Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.416 | 0.468 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.5349 | 0.6018 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.416 | 0.5723 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.416 | 0.468 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.416 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0024 | 0.1207 | 0.1661 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.6156 | 0.847 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.416 | 0.416 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.7268 | 0.7268 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.5349 | 0.5349 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.8888 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.5349 | 0.5349 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.416 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.7268 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0024 | 0.1207 | 0.1358 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.416 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.416 | 0.416 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0019 | 0.0095 | 0.0095 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.416 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.42 uM | Antagonist activity at human mGluR5 assessed as inhibition of glutamate-induced elevation of intracellular calcium concentration | ChEMBL. | 19931453 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.