Detailed information for compound 1088542

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.4 | Formula: C20H22N2O3
  • H donors: 1 H acceptors: 2 LogP: 0.8 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)C1=COC[C@@H]2[C@H]1C[C@@H]1N[C@H]2C[C@@]21c1ccccc1N(C2=O)C
  • InChi: 1S/C20H22N2O3/c1-11(23)13-9-25-10-14-12(13)7-18-20(8-16(14)21-18)15-5-3-4-6-17(15)22(2)19(20)24/h3-6,9,12,14,16,18,21H,7-8,10H2,1-2H3/t12-,14+,16-,18-,20-/m0/s1
  • InChiKey: JUWMPKQYUSKQSY-KWJBKDRPSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (5HT) receptor 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Trichomonas vaginalis DNA helicase recq, putative 0.00974289 0.164698 0.353931
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00568014 0.0583896 0.154249
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus g protein coupled receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus fmrfamide receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00568014 0.0583896 0.154249
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0162493 0.334951 0.731663
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00568014 0.0583896 0.0583896
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00364643 0.0051741 0.0051741
Loa Loa (eye worm) RecQ helicase 0.0208714 0.455896 0.455896
Brugia malayi neuropeptide F receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00364643 0.0051741 0.0136685
Schistosoma mansoni DNA helicase recq1 0.00672517 0.0857346 0.226487
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00568014 0.0583896 0.118067
Trichomonas vaginalis DNA helicase recq1, putative 0.0208714 0.455896 1
Schistosoma mansoni voltage-gated potassium channel 0.00531228 0.0487639 0.128821
Schistosoma mansoni biogenic amine receptor 0.00568014 0.0583896 0.154249
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0162493 0.334951 0.731663
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00364643 0.0051741 0.0051741
Echinococcus multilocularis rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Echinococcus multilocularis fmrfamide receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus voltage gated potassium channel 0.00531228 0.0487639 0.0967111
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Brugia malayi RE15519p 0.00568014 0.0583896 0.118067
Schistosoma mansoni neuropeptide f receptor 76f 0.00568014 0.0583896 0.154249
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067
Schistosoma mansoni voltage-gated potassium channel 0.0179152 0.37854 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00568014 0.0583896 0.118067
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0149062 0.299806 0.65369
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00568014 0.0583896 0.0583896
Onchocerca volvulus 0.00568014 0.0583896 0.5
Schistosoma mansoni opsin-like receptor 0.00568014 0.0583896 0.154249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00568014 0.0583896 0.154249
Echinococcus multilocularis neuropeptide Y receptor 0.00568014 0.0583896 0.118067
Echinococcus multilocularis neuropeptide receptor A26 0.00568014 0.0583896 0.118067
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00672517 0.0857346 0.0857346
Brugia malayi G protein-coupled receptor F59B2.13 0.00568014 0.0583896 0.118067
Schistosoma mansoni neuropeptide F-like receptor 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus granulosus serotonin receptor 0.00568014 0.0583896 0.118067
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.00974289 0.164698 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00568014 0.0583896 0.154249
Brugia malayi Dopamine receptor protein 2 0.00568014 0.0583896 0.118067
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00568014 0.0583896 0.118067
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00568014 0.0583896 0.118067
Schistosoma mansoni histamine h1 receptor 0.00568014 0.0583896 0.154249
Schistosoma mansoni neuropeptide receptor 0.00568014 0.0583896 0.154249
Onchocerca volvulus 0.00568014 0.0583896 0.5
Trichomonas vaginalis DNA helicase recq, putative 0.0208714 0.455896 1
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus granulosus rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) melatonin receptor type 1A 0.00568014 0.0583896 0.0583896
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00568014 0.0583896 0.118067
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00568014 0.0583896 0.154249
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.014405 0.286691 1
Schistosoma mansoni voltage-gated potassium channel 0.00531228 0.0487639 0.128821
Schistosoma mansoni neuropeptide F-like receptor 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00568014 0.0583896 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00568014 0.0583896 0.118067
Echinococcus granulosus peptide allatostatin:somatostatin 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) ATP-dependent DNA helicase 0.00672517 0.0857346 0.0857346
Schistosoma mansoni alpha-1 adrenergic receptor 0.00568014 0.0583896 0.154249
Entamoeba histolytica recQ family helicase, putative 0.00974289 0.164698 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00568014 0.0583896 0.154249
Onchocerca volvulus 0.00568014 0.0583896 0.5
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0149062 0.299806 0.65369
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Schistosoma mansoni amine GPCR 0.00568014 0.0583896 0.154249
Schistosoma mansoni hypothetical protein 0.00568014 0.0583896 0.154249
Echinococcus granulosus tm gpcr rhodopsin 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus granulosus neuropeptide receptor 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Schistosoma mansoni amine GPCR 0.00568014 0.0583896 0.154249
Echinococcus granulosus g-protein coupled receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus orexin receptor type 2 0.00568014 0.0583896 0.118067
Echinococcus granulosus g protein coupled receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00568014 0.0583896 0.154249
Schistosoma mansoni adenoreceptor 0.00568014 0.0583896 0.154249
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.00672517 0.0857346 0.299049
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0162493 0.334951 0.334951
Schistosoma mansoni myosin xvIII 0.00568014 0.0583896 0.154249
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00568014 0.0583896 0.118067
Echinococcus multilocularis g protein coupled receptor 0.00568014 0.0583896 0.118067
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.00672517 0.0857346 0.178737
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00364643 0.0051741 0.0136685
Schistosoma mansoni growth hormone secretagogue receptor 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) hypothetical protein 0.013946 0.27468 0.27468
Brugia malayi putative neuropeptide receptor NPR1 0.00568014 0.0583896 0.118067
Schistosoma mansoni neuropeptide receptor 0.00568014 0.0583896 0.154249
Schistosoma mansoni amine GPCR 0.00568014 0.0583896 0.154249
Schistosoma mansoni biogenic amine receptor 0.00568014 0.0583896 0.154249
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.00672517 0.0857346 0.178737
Brugia malayi G-protein coupled receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Brugia malayi ORL1-like opioid receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni amine GPCR 0.00568014 0.0583896 0.154249
Echinococcus granulosus rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0145772 0.291197 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Echinococcus multilocularis neuropeptide receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00364643 0.0051741 0.0136685
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Brugia malayi Tachykinin-like peptides receptor 99D 0.00568014 0.0583896 0.118067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00568014 0.0583896 0.154249
Brugia malayi Melatonin receptor type 1A 0.00568014 0.0583896 0.118067
Brugia malayi Serotonin receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis sex peptide receptor 0.00568014 0.0583896 0.118067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00568014 0.0583896 0.118067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00568014 0.0583896 0.154249
Echinococcus granulosus biogenic amine 5HT receptor 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00568014 0.0583896 0.118067
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00568014 0.0583896 0.118067
Brugia malayi GnHR receptor homolog 0.00568014 0.0583896 0.118067
Schistosoma mansoni biogenic amine receptor 0.00568014 0.0583896 0.154249
Schistosoma mansoni hypothetical protein 0.00568014 0.0583896 0.154249
Echinococcus granulosus bloom syndrome protein 0.0208714 0.455896 1
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Onchocerca volvulus 0.00568014 0.0583896 0.5
Schistosoma mansoni voltage-gated potassium channel 0.00364643 0.0051741 0.0136685
Brugia malayi G protein-coupled receptor 0.00568014 0.0583896 0.118067
Brugia malayi neuropeptide F receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus neuropeptide s receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00568014 0.0583896 0.154249
Echinococcus multilocularis g protein coupled receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus allatostatin A receptor 0.00568014 0.0583896 0.118067
Echinococcus multilocularis neuropeptides capa receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus neuropeptides capa receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00531228 0.0487639 0.0487639
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus granulosus neuropeptide Y receptor 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Brugia malayi Serotonin receptor 0.00568014 0.0583896 0.118067
Echinococcus multilocularis neuropeptide receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00568014 0.0583896 0.154249
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00568014 0.0583896 0.118067
Echinococcus multilocularis rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.0416652 1 1
Echinococcus multilocularis g-protein coupled receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus neuropeptide FF receptor 2 0.00568014 0.0583896 0.118067
Echinococcus multilocularis somatostatin receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) G-protein coupled receptor 0.00568014 0.0583896 0.0583896
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00568014 0.0583896 0.154249
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00568014 0.0583896 0.154249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis g protein coupled receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00568014 0.0583896 0.154249
Echinococcus multilocularis rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Echinococcus multilocularis allatostatin A receptor 0.00568014 0.0583896 0.118067
Treponema pallidum ATP-dependent DNA helicase 0.0034487 0.0000000000523395 0.5
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00364643 0.0051741 0.0136685
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Echinococcus multilocularis serotonin receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus tm gpcr rhodopsin 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Schistosoma mansoni biogenic amine (5HT) receptor 0.00568014 0.0583896 0.154249
Echinococcus multilocularis serotonin receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus g protein coupled receptor 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Brugia malayi putative neuropeptide receptor 0.00568014 0.0583896 0.118067
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067
Echinococcus multilocularis bloom syndrome protein 0.0208714 0.455896 1
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067
Echinococcus granulosus neuropeptide Y receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus granulosus ATP dependent DNA helicase Q1 0.00672517 0.0857346 0.178737
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067
Schistosoma mansoni neuropeptide receptor 0.00568014 0.0583896 0.154249
Echinococcus granulosus tm gpcr rhodopsin 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Brugia malayi sulfakinin receptor protein 0.00568014 0.0583896 0.118067
Echinococcus granulosus alpha 1A adrenergic receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus 7tm_1 domain containing protein 0.00568014 0.0583896 0.118067
Echinococcus granulosus biogenic amine 5HT receptor 0.00568014 0.0583896 0.118067
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Schistosoma mansoni neuropeptide receptor 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis orexin receptor type 2 0.00568014 0.0583896 0.118067
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00568014 0.0583896 0.118067
Schistosoma mansoni amine GPCR 0.00568014 0.0583896 0.154249
Schistosoma mansoni opsin-like receptor 0.00568014 0.0583896 0.154249
Echinococcus multilocularis neuropeptide FF receptor 2 0.00568014 0.0583896 0.118067
Giardia lamblia Sgs1 DNA helicase, putative 0.00672517 0.0857346 0.5
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus granulosus 7TM GPCR rhodopsin 0.00568014 0.0583896 0.118067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00568014 0.0583896 0.154249
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00568014 0.0583896 0.118067
Echinococcus granulosus neuropeptide receptor A26 0.00568014 0.0583896 0.118067
Brugia malayi Bloom's syndrome protein homolog 0.0208714 0.455896 1
Loa Loa (eye worm) neuropeptide F receptor 0.00568014 0.0583896 0.0583896
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) hypothetical protein 0.00364643 0.0051741 0.0051741
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.00974289 0.164698 0.5
Brugia malayi Dopamine receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00531228 0.0487639 0.0967111
Schistosoma mansoni hypothetical protein 0.00568014 0.0583896 0.154249
Brugia malayi follicle stimulating hormone receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00364643 0.0051741 0.0136685
Onchocerca volvulus 0.00568014 0.0583896 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00568014 0.0583896 0.118067
Echinococcus granulosus tachykinin peptides receptor 99D 0.00568014 0.0583896 0.118067
Schistosoma mansoni opsin-like receptor 0.00568014 0.0583896 0.154249
Echinococcus multilocularis rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.00531228 0.0487639 0.0967111
Schistosoma mansoni voltage-gated potassium channel 0.0179152 0.37854 1
Echinococcus multilocularis G protein coupled receptor 139 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.00568014 0.0583896 0.5
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.00672517 0.0857346 0.178737
Brugia malayi AKH receptor 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Loa Loa (eye worm) TYRA-2 protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00531228 0.0487639 0.0967111
Brugia malayi Dopamine receptor protein 1 0.00568014 0.0583896 0.118067
Echinococcus multilocularis neuropeptide Y receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni blooms syndrome DNA helicase 0.0174227 0.365654 0.965959
Echinococcus granulosus rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Echinococcus multilocularis rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.00672517 0.0857346 0.178737
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Loa Loa (eye worm) neuropeptide F receptor 0.00568014 0.0583896 0.0583896
Onchocerca volvulus 0.00568014 0.0583896 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00568014 0.0583896 0.118067
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00568014 0.0583896 0.154249
Echinococcus granulosus ATP dependent DNA helicase Q5 0.00672517 0.0857346 0.178737
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis dro:myosuppressin receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus granulosus dro:myosuppressin receptor 0.00568014 0.0583896 0.118067
Brugia malayi G-protein coupled receptor 0.00568014 0.0583896 0.118067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis G-protein coupled receptor, putative 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00568014 0.0583896 0.118067
Echinococcus multilocularis neuropeptide s receptor 0.00568014 0.0583896 0.118067
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Echinococcus multilocularis neuropeptides capa receptor 0.00568014 0.0583896 0.118067
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Onchocerca volvulus 0.00568014 0.0583896 0.5
Echinococcus granulosus neuropeptide receptor 0.00568014 0.0583896 0.118067
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067
Echinococcus granulosus neuropeptides capa receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus hypothetical protein 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Echinococcus multilocularis voltage gated potassium channel 0.00531228 0.0487639 0.0967111
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Brugia malayi larval opioid receptor 0.00568014 0.0583896 0.118067
Echinococcus multilocularis fmrfamide receptor 0.00568014 0.0583896 0.118067
Echinococcus granulosus somatostatin receptor 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00568014 0.0583896 0.0583896
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0178537 0.376932 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0162493 0.334951 0.731663
Schistosoma mansoni DNA helicase recq5 0.00672517 0.0857346 0.226487
Echinococcus granulosus rhodopsin orphan GPCR 0.00568014 0.0583896 0.118067
Echinococcus granulosus sex peptide receptor 0.00568014 0.0583896 0.118067
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.00974289 0.164698 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.00672517 0.0857346 0.299049
Echinococcus granulosus G protein coupled receptor 139 0.00568014 0.0583896 0.118067
Onchocerca volvulus 0.00568014 0.0583896 0.5
Schistosoma mansoni hypothetical protein 0.00568014 0.0583896 0.154249
Loa Loa (eye worm) G-protein coupled receptor 0.00568014 0.0583896 0.0583896
Loa Loa (eye worm) hypothetical protein 0.00568014 0.0583896 0.0583896
Brugia malayi hypothetical protein 0.00568014 0.0583896 0.118067

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 7.6 uM Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]-hypoxanthine incorporation assay ChEMBL. 23806072
IC50 (functional) > 100 uM Cytotoxicity against human KB cells by resazurin assay ChEMBL. 23806072
Inhibition (binding) = 15.8 % Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT1 expressed in african green monkey COS1 cells at 50 uM after 30 mins by liquid scintillation counting ChEMBL. 20189404
Inhibition (binding) = 26.8 % Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT2 expressed in african green monkey COS1 cells at 50 uM after 30 mins by liquid scintillation counting ChEMBL. 20189404

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum 23806072

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.