TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 502.608 | Formula: C26H22N4O3S2
H donors: 1 H acceptors: 3 LogP: 3.56 Rotable bonds: 4
Rule of 5 violations (Lipinski): 2
SMILES: Cc1ccc(cc1)CN1c2ccccc2C(=C(S1(=O)=O)/C=N/c1ccc2c(c1)n1CCN=c1s2)O
InChi: 1S/C26H22N4O3S2/c1-17-6-8-18(9-7-17)16-30-21-5-3-2-4-20(21)25(31)24(35(30,32)33)15-28-19-10-11-23-22(14-19)29-13-12-27-26(29)34-23/h2-11,14-15,31H,12-13,16H2,1H3/b28-15+
InChiKey: QDTIUJOXKBPJSQ-RWPZCVJISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0341823
Brugia malayi	G-protein coupled receptor	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00185095	0.0220621	0.242988
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.00185095	0.0220621	0.242988
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Brugia malayi	Cathepsin L-like precursor	0.00185095	0.0220621	0.0220621
Brugia malayi	G protein-coupled receptor F59B2.13	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	g protein coupled receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	neuropeptide F-like receptor	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.00895829	0.325603	0.310389
Schistosoma mansoni	neuropeptide receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	biogenic amine receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0341823
Echinococcus granulosus	neuropeptide s receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	neuropeptides capa receptor	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	g-protein coupled receptor	0.00263366	0.0554903	0.0341823
Echinococcus multilocularis	cathepsin b	0.00759018	0.267174	0.250641
Schistosoma mansoni	amine GPCR	0.00263366	0.0554903	0.0554903
Entamoeba histolytica	cysteine protease, putative	0.00185095	0.0220621	1
Schistosoma mansoni	biogenic amine receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	biogenic amine 5HT receptor	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00185095	0.0220621	0.242988
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.00346031	0.0907949	0.0907949
Onchocerca volvulus		0.00185095	0.0220621	0.397585
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	neuropeptide Y receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	cathepsin b	0.00759018	0.267174	0.267174
Echinococcus granulosus	cathepsin l1	0.00185095	0.0220621	0.0220621
Brugia malayi	follicle stimulating hormone receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00263366	0.0554903	0.0341823
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.00263366	0.0554903	0.0341823
Onchocerca volvulus		0.00185095	0.0220621	0.397585
Echinococcus granulosus	cathepsin b	0.00759018	0.267174	0.267174
Echinococcus granulosus	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0554903
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	ctsf protein	0.00185095	0.0220621	0.0220621
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00185095	0.0220621	0.242988
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Brugia malayi	G-protein coupled receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	GnHR receptor homolog	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.00759018	0.267174	0.267174
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Brugia malayi	Serotonin receptor	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Echinococcus granulosus	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0554903
Brugia malayi	Cathepsin L-like precursor	0.00185095	0.0220621	0.0220621
Echinococcus multilocularis	neuropeptide Y receptor	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.00185095	0.0220621	0.0220621
Brugia malayi	putative neuropeptide receptor NPR1	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0247491	1	1
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.00895829	0.325603	0.325603
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	histamine h1 receptor	0.00263366	0.0554903	0.0554903
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0247491	1	1
Brugia malayi	Dopamine receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	cathepsin B-like cysteine proteinase	0.00759018	0.267174	0.267174
Schistosoma mansoni	amine GPCR	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.00263366	0.0554903	1
Plasmodium vivax	vivapain-2	0.00185095	0.0220621	0.5
Loa Loa (eye worm)	cathepsin B	0.00346031	0.0907949	0.0907949
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0247491	1	1
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Onchocerca volvulus	Cathepsin L homolog	0.00185095	0.0220621	0.397585
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.00759018	0.267174	0.267174
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	fibroinase	0.00185095	0.0220621	0.0220621
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Brugia malayi	sulfakinin receptor protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	biogenic amine (5HT) receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0341823
Echinococcus granulosus	allatostatin A receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	neuropeptide receptor	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	hypothetical protein	0.00759018	0.267174	0.267174
Schistosoma mansoni	amine GPCR	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	7TM GPCR rhodopsin	0.00263366	0.0554903	0.0554903
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.00346031	0.0907949	0.0907949
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	amine GPCR	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Giardia lamblia	Cathepsin B precursor	0.00346031	0.0907949	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.00185095	0.0220621	0.5
Echinococcus granulosus	g protein coupled receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	neuropeptide Y receptor	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.00185095	0.0220621	0.242988
Onchocerca volvulus		0.00263366	0.0554903	1
Echinococcus granulosus	neuropeptide receptor A26	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	G protein coupled receptor 139	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00185095	0.0220621	0.0220621
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0247491	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.00263366	0.0554903	0.0341823
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	peptide allatostatin:somatostatin	0.00263366	0.0554903	0.0554903
Brugia malayi	Melatonin receptor type 1A	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	neuropeptide receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	serotonin receptor	0.00263366	0.0554903	0.0341823
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.00895829	0.325603	0.325603
Onchocerca volvulus		0.00263366	0.0554903	1
Schistosoma mansoni	neuropeptide receptor	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	tachykinin peptides receptor 99D	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	sex peptide receptor	0.00263366	0.0554903	0.0341823
Echinococcus multilocularis	neuropeptide receptor	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0247491	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	fmrfamide receptor	0.00263366	0.0554903	0.0341823
Trypanosoma cruzi	cysteine peptidase, putative	0.00185095	0.0220621	0.0220621
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Brugia malayi	Cathepsin L-like precursor	0.00185095	0.0220621	0.0220621
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0247491	1	1
Brugia malayi	Cathepsin L-like precursor	0.00185095	0.0220621	0.0220621
Echinococcus granulosus	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	dro:myosuppressin receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	Cathepsin L-like precursor	0.00185095	0.0220621	0.0220621
Echinococcus granulosus	g-protein coupled receptor	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.00263366	0.0554903	0.0341823
Echinococcus granulosus	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0554903
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.00263366	0.0554903	0.0554903
Toxoplasma gondii	cathepsin B	0.00346031	0.0907949	0.0702834
Brugia malayi	Papain family cysteine protease containing protein	0.00185095	0.0220621	0.0220621
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.00263366	0.0554903	0.0554903
Leishmania major		0.0247491	1	1
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	g protein coupled receptor	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.00185095	0.0220621	0.5
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.00895829	0.325603	0.310389
Trypanosoma brucei	cysteine peptidase C (CPC)	0.00346031	0.0907949	0.0702834
Brugia malayi	G protein-coupled receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	cathepsin b	0.00759018	0.267174	0.250641
Onchocerca volvulus		0.00185095	0.0220621	0.397585
Brugia malayi	neuropeptide F receptor	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00185095	0.0220621	0.242988
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.00185095	0.0220621	0.0220621
Onchocerca volvulus		0.00185095	0.0220621	0.397585
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	cathepsin F (C01 family)	0.00185095	0.0220621	0.0220621
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	biogenic amine (5HT) receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	opsin-like receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	allatostatin A receptor	0.00263366	0.0554903	0.0341823
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0341823
Onchocerca volvulus		0.00263366	0.0554903	1
Plasmodium vivax	vivapain-2	0.00185095	0.0220621	0.5
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0341823
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.00346031	0.0907949	0.0702834
Onchocerca volvulus		0.00185095	0.0220621	0.397585
Brugia malayi	AKH receptor	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	G-protein coupled receptor	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Entamoeba histolytica	cysteine proteinase, putative	0.00185095	0.0220621	1
Brugia malayi	larval opioid receptor	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	serotonin receptor	0.00263366	0.0554903	0.0341823
Echinococcus granulosus	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	cathepsin l cysteine peptidase	0.00185095	0.0220621	0.0220621
Echinococcus granulosus	neuropeptide receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	cathepsin L cysteine proteinase	0.00185095	0.0220621	0.0220621
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	biogenic amine receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	myosin xvIII	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Loa Loa (eye worm)	neuropeptide F receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	neuropeptide receptor A26	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	melatonin receptor type 1A	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Echinococcus granulosus	biogenic amine 5HT receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	hypothetical protein	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Entamoeba histolytica	cysteine proteinase, putative	0.00185095	0.0220621	1
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	TYRA-2 protein	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Loa Loa (eye worm)	G-protein coupled receptor	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.00263366	0.0554903	0.0554903
Brugia malayi	Dopamine receptor protein 1	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00185095	0.0220621	0.242988
Onchocerca volvulus		0.00185095	0.0220621	0.397585
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.00759018	0.267174	0.267174
Echinococcus granulosus	neuropeptides capa receptor	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.00346031	0.0907949	1
Echinococcus granulosus	tm gpcr rhodopsin	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	alpha-1 adrenergic receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	Cathepsin L-like precursor	0.00185095	0.0220621	0.0220621
Onchocerca volvulus		0.00263366	0.0554903	1
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0341823
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00263366	0.0554903	0.0341823
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00185095	0.0220621	0.242988
Echinococcus granulosus	7tm_1 domain containing protein	0.00263366	0.0554903	0.0554903
Brugia malayi	Serotonin receptor	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Loa Loa (eye worm)	neuropeptide F receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	G-protein coupled receptor, putative	0.00263366	0.0554903	0.0341823
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	sex peptide receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.00759018	0.267174	0.267174
Onchocerca volvulus		0.00263366	0.0554903	1
Onchocerca volvulus		0.00263366	0.0554903	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.00759018	0.267174	0.267174
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00185095	0.0220621	0.242988
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.00263366	0.0554903	0.0341823
Echinococcus granulosus	neuropeptide receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	fmrfamide receptor	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Brugia malayi	neuropeptide F receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	growth hormone secretagogue receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	opsin-like receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.00263366	0.0554903	0.0341823
Echinococcus granulosus	orexin receptor type 2	0.00263366	0.0554903	0.0554903
Brugia malayi	Tachykinin-like peptides receptor 99D	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	neuropeptide F-like receptor	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	g protein coupled receptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	amine GPCR	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.00263366	0.0554903	0.0341823
Schistosoma mansoni	opsin-like receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.00263366	0.0554903	0.0341823
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Onchocerca volvulus	Cathepsin F homolog	0.00185095	0.0220621	0.397585
Schistosoma mansoni	neuropeptide f receptor 76f	0.00263366	0.0554903	0.0554903
Brugia malayi	Dopamine receptor protein 2	0.00263366	0.0554903	0.0554903
Trypanosoma cruzi	cruzipain precursor, putative	0.00185095	0.0220621	0.0220621
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00263366	0.0554903	0.0554903
Onchocerca volvulus		0.00263366	0.0554903	1
Toxoplasma gondii	fructose-bisphospatase I	0.00895829	0.325603	0.310389
Schistosoma mansoni	adenoreceptor	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	g protein coupled receptor	0.00263366	0.0554903	0.0341823
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Onchocerca volvulus		0.00263366	0.0554903	1
Trypanosoma cruzi	cysteine peptidase, putative	0.00185095	0.0220621	0.0220621
Echinococcus multilocularis	g protein coupled receptor	0.00263366	0.0554903	0.0341823
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.00263366	0.0554903	0.0341823
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.00263366	0.0554903	1
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Trypanosoma cruzi	cysteine peptidase, putative	0.00185095	0.0220621	0.0220621
Echinococcus granulosus	serotonin receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	fructose-1,6-bisphosphatase	0.0247491	1	1
Onchocerca volvulus		0.00185095	0.0220621	0.397585
Echinococcus granulosus	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	tm gpcr rhodopsin	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Plasmodium falciparum	cysteine proteinase falcipain 3	0.00185095	0.0220621	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	tm gpcr rhodopsin	0.00263366	0.0554903	0.0554903
Giardia lamblia	Cathepsin B precursor	0.00346031	0.0907949	0.5
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Brugia malayi	putative neuropeptide receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	neuropeptides capa receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	neuropeptide FF receptor 2	0.00263366	0.0554903	0.0341823
Echinococcus multilocularis	neuropeptide s receptor	0.00263366	0.0554903	0.0341823
Loa Loa (eye worm)	cysteine protease	0.00185095	0.0220621	0.0220621
Brugia malayi	hypothetical protein	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	G protein coupled receptor 139	0.00263366	0.0554903	0.0554903
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.00263366	0.0554903	0.0554903
Toxoplasma gondii	fructose-bisphospatase II	0.0247491	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00185095	0.0220621	0.242988
Echinococcus granulosus	neuropeptide FF receptor 2	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0341823
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0247491	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.00263366	0.0554903	0.0341823
Echinococcus granulosus	alpha 1A adrenergic receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	ORL1-like opioid receptor	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	fmrfamide receptor	0.00263366	0.0554903	0.0341823
Schistosoma mansoni	neuropeptide receptor	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00263366	0.0554903	0.0341823
Trypanosoma cruzi	cysteine peptidase, putative	0.00185095	0.0220621	0.0220621
Echinococcus multilocularis	somatostatin receptor	0.00263366	0.0554903	0.0341823
Echinococcus multilocularis	orexin receptor type 2	0.00263366	0.0554903	0.0341823
Schistosoma mansoni	cathepsin F (C01 family)	0.00185095	0.0220621	0.0220621
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00263366	0.0554903	0.0554903
Onchocerca volvulus	Cathepsin L homolog	0.00185095	0.0220621	0.397585
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.00263366	0.0554903	0.0554903
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0341823
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.00263366	0.0554903	0.0554903
Brugia malayi	RE15519p	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	hypothetical protein	0.00263366	0.0554903	0.0554903
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.00263366	0.0554903	0.0554903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00185095	0.0220621	0.242988
Echinococcus multilocularis	dro:myosuppressin receptor	0.00263366	0.0554903	0.0341823
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00185095	0.0220621	0.242988
Echinococcus multilocularis	neuropeptide Y receptor	0.00263366	0.0554903	0.0341823
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.00263366	0.0554903	0.0554903
Loa Loa (eye worm)	hypothetical protein	0.00263366	0.0554903	0.0554903
Giardia lamblia	Cathepsin B precursor	0.00346031	0.0907949	0.5
Echinococcus granulosus	somatostatin receptor	0.00263366	0.0554903	0.0554903
Echinococcus granulosus	rhodopsin orphan GPCR	0.00263366	0.0554903	0.0554903

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	2.18 uM	ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye	ChEMBL.	20485428
EC50 (functional)	> 15 uM	ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye	ChEMBL.	20485428

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL589449

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1089264