Detailed information for compound 1088505

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 758.905 | Formula: C35H46N6O9S2
  • H donors: 7 H acceptors: 9 LogP: 2.62 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 3
  • SMILES: SC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccccc1)CO)NC(=O)CNS(=O)(=O)c1cccc2c1cccc2N(C)C
  • InChi: 1S/C35H46N6O9S2/c1-21(2)16-26(35(47)48)39-32(44)25(17-22-10-6-5-7-11-22)38-33(45)27(19-42)40-34(46)28(20-51)37-31(43)18-36-52(49,50)30-15-9-12-23-24(30)13-8-14-29(23)41(3)4/h5-15,21,25-28,36,42,51H,16-20H2,1-4H3,(H,37,43)(H,38,45)(H,39,44)(H,40,46)(H,47,48)/t25-,26-,27-,28-/m0/s1
  • InChiKey: RTNRWVDNRCBFCB-LJWNLINESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0879 0.113
Echinococcus multilocularis peregrin 0.0033 0.0548 0.0548
Echinococcus granulosus dna polymerase kappa 0.0043 0.0783 0.0783
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0057 0.0057
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0783 0.073
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0057 0.0037
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0142 0.0117
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0294 0.0239
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0121 0.0501
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0817 0.0817
Trypanosoma brucei unspecified product 0.003 0.0485 0.0588
Schistosoma mansoni hypothetical protein 0.0461 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108 0.2198 0.2198
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0226 0.3455
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0817 0.0817
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0879 0.113
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.2173 1
Trypanosoma brucei unspecified product 0.0043 0.0783 0.0997
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0069 0.0069
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0548 0.3848
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108 0.2198 0.2198
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0404 0.5
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.047 0.1619
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.0057 0.0057
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0832 0.0832
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0121 0.0088
Leishmania major DNA polymerase eta, putative 0.0042 0.0754 0.0958
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.006 0.0023
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0783 0.073
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0037
Leishmania major DNA polymerase eta, putative 0.0072 0.1417 0.1868
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1333 0.3313
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Schistosoma mansoni flap endonuclease-1 0.0027 0.0408 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0121 0.0088
Echinococcus granulosus cpg binding protein 0.0034 0.0578 0.0578
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.2173 0.2128
Leishmania major DNA polymerase kappa, putative 0.0013 0.0121 0.0088
Giardia lamblia PHD finger protein 15 0.0033 0.0548 0.2276
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0817 0.3325
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.2173 1
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0741 0.0741
Onchocerca volvulus Alhambra homolog 0.0033 0.0548 0.0036
Echinococcus multilocularis cpg binding protein 0.0034 0.0578 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.0057 0.0057
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0701 0.0701
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.1009 0.0958
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1333 0.1333
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0754 0.0958
Brugia malayi jmjC domain containing protein 0.0042 0.0741 0.1942
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0741 0.0689
Leishmania major mitochondrial DNA polymerase beta 0.034 0.7337 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0817 0.3325
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.2173 0.6017
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0817 0.0765
Giardia lamblia Kinase, PLK 0.0106 0.2173 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0879 0.113
Echinococcus multilocularis bloom syndrome protein 0.0027 0.042 0.042
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0404 0.5
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.1174 0.1174
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0097 0.0097
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0817 0.3555
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0037
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0121 0.0064
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.1417 0.1868
Loa Loa (eye worm) MBCTL1 0.0061 0.1174 0.3193
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.1174 0.1174
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.0057 0.0057
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.2173 0.2907
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0817 0.0817
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0817 0.3325
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.1009 0.1551
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.1009 0.0958
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0832 0.0832
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0057 0.0037
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0783 0.1809
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0103 0.0947
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0783 0.3157
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.2173 0.2907
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.042 0.137
Giardia lamblia DINP protein human, muc B family 0.0043 0.0783 0.3393
Schistosoma mansoni hypothetical protein 0.0033 0.0548 0.0494
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1333 0.3313
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.2173 0.5371
Mycobacterium ulcerans hypothetical protein 0.0179 0.3781 1
Onchocerca volvulus 0.017 0.3582 1
Brugia malayi Bromodomain containing protein 0.0033 0.0548 0.1393
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.034 0.7337 1
Echinococcus granulosus bloom syndrome protein 0.0027 0.042 0.042
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.132 0.3608
Leishmania major DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Echinococcus granulosus peregrin 0.0033 0.0548 0.0548
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.1465 0.4017
Schistosoma mansoni cpg binding protein 0.0032 0.0537 0.0483
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0783 0.0997
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.2173 0.2173
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0142 0.0117
Schistosoma mansoni DNA helicase recq1 0.0011 0.0069 0.0012
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.1009 0.2729
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.2173 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.042 0.137
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0783 0.0997
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.1009 0.0958
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.1174 0.1174
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0537 0.1395
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0121 0.0088
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0754 0.5465
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1333 0.1333
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0783 0.206
Echinococcus multilocularis phd:f box containing protein 0.0011 0.0057 0.0057
Leishmania major DNA damage repair protein, putative 0.0013 0.0121 0.0088
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.1417 0.1868
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0741 0.1972
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0817 0.1044
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.2173 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0069 0.0069
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.1465 0.3995
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0103 0.0947
Giardia lamblia DNA damage repair protein 0.0013 0.0121 0.0245
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.1174 0.1174
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.1009 0.1009
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0121 0.0088
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.1891 0.1845
Echinococcus multilocularis dna polymerase eta 0.0072 0.1417 0.1417
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.047 0.1908
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.034 0.7337 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0404 0.7077
Toxoplasma gondii hypothetical protein 0.0055 0.1035 0.766
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0061 0.1174 0.3193
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0142 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.1417 0.3858
Echinococcus multilocularis flap endonuclease 1 0.0029 0.047 0.047
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0548 0.1425
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1333 0.1284
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0212 0.45 0.45
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Loa Loa (eye worm) hypothetical protein 0.0013 0.01 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.2173 1
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.047 0.8424
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.1465 0.1465
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0121 0.1301
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0817 0.0817
Onchocerca volvulus 0.0094 0.1891 0.4447
Plasmodium falciparum flap endonuclease 1 0.0029 0.047 0.8424
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0347 0.5916
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.3379 0.4563
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.1009 0.1009
Schistosoma mansoni cpg binding protein 0.0034 0.0578 0.0524
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0783 0.0997
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0773 0.0773
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.047 0.0568
Schistosoma mansoni kinase 0.0054 0.1017 0.0966
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0097 0.0097
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0121 0.0501
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.1465 0.1465
Brugia malayi jmjC domain containing protein 0.0108 0.2198 0.6075
Schistosoma mansoni hypothetical protein 0.0327 0.7038 0.7021
Echinococcus granulosus flap endonuclease 1 0.0029 0.047 0.047
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1465 0.1934
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0783 0.0783
Schistosoma mansoni DNA helicase recq5 0.0011 0.0069 0.0012
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1465 0.1934
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0404 0.0478
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0817 0.0765
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0817 0.1044
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0817 0.0817
Schistosoma mansoni hypothetical protein 0.0011 0.006 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0404 0.5
Trypanosoma brucei polo-like protein kinase 0.0106 0.2173 0.2907
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0404 0.7077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.2173 0.6002
Schistosoma mansoni cpg binding protein 0.0034 0.0578 0.0524
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0121 0.0088
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0404 0.0775
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0548 0.0548
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0817 0.3325
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0783 0.3157
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0773 0.0773
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0278 0.0627
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.047 0.0568
Echinococcus granulosus dna polymerase eta 0.0072 0.1417 0.1417
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1333 0.2751
Loa Loa (eye worm) hypothetical protein 0.0056 0.1066 0.289
Brugia malayi mbt repeat family protein 0.0054 0.1009 0.2702
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0404 0.0775
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.0057 0.0057
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0069 0.0035
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.1891 0.5203
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.006 0.0004
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0161 0.3379 0.4563
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0783 0.3157
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0069 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0986 0.4157
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.1465 0.1416
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0237 0.0181
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0069 0.0072
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1333 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.2829 0.7872
Trypanosoma brucei mitochondrial DNA polymerase beta 0.034 0.7337 1
Plasmodium falciparum phd finger protein, putative 0.0033 0.0548 1
Loa Loa (eye worm) hypothetical protein 0.017 0.3582 1
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0783 0.1809
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.1891 0.1891
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0485 0.0588
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0069 0.0097
Entamoeba histolytica Flap nuclease, putative 0.0029 0.047 0.1619
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0121 0.0088
Schistosoma mansoni DNA polymerase eta 0.0072 0.1417 0.1368
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0817 0.1044
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0121 0.0088
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0783 0.1121
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0121 0.0088
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0121 0.0088
Loa Loa (eye worm) hypothetical protein 0.0033 0.0548 0.1425
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0548 0.0548
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.2173 0.2907
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.2173 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0548 0.0494
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0986 0.4157
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0404 0.0478
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0069 0.0097
Brugia malayi polk-prov protein 0.0013 0.0121 0.0181
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1176 0.877
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.047 0.3241
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1465 0.1934
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0817 0.1044
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.1174 0.1123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0072
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.1465 0.6515
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.1465 0.1934
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0741 0.0689
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0817 0.2156
Brugia malayi Flap endonuclease-1 0.0029 0.047 0.1174
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.1009 0.1009
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0783 0.2089
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.047 0.1206
Brugia malayi mbt repeat family protein 0.0054 0.1009 0.2702
Loa Loa (eye worm) hypothetical protein 0.0045 0.0817 0.2185
Brugia malayi PHD-finger family protein 0.0013 0.01 0.0124
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0069 0.0069
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.111 0.1447
Loa Loa (eye worm) hypothetical protein 0.0054 0.1009 0.2729
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0212 0.45 0.45
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0783 0.1121
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0783 0.0997
Trypanosoma brucei unspecified product 0.003 0.0485 0.0588
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0548 0.3848
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.006 0.0004
Echinococcus granulosus phd:f box containing protein 0.0011 0.0057 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0548 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0057 0.0057
Onchocerca volvulus 0.0054 0.1009 0.1551
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1333 0.1284
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.042 0.103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1333 0.3313
Loa Loa (eye worm) hypothetical protein 0.0094 0.1891 0.5221
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0222 0.1292
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0404 0.2723
Loa Loa (eye worm) hypothetical protein 0.0013 0.0121 0.0218
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0121 0.0088
Mycobacterium tuberculosis Conserved hypothetical protein 0.0179 0.3781 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.1891 0.1891
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.2173 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0069 0.0069
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0817 0.0817
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0879 0.113
Brugia malayi hypothetical protein 0.017 0.3582 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0537 0.1363
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0783 0.0783
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.2173 0.2173
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1333 0.1754
Brugia malayi AF-10 protein 0.0011 0.006 0.0008
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0069 0.0035
Entamoeba histolytica hypothetical protein 0.0026 0.0404 0.1293
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.2173 1
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0121 0.1301
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0121 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0783 0.0997
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0404 0.2723
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.047 0.0568
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0057 0.0037
Schistosoma mansoni jumonji domain containing protein 0.0085 0.171 0.1663
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1338 0.1289
Brugia malayi PHD-finger family protein 0.0033 0.0548 0.1393
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0485 0.0588
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0783 0.0783
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0404 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.3379 0.4563
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.006 0.0023
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.1174 0.3168
Echinococcus multilocularis dnaJ subfamily B 0.0461 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1417 0.388
Loa Loa (eye worm) RecQ helicase 0.0027 0.042 0.1063
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0485 0.0588
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.1009 0.1009

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 0 % Inhibition of FTase assessed as increase in fluorescence by spectrofluorimetry in presence of farnesyl diphosphate relative to DnGCVLS ChEMBL. 20005705

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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