Detailed information for compound 1087558

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.324 | Formula: C17H14FN5O
  • H donors: 2 H acceptors: 4 LogP: 1.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(cc(n1)c1cccc(c1)F)C(=O)NCc1ccccn1
  • InChi: 1S/C17H14FN5O/c18-12-5-3-4-11(8-12)14-9-15(23-17(19)22-14)16(24)21-10-13-6-1-2-7-20-13/h1-9H,10H2,(H,21,24)(H2,19,22,23)
  • InChiKey: KFWWKUUBQRSFND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0181 0.4293 0.6828
Trypanosoma cruzi histone deacetylase, putative 0.0087 0.1851 0.5005
Entamoeba histolytica histone deacetylase, putative 0.0158 0.3698 0.5291
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0396 0.1015
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0117 0.0103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.036 0.0338
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0064 0.0174
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0122 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0122 0.0202
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0064 0.0174
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.236 0.2342
Trypanosoma brucei histone deacetylase 4 0.0087 0.1851 0.5005
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0064 0.0174
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0887 0.1411
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0086 0.0232
Brugia malayi steroid hormone receptor 0.002 0.0122 0.0194
Loa Loa (eye worm) hypothetical protein 0.005 0.0887 0.1469
Loa Loa (eye worm) histone deacetylase 11 0.0055 0.1023 0.1693
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0086 0.0198
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.036 0.0338
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0207 0.0559
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0122 0.0099
Trypanosoma cruzi histone deacetylase 1, putative 0.0158 0.3698 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0117 0.0095
Echinococcus multilocularis serotonin transporter 0.0181 0.4293 0.428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Schistosoma mansoni hypothetical protein 0.0368 0.9148 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0122 0.0194
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0122 0.0108
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0064 0.0041
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0396 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.6932 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0158 0.3698 0.5319
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0122 0.0099
Brugia malayi hypothetical protein 0.0025 0.0239 0.0381
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0117 0.0095
Giardia lamblia GTOR 0.0018 0.0064 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Loa Loa (eye worm) hypothetical protein 0.0055 0.1023 0.1693
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0117 0.0095
Echinococcus granulosus histone deacetylase 1 0.0158 0.3698 0.3684
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0117 0.0095
Echinococcus granulosus GPCR family 2 0.005 0.0887 0.0866
Echinococcus multilocularis histone deacetylase 6 0.0087 0.1851 0.1832
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0117 0.0187
Onchocerca volvulus 0.0031 0.0396 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Schistosoma mansoni nAChR subunit 0.002 0.0117 0.0103
Schistosoma mansoni histone deacetylase 1 2 3 0.0055 0.1023 0.1096
Brugia malayi Nuclear hormone receptor-like 1 0.0248 0.6041 0.9608
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0086 0.017
Schistosoma mansoni nuclear hormone receptor 0.002 0.0122 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Schistosoma mansoni histone deacetylase 0.0158 0.3698 0.4027
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0023 0.5
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0064 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0086 0.0063
Loa Loa (eye worm) ACC-1 protein 0.002 0.0117 0.0194
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0064 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0122 0.0099
Entamoeba histolytica hypothetical protein 0.0106 0.236 0.3342
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0117 0.0095
Plasmodium falciparum histone deacetylase 2 0.0087 0.1851 0.4974
Brugia malayi Nuclear hormone receptor-like 1 0.0248 0.6041 0.9608
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.036 0.0369
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0023 0.0063
Loa Loa (eye worm) ACC-1 protein 0.002 0.0117 0.0194
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0117 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0122 0.0194
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0086 0.0063
Schistosoma mansoni nAChR subunit 0.002 0.0117 0.0103
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0248 0.6041 1
Brugia malayi glutathione reductase 0.0047 0.0822 0.1307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0064 0.0174
Echinococcus multilocularis histone deacetylase 6 0.0087 0.1851 0.1832
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0023 0.0063
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0238 0.0235
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0396 0.0374
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0117 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Brugia malayi Latrophilin receptor protein 2 0.005 0.0887 0.1411
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0149 0.0402
Echinococcus multilocularis nAChR subunit 0.002 0.0117 0.0095
Plasmodium vivax SET domain protein, putative 0.0029 0.036 0.0917
Toxoplasma gondii t-complex protein beta subunit 0.0023 0.0207 0.05
Leishmania major histone deacetylase, putative 0.0158 0.3698 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0064 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0122 0.0194
Trypanosoma brucei trypanothione reductase 0.0047 0.0822 0.2223
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Schistosoma mansoni histone deacetylase hda2 0.0055 0.1023 0.1096
Schistosoma mansoni hypothetical protein 0.005 0.0887 0.0947
Toxoplasma gondii thioredoxin reductase 0.0047 0.0822 0.2174
Schistosoma mansoni histone deacetylase 0.0158 0.3698 0.4027
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0887 0.1469
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Toxoplasma gondii histone deacetylase HDAC1 0.0087 0.1851 0.4974
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0122 0.0008
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0117 0.0095
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.3181 1
Brugia malayi nuclear hormone receptor 0.002 0.0122 0.0194
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0238 0.0643
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Loa Loa (eye worm) hypothetical protein 0.0181 0.4293 0.7107
Plasmodium falciparum histone deacetylase, putative 0.0087 0.1851 0.4974
Loa Loa (eye worm) norepinephrine transporter 0.0181 0.4293 0.7107
Entamoeba histolytica hypothetical protein 0.0106 0.236 0.3342
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0396 0.0409
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0122 0.0099
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0181 0.4293 0.468
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0207 0.05
Echinococcus granulosus histone deacetylase 7 0.0087 0.1851 0.1832
Schistosoma mansoni histone deacetylase 4 5 0.0087 0.1851 0.2003
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0239 0.0647
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0122 0.0008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0122 0.0108
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0207 0.0342
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.22 0.2182
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.2389 0.749
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0122 0.0194
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.1333 0.1436
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.036 0.0369
Brugia malayi Thioredoxin reductase 0.0047 0.0822 0.1307
Echinococcus granulosus serotonin transporter 0.0181 0.4293 0.428
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0396 0.0409
Echinococcus granulosus FTZ F1 alpha 0.002 0.0122 0.0099
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0117 0.0095
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0396 0.063
Trypanosoma cruzi histone deacetylase, putative 0.0087 0.1851 0.5005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0427 0.0708
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0122 0.0194
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0122 0.0108
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0117 0.0095
Brugia malayi Histone deacetylase 1 0.0158 0.3698 0.5881
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0117 0.0103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0064 0.0102
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0086 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Echinococcus multilocularis histone deacetylase 7 0.0087 0.1851 0.1832
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0122 0.0194
Brugia malayi hypothetical protein 0.0106 0.236 0.3753
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0023 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0122 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0202
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0396 0.0656
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0122 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0117 0.0187
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0086 0.0063
Schistosoma mansoni hypothetical protein 0.0107 0.2382 0.2585
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0064 0.0106
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0117 0.0194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.6932 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1122 0.1857
Loa Loa (eye worm) hypothetical protein 0.0067 0.1333 0.2207
Brugia malayi Cation transporter family protein 0.002 0.0117 0.0187
Trypanosoma cruzi histone deacetylase, putative 0.0087 0.1851 0.5005
Schistosoma mansoni hypothetical protein 0.005 0.0887 0.0947
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0117 0.0187
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0122 0.0108
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0396 0.0409
Schistosoma mansoni sodium/chloride dependent transporter 0.0031 0.0396 0.0409
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.2389 0.749
Schistosoma mansoni thyroid hormone receptor 0.0145 0.3378 0.3676
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0158 0.3698 0.5319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0656
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0202
Plasmodium vivax histone deacetylase 1, putative 0.0158 0.3698 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0239 0.0396
Leishmania major hypothetical protein, conserved 0.0025 0.0239 0.0647
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.6932 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0117 0.0103
Loa Loa (eye worm) histone deacetylase 0.0087 0.1851 0.3064
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0086 0.0063
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0117 0.0194
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0207 0.0184
Schistosoma mansoni hypothetical protein 0.0106 0.236 0.2561
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0207 0.0184
Loa Loa (eye worm) hypothetical protein 0.0181 0.4293 0.7107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0086 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0122 0.0194
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0396 0.0374
Onchocerca volvulus 0.0232 0.5635 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0064 0.0174
Brugia malayi nuclear receptor NHR-88 0.002 0.0122 0.0194
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0202
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0396 0.0409
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0239 0.0588
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.1122 0.1204
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.036 0.0338
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0202
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0117 0.0095
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0023 0.0037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0822 0.253
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0396 0.0409
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0064 0.0174
Loa Loa (eye worm) histone deacetylase 7A 0.0087 0.1851 0.3064
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0117 0.0187
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0031 0.0396 0.0409
Brugia malayi isocitrate dehydrogenase 0.0019 0.0086 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0122 0.0202
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0031 0.0396 0.0374
Plasmodium falciparum histone deacetylase 1 0.0158 0.3698 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0117 0.0095
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.22 0.2385
Giardia lamblia Histone deacetylase 0.0158 0.3698 0.5319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0656
Schistosoma mansoni sodium-dependent amino acid transporter 0.0031 0.0396 0.0409
Echinococcus granulosus histone deacetylase 6 0.0087 0.1851 0.1832
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0202
Toxoplasma gondii histone deacetylase HDAC5 0.0055 0.1023 0.2721
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0239 0.0588
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0064 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0122 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0122 0.0202
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0117 0.0187
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0031 0.0396 0.0374
Leishmania major histone deacetylase, putative 0.0087 0.1851 0.5005
Echinococcus multilocularis histone deacetylase 0.0087 0.1851 0.1832
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0117 0.0095
Mycobacterium tuberculosis Probable reductase 0.0107 0.2389 0.749
Toxoplasma gondii hypothetical protein 0.0031 0.0396 0.1015
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0207 0.0329
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0117 0.0194
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0117 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0238 0.0378
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0023 0.0063
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0238 0.0585
Giardia lamblia TCP-1 chaperonin subunit beta 0.0023 0.0207 0.0266
Loa Loa (eye worm) hypothetical protein 0.0158 0.3698 0.6121
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Loa Loa (eye worm) hypothetical protein 0.0021 0.0149 0.0246
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0023 0.0063
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0117 0.0187
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0031 0.0396 0.0374
Echinococcus granulosus geminin 0.0368 0.9148 0.9146
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0822 0.1361
Brugia malayi histone deacetylase 11 0.0055 0.1023 0.1627
Toxoplasma gondii histone deacetylase HDAC3 0.0158 0.3698 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0065 0.0176
Schistosoma mansoni histone deacetylase 4 5 0.0087 0.1851 0.2003
Trichomonas vaginalis histone deacetylase, putative 0.0158 0.3698 0.5319
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0239 0.0647
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0086 0.0232
Trypanosoma cruzi histone deacetylase, putative 0.0055 0.1023 0.2766
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0238 0.0215
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0117 0.0194
Loa Loa (eye worm) hypothetical protein 0.0181 0.4293 0.7107
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0822 0.0801
Plasmodium falciparum glutathione reductase 0.0047 0.0822 0.2174
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.236 0.2561
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0023 0.0073
Brugia malayi Pre-SET motif family protein 0.0204 0.4903 0.7797
Loa Loa (eye worm) glutathione reductase 0.0047 0.0822 0.1361
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0122 0.0099
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0117 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0023 0.5
Plasmodium falciparum amino acid transporter, putative 0.0031 0.0396 0.1015
Trichomonas vaginalis histone deacetylase, putative 0.0158 0.3698 0.5319
Brugia malayi Melibiase family protein 0.0067 0.1333 0.2121
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0207 0.0559
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0064 0.0174
Loa Loa (eye worm) hypothetical protein 0.0107 0.2382 0.3943
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0122 0.0099
Plasmodium falciparum transporter, putative 0.0031 0.0396 0.1015
Plasmodium vivax glutathione reductase, putative 0.0047 0.0822 0.2174
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.1333 0.1436
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.27 0.3926
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0023 0.0063
Brugia malayi ecdysteroid receptor 0.002 0.0122 0.0194
Echinococcus multilocularis thyroid hormone receptor alpha 0.0145 0.3378 0.3362
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0117 0.0187
Brugia malayi histone deacetylase 3 (HD3) 0.0158 0.3698 0.5881
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0064 0.0045
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0239 0.0588
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0122 0.0099
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0122 0.0202
Brugia malayi Cation transporter family protein 0.002 0.0117 0.0187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0122 0.0202
Echinococcus granulosus histone deacetylase 6 0.0087 0.1851 0.1832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0117 0.0187
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.036 0.0917
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.2389 0.749
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0332 0.031
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0117 0.0187
Loa Loa (eye worm) histone deacetylase 1 0.0158 0.3698 0.6121
Trichomonas vaginalis histone deacetylase, putative 0.0158 0.3698 0.5319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.036 0.0369
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.2855 0.2838
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0396 0.0409
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0396 0.1015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0122 0.0099
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.263 0.4354
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0117 0.0095
Schistosoma mansoni nAChR subunit 0.002 0.0117 0.0103
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0023 0.0063
Onchocerca volvulus 0.0059 0.1122 0.182
Schistosoma mansoni hypothetical protein 0.0125 0.2855 0.3103
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0023 0.0063
Echinococcus multilocularis GPCR, family 2 0.005 0.0887 0.0866
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0064 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.367 0.6074
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0117 0.0095
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0396 0.063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.4903 0.8115
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0122 0.0194
Onchocerca volvulus 0.0029 0.036 0.044
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.22 0.2182
Trypanosoma cruzi histone deacetylase 1, putative 0.0158 0.3698 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0031 0.0396 0.0374
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0086 0.017
Onchocerca volvulus 0.0031 0.0396 0.0505
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0117 0.0187
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.2389 0.749
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.6932 1
Leishmania major histone deacetylase, putative 0.0087 0.1851 0.5005
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0065 0.0176
Brugia malayi MH2 domain containing protein 0.0117 0.263 0.4183
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0117 0.0095
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0238 0.0643
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0122 0.0194
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0031 0.0396 0.0656
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.6932 1
Schistosoma mansoni coup transcription factor 0.002 0.0122 0.0108
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0238 0.0215
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0158 0.3698 0.5319
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.1333 0.1897
Trypanosoma brucei histone deacetylase 2 0.0055 0.1023 0.2766
Trichomonas vaginalis chaperonin, putative 0.0023 0.0207 0.0266
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0656
Trypanosoma brucei histone deacetylase 3 0.0087 0.1851 0.5005
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0207 0.0201
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0031 0.0396 0.063
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0117 0.0194
Leishmania major trypanothione reductase 0.0047 0.0822 0.2223
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0207 0.0329
Echinococcus multilocularis sodium and chloride dependent glycine 0.0031 0.0396 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0202
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0117 0.0187
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0023 0.0073
Plasmodium vivax amine transporter, putative 0.0031 0.0396 0.1015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0656
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.22 0.2182
Echinococcus multilocularis tumor protein p63 0.04 1 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0117 0.0095
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0207 0.0207
Echinococcus multilocularis histone deacetylase 6 0.0094 0.2032 0.2014
Entamoeba histolytica hypothetical protein 0.0106 0.236 0.3342
Treponema pallidum sodium- and chloride- dependent transporter 0.0181 0.4293 0.6181
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0086 0.0142
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0117 0.0187
Loa Loa (eye worm) LGC-31 protein 0.002 0.0117 0.0194
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0396 0.1015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0122 0.0194
Toxoplasma gondii melibiase subfamily protein 0.01 0.22 0.5923
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0117 0.0103
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.367 0.5836
Brugia malayi Histone deacetylase family protein 0.0087 0.1851 0.2944
Schistosoma mansoni hypothetical protein 0.005 0.0887 0.0947
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0086 0.017
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0086 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.036 0.0369
Loa Loa (eye worm) solute carrier family 6 member 4 0.0181 0.4293 0.7107
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0117 0.0187
Onchocerca volvulus 0.0031 0.0396 0.0505
Entamoeba histolytica hypothetical protein 0.0025 0.0238 0.0253
Loa Loa (eye worm) serotonin transporter b 0.0181 0.4293 0.7107
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0086 0.0232
Schistosoma mansoni hypothetical protein 0.005 0.0887 0.0947
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.22 0.2385
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0023 0.0063
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0887 0.0866
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0207 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Echinococcus granulosus nAChR subunit 0.002 0.0117 0.0095
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0064 0.0174
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0064 0.0174
Trypanosoma cruzi histone deacetylase, putative 0.0055 0.1023 0.2766
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0064 0.0174
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0887 0.0866
Echinococcus multilocularis geminin 0.0368 0.9148 0.9146
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0122 0.0108
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.2382 0.3788
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0023 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0656
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0122 0.0108
Plasmodium vivax histone deacetylase, putative 0.0087 0.1851 0.4974
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.3181 1
Trypanosoma brucei histone deacetylase 1 0.0158 0.3698 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0238 0.0311
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.2855 0.2838
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0117 0.0103
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.2389 0.749
Echinococcus granulosus histone deacetylase 8 0.0055 0.1023 0.1002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0122 0.0194
Echinococcus multilocularis histone deacetylase 8 0.0055 0.1023 0.1002
Loa Loa (eye worm) hypothetical protein 0.0157 0.367 0.6074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.6932 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0117 0.0187
Trichomonas vaginalis set domain proteins, putative 0.0232 0.5635 0.8123
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0064 0.0041
Plasmodium vivax histone deacetylase, putative 0.0055 0.1023 0.2721
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0086 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.6932 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.367 0.5836
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0822 0.2223
Echinococcus multilocularis histone deacetylase 3 0.0158 0.3698 0.3684
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.6932 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.0822 0.2174
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0064 0.0041
Plasmodium vivax histone deacetylase 2, putative 0.0087 0.1851 0.4974
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0207 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Schistosoma mansoni thyroid hormone receptor 0.0145 0.3378 0.3676
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0122 0.0099
Trichomonas vaginalis histone deacetylase, putative 0.0158 0.3698 0.5319
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0887 0.0866
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0031 0.0396 1
Echinococcus granulosus histone deacetylase 0.0087 0.1851 0.1832
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0656
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.236 0.2342
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0023 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0239 0.0588
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0117 0.0095
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.27 0.8475
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.22 0.2385
Loa Loa (eye worm) hypothetical protein 0.0031 0.0396 0.0656
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0122 0.0008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0822 0.0801
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0239 0.0647
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0122 0.0099
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0207 0.0201
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0117 0.0187
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0023 0.0063
Leishmania major histone deacetylase, putative 0.0158 0.3698 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0117 0.0194
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0023 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.6932 1
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0117 0.0095
Loa Loa (eye worm) hypothetical protein 0.0039 0.0609 0.1008
Loa Loa (eye worm) hypothetical protein 0.0247 0.6012 0.9951
Schistosoma mansoni histone deacetylase hda2 0.0094 0.2032 0.2202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Schistosoma mansoni nAChR subunit 0.002 0.0117 0.0103
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0207 0.0201
Loa Loa (eye worm) histone deacetylase 3 0.0158 0.3698 0.6121
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0117 0.0095
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0122 0.0108
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0023 0.0063
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0064 0.0112
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0023 0.0073
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0117 0.0095
Schistosoma mansoni nAChR subunit 0.002 0.0117 0.0103
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0031 0.0396 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0122 0.0108
Trichomonas vaginalis histone deacetylase, putative 0.0158 0.3698 0.5319
Brugia malayi histone deacetylase 1 (HD1) 0.0158 0.3698 0.5881
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.3181 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.6932 1
Schistosoma mansoni nAChR subunit 0.002 0.0117 0.0103
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0117 0.0095
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0117 0.0095
Onchocerca volvulus 0.002 0.0122 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0122 0.0099
Echinococcus granulosus sodium and chloride dependent glycine 0.0031 0.0396 0.0374
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.263 0.4354
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0086 0.0063
Schistosoma mansoni hypothetical protein 0.0368 0.9148 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0122 0.0194
Brugia malayi Cation transporter family protein 0.002 0.0117 0.0187
Brugia malayi hypothetical protein 0.0016 0.0013 0.002
Echinococcus granulosus histone deacetylase 6 0.0094 0.2032 0.2014
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0064 0.0174
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Schistosoma mansoni sodium/chloride dependent transporter 0.0181 0.4293 0.468
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0122 0.0194
Brugia malayi hypothetical protein 0.0031 0.0396 0.063
Onchocerca volvulus 0.0181 0.4293 0.7568
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0887 0.0866
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0086 0.017
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0064 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0122 0.0202
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0822 0.2174
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.22 0.2385
Trypanosoma brucei histone deacetylase, putative 0.0087 0.1851 0.5005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0031 0.0396 0.0409
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0023 0.0063
Trichomonas vaginalis histone deacetylase, putative 0.0158 0.3698 0.5319
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0031 0.0396 0.0374
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0117 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Echinococcus multilocularis histone deacetylase 1 0.0158 0.3698 0.3684
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0064 0.0045
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.27 0.8475
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0207 0.0266
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0194
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0086 0.0232
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.6932 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0055 0.1023 0.1641
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0117 0.0103
Toxoplasma gondii histone deacetylase HDAC2 0.0158 0.3698 1
Toxoplasma gondii histone deacetylase HDAC4 0.0055 0.1023 0.2721
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0031 0.0396 0.0374
Echinococcus granulosus histone deacetylase 3 0.0158 0.3698 0.3684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Entamoeba histolytica hypothetical protein 0.0106 0.236 0.3342
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0122 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0202
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0117 0.0095
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0064 0.0106
Brugia malayi Nuclear hormone receptor-like 1 0.0258 0.6288 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.6932 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0031 0.0396 0.063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0122 0.0194
Brugia malayi Histone deacetylase family protein 0.0087 0.1851 0.2944
Brugia malayi Pre-SET motif family protein 0.0029 0.036 0.0573
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0023 0.0063
Loa Loa (eye worm) hypothetical protein 0.0029 0.036 0.0596
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0023 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0122 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0064 0.006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0031 0.0396 0.1015
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0122 0.0194
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.27 0.8475
Toxoplasma gondii hypothetical protein 0.0031 0.0396 0.1015
Schistosoma mansoni nAChR subunit 0.002 0.0117 0.0103
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0122 0.0099
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0122 0.0202

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 18 nM Displacement of radioligand from human adenosine A2A receptor expressed in cells by topcount microplate scintillation counting ChEMBL. 19695884
Ki (binding) = 38 nM Displacement of radioligand from human adenosine A1 receptor expressed in cells by topcount microplate scintillation counting ChEMBL. 19695884

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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