Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.004 | 0.3056 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.3056 | 0.3861 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0665 | 0.0914 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.3056 | 0.4199 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.7277 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.3056 | 0.4199 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.9239 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0137 | 0.0173 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0325 | 0.0352 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.1086 | 0.1086 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.004 | 0.3056 | 0.3056 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4243 | 0.4592 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.3056 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.3048 | 0.4188 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.3469 | 0.3469 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.3056 | 0.3861 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0665 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3481 | 0.3768 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0137 | 0.0188 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0137 | 0.0188 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.3056 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0665 | 0.0914 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0325 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3903 | 0.4224 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.3048 | 0.4188 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.7277 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.3056 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.7915 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 88 % | Antagonist activity at PAR1 expressed in CHO cells assessed as inhibition of SFLLR-induced intracellular calcium release at 10 uM | ChEMBL. | 20042334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.