TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.493 | Formula: C26H24N4O4
H donors: 3 H acceptors: 3 LogP: 3.43 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCCOc1ccc2c(c1)Nc1n(CC2)nc(c1C(=O)N)c1ccc(cc1)Oc1ccccc1
InChi: 1S/C26H24N4O4/c27-25(32)23-24(18-7-9-20(10-8-18)34-19-4-2-1-3-5-19)29-30-13-12-17-6-11-21(33-15-14-31)16-22(17)28-26(23)30/h1-11,16,28,31H,12-15H2,(H2,27,32)
InChiKey: WOUUMNAKFPPZLC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	GPCR, family 2	0.0052	0.0542	0.0533
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0371	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Echinococcus multilocularis	muscleblind protein 1	0.0833	1	1
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0371	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0228	0.2676	0.4264
Schistosoma mansoni	cpg binding protein	0.0033	0.0313	0.0487
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.001	0.0032	0.0024
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0032	0.0024
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0132	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0132	0.0115
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0034	0.0324	0.0315
Schistosoma mansoni	nAChR subunit	0.0034	0.0324	0.0503
Mycobacterium tuberculosis	Probable oxidoreductase	0.0097	0.1083	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0184	0.3811
Onchocerca volvulus		0.0034	0.0324	0.1917
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0069	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0039	0.0376	0.0587
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0159	0.015
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Schistosoma mansoni	ferritin	0.001	0.0025	0.0026
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0034	0.0324	0.0315
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0034	0.0324	0.0315
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0235	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0034	0.0324	0.0315
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.001	0.0032	0.0024
Brugia malayi	RNA binding protein	0.0263	0.31	0.3089
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0039	0.0376	0.0367
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.0767	0.1213
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.001	0.0032	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0132	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0013	0.006	0.0043
Onchocerca volvulus		0.0034	0.0324	0.1917
Treponema pallidum	NADH oxidase	0.0013	0.0069	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0069	0.006
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0151	0.1738	0.1724
Onchocerca volvulus		0.0039	0.0376	0.2364
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0248	0.2962
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0376	0.036
Entamoeba histolytica	Ran family GTPase	0.0021	0.0159	0.0248
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.01	0.0083
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0069	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0052	0.0542	0.0533
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0034	0.0025
Schistosoma mansoni	hypothetical protein	0.0052	0.0542	0.0852
Brugia malayi	Carboxylesterase family protein	0.0039	0.0376	0.036
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Schistosoma mansoni	gliotactin	0.0039	0.0376	0.0587
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0052	0.0542	0.0533
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0034	0.0324	0.0315
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0034	0.0324	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1267	0.1252
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0013	0.0069	0.0413
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0018	0.0132	0.0115
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.354	0.3529
Brugia malayi	Serotonin receptor	0.0498	0.5945	0.5938
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0159	0.0142
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0016	0.01	0.0091
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0034	0.0324	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.0032	0.0024
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0034	0.0324	0.0307
Echinococcus granulosus	expressed protein	0.001	0.0025	0.0016
Brugia malayi	Cation transporter family protein	0.0034	0.0324	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0034	0.0324	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0376	0.036
Schistosoma mansoni	tar DNA-binding protein	0.0263	0.31	0.4942
Schistosoma mansoni	neurotransmitter gated ion channel	0.0016	0.01	0.0146
Echinococcus multilocularis	dnaJ subfamily B	0.0476	0.5677	0.5673
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0034	0.0324	0.0315
Schistosoma mansoni	ferritin light chain	0.001	0.0025	0.0026
Loa Loa (eye worm)	glutaminase 2	0.0266	0.3134	0.3122
Onchocerca volvulus		0.0033	0.0313	0.1828
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0038	0.0371	0.3275
Loa Loa (eye worm)	acetylcholine receptor protein	0.0016	0.01	0.0083
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.0032	0.0024
Echinococcus multilocularis	muscleblind protein	0.0833	1	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0034	0.0025
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0087	0.0965	0.8885
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0644	0.1015
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0644	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0034	0.0324	0.0307
Mycobacterium ulcerans	carboxylesterase, LipT	0.0039	0.0376	0.1129
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0034	0.0324	0.0307
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0039	0.0376	0.0367
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0034	0.0324	0.0307
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0016	0.01	0.0083
Brugia malayi	Thioredoxin reductase	0.0038	0.0371	0.0355
Echinococcus multilocularis	NCK adaptor protein	0.0009	0.0017	0.0008
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0676	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0034	0.0324	0.0307
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0087	0.0965	0.8885
Echinococcus granulosus	muscleblind protein	0.0833	1	1
Schistosoma mansoni	hypothetical protein	0.0052	0.0542	0.0852
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0066	0.0057
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0039	0.0376	0.12
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0151	0.1738	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0132	0.0115
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.001	0.0032	0.0024
Onchocerca volvulus		0.0039	0.0376	0.2364
Loa Loa (eye worm)	hypothetical protein	0.0013	0.006	0.0043
Schistosoma mansoni	hypothetical protein	0.0525	0.6264	1
Echinococcus granulosus	snurportin 1	0.03	0.354	0.3535
Echinococcus multilocularis	nAChR subunit	0.0018	0.0132	0.0123
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0034	0.0324	0.0315
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0087	0.0965	0.8885
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0032	0.0024
Schistosoma mansoni	hypothetical protein	0.0052	0.0542	0.0852
Echinococcus granulosus	nAChR subunit	0.0018	0.0132	0.0123
Schistosoma mansoni	tyrosine kinase	0.001	0.0032	0.0038
Entamoeba histolytica	hypothetical protein	0.0023	0.0184	0.0486
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0151	0.1738	0.1731
Trichomonas vaginalis	spcc417.12 protein, putative	0.0039	0.0376	0.12
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0644	0.199
Schistosoma mansoni	ferritin	0.001	0.0025	0.0026
Echinococcus granulosus	carboxylesterase 5A	0.0228	0.2676	0.267
Echinococcus granulosus	acetylcholinesterase	0.0228	0.2676	0.267
Loa Loa (eye worm)	carboxylesterase	0.0039	0.0376	0.036
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0097	0.1083	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0132	0.0115
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0165	0.191	0.1897
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0159	0.1481
Schistosoma mansoni	tar DNA-binding protein	0.0263	0.31	0.4942
Schistosoma mansoni	importin beta-1	0.0028	0.0248	0.0383
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.0032	0.0024
Brugia malayi	hypothetical protein	0.0016	0.01	0.0083
Echinococcus granulosus	glycine receptor subunit beta	0.0034	0.0324	0.0315
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0039	0.0376	0.3317
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0013	0.0069	0.0141
Onchocerca volvulus		0.0027	0.0235	0.1157
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0016	0.01	0.0083
Loa Loa (eye worm)	GABA receptor subunit	0.0018	0.0132	0.0115
Brugia malayi	Importin beta-1 subunit	0.0028	0.0248	0.0232
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0034	0.0324	0.0307
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0034	0.0324	0.0503
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.0032	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Brugia malayi	SRC-1	0.001	0.0032	0.0015
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0034	0.0324	0.0315
Echinococcus multilocularis	expressed protein	0.001	0.0025	0.0016
Echinococcus granulosus	para nitrobenzyl esterase	0.0039	0.0376	0.0367
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0034	0.0324	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0833	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Schistosoma mansoni	hypothetical protein	0.0107	0.1204	0.191
Brugia malayi	Carboxylesterase family protein	0.0039	0.0376	0.036
Echinococcus granulosus	tyrosine protein kinase Src42A	0.001	0.0032	0.0024
Echinococcus granulosus	intermediate filament protein	0.0027	0.0235	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0376	0.036
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0017	0.0013
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0184	0.0588
Echinococcus multilocularis	carboxylesterase 5A	0.0228	0.2676	0.267
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0034	0.0017
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0013	0.0069	0.0141
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0018	0.0132	0.0197
Echinococcus granulosus	neuroligin	0.0039	0.0376	0.0367
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0013	0.0069	0.0141
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0159	0.2969
Brugia malayi	hypothetical protein	0.0016	0.01	0.0083
Brugia malayi	latrophilin 2 splice variant baaae	0.0113	0.1277	0.1262
Onchocerca volvulus		0.0039	0.0376	0.2364
Loa Loa (eye worm)	RNA binding protein	0.0263	0.31	0.3089
Schistosoma mansoni	hypothetical protein	0.0476	0.5677	0.9061
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0039	0.0376	0.3317
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0034	0.0324	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0376	0.036
Plasmodium falciparum	importin beta, putative	0.0028	0.0248	0.5937
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1267	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Brugia malayi	Carboxylesterase family protein	0.0228	0.2676	0.2664
Loa Loa (eye worm)	carboxylesterase	0.0039	0.0376	0.036
Entamoeba histolytica	hypothetical protein	0.0107	0.1204	1
Mycobacterium ulcerans	glutaminase	0.0266	0.3134	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0644	0.585
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0542	0.0526
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0371	1
Schistosoma mansoni	acetylcholine receptor-related	0.0016	0.01	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0376	0.036
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0034	0.0324	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0066	0.0049
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0034	0.0324	0.0315
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0165	0.191	0.1897
Loa Loa (eye worm)	carboxylesterase	0.0228	0.2676	0.2664
Echinococcus multilocularis	neuroligin	0.0039	0.0376	0.0367
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0039	0.0376	0.3317
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0112	0.1267	0.2012
Brugia malayi	glutathione reductase	0.0038	0.0371	0.0355
Schistosoma mansoni	tar DNA-binding protein	0.0263	0.31	0.4942
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0034	0.0324	0.0307
Schistosoma mansoni	tar DNA-binding protein	0.0263	0.31	0.4942
Echinococcus multilocularis	glycine receptor subunit beta	0.0034	0.0324	0.0315
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0034	0.0324	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0132	0.0115
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0069	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1076	0.106
Brugia malayi	Carboxylesterase family protein	0.0039	0.0376	0.036
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0132	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Echinococcus granulosus	GPCR family 2	0.0052	0.0542	0.0533
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0052	0.0542	0.0533
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0087	0.0965	0.8885
Brugia malayi	excitatory GABA receptor EXP-1A	0.0034	0.0324	0.0307
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0034	0.0324	0.0307
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0034	0.0324	0.0307
Schistosoma mansoni	tyrosine kinase	0.001	0.0032	0.0038
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0034	0.0324	0.0315
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0371	0.4989
Echinococcus granulosus	acetylcholinesterase	0.0228	0.2676	0.267
Schistosoma mansoni	nAChR subunit	0.0034	0.0324	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0034	0.0324	0.0503
Onchocerca volvulus		0.0018	0.0132	0.0276
Onchocerca volvulus		0.0034	0.0324	0.1917
Echinococcus granulosus	tyrosine protein kinase Src64B	0.001	0.0032	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0229	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Brugia malayi	Latrophilin receptor protein 2	0.0052	0.0542	0.0526
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0052	0.0542	0.0533
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0016	0.01	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Echinococcus granulosus	dnaJ subfamily B	0.0476	0.5677	0.5673
Loa Loa (eye worm)	hypothetical protein	0.0165	0.191	0.1897
Echinococcus granulosus	lamin dm0	0.0027	0.0235	0.0226
Echinococcus multilocularis	tar DNA binding protein	0.0263	0.31	0.3094
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0151	0.1738	0.1731
Onchocerca volvulus		0.0039	0.0376	0.2364
Schistosoma mansoni	neurotransmitter gated ion channel	0.0016	0.01	0.0146
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0371	0.0355
Brugia malayi	hypothetical protein	0.0107	0.1204	0.1189
Brugia malayi	intermediate filament protein	0.0027	0.0235	0.0218
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0159	0.2969
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0083	0.0066
Onchocerca volvulus	Putative nachr subunit	0.0034	0.0324	0.1917
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.001	0.0032	0.0024
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0016	0.01	0.0091
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0069	0.5
Echinococcus multilocularis	cpg binding protein	0.0035	0.0336	0.0328
Echinococcus multilocularis	musashi	0.0027	0.0235	0.0226
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0235	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Schistosoma mansoni	transcription factor LCR-F1	0.0107	0.1204	0.191
Schistosoma mansoni	cpg binding protein	0.0035	0.0336	0.0524
Trichomonas vaginalis	glutaminase, putative	0.0266	0.3134	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0018	0.0132	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Schistosoma mansoni	acetylcholinesterase	0.0039	0.0376	0.0587
Echinococcus granulosus	NCK adaptor protein	0.0009	0.0017	0.0008
Schistosoma mansoni	ferritin light chain	0.001	0.0025	0.0026
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0107	0.1204	0.1196
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0017	0.0013
Echinococcus granulosus	nAChR subunit	0.0034	0.0324	0.0315
Entamoeba histolytica	hypothetical protein	0.0107	0.1204	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.01	0.0083
Onchocerca volvulus		0.0112	0.1267	1
Loa Loa (eye worm)	hypothetical protein	0.0228	0.2676	0.2664
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.0032	0.0015
Brugia malayi	TAR-binding protein	0.0263	0.31	0.3089
Brugia malayi	hypothetical protein	0.0016	0.01	0.0083
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0016	0.01	0.0146
Brugia malayi	RNA, U transporter 1	0.008	0.0876	0.086
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0112	0.1267	0.2012
Echinococcus multilocularis	lamin dm0	0.0027	0.0235	0.0226
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0034	0.0324	0.0503
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0313	0.0297
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0159	0.0142
Schistosoma mansoni	ran	0.0021	0.0159	0.0239
Schistosoma mansoni	tyrosine kinase	0.001	0.0032	0.0038
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0034	0.0324	0.0307
Leishmania major	trypanothione reductase	0.0038	0.0371	0.5264
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0151	0.1738	0.1731
Loa Loa (eye worm)	LGC-31 protein	0.0034	0.0324	0.0307
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0016	0.01	0.0091
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0235	0.0218
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0066	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0132	0.0115
Schistosoma mansoni	tar DNA-binding protein	0.0263	0.31	0.4942
Echinococcus granulosus	ferritin	0.001	0.0025	0.0016
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0034	0.0324	0.0307
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0159	0.2969
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0644	0.199
Loa Loa (eye worm)	hypothetical protein	0.0228	0.2676	0.2664
Echinococcus granulosus	BC026374 protein S09 family	0.0039	0.0376	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0032	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0376	0.036
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0097	0.1083	1
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0248	0.024
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0034	0.0324	0.0503
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0151	0.1738	0.2764
Schistosoma mansoni	ferritin	0.001	0.0025	0.0026
Schistosoma mansoni	apoferritin-2	0.001	0.0025	0.0026
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0034	0.0324	0.0307
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0034	0.0324	0.0315
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0378	0.0369
Schistosoma mansoni	cpg binding protein	0.0035	0.0336	0.0524
Trichomonas vaginalis	ran, putative	0.0021	0.0159	0.0506
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0644	0.0636
Trichomonas vaginalis	ferritin, putative	0.001	0.0025	0.008
Loa Loa (eye worm)	glutaminase	0.0266	0.3134	0.3122
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0313	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0833	1	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0052	0.0542	0.0526
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.001	0.0032	0.0024
Echinococcus multilocularis	nAChR subunit	0.0034	0.0324	0.0315
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0184	0.2006
Schistosoma mansoni	apoferritin-2	0.001	0.0025	0.0026
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0034	0.0324	0.0315
Schistosoma mansoni	ran	0.0021	0.0159	0.0239
Onchocerca volvulus		0.0018	0.0132	0.0276
Echinococcus granulosus	tyrosine protein kinase Lyn	0.001	0.0032	0.0024
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0151	0.1738	0.1731
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0132	0.0115
Brugia malayi	Carboxylesterase family protein	0.0039	0.0376	0.036
Echinococcus granulosus	lamin	0.0027	0.0235	0.0226
Brugia malayi	Cation transporter family protein	0.0034	0.0324	0.0307
Echinococcus multilocularis	ferritin	0.001	0.0025	0.0016
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0039	0.0376	0.0367
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0097	0.1083	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0016	0.01	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0034	0.0324	0.0315
Schistosoma mansoni	lamin	0.0027	0.0235	0.0361
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0248	0.5937
Brugia malayi	Carboxylesterase family protein	0.0228	0.2676	0.2664
Echinococcus granulosus	c src tyrosine kinase	0.001	0.0032	0.0024
Brugia malayi	glutaminase DH11.1	0.0266	0.3134	0.3122
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0132	0.0115
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.0032	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Schistosoma mansoni	nck2/grb4	0.0009	0.0017	0.0013
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0026	0.0009
Echinococcus granulosus	glycine receptor subunit beta	0.0034	0.0324	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0376	0.036
Echinococcus multilocularis	lamin	0.0027	0.0235	0.0226
Echinococcus multilocularis	para nitrobenzyl esterase	0.0039	0.0376	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0159	0.2969
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0034	0.0324	0.0307
Onchocerca volvulus		0.0027	0.0235	0.1157
Mycobacterium tuberculosis	Probable reductase	0.0087	0.0965	0.8885
Echinococcus granulosus	growth factor receptor bound protein 2	0.0009	0.0017	0.0008
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0263	0.31	0.3089
Onchocerca volvulus		0.0039	0.0376	0.2364
Onchocerca volvulus		0.0112	0.1267	1
Entamoeba histolytica	hypothetical protein	0.0107	0.1204	1
Schistosoma mansoni	nAChR subunit	0.0034	0.0324	0.0503
Schistosoma mansoni	nAChR subunit	0.0016	0.01	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Brugia malayi	hypothetical protein	0.0016	0.01	0.0083
Brugia malayi	hypothetical protein	0.0039	0.0376	0.036
Echinococcus granulosus	cpg binding protein	0.0035	0.0336	0.0328
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0644	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1277	0.1262
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0032	0.0024
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0034	0.0324	0.0315
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0644	0.1015
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0032	0.0024
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0034	0.0324	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0248	0.0232
Leishmania major	GTP-binding protein, putative	0.0021	0.0159	0.1563
Schistosoma mansoni	nAChR subunit	0.0034	0.0324	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0034	0.0324	0.0315
Schistosoma mansoni	hypothetical protein	0.0052	0.0542	0.0852
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0083	0.0066
Loa Loa (eye worm)	SRC-1	0.001	0.0032	0.0015
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0165	0.191	0.1897
Schistosoma mansoni	BC026374 protein (S09 family)	0.0039	0.0376	0.0587
Schistosoma mansoni	nAChR subunit	0.0016	0.01	0.0146
Echinococcus multilocularis	snurportin 1	0.03	0.354	0.3535
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.001	0.0032	0.0024
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0034	0.0324	0.0307
Brugia malayi	hypothetical protein	0.0016	0.01	0.0083
Schistosoma mansoni	neurotransmitter gated ion channel	0.0018	0.0132	0.0197
Echinococcus granulosus	geminin	0.0525	0.6264	0.6261
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0039	0.0376	0.0587
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.001	0.0032	0.0024
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0107	0.1204	0.1196
Brugia malayi	Cation transporter family protein	0.0112	0.1267	0.1252
Echinococcus granulosus	tar DNA binding protein	0.0263	0.31	0.3094
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0371	1
Schistosoma mansoni	glutaminase	0.0266	0.3134	0.4996
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0016	0.01	0.0083
Schistosoma mansoni	tyrosine kinase	0.001	0.0032	0.0038
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0009	0.0017	0.0013
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0159	0.2969
Onchocerca volvulus		0.0112	0.1267	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0016	0.01	0.0083
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0034	0.0324	0.0315
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0032	0.0024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0151	0.1738	0.2764
Loa Loa (eye worm)	ACC-1 protein	0.0034	0.0324	0.0307
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0644	0.199
Plasmodium falciparum	glutathione reductase	0.0038	0.0371	1
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0069	0.0219
Schistosoma mansoni	lamin	0.0027	0.0235	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0184	0.0588
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0248	0.5937
Echinococcus multilocularis	acetylcholinesterase	0.0228	0.2676	0.267
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0069	0.006
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0009	0.0017	0.0008
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0248	0.5937
Entamoeba histolytica	hypothetical protein	0.0107	0.1204	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0371	0.0355
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0132	0.0115
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0151	0.1738	0.2764
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0248	0.024
Trypanosoma brucei	trypanothione reductase	0.0038	0.0371	1
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0016	0.01	0.0091
Schistosoma mansoni	nAChR subunit	0.0034	0.0324	0.0503
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0184	0.0588
Echinococcus multilocularis	glycine receptor subunit beta	0.0034	0.0324	0.0315
Schistosoma mansoni	hypothetical protein	0.03	0.354	0.5646
Brugia malayi	RNA recognition motif domain containing protein	0.0263	0.31	0.3089
Schistosoma mansoni	adapter molecule crk	0.0009	0.0017	0.0013
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0026	0.0009
Mycobacterium tuberculosis	Probable dehydrogenase	0.0087	0.0965	0.8885
Schistosoma mansoni	hypothetical protein	0.0525	0.6264	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0034	0.0324	0.0315
Loa Loa (eye worm)	TAR-binding protein	0.0263	0.31	0.3089
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0159	0.015
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0034	0.0324	0.0307
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0069	0.0096
Schistosoma mansoni	hypothetical protein	0.0113	0.1277	0.2027
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0644	0.9477
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0032	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0083
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0039	0.0376	0.0587
Loa Loa (eye worm)	ACC-1 protein	0.0034	0.0324	0.0307
Schistosoma mansoni	nAChR subunit	0.0034	0.0324	0.0503
Schistosoma mansoni	nAChR subunit	0.0034	0.0324	0.0503
Echinococcus multilocularis	geminin	0.0525	0.6264	0.6261
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0378	0.0369
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0016	0.01	0.0091
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0034	0.0324	0.0315
Schistosoma mansoni	ferritin	0.001	0.0025	0.0026
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0034	0.0324	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0235	0.0218
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0034	0.0324	0.0307
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0087	0.0965	0.8885
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0039	0.0376	0.0587
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0235	0.0361
Echinococcus multilocularis	acetylcholinesterase	0.0228	0.2676	0.267
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0069	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0324	0.0307
Loa Loa (eye worm)	acetylcholinesterase 1	0.0228	0.2676	0.2664
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0052	0.0542	0.0526
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0159	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.5 nM	Inhibition of GST-tagged human LCK by scintillation counting	ChEMBL.	19945867

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL592261

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1087388