Detailed information for compound 1089350

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 204.224 | Formula: C8H16N2O4
  • H donors: 5 H acceptors: 4 LogP: -1.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1N[C@H]([C@H]([C@@H]1O)O)CNC(=O)C
  • InChi: 1S/C8H16N2O4/c1-4(12)9-2-5-7(13)8(14)6(3-11)10-5/h5-8,10-11,13-14H,2-3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1
  • InChiKey: UQEQPFWCYJXMDK-LXGUWJNJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0032 0.0209 0.0214
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0672 0.1937
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0176 0.0411
Echinococcus multilocularis acetylcholinesterase 0.065 0.7498 0.7498
Echinococcus granulosus nAChR subunit 0.0032 0.0209 0.0209
Brugia malayi beta-lactamase 0.0113 0.1165 0.1197
Echinococcus multilocularis cpg binding protein 0.0065 0.0594 0.0594
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.052 0.297
Schistosoma mansoni hypothetical protein 0.0086 0.0838 0.0838
Schistosoma mansoni apoferritin-2 0.0019 0.0052 0.0052
Onchocerca volvulus 0.0021 0.0075 0.0608
Toxoplasma gondii hypothetical protein 0.0047 0.0386 0.2966
Brugia malayi ecdysteroid receptor 0.0031 0.0194 0.02
Brugia malayi Importin beta-1 subunit 0.003 0.0179 0.0184
Echinococcus multilocularis expressed conserved protein 0.0132 0.1387 0.1387
Mycobacterium leprae Probable lipase LipE 0.0113 0.1165 0.7312
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0194 0.02
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.8272 0.8272
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0021 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3403 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0194 0.02
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Loa Loa (eye worm) Smad1 0.0016 0.0014 0.0014
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.025 0.1792
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0075 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0194 0.02
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0205 0.101
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2873 0.2873
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0086 0.0838 0.0838
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0075 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0194 0.02
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1165 0.3452
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0179 0.1185
Loa Loa (eye worm) hypothetical protein 0.0106 0.1076 0.1106
Echinococcus multilocularis para nitrobenzyl esterase 0.011 0.1123 0.1123
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0014 0.0014
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0075 0.0203
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0672 0.3911
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.025 0.025
Schistosoma mansoni nAChR subunit 0.0032 0.0209 0.0209
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0075 0.0101
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0032 0.0033
Mycobacterium ulcerans lipase LipD 0.0113 0.1165 0.6969
Entamoeba histolytica hypothetical protein 0.0145 0.1542 0.4477
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0032 0.0209 0.0214
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.02
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0672 0.0691
Echinococcus granulosus ferritin 0.0019 0.0052 0.0052
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0205 0.0198
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.02
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0075 0.0203
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0086 0.0394
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0194 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0194 0.02
Brugia malayi TAR-binding protein 0.0258 0.2873 0.2954
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0249 0.2763 0.2763
Entamoeba histolytica hypothetical protein 0.0145 0.1542 0.4477
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0209 0.0214
Brugia malayi Latrophilin receptor protein 2 0.0086 0.0838 0.0861
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.3403 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0672 0.3911
Loa Loa (eye worm) hypothetical protein 0.0072 0.0672 0.0691
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.052 0.052
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.052 0.4127
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.3403 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0075 0.0041
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0032 0.0209 0.0209
Echinococcus multilocularis muscleblind protein 1 0.0839 0.9727 0.9727
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0033
Brugia malayi hypothetical protein 0.0145 0.1542 0.1585
Loa Loa (eye worm) LGC-31 protein 0.0032 0.0209 0.0214
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.1165 0.334
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.1165 0.1349
Schistosoma mansoni ran 0.0022 0.0086 0.0086
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0194 0.0194
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0032 0.0209 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0194 0.02
Onchocerca volvulus 0.011 0.1123 0.9127
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.025 0.0639
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.1165 0.1165
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3403 1
Echinococcus multilocularis neuroligin 0.011 0.1123 0.1123
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.1165 0.1349
Loa Loa (eye worm) hypothetical protein 0.0839 0.9727 1
Leishmania major importin beta-1 subunit, putative 0.0024 0.0113 0.0217
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0075 0.0203
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.025 0.025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0086 0.0838 0.0838
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0032 0.0209 0.0209
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0552 0.0568
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0258 0.2873 0.2954
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0007 0.0007
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0176 0.0181
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0075 0.0077
Loa Loa (eye worm) hypothetical protein 0.0113 0.1165 0.1197
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0075 0.0041
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0075 0.0077
Loa Loa (eye worm) hypothetical protein 0.0054 0.0458 0.0471
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0075 0.0101
Schistosoma mansoni ferritin light chain 0.0019 0.0052 0.0052
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0458 0.0501
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0075 0.0203
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0015 0.0003 0.0003
Brugia malayi excitatory GABA receptor EXP-1A 0.0032 0.0209 0.0214
Echinococcus multilocularis tar DNA binding protein 0.0258 0.2873 0.2873
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.025 0.0645
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0017 0.0032 0.0033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0194 0.0194
Brugia malayi Carboxylesterase family protein 0.065 0.7498 0.7708
Mycobacterium tuberculosis Carboxylesterase LipT 0.011 0.1123 0.1299
Echinococcus granulosus expressed conserved protein 0.0132 0.1387 0.1387
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0075 0.0203
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0209 0.0214
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.1165 0.334
Brugia malayi hypothetical protein 0.0016 0.0021 0.0021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0209 0.0214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0271 0.3023 0.3107
Echinococcus multilocularis Smad4 0.0016 0.0014 0.0014
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0075 0.0283
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0075 0.0787
Schistosoma mansoni hypothetical protein 0.0086 0.0838 0.0838
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0032 0.0209 0.0214
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0194 0.0194
Loa Loa (eye worm) carboxylesterase 0.011 0.1123 0.1154
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.052 0.1471
Onchocerca volvulus 0.011 0.1123 0.9127
Loa Loa (eye worm) GABA receptor subunit 0.0017 0.0032 0.0033
Echinococcus multilocularis BC026374 protein (S09 family) 0.011 0.1123 0.1123
Mycobacterium ulcerans bacterioferritin BfrA 0.0019 0.0052 0.0059
Echinococcus granulosus snurportin 1 0.0319 0.3594 0.3594
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0032 0.0209 0.0214
Schistosoma mansoni acetylcholine receptor subunit beta 0.0015 0.0003 0.0003
Brugia malayi hypothetical protein 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.1165 0.1349
Echinococcus multilocularis ferritin 0.0019 0.0052 0.0052
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0075 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0075 0.0283
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.052 0.052
Onchocerca volvulus 0.0021 0.0075 0.0608
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0672 0.1937
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.3294 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0019 0.0052 0.046
Onchocerca volvulus 0.0031 0.0194 0.1579
Onchocerca volvulus Huntingtin homolog 0.0119 0.123 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.1165 0.1197
Loa Loa (eye worm) hypothetical protein 0.0072 0.0672 0.0691
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.025 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0672 0.1898
Schistosoma mansoni hypothetical protein 0.0145 0.1542 0.1542
Echinococcus granulosus nAChR subunit 0.0017 0.0032 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0424 0.046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0003 0.0003
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0032 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0075 0.0077
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0672 0.1937
Onchocerca volvulus Putative nachr subunit 0.0032 0.0209 0.1695
Brugia malayi Smad1 0.0016 0.0014 0.0014
Mycobacterium ulcerans beta-lactamase 0.0113 0.1165 0.6969
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0194 0.0194
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.1165 0.1165
Trichomonas vaginalis ferritin, putative 0.0019 0.0052 0.0028
Schistosoma mansoni BC026374 protein (S09 family) 0.011 0.1123 0.1123
Leishmania major GTP-binding protein, putative 0.0022 0.0086 0.0136
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0086 0.0136
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0032 0.0209 0.0209
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.052 0.297
Brugia malayi nuclear receptor RXR 0.0016 0.0021 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0271 0.3023 0.3107
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0075 0.0101
Onchocerca volvulus 0.0032 0.0209 0.1695
Brugia malayi hypothetical protein 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0075 0.0041
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0209 0.0214
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0672 0.3911
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0003 0.0003
Schistosoma mansoni nAChR subunit 0.0032 0.0209 0.0209
Entamoeba histolytica Flap nuclease, putative 0.003 0.0176 0.0425
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2873 0.2873
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0194 0.0194
Onchocerca volvulus 0.0015 0.0003 0.0022
Echinococcus granulosus muscleblind protein 0.0839 0.9727 0.9727
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0194 0.0194
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0113 0.021
Loa Loa (eye worm) hypothetical protein 0.0271 0.3023 0.3107
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0075 0.0203
Plasmodium vivax importin-beta 2, putative 0.003 0.0179 0.1224
Plasmodium falciparum importin beta, putative 0.003 0.0179 0.3301
Loa Loa (eye worm) hypothetical protein 0.065 0.7498 0.7708
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0075 0.0098
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0032 0.0209 0.0209
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.1165 0.1165
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0209 0.0214
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0672 0.4076
Brugia malayi Carboxylesterase family protein 0.011 0.1123 0.1154
Schistosoma mansoni ferritin 0.0019 0.0052 0.0052
Schistosoma mansoni ferritin 0.0019 0.0052 0.0052
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0014 0.0014
Brugia malayi hypothetical protein 0.0016 0.0021 0.0021
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0075 0.0101
Echinococcus granulosus para nitrobenzyl esterase 0.011 0.1123 0.1123
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0086 0.0086
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0075 0.0203
Schistosoma mansoni gliotactin 0.011 0.1123 0.1123
Loa Loa (eye worm) hypothetical protein 0.0113 0.1165 0.1197
Echinococcus granulosus flap endonuclease 1 0.003 0.0176 0.0176
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0033
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0014 0.0014
Brugia malayi steroid hormone receptor 0.0031 0.0194 0.02
Loa Loa (eye worm) carboxylesterase 0.011 0.1123 0.1154
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0032 0.0209 0.0214
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.0014
Brugia malayi Coelomocyte uptake defective protein 5 0.0065 0.0589 0.0606
Mycobacterium ulcerans carboxylesterase, LipT 0.011 0.1123 0.6709
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0194 0.02
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0194 0.0194
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0672 0.0691
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1165 0.3452
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3403 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0032 0.0209 0.0214
Schistosoma mansoni hypothetical protein 0.0319 0.3594 0.3594
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0194 0.0194
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0021 0.0021
Echinococcus granulosus importin subunit beta 1 0.003 0.0179 0.0179
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1468 0.4384
Echinococcus granulosus glycine receptor subunit beta 0.0032 0.0209 0.0209
Loa Loa (eye worm) mucolipin 1 0.0065 0.0589 0.0606
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.02
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0176 0.0411
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0101 0.0104
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0051 0.0051
Brugia malayi hypothetical protein 0.0015 0.0003 0.0003
Schistosoma mansoni ferritin 0.0019 0.0052 0.0052
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0841 0.9751 0.9751
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0075 0.0203
Schistosoma mansoni hypothetical protein 0.047 0.5377 0.5377
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Loa Loa (eye worm) hypothetical protein 0.0054 0.0458 0.0471
Brugia malayi hypothetical protein 0.0015 0.0003 0.0003
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.3294 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Schistosoma mansoni smad 0.0016 0.0014 0.0014
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0042 0.0042
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0086 0.0136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.1165 0.1349
Echinococcus multilocularis snurportin 1 0.0319 0.3594 0.3594
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3403 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0672 0.1898
Loa Loa (eye worm) hypothetical protein 0.0119 0.123 0.1265
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.2576 0.2649
Echinococcus granulosus glycine receptor subunit alpha 1 0.0032 0.0209 0.0209
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0032 0.0209 0.0209
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.052 0.052
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0458 0.5
Echinococcus multilocularis dnaJ subfamily B 0.047 0.5377 0.5377
Brugia malayi Inositol-1 0.0036 0.025 0.0257
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0032 0.0209 0.0214
Schistosoma mansoni Smad4 0.0016 0.0014 0.0014
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0075 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.1165 0.3452
Brugia malayi beta-lactamase family protein 0.0113 0.1165 0.1197
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.011 0.1123 0.1299
Schistosoma mansoni neuroligin 3 (S09 family) 0.011 0.1123 0.1123
Loa Loa (eye worm) hypothetical protein 0.011 0.1123 0.1154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0194 0.0194
Onchocerca volvulus 0.0015 0.0003 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0194 0.02
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0032 0.0209 0.0214
Schistosoma mansoni nAChR subunit 0.0015 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2873 0.2873
Echinococcus granulosus family S9 non peptidase ue S09 family 0.011 0.1123 0.1123
Mycobacterium ulcerans hypothetical protein 0.0113 0.1165 0.6969
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0194 0.0194
Brugia malayi RNA, U transporter 1 0.0085 0.083 0.0853
Schistosoma mansoni nAChR subunit 0.0032 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Brugia malayi Carboxylesterase family protein 0.011 0.1123 0.1154
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0075 0.0041
Schistosoma mansoni ferritin light chain 0.0019 0.0052 0.0052
Brugia malayi Serotonin receptor 0.0481 0.5503 0.5657
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0032 0.0209 0.0214
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0075 0.0041
Schistosoma mansoni nAChR subunit 0.0032 0.0209 0.0209
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.025 0.0639
Brugia malayi beta-lactamase family protein 0.0113 0.1165 0.1197
Echinococcus granulosus GPCR family 2 0.0086 0.0838 0.0838
Onchocerca volvulus 0.011 0.1123 0.9127
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.1542 0.1542
Onchocerca volvulus Huntingtin homolog 0.0119 0.123 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0032 0.0209 0.0209
Treponema pallidum bacterioferrin (TpF1) 0.0019 0.0052 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0194 0.02
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.02
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0458 0.3708
Onchocerca volvulus 0.0062 0.0552 0.4489
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.1165 0.1349
Echinococcus multilocularis importin subunit beta 1 0.003 0.0179 0.0179
Brugia malayi hypothetical protein 0.0015 0.0003 0.0003
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0075 0.0126
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0015 0.0003 0.0003
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0075 0.0203
Onchocerca volvulus 0.0113 0.1165 0.9468
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0075 0.0041
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0032 0.0209 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0194 0.02
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0194 0.1579
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0194 0.02
Brugia malayi Carboxylesterase family protein 0.065 0.7498 0.7708
Onchocerca volvulus 0.011 0.1123 0.9127
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0042 0.0042
Loa Loa (eye worm) latrophilin receptor protein 2 0.0086 0.0838 0.0861
Schistosoma mansoni nAChR subunit 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0458 0.0471
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.1366 0.1366
Schistosoma mansoni coup transcription factor 0.0031 0.0194 0.0194
Mycobacterium leprae conserved hypothetical protein 0.0113 0.1165 0.7312
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0176 0.1191
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0194 0.0194
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0075 0.0153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0672 0.0758
Echinococcus multilocularis nAChR subunit 0.0032 0.0209 0.0209
Echinococcus granulosus acetylcholinesterase 0.065 0.7498 0.7498
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.025 0.0618
Entamoeba histolytica hypothetical protein 0.0024 0.0113 0.0238
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.011 0.1123 0.1154
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0194 0.0194
Schistosoma mansoni cpg binding protein 0.0065 0.0594 0.0594
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0194 0.0194
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.025 0.1289
Loa Loa (eye worm) hypothetical protein 0.011 0.1123 0.1154
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0086 0.0089
Onchocerca volvulus 0.0015 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0075 0.0077
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0113 0.021
Brugia malayi RNA recognition motif domain containing protein 0.0258 0.2873 0.2954
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0314 0.0837
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0075 0.0203
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0007 0.0007
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0032 0.0209 0.0214
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0086 0.1063
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0075 0.0077
Schistosoma mansoni nAChR subunit 0.0032 0.0209 0.0209
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0672 0.1898
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0194 0.0194
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.0014
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0032 0.0209 0.0214
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0075 0.0203
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0075 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.025 0.0639
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0021 0.0021
Mycobacterium tuberculosis Conserved protein 0.0113 0.1165 0.1349
Loa Loa (eye worm) carboxylesterase 0.065 0.7498 0.7708
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Trichomonas vaginalis ran, putative 0.0022 0.0086 0.0132
Brugia malayi hypothetical protein 0.011 0.1123 0.1154
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0249 0.2763 0.2841
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.025 0.0618
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.02
Entamoeba histolytica Ran family GTPase 0.0022 0.0086 0.016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0194 0.0194
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0209 0.0214
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0075 0.0292
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0019 0.0052 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.02
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0003 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0194 0.0194
Schistosoma mansoni hypothetical protein 0.0862 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0179 0.0184
Echinococcus multilocularis sentrin specific protease 7 0.0145 0.1536 0.1536
Onchocerca volvulus 0.0106 0.1076 0.8747
Echinococcus granulosus tar DNA binding protein 0.0258 0.2873 0.2873
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0032 0.0209 0.0209
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.3403 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0014 0.0014
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0075 0.0101
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0032 0.0209 0.0214
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.065 0.7498 0.7498
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.2576 0.2649
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0032 0.0209 0.0209
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0014 0.0014
Echinococcus granulosus expressed protein 0.0019 0.0052 0.0052
Trichomonas vaginalis esterase, putative 0.0113 0.1165 0.334
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0075 0.0075
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1468 0.4384
Schistosoma mansoni hypothetical protein 0.0086 0.0838 0.0838
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0075 0.0041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0086 0.0838 0.0838
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.1201 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0054 0.0458 0.0471
Echinococcus multilocularis smad 0.0016 0.0014 0.0014
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0015 0.0003 0.0003
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.1574 0.9509
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0086 0.0136
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.1165 0.1349
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0194 0.02
Brugia malayi MH2 domain containing protein 0.0233 0.2576 0.2649
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0424 0.046
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0086 0.0089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0271 0.3023 0.3107
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.011 0.1123 0.1154
Onchocerca volvulus 0.0021 0.0075 0.0608
Echinococcus multilocularis glycine receptor subunit beta 0.0032 0.0209 0.0209
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2873 0.2873
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0209 0.0209
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0194 0.0194
Loa Loa (eye worm) oxidoreductase 0.0021 0.0075 0.0077
Brugia malayi Muscleblind-like protein 0.0839 0.9727 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0106 0.1076 0.1106
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0194 0.0194
Brugia malayi nuclear receptor NHR-88 0.0031 0.0194 0.02
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0421 0.1165
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.011 0.1123 0.3215
Loa Loa (eye worm) hypothetical protein 0.0054 0.0458 0.0471
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0015 0.0003 0.0003
Echinococcus granulosus microtubule associated protein 2 0.0716 0.8272 0.8272
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0075 0.0203
Echinococcus multilocularis carboxylesterase 5A 0.065 0.7498 0.7498
Onchocerca volvulus 0.0106 0.1076 0.8747
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0032 0.0209 0.0209
Brugia malayi nuclear hormone receptor 0.0031 0.0194 0.02
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0194 0.0194
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.1165 0.334
Echinococcus multilocularis nAChR subunit 0.0017 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0075 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3403 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0033
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0015 0.0003 0.0003
Echinococcus granulosus BC026374 protein S09 family 0.011 0.1123 0.1123
Loa Loa (eye worm) acetylcholinesterase 1 0.065 0.7498 0.7708
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0014 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0113 0.021
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0048 0.005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.02
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1468 0.4384
Mycobacterium ulcerans bacterioferritin BfrB 0.0019 0.0052 0.0059
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0672 0.3911
Mycobacterium tuberculosis Conserved protein 0.0113 0.1165 0.1349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.2763 0.2763
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0032 0.0209 0.0209
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0672 0.4076
Echinococcus granulosus smad 0.0016 0.0014 0.0014
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0015 0.0003 0.0003
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0032 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.025 0.0618
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0032 0.0032
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Mycobacterium ulcerans hypothetical protein 0.0072 0.0672 0.3911
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.1574 0.184
Echinococcus granulosus cpg binding protein 0.0065 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0075 0.0203
Brugia malayi CXXC zinc finger family protein 0.0062 0.0552 0.0568
Onchocerca volvulus 0.0032 0.0209 0.1695
Onchocerca volvulus 0.0021 0.0075 0.0608
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0086 0.0086
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0075 0.0077
Onchocerca volvulus 0.0072 0.0672 0.5463
Trichomonas vaginalis spcc417.12 protein, putative 0.011 0.1123 0.3215
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.3403 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0032 0.0209 0.0209
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0176 0.0411
Schistosoma mansoni apoferritin-2 0.0019 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0194 0.02
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0075 0.0203
Mycobacterium tuberculosis Conserved protein 0.0113 0.1165 0.1349
Loa Loa (eye worm) ACC-1 protein 0.0032 0.0209 0.0214
Schistosoma mansoni nAChR subunit 0.0032 0.0209 0.0209
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.025 0.0639
Brugia malayi Flap endonuclease-1 0.003 0.0176 0.0181
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0032 0.0209 0.0209
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0209 0.0214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3403 1
Brugia malayi Cation transporter family protein 0.0032 0.0209 0.0214
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.1574 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0086 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.2763 0.2763
Brugia malayi Cytochrome P450 family protein 0.0023 0.0101 0.0104
Loa Loa (eye worm) inositol-1 0.0036 0.025 0.0257
Loa Loa (eye worm) acetylcholine receptor protein 0.0015 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0194 0.02
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0209 0.0214
Schistosoma mansoni ran 0.0022 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.011 0.1123 0.1154
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.1165 0.334
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.1165 0.1349
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0672 0.3911
Loa Loa (eye worm) ACC-1 protein 0.0032 0.0209 0.0214
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0194 0.0194
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0014 0.0014
Brugia malayi Cation transporter family protein 0.0106 0.1076 0.1106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0075 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2873 0.2873
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0075 0.0098
Brugia malayi Cation transporter family protein 0.0032 0.0209 0.0214
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.065 0.7498 0.7708
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0007 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0021 0.0021
Echinococcus multilocularis GPCR, family 2 0.0086 0.0838 0.0838
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0075 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0113 0.1165 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3403 1
Schistosoma mansoni cpg binding protein 0.0065 0.0594 0.0594
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0194 0.0194
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0106 0.1076 0.1076
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0017 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0185 0.2011 0.2068
Onchocerca volvulus 0.0032 0.0209 0.1695
Loa Loa (eye worm) hypothetical protein 0.0113 0.1165 0.1197
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0075 0.0077
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0075 0.0041
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Loa Loa (eye worm) hypothetical protein 0.0091 0.09 0.0925
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0075 0.0153
Brugia malayi Carboxylesterase family protein 0.011 0.1123 0.1154
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0075 0.0203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0249 0.2763 0.2763
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.052 0.0576
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0042 0.0043
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0042 0.0029
Echinococcus multilocularis muscleblind protein 0.0839 0.9727 0.9727
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0194 0.02
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0033
Onchocerca volvulus 0.0106 0.1076 0.8747
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.1165 0.1165
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.3294 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0458 0.2584
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.011 0.1123 0.1123
Echinococcus multilocularis glycine receptor subunit beta 0.0032 0.0209 0.0209
Plasmodium falciparum flap endonuclease 1 0.003 0.0176 0.3213
Echinococcus granulosus carboxylesterase 5A 0.065 0.7498 0.7498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0194 0.02
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.1542 0.1542
Onchocerca volvulus 0.0113 0.1165 0.9468
Onchocerca volvulus 0.0017 0.0032 0.0263
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0042 0.0002
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0106 0.1076 0.1076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0194 0.02
Schistosoma mansoni mucolipin 0.0059 0.0526 0.0526
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0194 0.1579
Entamoeba histolytica hypothetical protein 0.0145 0.1542 0.4477
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0021 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0075 0.0203
Echinococcus granulosus glycine receptor subunit beta 0.0032 0.0209 0.0209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0249 0.2763 0.2763
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0458 1
Brugia malayi RNA binding protein 0.0258 0.2873 0.2954
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0032 0.0209 0.0209
Schistosoma mansoni flap endonuclease-1 0.0027 0.0142 0.0142
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0051 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0179 0.0423
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0145 0.1536 0.4462
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0314 0.0837
Loa Loa (eye worm) hypothetical protein 0.0086 0.0838 0.0861
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0194 0.1579
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0113 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.1165 0.334
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1653 0.1935
Brugia malayi Carboxylesterase family protein 0.011 0.1123 0.1154
Mycobacterium ulcerans hypothetical protein 0.0155 0.1653 1
Echinococcus multilocularis mucolipin 3 0.0065 0.0589 0.0589
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0021 0.0021
Schistosoma mansoni cpg binding protein 0.0062 0.0552 0.0552
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.1542 0.1542
Loa Loa (eye worm) RNA binding protein 0.0258 0.2873 0.2954
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3403 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0194 0.0194
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0194 0.02
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0086 0.0838 0.0861
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0145 0.1536 0.1536
Schistosoma mansoni inositol monophosphatase 0.0036 0.025 0.025
Echinococcus multilocularis expressed protein 0.0019 0.0052 0.0052
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0672 0.0758
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0209 0.0214
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Toxoplasma gondii ABC1 family protein 0.0113 0.1165 0.9684
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0042 0.0043
Schistosoma mansoni ferritin 0.0019 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0194 0.02
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0086 0.0382
Echinococcus granulosus mucolipin 3 0.0065 0.0589 0.0589
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0075 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0194 0.02
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0075 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0194 0.02
Schistosoma mansoni hypothetical protein 0.0086 0.0838 0.0838
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0019 0.0052 0.0014
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0015 0.0003 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.1165 0.1197
Brugia malayi latrophilin 2 splice variant baaae 0.0185 0.2011 0.2068
Loa Loa (eye worm) TAR-binding protein 0.0258 0.2873 0.2954
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.052 0.297
Schistosoma mansoni hypothetical protein 0.0185 0.2011 0.2011
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0075 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0424 0.046
Echinococcus granulosus neuroligin 0.011 0.1123 0.1123
Schistosoma mansoni nAChR subunit 0.0032 0.0209 0.0209
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0209 0.0209
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0051 0.0052
Entamoeba histolytica hypothetical protein 0.0145 0.1542 0.4477
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0176 0.1154
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.011 0.1123 0.1123
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0176 0.0398
Schistosoma mansoni hypothetical protein 0.0862 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.011 0.1123 0.1123
Echinococcus multilocularis flap endonuclease 1 0.003 0.0176 0.0176
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0032 0.0209 0.0209
Echinococcus multilocularis acetylcholinesterase 0.065 0.7498 0.7498
Schistosoma mansoni importin beta-1 0.003 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0113 0.1165 0.1197
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0176 0.0398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.2763 0.2763
Schistosoma mansoni neurotransmitter gated ion channel 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0113 0.1165 0.1197
Echinococcus granulosus Smad4 0.0016 0.0014 0.0014
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0194 0.0194
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0725 0.8376 1
Schistosoma mansoni acetylcholine receptor-related 0.0015 0.0003 0.0003
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.8272 0.8272
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.011 0.1123 0.1299
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.011 0.1123 0.1123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0249 0.2763 0.2763
Loa Loa (eye worm) hypothetical protein 0.0839 0.9727 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.3294 1
Echinococcus granulosus sentrin specific protease 7 0.0145 0.1536 0.1536
Onchocerca volvulus 0.0017 0.0032 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0194 0.02
Schistosoma mansoni neurotransmitter gated ion channel 0.0015 0.0003 0.0003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.1165 0.1197
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0033
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0033
Brugia malayi hypothetical protein 0.0119 0.123 0.1265
Loa Loa (eye worm) beta-lactamase 0.0113 0.1165 0.1197
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0194 0.02
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0194 0.0194
Echinococcus granulosus dnaJ subfamily B 0.047 0.5377 0.5377
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0314 0.0837
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0033
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0017 0.0032 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0672 0.3911
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0032 0.0209 0.0209
Onchocerca volvulus 0.011 0.1123 0.9127
Schistosoma mansoni inositol monophosphatase 0.0036 0.025 0.025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0424 0.046
Leishmania major hypothetical protein, conserved 0.0113 0.1165 0.3452
Loa Loa (eye worm) hypothetical protein 0.0072 0.0672 0.0691
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0015 0.0003 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0314 0.0837
Loa Loa (eye worm) hypothetical protein 0.011 0.1123 0.1154
Echinococcus multilocularis geminin 0.0862 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.1165 0.6969
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0672 0.3911
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0075 0.0283
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0214
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0075 0.0077
Echinococcus granulosus glycine receptor subunit alpha 1 0.0032 0.0209 0.0209
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0672 0.0691
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.052 0.052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0086 0.0838 0.0838
Loa Loa (eye worm) hypothetical protein 0.011 0.1123 0.1154
Echinococcus granulosus acetylcholinesterase 0.065 0.7498 0.7498
Schistosoma mansoni mucolipin 0.0065 0.0589 0.0589
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0209 0.0209
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0179 0.0423
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0075 0.0153
Onchocerca volvulus 0.0113 0.1165 0.9468
Schistosoma mansoni acetylcholinesterase 0.011 0.1123 0.1123
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.3594 0.3695
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0194 0.02
Loa Loa (eye worm) hypothetical protein 0.0119 0.123 0.1265
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0075 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0194 0.02
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.1165 0.6969
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0032 0.0209 0.0209
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0249 0.2763 0.2841
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0032 0.0209 0.0209

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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