	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0492	0.5701	0.6753
Mycobacterium ulcerans	putative regulatory protein	0.0023	0.01	0.5
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0323	0.3684	0.4363
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0033	0.0208	0.0246
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0352	0.0352
Onchocerca volvulus		0.0722	0.8443	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0181	0.0114
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0033	0.0208	0.0208
Echinococcus multilocularis	muscleblind protein 1	0.0157	0.1695	0.1695
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.04	0.0474
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0352	0.0416
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0113	0.0441
Onchocerca volvulus		0.0722	0.8443	1
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0033	0.0208	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0281	0.0333
Echinococcus granulosus	snurportin 1	0.0323	0.3684	0.4363
Loa Loa (eye worm)	hexokinase	0.0722	0.8443	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.07	0.0735
Entamoeba histolytica	hexokinase 1	0.0722	0.8443	1
Toxoplasma gondii	hypothetical protein	0.0065	0.0592	0.0605
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0316	0.3759
Loa Loa (eye worm)	hexokinase	0.0453	0.5229	0.6194
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0352	0.0416
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0316	0.3759
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.01	0.0229
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0181	0.0114
Echinococcus granulosus	importin subunit beta 1	0.003	0.0181	0.0215
Loa Loa (eye worm)	hypothetical protein	0.003	0.0181	0.0215
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0078	0.0752	0.0752
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.07	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Brugia malayi	metabotropic glutamate receptor type 2	0.0045	0.0362	0.0429
Onchocerca volvulus		0.0722	0.8443	1
Echinococcus multilocularis	snurportin 1	0.0323	0.3684	0.3684
Brugia malayi	hexokinase	0.0722	0.8443	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0033	0.0208	0.1992
Plasmodium vivax	hexokinase, putative	0.0722	0.8443	1
Onchocerca volvulus		0.0453	0.5229	0.6194
Toxoplasma gondii	GAF domain-containing protein	0.0023	0.01	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0229	0.2561	0.3033
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0074	0.07	0.07
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.07	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0181	0.0114
Schistosoma mansoni	metabotropic glutamate receptor	0.0078	0.0752	0.0891
Plasmodium falciparum	importin beta, putative	0.003	0.0181	0.0114
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0208	0.1992
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0024	0.0105	0.0124
Plasmodium vivax	importin-beta 2, putative	0.003	0.0181	0.0114
Leishmania major	hexokinase, putative	0.0722	0.8443	1
Loa Loa (eye worm)	hypothetical protein	0.0229	0.2561	0.3033
Trypanosoma cruzi	hexokinase, putative	0.0722	0.8443	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0086	0.0101
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.005	0.0419	0.0399
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.07	1
Loa Loa (eye worm)	glutamate receptor	0.0093	0.0933	0.1105
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Brugia malayi	Importin beta-1 subunit	0.003	0.0181	0.0215
Treponema pallidum	hexokinase (hxk)	0.0722	0.8443	0.5
Mycobacterium ulcerans	putative regulatory protein	0.0023	0.01	0.5
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Leishmania major	hexokinase, putative	0.0722	0.8443	1
Trypanosoma brucei	hexokinase	0.0722	0.8443	1
Mycobacterium leprae	conserved hypothetical protein	0.0023	0.01	0.5
Echinococcus multilocularis	hexokinase	0.0722	0.8443	0.8443
Schistosoma mansoni	hexokinase	0.0722	0.8443	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0086	0.0101
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.0419	0.5432
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Loa Loa (eye worm)	hexokinase type II	0.0722	0.8443	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.01	0.0118
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0115	0.1191	0.1191
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0106	0.1086	0.1286
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0074	0.07	1
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0074	0.07	0.0829
Echinococcus granulosus	hexokinase	0.0722	0.8443	1
Entamoeba histolytica	hypothetical protein	0.0025	0.0113	0.0032
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.07	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0352	0.0416
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.07	0.0735
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0086	0.0101
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0023	0.01	0.5
Brugia malayi	Hexokinase family protein	0.0453	0.5229	0.6194

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of human ERG by patch-clamp method	ChEMBL.	20196613
IC50 (binding)	= 0.3 nM	Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay	ChEMBL.	20196613

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL591942

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1087227