Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.2067 | 0.442 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0618 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0532 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0188 | 0.0402 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.4677 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1151 | 0.246 |
Onchocerca volvulus | 0.0027 | 0.072 | 1 | |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0532 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0618 | 0.1322 |
Echinococcus granulosus | lamin | 0.0027 | 0.072 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.072 | 0.1538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.271 | 0.2646 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.271 | 0.2646 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.072 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0532 | 0.1138 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0532 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1261 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0618 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0691 | 0.1478 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0087 | 0.0185 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1261 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.271 | 0.5794 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.4677 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0532 | 0.1138 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0532 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0618 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.271 | 0.5794 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.4677 | 0.4631 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.271 | 0.2646 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0532 | 0.1138 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0532 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1261 | 0.1185 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0532 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0532 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1261 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.072 | 0.1538 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0618 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0618 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.072 | 0.1538 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0087 | 0.0185 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1261 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.4677 | 0.4631 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0532 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1261 | 0.1185 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.072 | 0.0638 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.271 | 0.2646 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0532 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0618 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.072 | 0.1538 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.4677 | 0.4631 |
Schistosoma mansoni | lamin | 0.0027 | 0.072 | 0.0638 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0532 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0532 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.072 | 0.0638 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.271 | 0.2646 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1261 | 0.1185 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.2067 | 0.442 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.271 | 0.5794 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.271 | 0.5794 |
Onchocerca volvulus | 0.0027 | 0.072 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.4677 | 0.4631 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0532 | 0.1138 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.271 | 0.2646 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.072 | 0.0638 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1151 | 0.246 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.4677 | 0.4631 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0188 | 0.139 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0532 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0618 | 0.1322 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2067 | 0.442 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1261 | 0.1185 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0087 | 0.0185 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0618 | 0.5 |
Brugia malayi | RNA binding protein | 0.0062 | 0.271 | 0.5794 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.2067 | 0.442 |
Echinococcus multilocularis | geminin | 0.019 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.4677 | 0.4631 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0087 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0188 | 0.0402 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.072 | 0.0638 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0105 | 0.0224 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0618 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0532 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0188 | 0.0402 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1261 | 0.2696 |
Echinococcus multilocularis | musashi | 0.0027 | 0.072 | 0.0638 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.4677 | 0.4631 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.271 | 0.5794 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0188 | 0.0402 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.271 | 0.2646 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0188 | 0.0402 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1151 | 0.1073 |
Echinococcus multilocularis | lamin | 0.0027 | 0.072 | 0.0638 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.072 | 0.1538 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.69 | Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay | ChEMBL. | 20022507 |
IC50 (functional) | > 20 uM | Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay | ChEMBL. | 20022507 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.