Detailed information for compound 1089404

Basic information

Technical information
  • TDR Targets ID: 1089404
  • Name: (5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydrox ymethyl)-3-methyl-6-oxa-1,3-diazaspiro[4.5]de cane-2,4-dione
  • MW: 262.217 | Formula: C9H14N2O7
  • H donors: 5 H acceptors: 6 LogP: -3.2 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@@]2(NC(=O)N(C2=O)C)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C9H14N2O7/c1-11-7(16)9(10-8(11)17)6(15)5(14)4(13)3(2-12)18-9/h3-6,12-15H,2H2,1H3,(H,10,17)/t3-,4-,5+,6-,9+/m1/s1
  • InChiKey: RIUIMUSXAGXXON-FMTWGGRWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5S,7R,8S,9S,10R)-8,9,10-trihydroxy-3-methyl-7-methylol-6-oxa-1,3-diazaspiro[4.5]decane-2,4-quinone
  • 8,9,10-TRIHYDROXY-7-HYDROXYMETHYL-3-METHYL-6-OXA-1,3-DIAZA-SPIRO[4.5]DECANE-2,4-DIONE
  • GL7

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0033 0.0588 0.0842
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0084 0.0002
Plasmodium falciparum fructose-bisphosphate aldolase 0.0099 0.2775 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0814 0.1166
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0083 0.0119
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0084 0.0288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0083 0.0119
Onchocerca volvulus 0.0259 0.8013 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0074 0.195 0.3538
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0084 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0084 0.0002
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0023 0.0271 0.0932
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0814 0.0814
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.2905 1
Schistosoma mansoni alpha-glucosidase 0.0153 0.4547 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.2905 0.2905
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0023 0.0271 0.0932
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.195 0.6713
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0074 0.195 0.4183
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0099 0.2775 0.9554
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 1 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0356 0.1192
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.4638 1
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0074 0.195 0.3723
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0814 0.0814
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0814 0.0814
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0084 0.012
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0074 0.195 0.6713
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0084 0.0002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.4638 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0814 0.1385
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0588 0.1131
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0356 0.1192
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0074 0.195 0.6996
Loa Loa (eye worm) hypothetical protein 0.0054 0.1305 0.1869
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0074 0.195 0.6713
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0356 0.1225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 1 1
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0814 0.2801
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0049 0.1111 0.1592
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0084 0.0201
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0074 0.195 1
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0099 0.2775 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 1 1
Schistosoma mansoni kinase 0.0052 0.1239 0.259
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.6982 1
Trypanosoma brucei polo-like protein kinase 0.0103 0.2905 1
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0074 0.195 0.1653
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0074 0.195 0.6989
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0099 0.2775 0.3975
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0588 0.0957
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0282 0.0404
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0049 0.1111 0.1948
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0814 0.2801
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0099 0.2775 0.5102
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0084 0.0002
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0049 0.1111 0.1111
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0189 0.0393
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.5361 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.195 0.6713
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0356 0.0597
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 1 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0588 0.0842
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0074 0.195 0.4183
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0084 0.0201
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0074 0.195 0.6713
Brugia malayi fructose-bisphosphate aldolase 1 0.0099 0.2775 0.3975
Trichomonas vaginalis set domain proteins, putative 0.0259 0.8013 0.8013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1305 0.1869
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1194 0.1194
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0099 0.2775 0.6032
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0814 0.0814
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0026 0.0357 0.0601
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0099 0.2775 0.9554
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.2905 0.2905
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.195 0.6713
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0588 0.0957
Trypanosoma brucei glucosidase, putative 0.0039 0.0814 0.2801
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0739 0.1059
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.2905 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0074 0.195 0.4183
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0356 0.1225
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0084 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0588 0.1131
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.5361 1
Entamoeba histolytica hypothetical protein 0.0026 0.0356 0.0356
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0099 0.2775 0.9554
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.2499 0.3579
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0048 0.111 0.382
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0814 0.0814
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0282 0.0282
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0074 0.195 0.6713
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0074 0.195 0.3538
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0074 0.195 0.3538
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1305 0.1869
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.2905 1
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0099 0.2775 0.9554
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0074 0.195 0.6713
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0074 0.195 1
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0099 0.2775 0.5102
Brugia malayi fructose-bisphosphate aldolase 2 0.0099 0.2775 0.3975
Plasmodium vivax SET domain protein, putative 0.0033 0.0588 0.2018
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0023 0.0271 0.0932
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0049 0.1111 0.1111
Treponema pallidum fructose-bisphosphate aldolase 0.0319 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0083 0.0119
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0084 0.0288
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0084 0.012
Loa Loa (eye worm) RecQ helicase 0.0023 0.0282 0.0404
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0099 0.2775 0.5102
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.5361 0.7678
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.195 0.195
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.5361 0.7678
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0548 0.0882
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0074 0.195 0.6713
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0814 0.2801
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.195 0.195
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0026 0.0357 0.0004
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0099 0.2775 0.6032
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0282 0.0378
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1305 0.1869
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.5361 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0814 0.0814
Giardia lamblia Kinase, PLK 0.0103 0.2905 0.2019
Onchocerca volvulus 0.0033 0.0588 0.0733
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.2905 0.4161
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.2905 0.2905
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0051 0.1196 0.1714
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0588 0.1131
Loa Loa (eye worm) hypothetical protein 0.0091 0.2499 0.3579
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0084 0.0002
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0049 0.1111 0.1592
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0074 0.195 0.195
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.2905 0.4161
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 1 1
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0099 0.2775 0.5102
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.2905 0.2905
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0074 0.195 0.6996
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0099 0.2775 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0084 0.0288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 1 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0084 0.012
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0814 0.0814
Schistosoma mansoni hypothetical protein 0.0037 0.0739 0.1471
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0074 0.195 0.0945
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0814 0.1166
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0074 0.195 0.195
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.2905 0.2905
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0074 0.195 0.3538
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0048 0.111 0.382
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.195 0.195
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0026 0.0356 0.051
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.2905 0.2905
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.2905 0.3625
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0588 0.0957
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1194 0.1194
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0083 0.0119
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.195 0.6713
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0084 0.0288
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0084 0.0288
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0051 0.1196 0.1714
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0074 0.195 0.2793
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0099 0.2775 1
Onchocerca volvulus 0.0103 0.2897 0.3615
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0048 0.111 0.382
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0074 0.195 0.195
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0099 0.2775 0.3975
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0814 0.2859
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0074 0.195 0.4183
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0074 0.195 0.6934
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.2905 0.6322
Loa Loa (eye worm) hypothetical protein 0.0049 0.1111 0.1592
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0074 0.195 0.6713
Schistosoma mansoni alpha-glucosidase 0.0153 0.4547 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0282 0.0282
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.195 0.195
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0099 0.2775 0.5102
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0356 0.0356
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0099 0.2775 0.9554
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0099 0.2775 0.5102
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.195 0.195
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0814 0.1385
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0814 0.0814
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0084 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0127 0.0183
Brugia malayi Pre-SET motif family protein 0.0227 0.6982 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0739 0.1059
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.2499 0.5413
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.2499 0.4578
Giardia lamblia Fructose-bisphosphate aldolase 0.0319 1 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0356 0.1011
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0023 0.0271 0.0932
Echinococcus granulosus bloom syndrome protein 0.0023 0.0282 0.0378
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0814 0.0814
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0814 0.0814
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.2905 0.5347
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0023 0.0271 0.0388
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.2499 0.4578
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.2905 0.5347
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0356 0.1172
Onchocerca volvulus 0.0091 0.2499 0.3119
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0049 0.1111 0.1948
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.4638 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0588 0.2036
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0074 0.195 0.6713
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0048 0.111 0.382
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0814 0.0814
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0023 0.0271 0.0932
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.2905 0.2905
Schistosoma mansoni alpha glucosidase 0.0039 0.0814 0.1637
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0099 0.2775 1
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0099 0.2775 0.5102
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0099 0.2775 0.5102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0588 0.1131
Leishmania major fructose-1,6-bisphosphate aldolase 0.0099 0.2775 0.9554
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0121 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.2905 0.2905

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1200 uM Inhibition of rabbit muscle glycogen phosphorylase b ChEMBL. 19781947

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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