TDR Targets

Basic information

Technical information

TDR Targets ID: 1090309
Name: [5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidi n-1-yl]pyridazin-3-yl]-1,3,4-oxadiazol-2-yl]m ethanol
MW: 421.373 | Formula: C19H18F3N5O3
H donors: 1 H acceptors: 5 LogP: 2.08 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OCc1nnc(o1)c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F
InChi: 1S/C19H18F3N5O3/c20-19(21,22)13-3-1-2-4-15(13)29-12-7-9-27(10-8-12)16-6-5-14(23-24-16)18-26-25-17(11-28)30-18/h1-6,12,28H,7-11H2
InChiKey: ARWYZCAXZZDODL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[5-[6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidyl]pyridazin-3-yl]-1,3,4-oxadiazol-2-yl]methanol
[5-[6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-3-pyridazinyl]-1,3,4-oxadiazol-2-yl]methanol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Acyl-CoA desaturase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.2774	0.8121
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0371	0.0378
Onchocerca volvulus		0.0019	0.0408	0.0282
Brugia malayi	RNA binding protein	0.0071	0.2739	0.3135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Brugia malayi	Delta5 fatty acid desaturase	0.0018	0.0371	0.0424
Echinococcus multilocularis	JmjC domain containing protein 4	0.0017	0.0329	0.1079
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0408	0.1339
Leishmania major	fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative	0.0018	0.0371	0.0136
Trypanosoma cruzi	fatty acid desaturase, putative	0.0068	0.2611	0.7645
Plasmodium vivax	vivapain-2	0.0019	0.0408	0.1563
Echinococcus granulosus	jumonji domain containing 1A	0.0017	0.0329	0.1079
Leishmania major	cysteine peptidase A (CPA)	0.0019	0.0408	0.0257
Entamoeba histolytica	hypothetical protein	0.0078	0.3048	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Schistosoma mansoni	cathepsin F (C01 family)	0.0013	0.013	0.0426
Leishmania major	cathepsin L-like protease	0.0019	0.0408	0.0257
Echinococcus multilocularis	cpg binding protein	0.0033	0.1028	0.3373
Trypanosoma brucei	delta-6 fatty acid desaturase, putative	0.0018	0.0371	0.1086
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.2547	0.8359
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.0329	0.0329
Brugia malayi	acyl-CoA desaturase	0.0068	0.2611	0.2988
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0017	0.0329	0.126
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0019	0.0408	0.1338
Trichomonas vaginalis	set domain proteins, putative	0.0234	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.013	0.0101
Schistosoma mansoni	hypothetical protein	0.0016	0.0259	0.085
Echinococcus granulosus	phd:f box containing protein	0.0017	0.0329	0.1079
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0408	0.0421
Entamoeba histolytica	hypothetical protein	0.0078	0.3048	1
Echinococcus multilocularis	Fatty acid desaturase, type 1	0.0018	0.0371	0.1217
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0408	0.1339
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0.0371	0.5
Plasmodium vivax	JmjC domain containing protein	0.0017	0.0329	0.126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Loa Loa (eye worm)	fatty acid desaturase	0.0018	0.0371	0.0378
Echinococcus multilocularis	phd:f box containing protein	0.0017	0.0329	0.1079
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0949	0.1043
Leishmania major	cathepsin L-like protease	0.0019	0.0408	0.0257
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0037	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0408	0.0421
Trypanosoma cruzi	fatty acid desaturase, putative	0.0018	0.0371	0.1086
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0019	0.0408	0.1338
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2739	0.8989
Onchocerca volvulus		0.0086	0.3415	0.3329
Schistosoma mansoni	hypothetical protein	0.0016	0.0259	0.085
Schistosoma mansoni	protein phosphatase 2C	0.0017	0.0329	0.1079
Schistosoma mansoni	jumonji domain containing protein	0.0017	0.0329	0.1079
Schistosoma mansoni	phosphatidylserine receptor	0.0017	0.0329	0.1079
Plasmodium vivax	vivapain-2	0.0019	0.0408	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1756	0.1971
Toxoplasma gondii	cathepsin CPL	0.0019	0.0408	0.0416
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0408	0.0408
Loa Loa (eye worm)	acyl-CoA desaturase	0.0068	0.2611	0.2954
Leishmania major	cathepsin L-like protease	0.0072	0.2774	0.792
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1063	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0013	0.013	0.0101
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1756	0.1971
Loa Loa (eye worm)	FAT-3 protein	0.0018	0.0371	0.0378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Leishmania major	delta-12 fatty acid desaturase	0.0018	0.0371	0.0136
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0078	0.3048	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1756	0.201
Brugia malayi	Cathepsin L-like precursor	0.0013	0.013	0.0149
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.0329	0.0329
Echinococcus granulosus	tar DNA binding protein	0.0071	0.2739	0.8989
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0066	0.2505	0.8218
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0064	0.2426	0.7959
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0908	0.2978
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Leishmania major	cathepsin L-like protease	0.0072	0.2774	0.792
Schistosoma mansoni	transcription factor LCR-F1	0.0078	0.3048	1
Brugia malayi	jmjC domain containing protein	0.0017	0.0329	0.0376
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0408	0.0467
Echinococcus granulosus	cathepsin l1	0.0013	0.013	0.0426
Brugia malayi	RNA recognition motif domain containing protein	0.0071	0.2739	0.3135
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0408	0.1195
Schistosoma mansoni	cpg binding protein	0.0033	0.1028	0.3373
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0042	0.0139
Schistosoma mansoni	phd/f-box containing protein	0.0017	0.0329	0.1079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0408	0.0408
Echinococcus granulosus	lysine specific demethylase 5A	0.0066	0.2505	0.8218
Echinococcus granulosus	JmjC domain containing protein 4	0.0017	0.0329	0.1079
Schistosoma mansoni	cpg binding protein	0.0031	0.0949	0.3114
Loa Loa (eye worm)	hypothetical protein	0.0132	0.5465	0.6236
Trypanosoma brucei	cytochrome b5-dependent oleate desaturase	0.0018	0.0371	0.1086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Leishmania major	cathepsin L-like protease	0.0019	0.0408	0.0257
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.0329	0.0329
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0259	0.085
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0329	0.0329
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0259	0.0297
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0018	0.0371	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Schistosoma mansoni	hypothetical protein	0.0016	0.0259	0.085
Onchocerca volvulus	Huntingtin homolog	0.0132	0.5465	0.5405
Echinococcus granulosus	Fatty acid desaturase type 1	0.0018	0.0371	0.1217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0408	0.0408
Loa Loa (eye worm)	RNA binding protein	0.0071	0.2739	0.3102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0908	0.2978
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.2495	0.7306
Brugia malayi	Pre-SET motif family protein	0.003	0.0908	0.1039
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0.0408	0.1563
Brugia malayi	Cathepsin L-like precursor	0.0013	0.013	0.0149
Leishmania major	fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative	0.0018	0.0371	0.0136
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0259	0.085
Onchocerca volvulus		0.003	0.0908	0.0788
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0408	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1063	0.1174
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0066	0.2505	0.8218
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0259	0.0249
Leishmania major	cathepsin L-like protease	0.0072	0.2774	0.792
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0908	0.3038
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0408	0.1339
Trypanosoma cruzi	delta-4 fatty acid desaturase, putative	0.0018	0.0371	0.1086
Onchocerca volvulus		0.0086	0.3415	0.3329
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0259	0.085
Trypanosoma cruzi	cytochrome b5-dependent oleate desaturase	0.0018	0.0371	0.1086
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0408	0.0282
Brugia malayi	TAR-binding protein	0.0071	0.2739	0.3135
Echinococcus granulosus	GPCR family 2	0.0016	0.0259	0.085
Echinococcus granulosus	cathepsin l1	0.0019	0.0408	0.1339
Schistosoma mansoni	hypothetical protein	0.0078	0.3048	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0408	0.1339
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.2234	1
Leishmania major	fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative	0.0018	0.0371	0.0136
Brugia malayi	jmjC domain containing protein	0.0064	0.2426	0.2776
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0408	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0132	0.5465	0.6236
Leishmania major	fatty acid desaturase, putative	0.0018	0.0371	0.0136
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1756	0.201
Brugia malayi	jmjC domain containing protein	0.0017	0.0329	0.0376
Brugia malayi	cathepsin L-like precursor	0.0013	0.013	0.0149
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2739	0.8989
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.0068	0.2611	1
Echinococcus multilocularis	jumonji domain containing 1A	0.0017	0.0329	0.1079
Onchocerca volvulus		0.0019	0.0408	0.0282
Loa Loa (eye worm)	hypothetical protein	0.003	0.0908	0.0995
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.2774	0.8121
Leishmania major	fatty-acid desaturase, putative	0.0086	0.3415	1
Brugia malayi	Fatty acid desaturase family protein	0.0018	0.0371	0.0424
Toxoplasma gondii	sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein	0.0018	0.0371	0.022
Trypanosoma cruzi	sphingolipid delta 4 desaturase, putative	0.0018	0.0371	0.1086
Mycobacterium tuberculosis	Probable conserved membrane protein	0.0018	0.0371	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0408	0.0282
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0908	0.2978
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Trypanosoma brucei	delta-4 fatty acid desaturase	0.0018	0.0371	0.1086
Brugia malayi	Fatty acid desaturase family protein	0.0018	0.0371	0.0424
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0018	0.0371	0.1217
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0408	0.0408
Onchocerca volvulus		0.0019	0.0408	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0013	0.013	0.0101
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0078	0.3048	1
Echinococcus multilocularis	cysteine protease	0.0019	0.0408	0.1339
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0908	0.2978
Brugia malayi	Pre-SET motif family protein	0.0205	0.8737	1
Loa Loa (eye worm)	ctsf protein	0.0019	0.0408	0.0421
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.8737	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0908	0.2978
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0.0371	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0408	0.1339
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0.0408	0.1563
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0908	0.2978
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0408	0.0408
Trypanosoma cruzi	fatty acid desaturase, putative	0.0068	0.2611	0.7645
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Brugia malayi	jmjC domain containing protein	0.0066	0.2505	0.2867
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0949	0.1086
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0259	0.085
Entamoeba histolytica	hypothetical protein	0.0078	0.3048	1
Trypanosoma cruzi	fatty acid desaturase, putative	0.0086	0.3415	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.013	0.013
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2739	0.8989
Echinococcus granulosus	cpg binding protein	0.0033	0.1028	0.3373
Brugia malayi	jmjC domain containing protein	0.0017	0.0329	0.0376
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0017	0.0329	0.0963
Schistosoma mansoni	fatty acid desaturase	0.0018	0.0371	0.1217
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0.0408	0.1563
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0408	0.1339
Loa Loa (eye worm)	cysteine protease	0.0019	0.0408	0.0421
Brugia malayi	hypothetical protein	0.0132	0.5465	0.6255
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0017	0.0329	0.0963
Onchocerca volvulus		0.0018	0.0371	0.0244
Leishmania major	cathepsin L-like protease	0.0019	0.0408	0.0257
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0908	0.2978
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0017	0.0329	0.1079
Leishmania major	fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative	0.0018	0.0371	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0259	0.0249
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0408	0.0467
Loa Loa (eye worm)	fibroinase	0.0019	0.0408	0.0421
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Echinococcus granulosus	lysine specific demethylase 6a	0.0017	0.0329	0.1079
Leishmania major	cathepsin L-like protease	0.0019	0.0408	0.0257
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0042	0.0139
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0408	0.0282
Plasmodium falciparum	stearoyl-CoA desaturase	0.0068	0.2611	1
Entamoeba histolytica	hypothetical protein	0.0078	0.3048	1
Mycobacterium tuberculosis	Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f	0.0018	0.0371	0.5
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0064	0.2426	0.7959
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0018	0.0371	0.1217
Trypanosoma cruzi	delta-4 fatty acid desaturase, putative	0.0018	0.0371	0.1086
Schistosoma mansoni	hypothetical protein	0.0016	0.0259	0.085
Leishmania major	fatty acid desaturase, putative	0.0018	0.0371	0.0136
Trypanosoma brucei	fatty acid desaturase, putative	0.0086	0.3415	1
Onchocerca volvulus		0.0019	0.0408	0.0282
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0408	0.1339
Mycobacterium ulcerans	electron transfer protein FdxB	0.0018	0.0371	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0408	0.0467
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0259	0.0297
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0408	0.0467
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0408	0.0421
Leishmania major	delta-6 fatty acid desaturase	0.0018	0.0371	0.0136
Schistosoma mansoni	hypothetical protein	0.0034	0.1063	0.3488
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0408	0.0408
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0829	0.2721
Brugia malayi	hypothetical protein	0.0078	0.3048	0.3488
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.2774	0.8121
Brugia malayi	jmjC domain containing protein	0.0017	0.0329	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0329	0.0329
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0408	0.1339
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Echinococcus multilocularis	tar DNA binding protein	0.0071	0.2739	0.8989
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0408	0.1339
Schistosoma mansoni	jumonji domain containing protein	0.0064	0.2426	0.7959
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0408	0.0408
Onchocerca volvulus		0.0031	0.0949	0.083
Echinococcus granulosus	Sphingolipid delta4 desaturase DES1	0.0018	0.0371	0.1217
Trypanosoma cruzi	fatty acid desaturase, putative	0.0018	0.0371	0.1086
Leishmania major	delta-5 fatty acid desaturase	0.0018	0.0371	0.0136
Leishmania major	delta-4 fatty acid desaturase	0.0018	0.0371	0.0136
Plasmodium vivax	SET domain protein, putative	0.003	0.0908	0.3476
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2739	0.8989
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0017	0.0329	0.0963
Onchocerca volvulus		0.0019	0.0408	0.0282
Loa Loa (eye worm)	fatty acid desaturase	0.0018	0.0371	0.0378
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0408	0.0408
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0408	0.1339
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0408	0.0408
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2739	0.8989
Trypanosoma cruzi	cruzipain precursor, putative	0.0072	0.2774	0.8121
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0408	0.0408
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Schistosoma mansoni	cpg binding protein	0.0033	0.1028	0.3373
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0071	0.2739	0.3102
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0329	0.0329
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0013	0.013	0.0149
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0259	0.085
Trypanosoma brucei	sphingolipid delta 4 desaturase, putative	0.0018	0.0371	0.1086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.013	0.013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0408	0.0408
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Onchocerca volvulus		0.0019	0.0408	0.0282
Echinococcus multilocularis	lysine specific demethylase 6a	0.0017	0.0329	0.1079
Mycobacterium ulcerans	transmembrane alkane 1-monooxygenase AlkB	0.0018	0.0371	0.5
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3_2	0.0018	0.0371	0.5
Echinococcus multilocularis	cysteine protease	0.0019	0.0408	0.1339
Trypanosoma cruzi	major cysteine proteinase, putative	0.0056	0.2087	0.6111
Onchocerca volvulus	Huntingtin homolog	0.0132	0.5465	0.5405
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0408	0.0408
Echinococcus multilocularis	lysine specific demethylase 5A	0.0064	0.2426	0.7959
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.013	0.0426
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0371	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0071	0.2739	0.3102
Loa Loa (eye worm)	jmjC domain-containing protein	0.0066	0.2505	0.2832
Onchocerca volvulus		0.0019	0.0408	0.0282
Leishmania major	stearic acid desaturase, putative	0.0086	0.3415	1
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0371	0.5
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0408	0.0467
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2774	0.8121
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0408	0.1339

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.9 nM	Inhibition of SCD1 in rat liver microsomes	ChEMBL.	20004097

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL594901

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1090309