Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | 3-oxoacyl-[acyl-carrier-protein] synthase III | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | 3-oxoacyl-[acyl-carrier-protein] synthase III | 317 aa | 265 aa | 26.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0118 | 0.2838 | 0.2744 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0989 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1442 | 0.3298 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1442 | 0.133 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0129 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1442 | 0.133 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.1044 | 0.0927 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0131 | 0.3194 | 0.3105 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.1442 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.1044 | 0.0927 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0118 | 0.2838 | 0.2744 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.1044 | 0.0927 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.1442 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.1442 | 0.133 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.1044 | 0.0927 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.1442 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0131 | 0.3194 | 0.3105 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 1 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0118 | 0.2838 | 0.2744 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0.0129 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.1044 | 0.5 |
Leishmania major | trypanothione reductase | 0.0052 | 0.1044 | 0.697 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0989 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0118 | 0.2838 | 0.2744 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0129 | 0.1234 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0131 | 0.3194 | 0.3105 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.1044 | 0.697 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0989 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0989 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.1044 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.1044 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0118 | 0.2838 | 0.2744 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0989 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.1442 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.1044 | 0.697 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0129 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.1044 | 0.697 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.1044 | 0.0927 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0052 | 0.1044 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.1044 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1442 | 0.133 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0129 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1442 | 0.3298 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0118 | 0.2838 | 0.2744 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.1044 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0131 | 0.3194 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.31 ug ml-1 | Inhibition of Escherichia coli Beta-ketoacyl-ACP synthase III expressed in Escherichia coli BL21 (DE3) by liquid scintillation counting | ChEMBL. | 19884012 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.