Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.1176 | 0.1341 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2604 | 0.2968 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2141 | 0.3415 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2604 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2604 | 0.2968 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.8774 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2141 | 0.8223 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2604 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.1176 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.1129 | 0.1801 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.1176 | 0.1876 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2604 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.6271 | 0.7147 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.1176 | 0.4517 |
Onchocerca volvulus | 0.0029 | 0.1176 | 0.1176 | |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2604 | 0.2968 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.6271 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.6271 | 0.7147 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.1176 | 0.4517 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.6271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.6271 | 0.7147 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.6271 | 1 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0002 | 0 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.8774 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.1176 | 0.4517 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2141 | 0.3415 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.1176 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2604 | 0.2968 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2141 | 0.3415 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2141 | 0.8223 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2141 | 0.3415 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2604 | 0.2968 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2604 | 0.4152 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.1176 | 0.1876 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2604 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.2141 | 0.244 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.2141 | 0.244 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2604 | 0.4152 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2604 | 0.2968 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1176 | 0.1341 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2141 | 0.8223 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.1176 | 0.1876 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.1176 | 0.4517 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2604 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of Plasmodium falciparum falcipain-2 | ChEMBL. | 20045640 | |
IC50 (functional) | = 8.4 uM | Antimicrobial activity against chloroquine-resistant Plasmodium falciparum W2 | ChEMBL. | 20045640 |
IC50 (functional) | = 8.4 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by FACS analysis in presence of 10 % human serum | ChEMBL. | 21044845 |
IC50 (functional) | = 9.7 uM | Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D10 | ChEMBL. | 20045640 |
IC50 (functional) | = 9.7 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs | ChEMBL. | 21044845 |
IC50 (functional) | = 13.5 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 48 hrs | ChEMBL. | 21044845 |
MIC (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv by low-oxygen-recovery assay | ChEMBL. | 20045640 | |
MIC (functional) | > 128 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv by microplate Alamar blue assay | ChEMBL. | 20045640 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20045640 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.