Detailed information for compound 1089226

Basic information

Technical information
  • TDR Targets ID: 1089226
  • Name: 4-amino-5-(2-fluorobenzoyl)-2-[4-(phenoxy)phe nyl]-1H-pyrrole-3-carboxamide
  • MW: 415.416 | Formula: C24H18FN3O3
  • H donors: 3 H acceptors: 2 LogP: 4.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1C(=O)c1[nH]c(c(c1N)C(=O)N)c1ccc(cc1)Oc1ccccc1
  • InChi: 1S/C24H18FN3O3/c25-18-9-5-4-8-17(18)23(29)22-20(26)19(24(27)30)21(28-22)14-10-12-16(13-11-14)31-15-6-2-1-3-7-15/h1-13,28H,26H2,(H2,27,30)
  • InChiKey: RNNNKMODTHOTCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-amino-5-[(2-fluorophenyl)-oxomethyl]-2-[4-(phenoxy)phenyl]-1H-pyrrole-3-carboxamide
  • 4-amino-5-(2-fluorophenyl)carbonyl-2-[4-(phenoxy)phenyl]-1H-pyrrole-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.2142 0.6061
Schistosoma mansoni tar DNA-binding protein 0.0347 0.3534 0.4479
Echinococcus granulosus GPCR family 2 0.0069 0.0528 0.0669
Brugia malayi nuclear hormone receptor 0.01 0.0858 0.2429
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0289 0.23
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0528 0.0669
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0289 0.0818
Loa Loa (eye worm) hypothetical protein 0.026 0.2591 0.7332
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1195 0.2295
Schistosoma mansoni nuclear receptor nhr-48 0.0047 0.0289 0.0366
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Echinococcus granulosus FTZ F1 alpha 0.01 0.0858 0.1088
Echinococcus multilocularis tar DNA binding protein 0.0347 0.3534 0.3534
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0047 0.0289 0.0289
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0626 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Loa Loa (eye worm) RNA binding protein 0.0347 0.3534 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.01 0.0858 0.0858
Brugia malayi Nuclear hormone receptor family member nhr-31 0.01 0.0858 0.2429
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.01 0.0858 0.0858
Schistosoma mansoni hypothetical protein 0.0069 0.0528 0.0669
Schistosoma mansoni hypothetical protein 0.0069 0.0528 0.0669
Echinococcus granulosus intermediate filament protein 0.0029 0.0098 0.0124
Loa Loa (eye worm) hypothetical protein 0.01 0.0858 0.2429
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Brugia malayi ecdysteroid receptor 0.01 0.0858 0.2429
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0289 0.0366
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.1267 0.3586
Schistosoma mansoni hypothetical protein 0.0149 0.1395 0.1768
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0848 0.6508
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0741 0.5429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.01 0.0858 0.2429
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.2142 0.6061
Loa Loa (eye worm) hypothetical protein 0.01 0.0858 0.2429
Loa Loa (eye worm) hypothetical protein 0.01 0.0858 0.2429
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0276
Loa Loa (eye worm) hypothetical protein 0.01 0.0858 0.2429
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0741 0.5429
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0053 0.035 0.0443
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0395 0.0395
Onchocerca volvulus 0.0053 0.0354 0.2817
Loa Loa (eye worm) DR-78 0.0047 0.0289 0.0818
Brugia malayi hypothetical protein 0.0053 0.035 0.099
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0741 0.6553
Schistosoma mansoni microtubule-associated protein tau 0.0749 0.7891 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.035 0.099
Schistosoma mansoni Tr4/Tr2 (homologue) 0.01 0.0858 0.1088
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0053 0.035 0.099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.01 0.0858 0.0858
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.2142 0.6061
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0098 0.0276
Brugia malayi hypothetical protein 0.0047 0.0289 0.0818
Loa Loa (eye worm) hypothetical protein 0.0053 0.035 0.099
Brugia malayi orphan nuclear receptor NR2E1 0.0047 0.0289 0.0818
Schistosoma mansoni intermediate filament proteins 0.0029 0.0098 0.0124
Brugia malayi MH2 domain containing protein 0.0137 0.1267 0.3586
Loa Loa (eye worm) hypothetical protein 0.0053 0.035 0.099
Brugia malayi steroid hormone receptor 0.01 0.0858 0.2429
Loa Loa (eye worm) hypothetical protein 0.0053 0.035 0.099
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0181 0.0181
Brugia malayi nuclear receptor NHR-88 0.01 0.0858 0.2429
Loa Loa (eye worm) steroid hormone receptor 0.01 0.0858 0.2429
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.01 0.0858 0.1088
Brugia malayi Inositol-1 0.0078 0.0626 0.177
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0047 0.0289 0.23
Loa Loa (eye worm) glutaminase 2 0.0307 0.3105 0.8787
Mycobacterium tuberculosis Probable reductase 0.0089 0.0741 0.5429
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.1395 0.3947
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.01 0.0858 0.2429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.01 0.0858 0.2429
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0047 0.0289 0.0366
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0202 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.0626 0.5
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0741 0.5429
Brugia malayi Nuclear hormone receptor family member nhr-41 0.01 0.0858 0.2429
Brugia malayi nuclear receptor NHR-88 0.0047 0.0289 0.0818
Brugia malayi Thioredoxin reductase 0.0039 0.0202 0.057
Loa Loa (eye worm) glutaminase 0.0307 0.3105 0.8787
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0202 0.057
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0047 0.0289 0.0366
Echinococcus multilocularis microtubule associated protein 2 0.0749 0.7891 0.7891
Schistosoma mansoni retinoid-x-receptor (RXR) 0.01 0.0858 0.1088
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0181 0.0229
Schistosoma mansoni glutaminase 0.0307 0.3105 0.3935
Echinococcus granulosus tar DNA binding protein 0.0347 0.3534 0.4479
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.01 0.0858 0.0858
Echinococcus granulosus lamin dm0 0.0029 0.0098 0.0124
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0395 0.05
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1195 0.2295
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0528 0.1493
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0289 0.0289
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0626 0.427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.01 0.0858 0.2429
Schistosoma mansoni tar DNA-binding protein 0.0347 0.3534 0.4479
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.035 0.099
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0626 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.01 0.0858 0.1088
Loa Loa (eye worm) hypothetical protein 0.0053 0.035 0.099
Brugia malayi hypothetical protein 0.0047 0.0289 0.0818
Echinococcus multilocularis lamin dm0 0.0029 0.0098 0.0098
Brugia malayi hypothetical protein 0.026 0.2591 0.7332
Brugia malayi hypothetical protein 0.0053 0.035 0.099
Brugia malayi Nuclear hormone receptor E75 0.0047 0.0289 0.0818
Onchocerca volvulus 0.0029 0.0098 0.0776
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.1195 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.01 0.0858 0.2429
Echinococcus granulosus nuclear receptor 2DBD gamma 0.01 0.0858 0.1088
Loa Loa (eye worm) nuclear hormone receptor 0.0047 0.0289 0.0818
Echinococcus multilocularis GPCR, family 2 0.0069 0.0528 0.0528
Plasmodium falciparum thioredoxin reductase 0.0039 0.0202 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.01 0.0858 0.2429
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.01 0.0858 0.1088
Schistosoma mansoni tar DNA-binding protein 0.0347 0.3534 0.4479
Schistosoma mansoni survival motor neuron protein 0.0053 0.0354 0.0448
Brugia malayi nuclear hormone receptor 0.0047 0.0289 0.0818
Echinococcus multilocularis FTZ F1 alpha 0.01 0.0858 0.0858
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1195 0.1514
Onchocerca volvulus Bile acid receptor homolog 0.01 0.0858 0.6831
Echinococcus granulosus nuclear receptor 2DBD gamma 0.01 0.0858 0.1088
Brugia malayi intermediate filament protein 0.0029 0.0098 0.0276
Schistosoma mansoni lamin 0.0029 0.0098 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.01 0.0858 0.2429
Echinococcus granulosus nuclear receptor nhr 48 0.0047 0.0289 0.0366
Echinococcus granulosus ecdysone induced protein 78C 0.01 0.0858 0.1088
Brugia malayi conserved hypotetical protein 0.0047 0.0289 0.0818
Schistosoma mansoni tar DNA-binding protein 0.0347 0.3534 0.4479
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.1195 0.1195
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.2142 0.6061
Echinococcus granulosus lamin 0.0029 0.0098 0.0124
Loa Loa (eye worm) hypothetical protein 0.01 0.0858 0.2429
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0626 0.0793
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.035 0.099
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0053 0.035 0.0443
Schistosoma mansoni RAR-like nuclear receptor 0.01 0.0858 0.1088
Brugia malayi hypothetical protein 0.0037 0.0181 0.0512
Schistosoma mansoni lipoxygenase 0.0057 0.0395 0.05
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.1267 0.3586
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0289 0.0366
Echinococcus multilocularis ecdysone induced protein 78C 0.01 0.0858 0.0858
Loa Loa (eye worm) glutathione reductase 0.0039 0.0202 0.057
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0626 0.0626
Onchocerca volvulus Huntingtin homolog 0.0136 0.1256 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0047 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.0037 0.0181 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-3 0.01 0.0858 0.2429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.01 0.0858 0.2429
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0528 0.1493
Brugia malayi nuclear receptor NHR-67 0.0047 0.0289 0.0818
Schistosoma mansoni steroid hormone receptor ad4bp 0.01 0.0858 0.1088
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0047 0.0289 0.0366
Echinococcus granulosus survival motor neuron protein 1 0.026 0.2591 0.3284
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Schistosoma mansoni coup transcription factor 0.01 0.0858 0.1088
Echinococcus multilocularis thyroid hormone receptor alpha 0.01 0.0858 0.0858
Plasmodium falciparum glutathione reductase 0.0039 0.0202 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0528 0.1493
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0098 0.0276
Schistosoma mansoni lamin 0.0029 0.0098 0.0124
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0053 0.035 0.035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0181 0.0229
Loa Loa (eye worm) hypothetical protein 0.0149 0.1395 0.3947
Onchocerca volvulus 0.0047 0.0289 0.23
Brugia malayi nuclear hormone receptor family member odr-7 0.0047 0.0289 0.0818
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0289 0.0366
Brugia malayi RNA binding protein 0.0347 0.3534 1
Trichomonas vaginalis glutaminase, putative 0.0307 0.3105 1
Brugia malayi RNA recognition motif domain containing protein 0.0347 0.3534 1
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1195 0.1514
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0289 0.0366
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0528 0.0669
Schistosoma mansoni inositol monophosphatase 0.0078 0.0626 0.0793
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0741 0.5429
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.01 0.0858 0.1088
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.026
Loa Loa (eye worm) TAR-binding protein 0.0347 0.3534 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0354 0.1001
Loa Loa (eye worm) hypothetical protein 0.0136 0.1256 0.3555
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.01 0.0858 0.6831
Schistosoma mansoni hypothetical protein 0.0069 0.0528 0.0669
Plasmodium vivax glutathione reductase, putative 0.0039 0.0202 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.01 0.0858 0.2429
Onchocerca volvulus 0.01 0.0858 0.6831
Brugia malayi Nuclear hormone receptor family member nhr-49 0.01 0.0858 0.2429
Brugia malayi tailless protein 0.0047 0.0289 0.0818
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.01 0.0858 0.1088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.01 0.0858 0.2429
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.01 0.0858 0.1088
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0537 0.3379
Schistosoma mansoni nuclear receptor 0.0047 0.0289 0.0366
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Schistosoma mansoni thyroid hormone receptor 0.01 0.0858 0.1088
Onchocerca volvulus 0.0047 0.0289 0.23
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0626 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0741 0.5429
Brugia malayi glutathione reductase 0.0039 0.0202 0.057
Schistosoma mansoni hypothetical protein 0.0069 0.0528 0.0669
Schistosoma mansoni hypothetical protein 0.0053 0.0354 0.0448
Loa Loa (eye worm) hypothetical protein 0.0136 0.1256 0.3555
Echinococcus granulosus thyroid hormone receptor alpha 0.0047 0.0289 0.0366
Echinococcus multilocularis musashi 0.0029 0.0098 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.01 0.0858 0.2429
Brugia malayi Nuclear hormone receptor family member nhr-1 0.01 0.0858 0.2429
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.1195 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Brugia malayi hypothetical protein 0.0136 0.1256 0.3555
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0848 0.6508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.01 0.0858 0.0858
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0289 0.0289
Loa Loa (eye worm) nuclear receptor NHR-67 0.0047 0.0289 0.0818
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.01 0.0858 0.1088
Echinococcus granulosus microtubule associated protein 2 0.0749 0.7891 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0047 0.0289 0.0818
Echinococcus multilocularis nuclear receptor nhr 48 0.0047 0.0289 0.0289
Schistosoma mansoni inositol monophosphatase 0.0078 0.0626 0.0793
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1195 0.2295
Schistosoma mansoni thyroid hormone receptor 0.01 0.0858 0.1088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.01 0.0858 0.2429
Mycobacterium ulcerans glutaminase 0.0307 0.3105 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.2591 0.2591
Brugia malayi ecdysone receptor 0.0047 0.0289 0.0818
Brugia malayi nuclear hormone receptor family member nhr-6 0.0047 0.0289 0.0818
Onchocerca volvulus 0.0029 0.0098 0.0776
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0098 0.0276
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0047 0.0289 0.0289
Schistosoma mansoni tar DNA-binding protein 0.0347 0.3534 0.4479
Loa Loa (eye worm) inositol-1 0.0078 0.0626 0.177
Brugia malayi Nuclear hormone receptor family member nhr-40 0.01 0.0858 0.2429
Brugia malayi glutaminase DH11.1 0.0307 0.3105 0.8787
Brugia malayi Nuclear hormone receptor family member nhr-14 0.01 0.0858 0.2429
Schistosoma mansoni retinoic acid receptor RXR 0.01 0.0858 0.1088
Onchocerca volvulus Huntingtin homolog 0.0136 0.1256 1
Schistosoma mansoni nuclear receptor 0.0047 0.0289 0.0366
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0207 0.0263
Onchocerca volvulus Protein ultraspiracle homolog 0.01 0.0858 0.6831
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.1195 0.1514
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0047 0.0289 0.0818
Loa Loa (eye worm) hypothetical protein 0.01 0.0858 0.2429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.01 0.0858 0.2429
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0347 0.3534 1
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.1195 1
Echinococcus multilocularis lamin 0.0029 0.0098 0.0098
Schistosoma mansoni zinc finger protein 0.0047 0.0289 0.0366
Loa Loa (eye worm) hypothetical protein 0.0069 0.0528 0.1493
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0528 0.0528
Echinococcus granulosus retinoic acid receptor rxr beta a 0.01 0.0858 0.1088
Brugia malayi TAR-binding protein 0.0347 0.3534 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0626 0.427
Echinococcus granulosus Nuclear hormone receptor HR96 0.0047 0.0289 0.0366
Brugia malayi nuclear receptor RXR 0.0053 0.035 0.099
Brugia malayi photoreceptor-specific nuclear receptor 0.01 0.0858 0.2429
Loa Loa (eye worm) hypothetical protein 0.0047 0.0289 0.0818
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0626 1
Brugia malayi nuclear receptor RXR 0.0047 0.0289 0.0818
Brugia malayi Steroid receptor seven-up type 2 0.01 0.0858 0.2429
Schistosoma mansoni nuclear hormone receptor 0.01 0.0858 0.1088
Loa Loa (eye worm) hypothetical protein 0.01 0.0858 0.2429
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0207 0.0207
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.0858 0.2429
Loa Loa (eye worm) hypothetical protein 0.01 0.0858 0.2429
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0848 0.6508
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.01 0.0858 0.0858
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.035 0.0443
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.01 0.0858 0.1088

Activities

Activity type Activity value Assay description Source Reference
C50 (binding) = 1.5 nM Inhibition of human recombinant Lck expressed in insect cells by Packard topcount method ChEMBL. 19945869

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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