Detailed information for compound 1089386

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.401 | Formula: C20H13N3O2S
  • H donors: 0 H acceptors: 1 LogP: 3.65 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1csc2c1c1nc3ccccc3c(=O)n1cn2
  • InChi: 1S/C20H13N3O2S/c1-25-13-8-6-12(7-9-13)15-10-26-19-17(15)18-22-16-5-3-2-4-14(16)20(24)23(18)11-21-19/h2-11H,1H3
  • InChiKey: YRKDAFCXVIOEMP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus insulin receptor 0.0046 0.0172 0.1669
Onchocerca volvulus 0.0366 0.1975 0.5849
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0026 0.0133
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0189 0.0783
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0026 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0026 0.0109
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.0172 0.1669
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0136 0.0988
Toxoplasma gondii kinesin motor domain-containing protein 0.0026 0.0058 0.0648
Loa Loa (eye worm) hypothetical protein 0.007 0.0308 0.1558
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0369 0.8055
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0449 0.2438 0.2516
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0263 0.133
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0026 0.0109
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0457 0.4429
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0366 0.1975 0.8172
Echinococcus multilocularis protoporphyrinogen oxidase 0.0126 0.0623 0.1417
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0026 0.0133
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0026 0.0133
Leishmania major telomerase reverse transcriptase, putative 0.0167 0.0853 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0026 0.0109
Loa Loa (eye worm) hypothetical protein 0.0137 0.0683 0.346
Loa Loa (eye worm) hypothetical protein 0.0126 0.0623 0.3154
Brugia malayi RNA binding protein 0.0062 0.0263 0.1087
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1666 0.929 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0048 0.0182 0.2106
Echinococcus granulosus epidermal growth factor receptor 0.0144 0.0725 0.7029
Echinococcus granulosus cathepsin b 0.0137 0.0683 0.6624
Loa Loa (eye worm) hypothetical protein 0.0152 0.0769 0.3893
Schistosoma mansoni tyrosine kinase 0.0077 0.0344 0.1744
Brugia malayi TAR-binding protein 0.0062 0.0263 0.1087
Mycobacterium tuberculosis Conserved protein 0.007 0.0308 0.019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0026 0.0255
Loa Loa (eye worm) hypothetical protein 0.0126 0.0623 0.3154
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0157 0.5052
Loa Loa (eye worm) ShTK domain-containing protein 0.0366 0.1975 1
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0349 0.0794
Toxoplasma gondii cathepsin B 0.0048 0.0182 0.2106
Trypanosoma cruzi UDP-galactopyranose mutase 0.0126 0.0623 0.7289
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0429 0.0975
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0126 0.0623 0.0496
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0189 0.0958
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0026 0.0109
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0126 0.0623 0.3154
Onchocerca volvulus 0.0126 0.0623 0.1791
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0136 0.0391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0429 0.0975
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0126 0.0623 0.1813
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0026 0.006
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0743 0.3764
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0308 0.3586
Echinococcus multilocularis epidermal growth factor receptor 0.0144 0.0725 0.1649
Brugia malayi CHE-14 protein 0.0042 0.0146 0.0604
Brugia malayi Protein kinase domain containing protein 0.0046 0.0172 0.0712
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0126 0.0623 0.7289
Mycobacterium tuberculosis Conserved hypothetical protein 0.0126 0.0623 0.0534
Echinococcus granulosus geminin 0.0166 0.0849 0.8234
Echinococcus granulosus cathepsin b 0.0137 0.0683 0.6624
Echinococcus multilocularis protein dispatched 1 0.0047 0.0179 0.0407
Schistosoma mansoni hypothetical protein 0.0166 0.0849 0.4301
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0624 0.3424 1
Schistosoma mansoni kinesin eg-5 0.0026 0.0058 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0026 0.0109
Echinococcus granulosus tar DNA binding protein 0.0062 0.0263 0.2547
Schistosoma mansoni thyroid hormone receptor 0.002 0.0026 0.0133
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0624 0.3424 0.3594
Brugia malayi DNA polymerase I family protein 0.0016 0.0003 0.0011
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0126 0.0623 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0026 0.0109
Loa Loa (eye worm) hypothetical protein 0.007 0.0308 0.1558
Loa Loa (eye worm) hypothetical protein 0.007 0.0308 0.1558
Brugia malayi ecdysteroid receptor 0.002 0.0026 0.0109
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0308 0.019
Schistosoma mansoni tyrosine kinase 0.0077 0.0344 0.1744
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0026 0.0255
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0308 0.3586
Brugia malayi nuclear receptor NHR-88 0.002 0.0026 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0026 0.0133
Giardia lamblia Cathepsin B precursor 0.0048 0.0182 0.1559
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0167 0.0853 1
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0612 0.3358 1
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0308 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0263 0.133
Brugia malayi ShTK domain containing protein 0.0366 0.1975 0.8172
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0624 0.3424 0.3335
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0263 0.133
Onchocerca volvulus 0.007 0.0308 0.0845
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0429 0.217
Loa Loa (eye worm) hypothetical protein 0.0034 0.0102 0.0514
Loa Loa (eye worm) TK/EGFR protein kinase 0.0144 0.0725 0.3671
Brugia malayi nuclear hormone receptor 0.002 0.0026 0.0109
Mycobacterium ulcerans lipase LipD 0.007 0.0308 0.0176
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0133
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0366 0.1975 0.8172
Trypanosoma brucei telomerase reverse transcriptase 0.0167 0.0853 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0026 0.0255
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0146 0.0332
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0308 0.0176
Echinococcus multilocularis cathepsin b 0.0137 0.0683 0.1554
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0743 0.3076
Echinococcus multilocularis 0.0126 0.0623 0.1417
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0026 0.0109
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0157 0.1812
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0126 0.0623 0.1417
Loa Loa (eye worm) ShTK domain-containing protein 0.0366 0.1975 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0263 0.0598
Schistosoma mansoni patched 1 0.0042 0.0146 0.074
Loa Loa (eye worm) hypothetical protein 0.0126 0.0623 0.3154
Loa Loa (eye worm) acetyltransferase 0.0148 0.0743 0.3764
Loa Loa (eye worm) cathepsin B 0.0048 0.0182 0.0921
Onchocerca volvulus 0.007 0.0308 0.0845
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0026 0.0133
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0308 1
Brugia malayi Kinesin motor domain containing protein 0.0026 0.0058 0.0239
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0134 0.1542
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0019 0.0021 0.0214
Schistosoma mansoni hypothetical protein 0.004 0.0138 0.0697
Echinococcus multilocularis kinesin family 1 0.0199 0.1032 0.2346
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0308 0.1558
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0308 0.2983
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0133
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.0172 0.0872
Mycobacterium leprae Probable lipase LipE 0.007 0.0308 0.2098
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0167 0.0853 1
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0308 0.019
Loa Loa (eye worm) kinesin-like protein KLP2 0.0026 0.0058 0.0293
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0026 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0026 0.0133
Brugia malayi hypothetical protein 0.0126 0.0623 0.2577
Schistosoma mansoni tyrosine kinase 0.0046 0.0172 0.0872
Brugia malayi Muscleblind-like protein 0.0152 0.0769 0.3181
Loa Loa (eye worm) hypothetical protein 0.0097 0.0457 0.2313
Echinococcus multilocularis insulin receptor 0.0046 0.0172 0.0392
Plasmodium vivax telomerase reverse transcriptase, putative 0.0167 0.0853 0.2487
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0429 0.217
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0026 0.0255
Echinococcus multilocularis 0.0045 0.0164 0.0373
Trypanosoma cruzi UDP-galactopyranose mutase 0.0126 0.0623 0.7289
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0026 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0026 0.0133
Echinococcus granulosus lysine specific histone demethylase 1A 0.0126 0.0623 0.6038
Schistosoma mansoni coup transcription factor 0.002 0.0026 0.0133
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.0683 0.346
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0026 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0026 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0263 0.133
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0308 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0465 0.2356
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0133
Schistosoma mansoni tyrosine kinase 0.0046 0.0172 0.0872
Mycobacterium ulcerans DNA polymerase I 0.0055 0.0224 0.0091
Schistosoma mansoni tyrosine kinase 0.0144 0.0725 0.3671
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0146 0.1416
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0369 0.8055
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0369 0.8055
Onchocerca volvulus 0.0366 0.1975 0.5849
Plasmodium vivax kinesin-5 0.0026 0.0058 0.0161
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0133
Mycobacterium ulcerans beta-lactamase 0.007 0.0308 0.0176
Echinococcus multilocularis geminin 0.0166 0.0849 0.1932
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0014
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0134 0.1542
Treponema pallidum DNA polymerase I (polA) 0.0055 0.0224 0.5
Echinococcus multilocularis muscleblind protein 0.0152 0.0769 0.1749
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0182 0.0921
Onchocerca volvulus 0.007 0.0308 0.0845
Schistosoma mansoni amine oxidase 0.0126 0.0623 0.3154
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0146 0.074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0026 0.0133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0308 0.1558
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0624 0.3424 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0137 0.0683 0.8
Brugia malayi Furin-like cysteine rich region family protein 0.0144 0.0725 0.3
Loa Loa (eye worm) hypothetical protein 0.0049 0.0189 0.0958
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0624 0.3424 1
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0366 0.1975 0.8172
Plasmodium falciparum kinesin-5 0.0026 0.0058 0.0161
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0743 0.1691
Loa Loa (eye worm) hypothetical protein 0.007 0.0308 0.1558
Loa Loa (eye worm) hypothetical protein 0.0152 0.0769 0.3893
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0026 0.006
Mycobacterium ulcerans hypothetical protein 0.007 0.0308 0.0176
Schistosoma mansoni nuclear hormone receptor 0.002 0.0026 0.0133
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0055 0.0224 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0308 0.3586
Schistosoma mansoni tyrosinase precursor 0.0366 0.1975 1
Leishmania major UDP-galactopyranose mutase 0.0126 0.0623 0.7289
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0349 0.3384
Loa Loa (eye worm) hypothetical protein 0.007 0.0308 0.1558
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0157 0.5052
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0026 0.0109
Plasmodium vivax hypothetical protein, conserved 0.0126 0.0623 0.1813
Loa Loa (eye worm) hypothetical protein 0.0051 0.0199 0.1006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0308 0.0176
Schistosoma mansoni tyrosine kinase 0.0077 0.0344 0.1744
Loa Loa (eye worm) hypothetical protein 0.0126 0.0623 0.3154
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0308 0.1273
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.069 0.1571
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0026 0.0109
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0308 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0308 0.07
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0026 0.006
Schistosoma mansoni hypothetical protein 0.004 0.0138 0.0697
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0026 0.0133
Mycobacterium ulcerans oxidoreductase 0.0126 0.0623 0.0496
Giardia lamblia Cathepsin B precursor 0.0048 0.0182 0.1559
Giardia lamblia Telomerase catalytic subunit 0.0167 0.0853 1
Plasmodium falciparum telomerase reverse transcriptase 0.0167 0.0853 0.2487
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0349 0.3384
Echinococcus multilocularis protein patched 0.0042 0.0146 0.0332
Schistosoma mansoni hypothetical protein 0.004 0.0138 0.0697
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0263 0.1087
Loa Loa (eye worm) hypothetical protein 0.007 0.0308 0.1558
Mycobacterium ulcerans dehydrogenase 0.0126 0.0623 0.0496
Schistosoma mansoni amine oxidase 0.0126 0.0623 0.3154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0026 0.0109
Schistosoma mansoni hypothetical protein 0.0034 0.0102 0.0514
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0126 0.0623 0.1813
Brugia malayi cathepsin B-like cysteine proteinase 0.0137 0.0683 0.2827
Schistosoma mansoni hypothetical protein 0.0166 0.0849 0.4301
Plasmodium vivax hypothetical protein, conserved 0.0126 0.0623 0.1813
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0134 0.1542
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0624 0.3424 0.3335
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0048 0.0182 0.2106
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0026 0.0255
Toxoplasma gondii histone lysine-specific demethylase 0.0126 0.0623 0.7289
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0157 0.045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0026 0.0109
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0133
Echinococcus granulosus muscleblind protein 0.0152 0.0769 0.7453
Brugia malayi steroid hormone receptor 0.002 0.0026 0.0109
Schistosoma mansoni tyrosinase precursor 0.0366 0.1975 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0429 0.217
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0039 0.0134 0.0383
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0026 0.0133
Echinococcus granulosus lysine specific histone demethylase 1A 0.0126 0.0623 0.6038
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0026 0.006
Echinococcus granulosus kinesin family 1 0.0199 0.1032 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0429 0.4154
Toxoplasma gondii RNA-directed DNA polymerase 0.0167 0.0853 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0157 0.1812
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0126 0.0623 0.1813
Giardia lamblia Cathepsin B precursor 0.0048 0.0182 0.1559
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0133
Onchocerca volvulus 0.0366 0.1975 0.5849
Schistosoma mansoni DNA polymerase I 0.0016 0.0003 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0429 0.4154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0429 0.217
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0429 0.1773
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0026 0.006
Chlamydia trachomatis protoporphyrinogen oxidase 0.0126 0.0623 0.1246
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.072 0.698
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0126 0.0623 0.1813
Entamoeba histolytica kinesin, putative 0.0026 0.0058 0.1215
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0026 0.0109
Loa Loa (eye worm) beta-lactamase 0.007 0.0308 0.1558
Brugia malayi beta-lactamase family protein 0.007 0.0308 0.1273
Leishmania major hypothetical protein, conserved 0.007 0.0308 0.3586
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0308 0.019
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0308 0.019
Brugia malayi beta-lactamase 0.007 0.0308 0.1273
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.0683 0.346
Echinococcus granulosus expressed conserved protein 0.0091 0.0424 0.4109
Plasmodium vivax hypothetical protein, conserved 0.007 0.0308 0.0892
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0797 0.4396 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0026 0.0109
Loa Loa (eye worm) hypothetical protein 0.0126 0.0623 0.3154
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0263 0.133
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0137 0.0683 0.346
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0308 0.019
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0624 0.3424 1
Loa Loa (eye worm) tyrosinase 1 0.0366 0.1975 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.0172 0.0392
Brugia malayi Common central domain of tyrosinase family protein 0.0366 0.1975 0.8172
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0308 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0349 0.1767
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0308 0.019
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0624 0.3424 0.3335
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0182 0.5874
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.0683 0.346
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0263 0.133
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0769 0.1749
Brugia malayi Telomerase reverse transcriptase 0.0445 0.2417 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0026 0.0133
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0026 0.0133
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0308 0.019
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0026 0.006
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0126 0.0623 0.3154
Loa Loa (eye worm) hypothetical protein 0.0126 0.0623 0.3154
Mycobacterium ulcerans monoamine oxidase 0.0126 0.0623 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0026 0.0109
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0039 0.0134 0.0383
Trichomonas vaginalis esterase, putative 0.007 0.0308 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0308 0.1558
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0026 0.0133
Loa Loa (eye worm) RNA binding protein 0.0062 0.0263 0.133
Loa Loa (eye worm) hypothetical protein 0.0366 0.1975 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0126 0.0623 0.0534
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0457 0.189
Loa Loa (eye worm) hypothetical protein 0.0366 0.1975 1
Echinococcus multilocularis expressed conserved protein 0.0091 0.0424 0.0964
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0026 0.0109
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0026 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0189 0.0783
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0157 0.152
Schistosoma mansoni tyrosine kinase 0.0078 0.0349 0.1767
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0146 0.4701
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0026 0.0255
Mycobacterium tuberculosis Conserved protein 0.007 0.0308 0.019
Brugia malayi SWIRM domain containing protein 0.0126 0.0623 0.2577
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0026 0.0255
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0369 0.8055
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0026 0.006
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0366 0.1975 0.8172
Loa Loa (eye worm) hypothetical protein 0.0042 0.0146 0.074
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0133
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0457 0.1039
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0136 0.2946
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1792 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0263 0.133
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0146 0.1416
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0026 0.0109
Mycobacterium leprae conserved hypothetical protein 0.007 0.0308 0.2098
Toxoplasma gondii ABC1 family protein 0.007 0.0308 0.3586
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0039 0.0134 0.1542
Onchocerca volvulus 0.0366 0.1975 0.5849
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0026 0.0255
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0102 0.042
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0048 0.0182 0.2106
Brugia malayi beta-lactamase family protein 0.007 0.0308 0.1273
Schistosoma mansoni hypothetical protein 0.0173 0.0886 0.4487
Brugia malayi amine oxidase, flavin-containing family protein 0.0126 0.0623 0.2577
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0026 0.0133
Mycobacterium tuberculosis Conserved protein 0.007 0.0308 0.019
Plasmodium falciparum protoporphyrinogen oxidase 0.0126 0.0623 0.1813
Schistosoma mansoni hypothetical protein 0.004 0.0138 0.0697
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.069 0.6693
Schistosoma mansoni thyroid hormone receptor 0.002 0.0026 0.0133
Echinococcus multilocularis cathepsin b 0.0137 0.0683 0.1554
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0369 0.8055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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