Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0121 | 0.3206 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0113 | 0.2919 | 0.3177 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0121 | 0.3206 | 0.3223 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.03 | 0.9948 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0059 | 0.0866 | 0.0799 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0038 | 0.0078 | 0.0078 |
Brugia malayi | Cytochrome P450 family protein | 0.0119 | 0.3132 | 0.3149 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0113 | 0.2919 | 0.2879 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.3171 | 0.3452 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0059 | 0.0866 | 0.0799 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0147 | 0.4194 | 0.3665 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0059 | 0.0866 | 0.2701 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1268 | 0.3956 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.007 | 0.1268 | 0.138 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.03 | 0.9948 | 1 |
Onchocerca volvulus | 0.0038 | 0.0078 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0059 | 0.0866 | 0.0799 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0147 | 0.4194 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0121 | 0.3206 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0113 | 0.2919 | 0.3177 |
Echinococcus multilocularis | 0.0059 | 0.0866 | 0.087 | |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0121 | 0.3206 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0119 | 0.3132 | 0.341 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0866 | 0.087 |
Giardia lamblia | Kinase, CMGC CLK | 0.0121 | 0.3206 | 0.3206 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0121 | 0.3206 | 0.3223 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.03 | 0.9948 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0159 | 0.4622 | 0.4647 |
Echinococcus granulosus | hypothetical protein | 0.012 | 0.3171 | 0.3188 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0059 | 0.0866 | 0.0799 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 1 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.007 | 0.1268 | 0.1275 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0113 | 0.2919 | 0.9105 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0121 | 0.3206 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0703 | 0.0765 |
Leishmania major | protein kinase, putative | 0.0121 | 0.3206 | 0.3223 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0113 | 0.2919 | 0.9105 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0059 | 0.0866 | 0.2701 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0121 | 0.3206 | 0.3223 |
Trypanosoma brucei | cytochrome P450, putative | 0.0113 | 0.2919 | 0.9105 |
Brugia malayi | Cytochrome P450 family protein | 0.0113 | 0.2919 | 0.2934 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.0866 | 0.087 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0059 | 0.0866 | 0.0799 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.1268 | 0.1275 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.03 | 0.9948 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.03 | 0.9948 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.03 | 0.9948 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0147 | 0.4194 | 0.4171 |
Echinococcus granulosus | single minded 2 | 0.0038 | 0.0078 | 0.0078 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0059 | 0.0866 | 0.0799 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0301 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0059 | 0.0866 | 0.0799 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0121 | 0.3206 | 1 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0059 | 0.0866 | 0.0799 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0121 | 0.3206 | 1 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0059 | 0.0866 | 0.0799 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0121 | 0.3206 | 0.3223 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0059 | 0.0866 | 0.0799 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0121 | 0.3206 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0113 | 0.2919 | 0.3177 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 0.1268 | 0.1275 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.5124 | 0.5577 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.03 | 0.9948 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.1268 | 0.1275 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 0.1268 | 0.1275 |
Brugia malayi | PAS domain containing protein | 0.0051 | 0.0579 | 0.0582 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.03 | 0.9948 | 1 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0059 | 0.0866 | 0.0799 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0059 | 0.0866 | 0.0799 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 1 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0121 | 0.3206 | 1 |
Leishmania major | protein kinase, putative | 0.0121 | 0.3206 | 0.3223 |
Brugia malayi | hypothetical protein | 0.0172 | 0.5124 | 0.5151 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0121 | 0.3206 | 0.3223 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0059 | 0.0866 | 0.087 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1268 | 0.3956 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0121 | 0.3206 | 0.3206 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0159 | 0.4622 | 0.5031 |
Loa Loa (eye worm) | cytochrome P450 | 0.0059 | 0.0866 | 0.0943 |
Leishmania major | cytochrome p450-like protein | 0.0059 | 0.0866 | 0.087 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0059 | 0.0866 | 0.0799 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.0666 | 0.0669 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0165 | 0.0166 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0059 | 0.0866 | 0.087 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0051 | 0.0579 | 0.0582 |
Leishmania major | cytochrome p450-like protein | 0.0059 | 0.0866 | 0.087 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0059 | 0.0866 | 0.0799 |
Brugia malayi | cytochrome P450 | 0.0059 | 0.0866 | 0.087 |
Schistosoma mansoni | single-minded | 0.0051 | 0.0579 | 0.0582 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0059 | 0.0866 | 0.0799 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0121 | 0.3206 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.0666 | 0.0669 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.028 | 0.9187 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 1 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0038 | 0.0078 | 0.0078 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0301 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0301 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0113 | 0.2919 | 0.2934 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.0666 | 0.0669 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0121 | 0.3206 | 0.349 |
Schistosoma mansoni | cytochrome P450 | 0.0059 | 0.0866 | 0.087 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0059 | 0.0866 | 0.0799 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0165 | 0.0166 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0059 | 0.0866 | 0.0799 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0059 | 0.0866 | 0.0799 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0059 | 0.0866 | 0.2701 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0059 | 0.0866 | 0.0799 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0059 | 0.0866 | 0.0799 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0059 | 0.0866 | 0.2701 |
Echinococcus multilocularis | 0.012 | 0.3171 | 0.3188 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1268 | 0.3956 |
Brugia malayi | Cytochrome P450 family protein | 0.0113 | 0.2919 | 0.2934 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 25 ug ml-1 | Antiproliferative activity against human LoVo cells | ChEMBL. | 20022253 |
IC50 (functional) | > 100 ug ml-1 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release | ChEMBL. | 20022253 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.