Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0104 | 0.0514 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.103 | 0.2815 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0241 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1868 | 0.5105 |
Echinococcus granulosus | snurportin 1 | 0.0297 | 0.3659 | 0.6755 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0073 | 0.02 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.103 | 0.103 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0104 | 0.0052 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.1868 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 0.1868 | 0.1868 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0022 | 0.0073 | 0.0392 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0.0073 | 0.0135 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0022 | 0.0073 | 0.0392 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0155 | 0.0828 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.1795 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0022 | 0.0073 | 0.02 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0444 | 0.102 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0026 | 0.007 |
Brugia malayi | RNA, U transporter 1 | 0.0079 | 0.0822 | 0.4402 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0327 | 0.0687 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0073 | 0.0073 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0448 | 0.2401 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0559 | 0.1527 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0297 | 0.3659 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0448 | 0.2401 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0026 | 0.007 |
Echinococcus granulosus | muscleblind protein | 0.016 | 0.1868 | 0.3448 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0104 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0.0073 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0073 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0026 | 0.007 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0559 | 0.1527 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0104 | 0.0559 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0559 | 0.0559 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0109 | 0.1208 | 0.6467 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0155 | 0.0155 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0022 | 0.0073 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0104 | 0.0285 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0559 | 0.1347 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0104 | 0.0559 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0104 | 0.0446 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.103 | 0.1901 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.1592 | 0.4178 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0104 | 0.0285 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0022 | 0.0073 | 0.0392 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0327 | 0.0687 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 0.1868 | 0.1868 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0155 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0073 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0073 | 0.02 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0104 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0104 | 0.0446 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0026 | 0.0071 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0104 | 0.0446 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0104 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0297 | 0.3659 | 0.3659 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0292 | 0.3594 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.3594 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.3594 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.0073 | 0.0392 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.0073 | 0.02 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.1592 | 0.4292 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0.0073 | 0.0073 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0086 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0104 | 0.0285 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0073 | 0.0073 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0022 | 0.0073 | 0.0392 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0104 | 0.0446 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.103 | 0.1901 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0.0073 | 0.02 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0026 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0109 | 0.1208 | 0.1208 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0155 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0073 | 0.0135 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0109 | 0.1208 | 0.6467 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0559 | 0.3063 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0022 | 0.0073 | 0.0392 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0073 | 0.0135 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.0073 | 0.0135 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0155 | 0.0423 |
Brugia malayi | ecdysteroid receptor | 0.0022 | 0.0073 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1208 | 0.3302 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0559 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0022 | 0.0073 | 0.0392 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0559 | 0.1031 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.0073 | 0.0392 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0109 | 0.1208 | 0.3302 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0.0073 | 0.02 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0104 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0104 | 0.0446 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0022 | 0.0073 | 0.0392 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.3659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0241 | 0.0658 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0559 | 0.3013 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.0073 | 0.0135 |
Brugia malayi | nuclear hormone receptor | 0.0022 | 0.0073 | 0.0392 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0022 | 0.0073 | 0.02 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0104 | 0.0446 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0155 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.0073 | 0.02 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0109 | 0.1208 | 0.1208 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0026 | 0.007 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0022 | 0.0073 | 0.0392 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.103 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0073 | 0.02 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.103 | 0.2815 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0022 | 0.0073 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0448 | 0.1226 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0.0073 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0026 | 0.007 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0022 | 0.0073 | 0.0392 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.0073 | 0.02 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0104 | 0.0514 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0241 | 0.1289 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0.0073 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1868 | 0.5105 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0109 | 0.1208 | 0.223 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0086 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0.0073 | 0.02 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0327 | 0.0501 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0448 | 0.1226 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.103 | 0.5513 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0559 | 0.3013 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0406 | 0.6213 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0022 | 0.0073 | 0.02 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0104 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0073 | 0.02 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.0073 | 0.02 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.103 | 0.2815 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0104 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0073 | 0.0392 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0.0073 | 0.02 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0327 | 0.0687 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0.0073 | 0.0135 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.0073 | 0.0392 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0292 | 0.3594 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0927 | 0.2534 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0022 | 0.0073 | 0.02 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0.0073 | 0.0073 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0086 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0104 | 0.0052 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0104 | 0.0559 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.0073 | 0.0073 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.0073 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0073 | 0.02 |
Brugia malayi | nuclear receptor NHR-88 | 0.0022 | 0.0073 | 0.0392 |
Brugia malayi | steroid hormone receptor | 0.0022 | 0.0073 | 0.0392 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0022 | 0.0073 | 0.02 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0.0073 | 0.02 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0559 | 0.3013 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.103 | 0.2815 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0022 | 0.0073 | 0.02 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0104 | 0.0446 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0104 | 0.0446 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.0073 | 0.0135 |
Echinococcus granulosus | FTZ F1 alpha | 0.0433 | 0.5417 | 1 |
Onchocerca volvulus | 0.0024 | 0.0104 | 1 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.1795 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0155 | 0.0285 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.1592 | 0.4292 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 96 % | Antagonist activity at PAR1 expressed in CHO cells assessed as inhibition of SFLLR-induced intracellular calcium release at 10 uM | ChEMBL. | 20042334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.