Detailed information for compound 108955

Basic information

Technical information
  • TDR Targets ID: 108955
  • Name: [7-chloro-4-(2,2-dimethylpropanoyloxy)benzo[f ][1,3]benzodioxol-9-yl] 2,2-dimethylpropanoat e
  • MW: 406.857 | Formula: C21H23ClO6
  • H donors: 0 H acceptors: 2 LogP: 5.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)c(OC(=O)C(C)(C)C)c1c(c2OC(=O)C(C)(C)C)OCO1
  • InChi: 1S/C21H23ClO6/c1-20(2,3)18(23)27-14-12-8-7-11(22)9-13(12)15(17-16(14)25-10-26-17)28-19(24)21(4,5)6/h7-9H,10H2,1-6H3
  • InChiKey: BARLWEBETYTEEN-UHFFFAOYSA-N  

Network

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Synonyms

  • 2,2-dimethylpropanoic acid [7-chloro-4-(2,2-dimethyl-1-oxopropoxy)-9-benzo[f][1,3]benzodioxolyl] ester
  • 2,2-dimethylpropionic acid (7-chloro-4-pivaloyloxy-benzo[f][1,3]benzodioxol-9-yl) ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0085 0.0626
Echinococcus multilocularis geminin 0.0183 0.1155 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.008 0.5
Loa Loa (eye worm) DR-78 0.001 0.0011 0.0071
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0515 0.0677
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0002 0.0015
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0011 0.0069
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1524 1 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1524 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0253 0.219
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0889
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0011 0.0096
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0015
Trichomonas vaginalis C-MYB, putative 0.002 0.008 0.032
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0011 0.0096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0253 0.219
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0085 0.0626
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0119 0.0777
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0085 0.0626
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0199 0.1721
Trypanosoma brucei trypanothione reductase 0.0038 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Echinococcus granulosus protein jagged 1 0.0008 0.0002 0.0015
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0011 0.0096
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0119 0.0889
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0085 0.0626
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0195 0.1465
Onchocerca volvulus 0.003 0.0147 0.096
Schistosoma mansoni zinc finger protein 0.001 0.0011 0.0096
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0889
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0085 0.0626
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0835
Echinococcus granulosus protein jagged 2 0.0008 0.0002 0.0015
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0009 0.0057
Brugia malayi conserved hypotetical protein 0.001 0.0011 0.0071
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0085 0.0732
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.043 0.278 0.2757
Echinococcus multilocularis protein jagged 2 0.0008 0.0002 0.0015
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0032 0.0279
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0112 0.4894
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0085 0.0626
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0085 0.0626
Loa Loa (eye worm) hypothetical protein 0.003 0.0147 0.1098
Onchocerca volvulus Peroxidase homolog 0.0026 0.0119 0.0777
Echinococcus multilocularis neural cadherin 0.0008 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Schistosoma mansoni hypothetical protein 0.0183 0.1155 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0734 0.5534
Echinococcus granulosus cpg binding protein 0.003 0.0146 0.1265
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1094 0.7166 1
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.002 0.0176
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.008 0.5
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.008 0.0324
Leishmania major trypanothione reductase 0.0038 0.0195 1
Brugia malayi hypothetical protein 0.001 0.0011 0.0071
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0889
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0626
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0112 0.4894
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0131
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.0096
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0195 1
Trichomonas vaginalis pc-MYB2, putative 0.002 0.008 0.032
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.0096
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0032 0.011
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0119 0.0777
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.0096
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0011 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0147 0.1272
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0579 0.0767
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0096
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0085 0.0732
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0015
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0085 0.0732
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.008 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0085 0.0626
Plasmodium falciparum glutathione reductase 0.0038 0.0195 1
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0002 0.000000054599
Schistosoma mansoni nuclear receptor 0.001 0.0011 0.0096
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0085 0.0732
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0085 0.0547
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0253 0.219
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0011 0.0071
Schistosoma mansoni notch 0.0008 0.0002 0.0015
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0015
Echinococcus multilocularis cpg binding protein 0.003 0.0146 0.1265
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0019 0.0164
Echinococcus granulosus notch 0.0008 0.0002 0.0015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0199 0.1721
Giardia lamblia Myb 1-like protein 0.002 0.008 1
Schistosoma mansoni notch 0.0008 0.0002 0.0015
Echinococcus granulosus protein jagged 2 0.0008 0.0002 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0085 0.0732
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0147 0.1272
Echinococcus multilocularis notch 0.0008 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0011 0.0096
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0085 0.0732
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0112 0.4894
Schistosoma mansoni nuclear receptor 0.001 0.0011 0.0096
Brugia malayi steroid hormone receptor 0.0021 0.0085 0.0626
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0579 0.0096
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0002 0.0015
Echinococcus granulosus neurogenic locus notch protein 4 0.0008 0.0002 0.0015
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0579 0.0767
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0011 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0085 0.0626
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0011 0.0071
Echinococcus granulosus neurogenic locus protein delta 0.0008 0.0002 0.0015
Echinococcus granulosus protein jagged 1 0.0008 0.0002 0.0015
Onchocerca volvulus Peroxidase homolog 0.0026 0.0119 0.0777
Onchocerca volvulus 0.0026 0.0119 0.0777
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Loa Loa (eye worm) hypothetical protein 0.0163 0.1024 0.7731
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0085 0.0626
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0019 0.0164
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1514 1
Echinococcus multilocularis protein jagged 1 0.0008 0.0002 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0085 0.0732
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0071
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0085 0.0732
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0085 0.0732
Brugia malayi hypothetical protein 0.0011 0.0019 0.0131
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.008 0.5
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0085 0.0732
Schistosoma mansoni notch 0.0008 0.0002 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0253 0.1899
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0119 0.0889
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0032 0.011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.002 0.008 0.0282
Echinococcus multilocularis fibropellin Ia 0.0008 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0626
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.008 0.032
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0085 0.0732
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0011 0.0071
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0253 0.1899
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0147 0.1272
Schistosoma mansoni cell polarity protein 0.0008 0.0002 0.0015
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0019 0.0164
Brugia malayi nuclear receptor RXR 0.001 0.0011 0.0071
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0011 0.0096
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0734 0.5534
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0119 0.0889
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0085 0.0732
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0011 0.0071
Brugia malayi Thioredoxin reductase 0.0038 0.0195 0.1465
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0071
Trichomonas vaginalis pc-MYB2, putative 0.002 0.008 0.032
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0085 0.0732
Echinococcus granulosus fibropellin Ia 0.0008 0.0002 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0355 0.3075
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0012 0.01
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0085 0.0626
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0312 0.1117
Schistosoma mansoni coup transcription factor 0.0021 0.0085 0.0732
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.008 0.032
Echinococcus multilocularis peroxidasin 0.0026 0.0119 0.1032
Brugia malayi nuclear receptor RXR 0.0011 0.0019 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0085 0.0626
Plasmodium vivax glutathione reductase, putative 0.0038 0.0195 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0085 0.0732
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0085 0.0732
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0096
Brugia malayi hypothetical protein 0.0026 0.0119 0.0889
Schistosoma mansoni cpg binding protein 0.003 0.0146 0.1265
Brugia malayi ecdysone receptor 0.001 0.0011 0.0071
Onchocerca volvulus 0.0238 0.1514 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.043 0.278 0.2757
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0515 0.0677
Echinococcus multilocularis fat cadherin tumor suppressor 0.0008 0.0002 0.0015
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0119 0.0777
Trichomonas vaginalis C-MYB, putative 0.002 0.008 0.032
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0085 0.0732
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0085 0.0732
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0085 0.0732
Brugia malayi Blistered cuticle protein 3 0.0026 0.0119 0.0889
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0019 0.0131
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0626
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0096
Schistosoma mansoni notch 0.0008 0.0002 0.0015
Brugia malayi CXXC zinc finger family protein 0.0029 0.0135 0.101
Brugia malayi ecdysteroid receptor 0.0021 0.0085 0.0626
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0071
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0112 0.4894
Echinococcus granulosus neural cadherin 0.0008 0.0002 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0085 0.0732
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0147 0.0523
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0085 0.0732
Echinococcus granulosus slit 2 protein 0.0008 0.0002 0.0015
Echinococcus multilocularis neurogenic locus notch protein 4 0.0008 0.0002 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0012 0.01
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0253 0.219
Onchocerca volvulus 0.001 0.0011 0.0062
Schistosoma mansoni notch 0.0008 0.0002 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0085 0.0626
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0085 0.0547
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Onchocerca volvulus 0.0026 0.0119 0.0777
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0009 0.0057
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0085 0.0732
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0085 0.0732
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0085 0.0732
Onchocerca volvulus 0.001 0.0011 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0626
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Echinococcus multilocularis slit 2 protein 0.0008 0.0002 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0147 0.1272
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.008 0.032
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1094 0.7166 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.043 0.278 1
Schistosoma mansoni notch 0.0008 0.0002 0.0015
Trichomonas vaginalis MYB72, putative 0.002 0.008 0.032
Brugia malayi nuclear receptor NHR-67 0.001 0.0011 0.0071
Brugia malayi EGF-like domain containing protein 0.0008 0.0002 0.000000062439
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0119 0.0777
Brugia malayi Pre-SET motif family protein 0.0209 0.1324 1
Brugia malayi Pre-SET motif family protein 0.003 0.0147 0.1098
Onchocerca volvulus 0.0021 0.0085 0.0547
Loa Loa (eye worm) glutathione reductase 0.0038 0.0195 0.1465
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.000000062439
Echinococcus granulosus peroxidasin 0.0026 0.0119 0.1032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0626
Schistosoma mansoni cpg binding protein 0.003 0.0146 0.1265
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0515 0.0677
Brugia malayi tailless protein 0.001 0.0011 0.0071
Trichomonas vaginalis MYB3r3, putative 0.002 0.008 0.032
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0085 0.0626
Brugia malayi notch-like transmembrane receptor 0.0008 0.0002 0.000000062439
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0019 0.0164
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0515 0.0677
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.008 0.032
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0032 0.3883
Plasmodium falciparum thioredoxin reductase 0.0038 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0131
Plasmodium vivax SET domain protein, putative 0.003 0.0147 0.7027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0085 0.0626
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0085 0.0547
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0011 0.0071
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0119 0.0889
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0253 0.219
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0008 0.0002 0.0015
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.008 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0085 0.0626
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0011 0.0096
Brugia malayi hypothetical protein 0.0011 0.0019 0.0131
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0131
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0085 0.0732
Schistosoma mansoni cpg binding protein 0.0029 0.0135 0.1171
Mycobacterium tuberculosis Probable reductase 0.0086 0.0515 0.0677
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1324 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.0096
Leishmania major hypothetical protein, conserved 0.0025 0.0112 0.4894
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.008 0.0324
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0889
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0085 0.0732
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0085 0.0732
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.4894
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0085 0.0732
Brugia malayi MH2 domain containing protein 0.0119 0.0734 0.5534
Schistosoma mansoni hypothetical protein 0.0011 0.002 0.0176
Schistosoma mansoni slit 0.0008 0.0002 0.0015
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1524 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0011 0.0096
Brugia malayi glutathione reductase 0.0038 0.0195 0.1465
Loa Loa (eye worm) histone methyltransferase 0.001 0.0012 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0085 0.0626
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0011 0.0071
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0135 0.101
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.4894
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0515 0.0677
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.008 0.5
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0002 0.000000054599
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0085 0.0732
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0253 0.219
Brugia malayi hypothetical protein 0.0025 0.0112 0.0835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0253 0.219
Onchocerca volvulus 0.0029 0.0135 0.0883
Schistosoma mansoni peroxidasin 0.0026 0.0119 0.1032
Toxoplasma gondii thioredoxin reductase 0.0038 0.0195 0.0697
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Brugia malayi nuclear receptor NHR-88 0.0021 0.0085 0.0626
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0112 0.0397
Echinococcus granulosus delta-like protein 1 0.0008 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0131
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0019 0.0131
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0195 0.0229
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0085 0.0626
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0032 0.023
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0032 0.0279
Echinococcus granulosus geminin 0.0183 0.1155 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0119 0.0889
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0085 0.0732
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0147 0.1272
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0011 0.0071
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.002 0.0176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0626
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0119 0.0889
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0119 0.0889
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0002 0.0015
Schistosoma mansoni peroxidasin 0.0026 0.0119 0.1032
Trichomonas vaginalis MYB, putative 0.002 0.008 0.0324
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0011 0.0062
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0195 1
Brugia malayi hypothetical protein 0.0016 0.0053 0.0388
Schistosoma mansoni hypothetical protein 0.0183 0.1155 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0085 0.0732
Brugia malayi hypothetical protein 0.0163 0.1024 0.7731
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0085 0.0626
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0579 0.0767
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0626
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0085 0.0626
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0085 0.0626
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0147 0.1272
Onchocerca volvulus 0.0026 0.0119 0.0777
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0085 0.0626
Schistosoma mansoni septate junction protein 0.0008 0.0002 0.0015
Brugia malayi nuclear hormone receptor 0.0021 0.0085 0.0626
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0019 0.0131
Brugia malayi hypothetical protein 0.001 0.0011 0.0071
Brugia malayi Peroxidasin 0.0026 0.0119 0.0889
Onchocerca volvulus 0.0163 0.1024 0.6761
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.043 0.278 0.3405
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0085 0.0626
Echinococcus multilocularis protein jagged 1 0.0008 0.0002 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0136 0.1173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0147 0.1272
Schistosoma mansoni laminin gamma-3 chain 0.0008 0.0002 0.0015
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0011 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0626
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0085 0.0626
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0032 0.0279

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 8 % Percent inhibition of arachidonic acid induced mouse ear edema at 2 mg of total dose ChEMBL. 3141623
Inhibition (functional) = 8 % Percent inhibition of arachidonic acid induced mouse ear edema at 2 mg of total dose ChEMBL. 3141623

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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