TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.225 | Formula: C14H11BrFN3S
H donors: 2 H acceptors: 0 LogP: 3.87 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=S)N/N=C(\c1ccccc1F)/c1cccc(c1)Br
InChi: 1S/C14H11BrFN3S/c15-10-5-3-4-9(8-10)13(18-19-14(17)20)11-6-1-2-7-12(11)16/h1-8H,(H3,17,19,20)/b18-13-
InChiKey: AIKOOBLSJSJYFJ-AQTBWJFISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0733	0.1049
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0198	0.0888
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0733	0.0733
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0075	0.2566	0.2566
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.1909	0.273
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.0733	0.0733
Loa Loa (eye worm)	CYP4Cod1	0.0068	0.2244	0.2244
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.003	0.0669	0.2303
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.003	0.0669	0.2303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0733	0.2319
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.0733	0.2858
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.0733	0.0733
Onchocerca volvulus		0.0032	0.0733	0.3167
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.003	0.0669	0.2303
Schistosoma mansoni	ap endonuclease	0.0019	0.0198	0.0283
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.1909	0.7439
Brugia malayi	Cytochrome P450 family protein	0.0068	0.2244	0.2244
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.0733	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0251	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1136	0.4427
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.003	0.0669	0.1012
Brugia malayi	cathepsin L-like precursor	0.0023	0.0356	0.0356
Trypanosoma cruzi	cytochrome P450, putative	0.0068	0.2244	0.3395
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.003	0.0669	0.3005
Echinococcus multilocularis	cysteine protease	0.0032	0.0733	0.0733
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0733	0.2858
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0356	0.0356
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1136	0.4427
Onchocerca volvulus		0.0032	0.0733	0.3167
Trypanosoma brucei	unspecified product	0.0035	0.0854	0.3328
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1136	0.4427
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0234	0.9275	0.9275
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0733	0.2319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.018	0.0702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Brugia malayi	cathepsin B-like cysteine proteinase	0.0171	0.6612	0.6612
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.003	0.0669	0.1012
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.018	0.0272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.2227	0.9913
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0198	0.0319
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0041	0.1136	0.4006
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.003	0.0669	0.3005
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	0.6612	0.9458
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0733	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Plasmodium vivax	vivapain-2	0.0032	0.0733	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0075	0.2566	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.1909	0.7245
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.2566	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0075	0.2566	0.3671
Mycobacterium leprae	putative cytochrome p450	0.003	0.0669	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0733	0.2319
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.003	0.0669	0.3005
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0075	0.2566	0.2566
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0198	0.0771
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	0.6612	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0733	0.0733
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.003	0.0669	0.3005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.1136	0.1718
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Onchocerca volvulus		0.0032	0.0733	0.3167
Toxoplasma gondii	cytochrome p450 superfamily protein	0.003	0.0669	0.2323
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.1136	0.4583
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1136	0.4427
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.018	0.0272
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.0733	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0733	0.0733
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0733	0.1109
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0356	0.051
Loa Loa (eye worm)	cytochrome P450 family protein	0.0068	0.2244	0.2244
Echinococcus granulosus	cathepsin l1	0.0032	0.0733	0.0733
Echinococcus multilocularis	ubiquitin specific protease 41	0.0075	0.2566	0.2566
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0733	0.2319
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.003	0.0669	0.2303
Leishmania major	cathepsin L-like protease	0.0032	0.0733	0.2858
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.003	0.0669	0.2303
Schistosoma mansoni	ap endonuclease	0.0019	0.0198	0.0283
Onchocerca volvulus		0.0032	0.0733	0.3167
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0198	0.0198
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0075	0.2566	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0198	0.0198
Brugia malayi	cytochrome P450	0.003	0.0669	0.0669
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0356	0.1388
Echinococcus granulosus	cathepsin l1	0.0023	0.0356	0.0356
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.003	0.0669	0.3005
Leishmania major	cathepsin L-like protease	0.0032	0.0733	0.2858
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.003	0.0669	0.2303
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0733	0.0733
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.003	0.0669	0.2303
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0709	0.2765
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.0733	0.3167
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.2227	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.0733	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.2227	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.018	0.0258
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.003	0.0669	0.3005
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.018	0.0702
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0198	0.0299
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0075	0.2566	0.2566
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Brugia malayi	polk-prov protein	0.0031	0.0709	0.0709
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.2227	0.2227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.2227	0.9913
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0709	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0733	0.0733
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.018	0.018
Brugia malayi	Cytochrome P450 family protein	0.0068	0.2244	0.2244
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0733	0.2319
Echinococcus granulosus	cathepsin b	0.0171	0.6612	0.6612
Onchocerca volvulus		0.0032	0.0733	0.3167
Leishmania major	cytochrome p450-like protein	0.0068	0.2244	0.8747
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0709	0.2765
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Schistosoma mansoni	hypothetical protein	0.018	0.6991	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.018	0.0272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0733	0.2319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.003	0.0669	0.3005
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0733	0.1109
Loa Loa (eye worm)	ctsf protein	0.0032	0.0733	0.0733
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.1909	0.7439
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0075	0.2566	1
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0282	0.1098
Echinococcus multilocularis	survival motor neuron protein 1	0.0251	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.018	0.018
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0733	0.0733
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0282	0.1266
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0733	0.0733
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.6612	0.9458
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0356	0.0539
Leishmania major	cathepsin L-like protease	0.0032	0.0733	0.2858
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0733	0.2858
Mycobacterium leprae	Conserved hypothetical protein	0.003	0.0669	0.5
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0198	0.0319
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.6612	0.9458
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.003	0.0669	0.3005
Leishmania major	cathepsin L-like protease	0.0032	0.0733	0.2858
Loa Loa (eye worm)	cytochrome P450 family protein	0.0068	0.2244	0.2244
Echinococcus multilocularis		0.003	0.0669	0.0669
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0198	0.0299
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.003	0.0669	0.1012
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.003	0.0669	0.2607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.018	0.0702
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.0733	0.1109
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.003	0.0669	0.2303
Entamoeba histolytica	cysteine proteinase 2	0.0019	0.018	0.0702
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0198	0.0771
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1136	0.4427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0356	0.0738
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0075	0.2566	1
Loa Loa (eye worm)	fibroinase	0.0032	0.0733	0.0733
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.003	0.0669	0.2303
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0733	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0356	0.0356
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.2227	0.3185
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1136	0.4427
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0733	0.0733
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0198	0.0771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0075	0.2566	0.3671
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0075	0.2566	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0733	0.1109
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.018	0.0272
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.003	0.0669	0.2303
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0075	0.2566	0.2566
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0356	0.0356
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0733	0.1049
Echinococcus multilocularis	cathepsin b	0.0171	0.6612	0.6612
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.003	0.0669	0.3005
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1136	0.4427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.003	0.0669	0.3005
Giardia lamblia	Cathepsin B precursor	0.006	0.1909	0.7225
Toxoplasma gondii	cathepsin B	0.006	0.1909	0.8433
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.003	0.0669	0.2303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0733	0.2319
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0356	0.0356
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0198	0.0198
Echinococcus granulosus	cathepsin b	0.0171	0.6612	0.6612
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0669	0.0669
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.003	0.0669	0.3005
Echinococcus granulosus	cysteine protease	0.0019	0.018	0.018
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0282	0.1098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0356	0.0356
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.003	0.0669	0.2607
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.003	0.0669	0.3005
Echinococcus multilocularis	cathepsin b	0.0171	0.6612	0.6612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0282	0.1098
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.003	0.0669	0.2303
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0068	0.2244	1
Schistosoma mansoni	hypothetical protein	0.0051	0.1548	0.2214
Echinococcus granulosus	dna polymerase kappa	0.0041	0.1136	0.1136
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0733	0.3167
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.003	0.0669	0.3005
Brugia malayi	Cytochrome P450 family protein	0.003	0.0669	0.0669
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.003	0.0669	0.2303
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.003	0.0669	0.2303
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0075	0.2566	0.2566
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Echinococcus granulosus	survival motor neuron protein 1	0.0251	1	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0075	0.2566	0.3881
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.018	0.0702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0733	0.0733
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.003	0.0669	0.2303
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.2227	0.2227
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0733	0.2858
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.1136	0.1718
Onchocerca volvulus		0.0032	0.0733	0.3167
Loa Loa (eye worm)	cathepsin B	0.006	0.1909	0.1909
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.003	0.0669	0.3005
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.2227	0.8678
Schistosoma mansoni	hypothetical protein	0.003	0.0669	0.0957
Leishmania major	cytochrome p450-like protein	0.003	0.0669	0.2607
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2566	0.2566
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.1136	0.4427
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.003	0.0669	0.2303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0733	0.2319
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0075	0.2566	0.3881
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.1136	0.1718
Leishmania major	cytochrome p450-like protein	0.003	0.0669	0.2607
Echinococcus multilocularis	cathepsin L	0.0019	0.018	0.018
Leishmania major	cathepsin L-like protease	0.0032	0.0733	0.2858
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.003	0.0669	0.3005
Echinococcus granulosus	ubiquitin specific protease 41	0.0075	0.2566	0.2566
Giardia lamblia	Cathepsin B precursor	0.006	0.1909	0.7225
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.018	0.0702
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.003	0.0669	0.3005
Plasmodium vivax	vivapain-2	0.0032	0.0733	1
Schistosoma mansoni	survival motor neuron protein	0.0051	0.1548	0.2214
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0733	0.2319
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0198	0.5
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0356	0.0356
Leishmania major	cathepsin L-like protease	0.0032	0.0733	0.2858
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.018	0.0258
Leishmania major	cathepsin L-like protease	0.0032	0.0733	0.2858
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.1136	0.1136
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.003	0.0669	0.2303
Trypanosoma brucei	cytochrome P450, putative	0.0068	0.2244	0.8747
Entamoeba histolytica	cysteine proteinase 1, putative	0.0019	0.018	0.0702
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.0733	0.0733
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.003	0.0669	0.2303
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.1136	0.1718
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0733	0.0733
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.1136	0.4427
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0282	0.0355
Toxoplasma gondii	cathepsin CPL	0.0032	0.0733	0.264
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0733	0.1109
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0198	0.5
Echinococcus multilocularis	geminin	0.018	0.6991	0.6991
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0198	0.0198
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.1136	0.4583
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1136	0.4427
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0733	0.2319
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.018	0.018
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.2227	0.9913
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0733	0.3167
Echinococcus granulosus	cathepsin L	0.0019	0.018	0.018
Echinococcus multilocularis	cysteine protease	0.0032	0.0733	0.0733
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.003	0.0669	0.2303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0733	0.2319
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.0733	1
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.003	0.0669	0.2303
Giardia lamblia	Cathepsin B precursor	0.006	0.1909	0.7225
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Schistosoma mansoni	cytochrome P450	0.003	0.0669	0.0957
Echinococcus granulosus	geminin	0.018	0.6991	0.6991
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.009	0.035
Trichomonas vaginalis	DNA polymerase eta, putative	0.0041	0.1136	0.4006
Loa Loa (eye worm)	cytochrome P450	0.003	0.0669	0.0669
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.6612	0.9458
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.1548	0.1548
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.009	0.035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0356	0.0738
Onchocerca volvulus		0.0051	0.1548	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.009	0.035
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0198	0.0074
Brugia malayi	Cytochrome P450 family protein	0.003	0.0669	0.0669
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.003	0.0669	0.3005
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0957	0.0957
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.018	0.0272
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.018	0.0258
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.1909	0.2887
Brugia malayi	follicle stimulating hormone receptor	0.0234	0.9275	0.9275
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0198	0.0074
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0075	0.2566	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.003	0.0669	0.3005
Echinococcus granulosus	cytochrome P450 2K1	0.003	0.0669	0.0669
Leishmania major	cathepsin L-like protease	0.0032	0.0733	0.2858
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.003	0.0669	0.3005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0733	0.2319
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.018	0.0702
Onchocerca volvulus		0.0032	0.0733	0.3167
Loa Loa (eye worm)	cysteine protease	0.0032	0.0733	0.0733
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.2227	0.3185
Trypanosoma brucei	DNA polymerase IV, putative	0.0035	0.0854	0.3328
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0733	0.2858
Schistosoma mansoni	hypothetical protein	0.018	0.6991	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.003	0.0669	0.3005
Trypanosoma cruzi	cytochrome P450, putative	0.0068	0.2244	0.3395
Loa Loa (eye worm)	hypothetical protein	0.0171	0.6612	0.6612
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.1136	0.4427
Entamoeba histolytica	cysteine protease, putative	0.0019	0.018	0.0702

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 40.5 %	Inhibition of human DU145 cells migration at 20 uM after 24 hrs by Matrigel assay relative to control	ChEMBL.	20089402
Activity (functional)	= 61.5 %	Inhibition of human DU145 cells invasion at 20 uM after 24 hrs by Matrigel assay relative to control	ChEMBL.	20089402
GI50 (functional)	= 13.8 uM	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	ChEMBL.	20089402
GI50 (functional)	= 23.5 uM	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	ChEMBL.	20089402
IC50 (binding)	= 30.5 nM	Inhibition of human liver cathepsin L	ChEMBL.	20089402
IC50 (binding)	> 10000 nM	Inhibition of human liver cathepsin B	ChEMBL.	20089402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL589280

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1088759