Detailed information for compound 1087471

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.287 | Formula: C17H11N3O4
  • H donors: 1 H acceptors: 4 LogP: 1.4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(Cn2c(=O)c(=O)[nH]c3c2cccc3)C(=O)c2c1cccc2
  • InChi: 1S/C17H11N3O4/c21-14-17(24)19(13-8-4-3-7-12(13)18-14)9-20-15(22)10-5-1-2-6-11(10)16(20)23/h1-8H,9H2,(H,18,21)
  • InChiKey: MVZUQGDWQIPLMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0293 0.0293
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0105 0.1174 0.741
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.079 0.477
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0153 0.0153
Onchocerca volvulus 0.0023 0.0153 0.0987
Schistosoma mansoni acetyl-CoA synthetase 0.0031 0.0249 0.0249
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0293 0.0688
Schistosoma mansoni lipoxygenase 0.0139 0.1596 0.1596
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0153 0.0982
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0097 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0079 0.0843 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0249 0.0426
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0157 0.1816 0.4264
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0097 0.0229
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0153 0.0359
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0249 0.1058
Onchocerca volvulus 0.0023 0.0153 0.0982
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0105 0.1174 0.7104
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0153 0.0153
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0031 0.0249 0.1058
Onchocerca volvulus 0.0031 0.0249 0.16
Schistosoma mansoni hypothetical protein 0.0035 0.0293 0.0293
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0094 0.0094
Entamoeba histolytica acyl-CoA synthetase, putative 0.0105 0.1174 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0153 0.0153
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0097 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0157 0.1816 0.1816
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0033 0.0078
Echinococcus multilocularis dna polymerase eta 0.0053 0.0521 0.0521
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0016 0.0038
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0359
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.1382 0.8837
Brugia malayi RNA recognition motif domain containing protein 0.0353 0.4258 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0031 0.0249 0.0426
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0094 0.5
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.0843 0.2069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0153 0.0359
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0105 0.1174 0.2758
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0153 0.0153
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.198
Mycobacterium ulcerans acyl-CoA synthetase 0.0105 0.1174 0.2985
Onchocerca volvulus Huntingtin homolog 0.0136 0.1554 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0094 0.0749
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.122 0.2866
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0097 0.0058
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0031 0.0249 0.0426
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0031 0.0249 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0353 0.4258 0.4258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.1174 0.741
Leishmania major 4-coumarate:coa ligase-like protein 0.0105 0.1174 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0153 0.0153
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0153 0.0359
Brugia malayi hypothetical protein 0.0012 0.0016 0.0038
Echinococcus granulosus cpg binding protein 0.0034 0.0285 0.0285
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.1382 0.87
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0249 0.0426
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0153 0.0153
Loa Loa (eye worm) glutathione reductase 0.0054 0.053 0.1244
Loa Loa (eye worm) hypothetical protein 0.0136 0.1554 0.3649
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0153 0.0153
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0153 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0249 0.0426
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0031 0.0249 0.0584
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0153 0.0153
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0147 0.0346
Schistosoma mansoni hypothetical protein 0.0191 0.2233 0.2233
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0249 0.0426
Loa Loa (eye worm) hypothetical protein 0.0031 0.0249 0.0584
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0033 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.198
Echinococcus multilocularis GPCR, family 2 0.0035 0.0293 0.0293
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0097 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0147 0.0146
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0094 0.0094
Onchocerca volvulus 0.0031 0.0249 0.16
Schistosoma mansoni tar DNA-binding protein 0.0353 0.4258 0.4258
Loa Loa (eye worm) hypothetical protein 0.0075 0.0791 0.1858
Schistosoma mansoni hypothetical protein 0.0043 0.0396 0.0396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0153 0.0359
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0249 0.0426
Schistosoma mansoni hypothetical protein 0.0035 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0136 0.1554 0.3649
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0153 0.0153
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0263 0.0617
Brugia malayi hypothetical protein 0.0023 0.0153 0.036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.1382 0.8837
Brugia malayi TAR-binding protein 0.0353 0.4258 1
Loa Loa (eye worm) glutaminase 2 0.031 0.3713 0.872
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0097 0.0097
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.053 0.053
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0153 0.0982
Mycobacterium ulcerans acetyl-CoA synthetase 0.0031 0.0249 0.0426
Echinococcus multilocularis microtubule associated protein 2 0.0815 1 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0147 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0153 0.0359
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0094 0.0749
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0016 0.0016
Trichomonas vaginalis glutaminase, putative 0.031 0.3713 1
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0153 0.0787
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0153 0.0153
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0249 0.4026
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.053 0.1244
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0153 0.0359
Entamoeba histolytica hypothetical protein 0.0043 0.0396 0.2422
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0153 0.0787
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0326 0.5319
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0147 0.0147
Brugia malayi nuclear hormone receptor 0.0023 0.0153 0.0359
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0031 0.0249 0.0426
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0359
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0147 0.0146
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0153 0.0153
Plasmodium falciparum thioredoxin reductase 0.0054 0.053 0.5811
Brugia malayi glutathione reductase 0.0054 0.053 0.1244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0157 0.1816 0.1816
Brugia malayi hypothetical protein 0.0043 0.0396 0.093
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0038
Mycobacterium ulcerans glutaminase 0.031 0.3713 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0031 0.0249 0.0426
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0396 0.0396
Brugia malayi AMP-binding enzyme family protein 0.0105 0.1174 0.2758
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0094 0.0749
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0153 0.0359
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0105 0.1174 0.2985
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0097 0.0097
Leishmania major trypanothione reductase 0.0054 0.053 0.4028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0359
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0147 0.1871
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0249 0.1427
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.053 0.5811
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0031 0.0249 0.3543
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0157 0.1816 0.1816
Brugia malayi Doublecortin family protein 0.0023 0.0153 0.036
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0153 0.0153
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0031 0.0249 0.0584
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0031 0.0249 0.1058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0249 0.1058
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0094 0.0222
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0153 0.036
Echinococcus granulosus geminin 0.0191 0.2233 0.2233
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.198
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0249 0.3543
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0094 0.0749
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0249 0.1058
Brugia malayi AMP-binding enzyme family protein 0.0105 0.1174 0.2758
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0353 0.4258 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0031 0.0249 0.2059
Entamoeba histolytica hypothetical protein 0.0043 0.0396 0.2422
Echinococcus granulosus RUN 0.0023 0.0153 0.0153
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0031 0.0249 0.1058
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0147 0.0147
Leishmania major acetyl-CoA synthetase, putative 0.0031 0.0249 0.1427
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0031 0.0249 0.0987
Brugia malayi hypothetical protein 0.0012 0.0016 0.0038
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.0249 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0153 0.0359
Trypanosoma brucei DNA polymerase eta, putative 0.0053 0.0521 0.9826
Leishmania major 4-coumarate:coa ligase-like protein 0.0105 0.1174 1
Onchocerca volvulus 0.0105 0.1174 0.7559
Brugia malayi steroid hormone receptor 0.0023 0.0153 0.0359
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0105 0.1174 0.2985
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0157 0.1816 0.1816
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0053 0.0521 0.1224
Entamoeba histolytica hypothetical protein 0.0043 0.0396 0.2422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0157 0.1816 0.1816
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0521 0.1224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0157 0.1816 0.1816
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0147 0.0146
Brugia malayi Thioredoxin reductase 0.0054 0.053 0.1244
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0031 0.0249 0.0426
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0105 0.1174 0.2758
Schistosoma mansoni rab6-interacting 0.0023 0.0153 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0153 0.0359
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0153 0.0153
Brugia malayi CXXC zinc finger family protein 0.0032 0.0263 0.0617
Schistosoma mansoni hypothetical protein 0.0035 0.0293 0.0293
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0079 0.0843 0.5137
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.053 0.053
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0791 0.1858
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0153 0.0153
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0153 0.0153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0147 0.1212
Loa Loa (eye worm) RNA binding protein 0.0353 0.4258 1
Brugia malayi nuclear receptor RXR 0.0012 0.0016 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Trichomonas vaginalis antibiotic synthetase, putative 0.0031 0.0249 0.0426
Leishmania major acetyl-CoA synthetase, putative 0.0031 0.0249 0.1427
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0326 0.4408
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0249 0.0584
Echinococcus multilocularis tar DNA binding protein 0.0353 0.4258 0.4258
Loa Loa (eye worm) hypothetical protein 0.0105 0.1174 0.2758
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0249 0.0584
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.1382 0.8837
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0031 0.0249 0.0584
Loa Loa (eye worm) hypothetical protein 0.021 0.2469 0.5799
Schistosoma mansoni cpg binding protein 0.0034 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0038
Entamoeba histolytica acyl-coA synthetase, putative 0.0105 0.1174 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0031 0.0249 0.1058
Schistosoma mansoni cpg binding protein 0.0032 0.0263 0.0263
Schistosoma mansoni tar DNA-binding protein 0.0353 0.4258 0.4258
Schistosoma mansoni hypothetical protein 0.0191 0.2233 0.2233
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.1382 0.8837
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0031 0.0249 0.1058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.122 0.2866
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0521 0.9812
Schistosoma mansoni rab6-interacting 0.0023 0.0153 0.0153
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0105 0.1174 0.2985
Plasmodium vivax glutathione reductase, putative 0.0054 0.053 0.5811
Onchocerca volvulus 0.0023 0.0153 0.0987
Brugia malayi nuclear receptor NHR-88 0.0023 0.0153 0.0359
Treponema pallidum NADH oxidase 0.0019 0.0094 0.5
Plasmodium falciparum acyl-CoA synthetase 0.0079 0.0843 1
Schistosoma mansoni DNA polymerase eta 0.0053 0.0521 0.0521
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0097 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.079 0.477
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0249 0.0584
Leishmania major DNA polymerase eta, putative 0.0037 0.0326 0.2143
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.079 0.477
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0031 0.0249 0.0426
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0153 0.0153
Leishmania major DNA polymerase kappa, putative 0.0023 0.0147 0.0488
Onchocerca volvulus 0.0031 0.0249 0.16
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0153 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0153 0.0359
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.0249 0.0584
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0293 0.0293
Schistosoma mansoni tar DNA-binding protein 0.0353 0.4258 0.4258
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.198
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0035 0.0293 0.0293
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0293 0.0688
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0249 0.0426
Brugia malayi ecdysteroid receptor 0.0023 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0153 0.0359
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.1552 1
Echinococcus granulosus tar DNA binding protein 0.0353 0.4258 0.4258
Leishmania major 4-coumarate:coa ligase-like protein 0.0105 0.1174 1
Schistosoma mansoni hypothetical protein 0.0075 0.0791 0.0791
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0097 0.0097
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0097 0.007
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.1552 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0249 0.0426
Mycobacterium ulcerans acyl-CoA synthetase 0.0105 0.1174 0.2985
Echinococcus multilocularis RUN 0.0023 0.0153 0.0153
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0097 0.0229
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0359
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0139 0.1596 0.1596
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0153 0.0153
Brugia malayi AMP-binding enzyme family protein 0.0105 0.1174 0.2758
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Plasmodium falciparum glutathione reductase 0.0054 0.053 0.5811
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0153 0.0359
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.021 0.2469 0.5799
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.053 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0396 0.0396
Schistosoma mansoni tar DNA-binding protein 0.0353 0.4258 0.4258
Toxoplasma gondii propionate-CoA ligase 0.0031 0.0249 0.2936
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0153 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0153 0.0359
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0293 0.0293
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0016 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0249 0.0584
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0097 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0153 0.0359
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0153 0.0153
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.2398 0.6366
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0153 0.0153
Brugia malayi glutaminase DH11.1 0.031 0.3713 0.872
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0097 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Entamoeba histolytica acyl-CoA synthetase, putative 0.0105 0.1174 1
Schistosoma mansoni hypothetical protein 0.0023 0.0153 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0105 0.1174 0.2985
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0097 0.0813
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0016 0.0016
Brugia malayi hypothetical protein 0.0136 0.1554 0.3649
Plasmodium vivax acetyl-CoA synthetase, putative 0.0031 0.0249 0.2059
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0293 0.0688
Onchocerca volvulus 0.0031 0.0249 0.16
Loa Loa (eye worm) hypothetical protein 0.0109 0.122 0.2866
Schistosoma mansoni microtubule-associated protein tau 0.0815 1 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0031 0.0249 0.0426
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0031 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.198
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0094 0.0094
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0097 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0016 0.0038
Echinococcus granulosus dna polymerase eta 0.0053 0.0521 0.0521
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0147 0.0488
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0153 0.0153
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0097 0.0813
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0153 0.0153
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0157 0.1816 0.4264
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0153 0.0153
Onchocerca volvulus Huntingtin homolog 0.0136 0.1554 1
Trypanosoma brucei trypanothione reductase 0.0054 0.053 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0147 0.0147
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0097 0.0028
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.053 0.2985
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0147 0.1212
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0153 0.0153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0147 0.1212
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0195 0.0691
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0139 0.1596 0.1596
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0031 0.0249 0.1058
Echinococcus multilocularis cpg binding protein 0.0034 0.0285 0.0285
Entamoeba histolytica hypothetical protein 0.0043 0.0396 0.2422
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0359
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0094 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0396 0.0396
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0031 0.0249 0.0426
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0105 0.1174 0.7104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0147 0.1212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0153 0.0359
Brugia malayi isocitrate dehydrogenase 0.0019 0.0097 0.0229
Schistosoma mansoni polycystin 1-related 0.0023 0.0153 0.0153
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0249 0.3543
Loa Loa (eye worm) hypothetical protein 0.0035 0.0293 0.0688
Toxoplasma gondii thioredoxin reductase 0.0054 0.053 0.8287
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Schistosoma mansoni loxhd1 0.0023 0.0153 0.0153
Trypanosoma brucei unspecified product 0.0023 0.0147 0.1871
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0147 0.1871
Plasmodium vivax acyl-CoA synthetase, putative 0.0079 0.0843 1
Mycobacterium ulcerans hypothetical protein 0.0105 0.1174 0.2985
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0153 0.0359
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0147 0.0346
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.079 0.477
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0153 0.0359
Mycobacterium tuberculosis Probable reductase 0.0122 0.1382 0.8837
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0097 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.071 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0147 0.1871
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0153 0.0359
Schistosoma mansoni cpg binding protein 0.0034 0.0285 0.0285
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0105 0.1174 0.2985
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0038
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.1552 1
Brugia malayi hypothetical protein 0.0023 0.0153 0.036
Loa Loa (eye worm) oxidoreductase 0.0031 0.0249 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0153 0.0359
Schistosoma mansoni glutaminase 0.031 0.3713 0.3713
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0147 0.0362
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.122 0.2866
Leishmania major DNA polymerase eta, putative 0.0053 0.0521 0.3953
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0293 0.0293
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.1552 1
Loa Loa (eye worm) TAR-binding protein 0.0353 0.4258 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0031 0.0249 0.2936
Onchocerca volvulus 0.0032 0.0263 0.169
Brugia malayi RNA binding protein 0.0353 0.4258 1
Loa Loa (eye worm) glutaminase 0.031 0.3713 0.872
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0249 0.0426
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0153 0.0153
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0147 0.1871
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0031 0.0249 0.3543
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0097 0.0097
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0147 0.0147
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0031 0.0249 0.4026
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0031 0.0249 0.1058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0157 0.1816 0.1816
Giardia lamblia DINP protein human, muc B family 0.0023 0.0147 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0153 0.0153
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0249 0.1058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0359
Echinococcus granulosus GPCR family 2 0.0035 0.0293 0.0293
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0153 0.0153
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0147 0.0362
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0016 0.0016
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0153 0.0982
Schistosoma mansoni lipoxygenase 0.0097 0.1075 0.1075
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0153 0.0153
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.1382 0.8837
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0031 0.0249 0.0426
Echinococcus multilocularis geminin 0.0191 0.2233 0.2233
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0031 0.0249 0.2936
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0153 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0153 0.0359
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0619 1
Schistosoma mansoni coup transcription factor 0.0023 0.0153 0.0153

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) = 10.593 mm Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by alamar blue assay ChEMBL. 19962890
IZ (functional) = 23 mm Antifungal activity against Candida albicans at 100 ug/disk by agar plate disk diffusion method ChEMBL. 19962890
IZ (functional) = 30 mm Antibacterial activity against Escherichia coli at 100 ug/disk by agar plate disk diffusion method ChEMBL. 19962890

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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