Detailed information for compound 108845

Basic information

Technical information
  • TDR Targets ID: 108845
  • Name: 1-cyclohexyl-3-(3-methoxypropyl)urea
  • MW: 214.305 | Formula: C11H22N2O2
  • H donors: 2 H acceptors: 1 LogP: 1.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNC(=O)NC1CCCCC1
  • InChi: 1S/C11H22N2O2/c1-15-9-5-8-12-11(14)13-10-6-3-2-4-7-10/h10H,2-9H2,1H3,(H2,12,13,14)
  • InChiKey: MOONSPLDKBKNNN-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus epoxide hydrolase 2, cytoplasmic Starlite/ChEMBL References
Homo sapiens epoxide hydrolase 2, cytoplasmic Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans epoxide hydrolase EphA Get druggable targets OG5_129061 All targets in OG5_129061
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) Get druggable targets OG5_129061 All targets in OG5_129061

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0243 0.1103 0.1538
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0015 0.0335
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.046 0.2125 0.5729
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0004 0.0154
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0104 0.2282
Trypanosoma brucei unspecified product 0.003 0.0093 0.2038
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0011 0.0003 0.0008
Mycobacterium ulcerans hypothetical protein 0.0011 0.0003 0.0003
Brugia malayi alpha/beta hydrolase 0.0011 0.0003 0.0016
Echinococcus granulosus abhydrolase domain containing protein 3 0.0011 0.0003 0.0008
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0091 0.0487
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0177
Loa Loa (eye worm) hypothetical protein 0.0057 0.0223 0.105
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0216 0.7938
Trichomonas vaginalis MYB, putative 0.0061 0.0239 0.8775
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0599 0.2784 0.3885
Trypanosoma brucei unspecified product 0.0043 0.0157 0.3431
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0004 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0269 0.1226 0.5766
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0297 0.08
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0091 0.0315
Leishmania major trypanothione reductase 0.0107 0.0456 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8725
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0127 0.0127
Trichomonas vaginalis hydrolase, putative 0.0011 0.0003 0.0108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0223 0.1199
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0395 0.1819 0.2537
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0021 0.0757
Onchocerca volvulus 0.003 0.0093 0.6383
Schistosoma mansoni smad1 5 8 and 0.0018 0.0038 0.0104
Schistosoma mansoni hypothetical protein 0.0018 0.0038 0.0101
Giardia lamblia hypothetical protein 0.0056 0.0216 0.1018
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0157 0.0422
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.046 0.2125 0.5729
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0015 0.0335
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0012 0.0032
Schistosoma mansoni hypothetical protein 0.0547 0.254 0.6846
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0297 0.1396
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0011 0.0003 0.0108
Mycobacterium ulcerans lipase/esterase 0.0011 0.0003 0.0003
Plasmodium falciparum thioredoxin reductase 0.0107 0.0456 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0216 0.474
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Echinococcus multilocularis geminin 0.0547 0.254 0.6846
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0239 0.0643
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0216 0.474
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0216 0.4706
Loa Loa (eye worm) Smad1 0.0018 0.0038 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0216 0.0583
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.1279
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0004 0.0022
Mycobacterium ulcerans epoxide hydrolase EphE 0.0011 0.0003 0.0003
Mycobacterium ulcerans epoxide hydrolase EphF 0.0011 0.0003 0.0003
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0011 0.0003 0.0003
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0015 0.0044
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.046 0.2125 0.5729
Onchocerca volvulus Lipase homolog 0.0011 0.0003 0.0203
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0216 0.7938
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0216 0.474
Mycobacterium ulcerans hypothetical protein 0.0011 0.0003 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.031 0.0836
Mycobacterium ulcerans oxidoreductase 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0011 0.0003 0.0004
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0154
Leishmania major hypothetical protein, conserved 0.0056 0.0216 0.4706
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0104 0.2232
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0093 0.2038
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0216 0.0583
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0157 0.0422
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0216 0.0583
Mycobacterium ulcerans lignin peroxidase LipJ 0.0011 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0003 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0004 0.0154
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Echinococcus multilocularis abhydrolase domain containing 3 0.0011 0.0003 0.0008
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0012 0.0032
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0599 0.2784 0.2784
Echinococcus granulosus chromobox protein 1 0.0068 0.0272 0.0734
Mycobacterium ulcerans hydrolase 0.0011 0.0003 0.0003
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0216 0.474
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.474
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0145 0.5327
Leishmania major DNA polymerase kappa, putative 0.0043 0.0157 0.3389
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0297 0.08
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0061 0.0239 0.0849
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0216 0.1162
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0216 0.0583
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0004 0.0011
Echinococcus multilocularis Chromo domain 0.0011 0.0004 0.0011
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0272 0.1282
Loa Loa (eye worm) helicase 0.0011 0.0004 0.002
Mycobacterium tuberculosis Probable oxidoreductase 0.0271 0.1231 0.1718
Giardia lamblia Hypothetical protein 0.0056 0.0216 0.1018
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.015 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0093 0.2038
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0091 0.0487
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0216 0.474
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.002
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.474
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0157 0.5747
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0127 0.2773
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Schistosoma mansoni chromobox protein 0.0068 0.0272 0.0734
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.0003 0.0003
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0127 0.2773
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0157 0.0737
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0003 0.0065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0223 0.1199
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0127 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0297 0.08
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0127 0.0341
Echinococcus granulosus tar DNA binding protein 0.0073 0.0297 0.08
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0011 0.0003 0.0004
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0127 0.2773
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0319
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0038 0.0101
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0085 0.0228
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0127 0.0341
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.474
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0003 0.0065
Echinococcus multilocularis thioredoxin glutathione reductase 0.0107 0.0456 0.123
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0404 0.1861 0.8755
Schistosoma mansoni hypothetical protein 0.0018 0.0038 0.0101
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0104 0.3821
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0127 0.2726
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0071 0.0246
Loa Loa (eye worm) hypothetical protein 0.0128 0.0556 0.2614
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0216 0.0583
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Brugia malayi Smad1 0.0018 0.0038 0.0207
Schistosoma mansoni hypothetical protein 0.0547 0.254 0.6846
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0038 0.0177
Entamoeba histolytica hypothetical protein 0.0076 0.031 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8725
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0127 0.2773
Plasmodium vivax alpha/beta hydrolase, putative 0.0011 0.0003 0.0065
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.474
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1526 0.7167 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0127 0.2773
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0127 0.4644
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0068 0.1485
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.031 0.0836
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.1279
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0216 0.7938
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0297 0.08
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0216 0.474
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0216 0.474
Echinococcus multilocularis chromobox protein 1 0.0068 0.0272 0.0734
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Mycobacterium ulcerans peroxidase BpoB 0.0011 0.0003 0.0003
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0216 0.0583
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Brugia malayi MH2 domain containing protein 0.0018 0.0038 0.0207
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0004 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0068 0.1485
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0216 0.0583
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0004 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0093 0.2038
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0011 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0021 0.0757
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0127 0.0595
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0011 0.0003 0.0008
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0004 0.0011
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0011 0.0003 0.0065
Entamoeba histolytica hypothetical protein 0.0076 0.031 1
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0011 0.0003 0.0004
Mycobacterium ulcerans bromoperoxidase BpoC 0.0011 0.0003 0.0003
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Plasmodium vivax thioredoxin reductase, putative 0.0107 0.0456 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0145 0.5327
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0131 0.4826
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0216 0.474
Mycobacterium leprae Probable exported protease 0.0011 0.0003 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.1279
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0127 0.0127
Mycobacterium ulcerans proline iminopeptidase PIP 0.0011 0.0003 0.0003
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0023 0.0726
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0004 0.0154
Schistosoma mansoni DNA helicase recq5 0.0029 0.0091 0.0244
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0127 0.0444
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0216 0.1018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.002
Treponema pallidum ATP-dependent DNA helicase 0.0015 0.0023 0.0023
Loa Loa (eye worm) PDE1B protein 0.0056 0.0216 0.1018
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.0216 0.1162
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.0292 0.6395
Echinococcus granulosus bloom syndrome protein 0.0043 0.0156 0.0419
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0068 0.1485
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8725
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.1879 0.5064
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0127 0.2773
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0127 0.2726
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.046 0.2125 0.5729
Onchocerca volvulus 0.0011 0.0004 0.0288
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8725
Echinococcus granulosus GPCR family 2 0.0018 0.0038 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0157 0.0218
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0104 0.3356
Echinococcus multilocularis smad 0.0018 0.0038 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0038 0.0101
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.015 0.3298
Mycobacterium tuberculosis Conserved protein 0.0011 0.0003 0.0004
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0243 0.1103 0.1538
Echinococcus granulosus Chromo domain 0.0011 0.0004 0.0011
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Mycobacterium ulcerans hydrolase 0.0011 0.0003 0.0003
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0015 0.0335
Trichomonas vaginalis MYB3r3, putative 0.006 0.0238 0.8725
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0127 0.2773
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Leishmania major hypothetical protein, conserved 0.0025 0.0068 0.1429
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0023 0.0494
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0216 0.0583
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0068 0.1485
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0004 0.0135
Echinococcus granulosus cpg binding protein 0.003 0.0095 0.0255
Mycobacterium ulcerans haloalkane dehalogenase 0.0011 0.0003 0.0003
Brugia malayi MH1 domain containing protein 0.0018 0.0038 0.0207
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0011 0.0003 0.0014
Schistosoma mansoni hypothetical protein 0.0018 0.0038 0.0101
Echinococcus multilocularis GPCR, family 2 0.0018 0.0038 0.0101
Mycobacterium ulcerans hypothetical protein 0.0013 0.0015 0.0015
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0104 0.2282
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0127 0.2773
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0271 0.1231 0.1718
Brugia malayi Alpha/beta hydrolase 0.0011 0.0003 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0003 0.0065
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0011 0.0003 0.0065
Trichomonas vaginalis DNA helicase recq, putative 0.0043 0.0156 0.5711
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Schistosoma mansoni hypothetical protein 0.0039 0.0137 0.037
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0216 0.0583
Echinococcus granulosus Smad4 0.0018 0.0038 0.0104
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0091 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0011 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0154
Mycobacterium ulcerans haloalkane dehalogenase 0.0011 0.0003 0.0003
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0216 0.1162
Schistosoma mansoni cpg binding protein 0.0029 0.0087 0.0235
Schistosoma mansoni Smad4 0.0018 0.0038 0.0104
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0646
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.0216 0.4706
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0216 0.474
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0038 0.0101
Echinococcus granulosus chromobox protein 2 0.0011 0.0004 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0157 0.0422
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0271 0.1231 0.1718
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0011 0.0003 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0272 1
Onchocerca volvulus 0.0012 0.0007 0.0492
Leishmania major DNA polymerase eta, putative 0.0042 0.015 0.3255
Echinococcus granulosus smad 0.0018 0.0038 0.0104
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0023 0.007
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2125 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0038 0.0101
Brugia malayi Protein cec-1. 0.0011 0.0004 0.0022
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0038 0.0104
Trichomonas vaginalis hypothetical protein 0.0011 0.0004 0.0154
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0127 0.0341
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0216 0.474
Brugia malayi hypothetical protein 0.0016 0.0027 0.0143
Mycobacterium ulcerans exported protease 0.0011 0.0003 0.0003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Mycobacterium ulcerans epoxide hydrolase EphA 0.0395 0.1819 0.1819
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0427
Trichomonas vaginalis C-MYB, putative 0.006 0.0238 0.8725
Loa Loa (eye worm) hypothetical protein 0.0056 0.0216 0.1018
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0004 0.0135
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0074 0.1622
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8725
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0004 0.0022
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0015 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.1279
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0127 0.2773
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0297 0.1396
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0243 0.1103 0.1538
Echinococcus multilocularis dna polymerase eta 0.0072 0.0292 0.0786
Brugia malayi glutathione reductase 0.0107 0.0456 0.2452
Loa Loa (eye worm) hypothetical protein 0.0072 0.0292 0.1373
Echinococcus granulosus Chromobox protein 3 0.0011 0.0004 0.0011
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0239 0.8775
Mycobacterium tuberculosis Probable exported protease 0.0011 0.0003 0.0004
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0011 0.0003 0.0108
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0142 0.3116
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0011 0.0003 0.0065
Brugia malayi CHD4 protein 0.0013 0.0012 0.0064
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0292 0.1568
Loa Loa (eye worm) hypothetical protein 0.046 0.2125 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.046 0.2125 0.7631
Entamoeba histolytica hypothetical protein 0.0011 0.0004 0.0135
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0011 0.0003 0.0065
Echinococcus granulosus thioredoxin glutathione reductase 0.0107 0.0456 0.123
Plasmodium falciparum thioredoxin reductase 0.0037 0.0127 0.2773
Plasmodium falciparum epoxide hydrolase 1 0.0011 0.0003 0.0065
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0157 0.0218
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Giardia lamblia ENC6 protein 0.0011 0.0003 0.0014
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8725
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0038 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0216 0.7938
Echinococcus granulosus microtubule associated protein 2 0.0795 0.371 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0127 0.2773
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Trichomonas vaginalis pc-MYB2, putative 0.006 0.0238 0.8725
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Mycobacterium ulcerans epoxide hydrolase EphB 0.0011 0.0003 0.0003
Treponema pallidum NADH oxidase 0.0037 0.0127 0.0127
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0011 0.0003 0.0004
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0091 0.1988
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0015 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0079 0.2899
Schistosoma mansoni chromobox protein 0.0011 0.0004 0.0011
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0216 0.0583
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0038 0.0202
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0106
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.0216 0.0583
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0127 0.2773
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0216 0.474
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0157 0.5046
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0004 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0216 0.474
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0015 0.0335
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0243 0.1103 0.1538
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0216 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0154
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0011 0.0003 0.0108
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.474
Plasmodium falciparum glutathione reductase 0.0107 0.0456 1
Schistosoma mansoni cpg binding protein 0.003 0.0095 0.0255
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0127 0.2773
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2125 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0157 0.3431
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0038 0.0104
Loa Loa (eye worm) hypothetical protein 0.0056 0.0216 0.1018
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.0216 0.474
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.0003 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0223 0.105
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0015 0.0335
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0216 0.0583
Mycobacterium leprae Probable exported protease 0.0011 0.0003 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0018 0.0675
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0297 0.1594
Mycobacterium tuberculosis Probable dehydrogenase 0.0243 0.1103 0.1538
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0011 0.0003 0.0004
Entamoeba histolytica hypothetical protein 0.0011 0.0004 0.0135
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0004 0.0154
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0004 0.0154
Brugia malayi RNA binding protein 0.0073 0.0297 0.1594
Mycobacterium ulcerans exported protease 0.0011 0.0003 0.0003
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0091 0.0427
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0072
Schistosoma mansoni hypothetical protein 0.0407 0.1879 0.5064
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0216 0.0583
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0216 0.474
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0003 0.0065
Leishmania major DNA polymerase eta, putative 0.0072 0.0292 0.6372
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0127 0.0444
Trypanosoma cruzi trypanothione reductase, putative 0.0107 0.0456 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0216 0.474
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0011 0.0003 0.0095
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0145 1
Schistosoma mansoni DNA polymerase eta 0.0072 0.0292 0.0786
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0011 0.0003 0.0008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0068 0.1485
Onchocerca volvulus 0.0011 0.0004 0.0288
Leishmania major DNA polymerase kappa, putative 0.0013 0.0015 0.0272
Loa Loa (eye worm) glutathione reductase 0.0107 0.0456 0.2147
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0216 0.0583
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Trichomonas vaginalis C-MYB, putative 0.006 0.0238 0.8725
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.1279
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0216 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0131 0.4826
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0015 0.0335
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0091 0.0244
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0003 0.0003
Brugia malayi TAR-binding protein 0.0073 0.0297 0.1594
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0127 0.0177
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0157 0.3389
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0127 0.4644
Loa Loa (eye worm) RNA binding protein 0.0073 0.0297 0.1396
Schistosoma mansoni DNA helicase recq1 0.0029 0.0091 0.0244
Echinococcus multilocularis microtubule associated protein 2 0.0795 0.371 1
Entamoeba histolytica hypothetical protein 0.0011 0.0003 0.0095
Brugia malayi MH2 domain containing protein 0.0018 0.0038 0.0207
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0015 0.0335
Echinococcus granulosus abhydrolase domain containing protein 11 0.0011 0.0003 0.0008
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0216 0.474
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 0.7662
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0012 0.0056
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 0.7662
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0015 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0127 0.2773
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0216 0.7938
Loa Loa (eye worm) hypothetical protein 0.0056 0.0216 0.1018
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.474
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0004 0.0011
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0216 0.7938
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0239 0.8775
Schistosoma mansoni smad 0.0018 0.0038 0.0104
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0091 0.0244
Giardia lamblia DNA damage repair protein 0.0013 0.0015 0.0072
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0004 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0154
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0599 0.2784 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0091 0.0315
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0404 0.1861 0.5016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0127 0.2726
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0011 0.0003 0.0008
Brugia malayi hypothetical protein 0.0011 0.0004 0.0022
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0011 0.0003 0.0108
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0004 0.001
Brugia malayi Thioredoxin reductase 0.0107 0.0456 0.2452
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0035 0.1279
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0011 0.0003 0.0016
Echinococcus multilocularis abhydrolase domain containing protein 0.0011 0.0003 0.0008
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0216 0.474
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0023 0.0494
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0216 0.0583
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0011 0.0003 0.0108
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0011 0.0003 0.0004
Onchocerca volvulus Lipase homolog 0.0011 0.0003 0.0203
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0004 0.0092
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0208 0.0737
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0004 0.0011
Mycobacterium ulcerans lipase/esterase 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.002
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0004 0.0004
Echinococcus multilocularis Smad4 0.0018 0.0038 0.0104
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 0.7662
Loa Loa (eye worm) transcription factor SMAD2 0.0269 0.1226 0.5766
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0216 0.474
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0216 0.0583
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0011 0.0003 0.0004
Plasmodium falciparum alpha/beta hydrolase, putative 0.0011 0.0003 0.0065
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.002
Trypanosoma brucei unspecified product 0.003 0.0093 0.2038
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0004 0.0154
Brugia malayi Bloom's syndrome protein homolog 0.0043 0.0156 0.0836
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0011 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0014
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0216 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0015 0.0335
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0012 0.0032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Brugia malayi Heterochromatin protein 1 0.0068 0.0272 0.1464
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0004 0.0092
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0011 0.0003 0.0203
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0011 0.0003 0.0108
Schistosoma mansoni microtubule-associated protein tau 0.0795 0.371 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0004 0.0135
Echinococcus multilocularis bloom syndrome protein 0.0043 0.0156 0.0419
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0015 0.0335
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0157 0.3431
Echinococcus multilocularis chromobox protein 1 0.0068 0.0272 0.0734
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0038 0.0202
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Onchocerca volvulus 0.0029 0.0087 0.5994
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0404 0.1861 0.5016
Brugia malayi UPF0017 protein CG3488 0.0011 0.0003 0.0016
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0087 0.0409
Mycobacterium tuberculosis Probable reductase 0.0243 0.1103 0.1538
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0127 0.2773
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.008 0.0431
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.474
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0091 0.0244
Brugia malayi hydrolase, alpha/beta fold family protein 0.0011 0.0003 0.0016
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0011 0.0003 0.0108
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.031 0.0836
Schistosoma mansoni chromobox protein 0.0068 0.0272 0.0734
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0011 0.0003 0.0008
Leishmania major hypothetical protein, conserved 0.0056 0.0216 0.4706
Schistosoma mansoni cpg binding protein 0.003 0.0095 0.0255
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0015 0.0335
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0011 0.0003 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0216 0.474
Trypanosoma brucei trypanothione reductase 0.0107 0.0456 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0404 0.1861 1
Schistosoma mansoni hydrolase 0.0011 0.0003 0.0008
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0004 0.0004
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0011 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.002
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0127 0.0127
Entamoeba histolytica hypothetical protein 0.0076 0.031 1
Brugia malayi hypothetical protein 0.0025 0.0068 0.0364
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0157 0.0841
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0243 0.1103 0.1538
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0127 0.2773
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0157 0.3431
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0599 0.2784 0.2784
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0131 0.9059
Trichomonas vaginalis pc-MYB2, putative 0.006 0.0238 0.8725
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 0.7662
Trypanosoma cruzi hydrolase-like protein, putative 0.0011 0.0003 0.0065
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.046 0.2125 0.5729
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0127 0.2726
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0216 0.0583
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Loa Loa (eye worm) hypothetical protein 0.0038 0.0131 0.0619
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0015 0.0335
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0011 0.0003 0.0095
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0157 0.0422
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0003 0.0065
Plasmodium falciparum glutathione reductase 0.0037 0.0127 0.2773
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0216 0.0583
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0011 0.0003 0.0004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0271 0.1231 0.1718
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0216 0.474
Echinococcus granulosus dna polymerase eta 0.0072 0.0292 0.0786
Brugia malayi hydrolase, alpha/beta fold family protein 0.0011 0.0003 0.0016
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Entamoeba histolytica recQ family helicase, putative 0.0014 0.002 0.0639
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0216 0.0583
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0216 0.1162
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0216 0.474
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0004 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0127 0.2773
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0014 0.002 0.0435
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0004 0.0022
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0038 0.0104
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Leishmania major DNA damage repair protein, putative 0.0013 0.0015 0.0272
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0011 0.0003 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0157 0.0157
Echinococcus multilocularis cpg binding protein 0.003 0.0095 0.0255
Brugia malayi CXXC zinc finger family protein 0.0029 0.0087 0.0468
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0007 0.0019
Entamoeba histolytica hypothetical protein 0.0011 0.0004 0.0135
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0216 0.0583
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.0292 0.6395
Loa Loa (eye worm) RecQ helicase 0.0043 0.0156 0.0732
Toxoplasma gondii thioredoxin reductase 0.0107 0.0456 0.163
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.046 0.2125 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0297 0.08
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0154
Trichomonas vaginalis DNA helicase recq1, putative 0.0043 0.0156 0.5711
Schistosoma mansoni hypothetical protein 0.0076 0.031 0.0836
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0127 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0157 0.3431
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0004 0.0092
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0038 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0015 0.0335
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0038 0.0181
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0035 0.1279
Schistosoma mansoni chromobox protein 0.0011 0.0004 0.0011
Brugia malayi MH1 domain containing protein 0.0018 0.0038 0.0207
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0127 0.0127
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0297 0.08
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0038 0.0104
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2125 1 1
Trypanosoma cruzi hydrolase-like protein 0.0011 0.0003 0.0065
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0011 0.0003 0.0003
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0023 0.0061
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0068 0.1485
Echinococcus granulosus geminin 0.0547 0.254 0.6846
Mycobacterium ulcerans hypothetical protein 0.0011 0.0003 0.0003
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0091 0.0244
Echinococcus granulosus chromobox protein 1 0.0068 0.0272 0.0734
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0011 0.0003 0.0004
Echinococcus granulosus abhydrolase domain containing protein 0.0011 0.0003 0.0008
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0107 0.0456 0.0637
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.008 0.0431
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0216 0.474
Loa Loa (eye worm) hydrolase 0.0011 0.0003 0.0014
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0216 0.0583
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0127 0.2773
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0068 0.0233
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Loa Loa (eye worm) thioredoxin reductase 0.0107 0.0456 0.2147
Brugia malayi chromobox protein homolog 3 0.0038 0.0131 0.0707
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0154
Schistosoma mansoni smad1 5 8 and 0.0018 0.0038 0.0104
Schistosoma mansoni hypothetical protein 0.0018 0.0038 0.0101
Brugia malayi MH2 domain containing protein 0.0269 0.1226 0.6586
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1526 0.7167 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.1279
Mycobacterium ulcerans hypothetical protein 0.0011 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0076 0.031 1
Giardia lamblia Myb 1-like protein 0.0061 0.0239 0.1125
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0004 0.0011
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0004 0.001
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0004 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0436
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0216 0.0767
Giardia lamblia DINP protein human, muc B family 0.0043 0.0157 0.0737
Echinococcus multilocularis chromobox protein 2 0.0011 0.0004 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0137 0.0738
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0157 0.5747
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0127 0.068
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Plasmodium vivax glutathione reductase, putative 0.0107 0.0456 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0014
Brugia malayi SET domain containing protein 0.0012 0.0007 0.0038
Brugia malayi hypothetical protein 0.0076 0.031 0.1667
Echinococcus granulosus dnaJ subfamily B 0.0407 0.1879 0.5064
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0157 0.0422
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0216 0.7938
Brugia malayi polk-prov protein 0.0013 0.0015 0.0082
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0272 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0216 0.474
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0079 0.2899
Trypanosoma cruzi hydrolase-like protein, putative 0.0011 0.0003 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0154
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0157 0.0157
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0011 0.0003 0.0014
Trichomonas vaginalis MYB72, putative 0.006 0.0238 0.8725
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0216 0.474
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0216 0.7938
Echinococcus granulosus dna polymerase kappa 0.0043 0.0157 0.0422
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 0.7662
Schistosoma mansoni smad1 5 8 and 0.0018 0.0038 0.0104

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.33 uM Tested for 50 % inhibitory concentration against mouse soluble epoxide hydrolase (sEH) ChEMBL. 15056008
IC50 (binding) = 0.33 uM Tested for 50 % inhibitory concentration against mouse soluble epoxide hydrolase (sEH) ChEMBL. 15056008
IC50 (binding) = 6.2 uM Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH) ChEMBL. 15056008
IC50 (binding) = 6.2 uM Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH) ChEMBL. 15056008

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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