TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 470.949 | Formula: C24H27ClN4O4
H donors: 2 H acceptors: 4 LogP: 3.31 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OCCc1c(OC)c(cc2c1ncnc2NCc1ccc(c(c1)Cl)OC)N(C(=O)C1CC1)C
InChi: 1S/C24H27ClN4O4/c1-29(24(31)15-5-6-15)19-11-17-21(16(8-9-30)22(19)33-3)27-13-28-23(17)26-12-14-4-7-20(32-2)18(25)10-14/h4,7,10-11,13,15,30H,5-6,8-9,12H2,1-3H3,(H,26,27,28)
InChiKey: SCCDLMZULFWSNO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Phosphodiesterase 6A	Starlite/ChEMBL	References
Bos taurus	Phosphodiesterase 5A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Drosophila melanogaster	Phosphodiesterase 6	Phosphodiesterase 6A	859 aa	778 aa	32.4 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	741 aa	23.8 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	775 aa	24.6 %
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Phosphodiesterase 6A	859 aa	816 aa	30.3 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	794 aa	23.3 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	779 aa	24.4 %
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	756 aa	22.9 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	775 aa	23.4 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	799 aa	25.3 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	818 aa	25.3 %
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	748 aa	23.7 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	696 aa	22.0 %
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	802 aa	22.1 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	784 aa	23.2 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	Phosphodiesterase 6A	859 aa	774 aa	25.3 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	Phosphodiesterase 6A	859 aa	818 aa	25.3 %
Trichomonas vaginalis	conserved hypothetical protein	Phosphodiesterase 6A	859 aa	698 aa	18.9 %
Leishmania donovani	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	776 aa	24.7 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	733 aa	21.7 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	787 aa	23.8 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	747 aa	23.3 %
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Phosphodiesterase 6A	859 aa	813 aa	30.6 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	801 aa	24.7 %
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	789 aa	25.6 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Phosphodiesterase 6A	859 aa	819 aa	29.3 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	781 aa	23.8 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	771 aa	24.3 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	788 aa	25.4 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	782 aa	24.7 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	745 aa	21.7 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	709 aa	23.8 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Phosphodiesterase 6A	859 aa	779 aa	24.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0156	0.4034	0.423
Plasmodium falciparum	ataxin-2 like protein, putative	0.0084	0.179	0.7356
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0157	0.4088	0.5342
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0056	0.0926	0.0923
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0101	0.2312	0.2312
Giardia lamblia	Multidrug resistance-associated protein 1	0.0028	0.0052	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0856	0.1118
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0255	0.0006
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0036	0.029	0.0246
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0251	0.0251
Trypanosoma cruzi	PAB1-binding protein , putative	0.0084	0.179	0.1842
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0036	0.029	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0036	0.029	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.2486	0.32
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.2486	0.32
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0251	0.0328
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0157	0.4088	0.5342
Plasmodium falciparum	thioredoxin reductase	0.0036	0.029	0.1039
Leishmania major	hypothetical protein, conserved	0.0084	0.179	0.1842
Plasmodium falciparum	ataxin-2 like protein, putative	0.0084	0.179	0.7356
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0057	0.0938	0.0938
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0057	0.0938	0.1226
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0036	0.029	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0938	0.1226
Echinococcus multilocularis	ecdysone induced protein 78C	0.0057	0.0938	0.0938
Brugia malayi	multidrug resistance related protein 1	0.0029	0.0059	0.0078
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0029	0.0059	0.0059
Leishmania major	trypanothione reductase	0.0104	0.2418	0.251
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0057	0.0938	0.0938
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.2486	0.32
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0057	0.0938	0.0938
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.018	0.018
Schistosoma mansoni	alpha glucosidase	0.0035	0.0255	0.0255
Brugia malayi	hypothetical protein	0.0084	0.179	0.2339
Schistosoma mansoni	hypothetical protein	0.0346	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0057	0.0938	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0938	0.1226
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0055	0.0887	0.1159
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0237	0.6589	0.8844
Giardia lamblia	Multidrug resistance-associated protein 1	0.0029	0.0059	0.0639
Onchocerca volvulus	Protein ultraspiracle homolog	0.0057	0.0938	0.1297
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0057	0.0938	0.1226
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0173	0.4585	0.6047
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0264	0.7417	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0264	0.7417	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0255	0.0255
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0057	0.0938	0.1226
Giardia lamblia	Multidrug resistance-associated protein 1	0.0029	0.0059	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0251	0.0328
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0106	0.2486	0.2486
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0329	0.9456	1
Schistosoma mansoni	lamin	0.0055	0.0887	0.0887
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0057	0.0938	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1198	0.1566
Schistosoma mansoni	alpha-glucosidase	0.0135	0.3402	0.3402
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0057	0.0938	0.1226
Trypanosoma cruzi	trypanothione reductase, putative	0.0104	0.2418	0.251
Echinococcus granulosus	thioredoxin glutathione reductase	0.0104	0.2418	0.2418
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0101	0.2312	0.2312
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0255	0.0334
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0036	0.029	0.0246
Onchocerca volvulus	Bile acid receptor homolog	0.0057	0.0938	0.1297
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0057	0.0938	0.0938
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0038	0.0341	0.0341
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1919	0.2389
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0101	0.2312	0.2312
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0157	0.4088	0.4088
Schistosoma mansoni	jumonji domain containing protein	0.0073	0.1456	0.1456
Schistosoma mansoni	multidrug resistance protein	0.0029	0.0059	0.0059
Brugia malayi	PHD-finger family protein	0.0028	0.0044	0.0057
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0036	0.029	0.029
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0057	0.0938	0.0938
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0237	0.6589	0.8844
Toxoplasma gondii	hypothetical protein	0.0053	0.0823	0.3281
Schistosoma mansoni	RAR-like nuclear receptor	0.0057	0.0938	0.0938
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0036	0.029	0.0092
Toxoplasma gondii	ABC1 family protein	0.0035	0.0251	0.0872
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0101	0.2312	0.2312
Onchocerca volvulus		0.0035	0.0251	0.0347
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0057	0.0938	0.1226
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0036	0.029	0.1039
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0065	0.1198	0.1357
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0065	0.1198	0.1198
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0036	0.029	0.0246
Mycobacterium leprae	conserved hypothetical protein	0.0047	0.0631	0.0531
Plasmodium falciparum	GAF domain-related protein, putative	0.0047	0.0631	0.2476
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0251	0.0251
Schistosoma mansoni	hypothetical protein	0.0346	1	1
Onchocerca volvulus		0.0091	0.2011	0.2779
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0047	0.0631	0.0531
Schistosoma mansoni	nuclear hormone receptor	0.0057	0.0938	0.0938
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0029	0.0059	0.0059
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.003	0.01	0.01
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0237	0.6589	0.8844
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0631	0.0545
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0255	0.0208
Brugia malayi	beta-lactamase family protein	0.0035	0.0251	0.0328
Brugia malayi	intermediate filament protein	0.0055	0.0887	0.1159
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0036	0.029	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0057	0.0938	0.1226
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0057	0.0938	0.0938
Mycobacterium ulcerans	hypothetical protein	0.0173	0.4585	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.003	0.0086	0.0113
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.061	0.0586
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0092	0.2049	0.2049
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.4034	0.423
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0057	0.0938	0.0938
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0101	0.2312	0.2312
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0047	0.0631	0.0878
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0938	0.1226
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0036	0.029	0.1039
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0065	0.1198	0.1198
Toxoplasma gondii	NADPH-glutathione reductase	0.0036	0.029	0.1039
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0142	0.0142
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Schistosoma mansoni	multidrug resistance protein	0.0029	0.0059	0.0059
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0255	0.0006
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0057	0.0938	0.0938
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.6116	0.8185
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0036	0.029	0.0092
Brugia malayi	jmjC domain containing protein	0.0034	0.0229	0.0299
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0057	0.0938	0.0938
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.018	0.018
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0255	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0038	0.0341	0.0341
Echinococcus multilocularis	tar DNA binding protein	0.0139	0.3524	0.3524
Toxoplasma gondii	hypothetical protein	0.0088	0.1919	0.79
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0057	0.0938	0.1226
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0106	0.2486	0.2582
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.0255	0.0006
Mycobacterium ulcerans	putative regulatory protein	0.0047	0.0631	0.0878
Schistosoma mansoni	multidrug resistance protein	0.0029	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0938	0.1226
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0106	0.2486	0.2486
Schistosoma mansoni	multidrug resistance protein	0.0029	0.0059	0.0059
Schistosoma mansoni	retinoic acid receptor RXR	0.0057	0.0938	0.0938
Brugia malayi	Bromodomain containing protein	0.0028	0.0044	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0938	0.1226
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Loa Loa (eye worm)	transcription factor SMAD2	0.0271	0.7652	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.029	0.0246
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0106	0.2486	0.32
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0237	0.6589	0.8844
Leishmania major	mitochondrial DNA polymerase beta	0.0329	0.9456	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0029	0.0059	0.0078
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0255	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0057	0.0938	0.1226
Brugia malayi	RNA binding protein	0.0139	0.3524	0.4605
Echinococcus granulosus	FTZ F1 alpha	0.0057	0.0938	0.0938
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0057	0.0938	0.0938
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0036	0.029	0.0055
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0059	0.1017	0.1097
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.003	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0673	0.088
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.003	0.01	0.01
Onchocerca volvulus		0.0258	0.7236	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0938	0.1226
Loa Loa (eye worm)	glutathione reductase	0.0104	0.2418	0.316
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1198	0.1357
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0029	0.0059	0.0078
Brugia malayi	nuclear receptor NHR-88	0.0057	0.0938	0.1226
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0057	0.0938	0.1297
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0044	0.0044
Trypanosoma brucei	trypanothione reductase	0.0104	0.2418	0.251
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.029	0.0246
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0057	0.0938	0.0938
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0059	0.1017	0.1097
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.003	0.01	0.0131
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0057	0.0938	0.0938
Loa Loa (eye worm)	hypothetical protein	0.003	0.01	0.0131
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0036	0.029	0.029
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.061	0.0586
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0251	0.0251
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0106	0.2486	0.32
Echinococcus multilocularis	FTZ F1 alpha	0.0057	0.0938	0.0938
Toxoplasma gondii	hypothetical protein	0.0047	0.0631	0.2476
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.3524	0.3524
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0061	0.1082	0.1082
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.01	0.01
Trichomonas vaginalis	mercuric reductase, putative	0.0036	0.029	0.0057
Plasmodium vivax	glutathione reductase, putative	0.0104	0.2418	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.4034	0.423
Echinococcus multilocularis	lamin	0.0055	0.0887	0.0887
Schistosoma mansoni	hypothetical protein	0.0028	0.0044	0.0044
Echinococcus granulosus	peregrin	0.0028	0.0044	0.0044
Loa Loa (eye worm)	steroid hormone receptor	0.0057	0.0938	0.1226
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0255	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0104	0.2418	0.3024
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0106	0.2486	0.2582
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0057	0.0938	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0631	0.0825
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0389	0.0389
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0106	0.2486	0.2582
Brugia malayi	Thioredoxin reductase	0.0104	0.2418	0.316
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0036	0.029	0.0092
Loa Loa (eye worm)	TAR-binding protein	0.0139	0.3524	0.4605
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.01	0.0131
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.2486	0.32
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0044	0.0057
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0057	0.0938	0.1226
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0329	0.9456	1
Onchocerca volvulus		0.0055	0.0887	0.1226
Loa Loa (eye worm)	hypothetical protein	0.003	0.01	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0251	0.0328
Plasmodium falciparum	thioredoxin reductase	0.0104	0.2418	1
Onchocerca volvulus		0.0033	0.018	0.0248
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0251	0.0328
Echinococcus granulosus	multidrug resistance associated protein 1	0.0029	0.0059	0.0059
Plasmodium vivax	ataxin-2 like protein, putative	0.0084	0.179	0.7356
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0157	0.4088	0.4088
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0059	0.0078
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0036	0.029	0.0246
Schistosoma mansoni	alpha-glucosidase	0.0135	0.3402	0.3402
Leishmania major	alpha glucosidase II subunit, putative	0.0035	0.0255	0.0208
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0389	0.0389
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0329	0.9456	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0237	0.6589	0.8844
Mycobacterium tuberculosis	Probable oxidoreductase	0.0264	0.7417	1
Brugia malayi	ecdysteroid receptor	0.0057	0.0938	0.1226
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.3524	0.3524
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0057	0.0938	0.1226
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0057	0.0938	0.1226
Trichomonas vaginalis	glutathione reductase, putative	0.0036	0.029	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0251	0.0328
Brugia malayi	cytoplasmic intermediate filament protein	0.003	0.0086	0.0113
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0057	0.0938	0.1226
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0036	0.029	0.1039
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0059	0.1017	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0084	0.179	0.2339
Giardia lamblia	MRP-like ABC transporter	0.0029	0.0059	0.0639
Brugia malayi	TAR-binding protein	0.0139	0.3524	0.4605
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0036	0.029	0.0246
Trichomonas vaginalis	set domain proteins, putative	0.0258	0.7236	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0036	0.029	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0938	0.1226
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0101	0.2312	0.2312
Loa Loa (eye worm)	hypothetical protein	0.0033	0.018	0.0235
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.2486	0.32
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0057	0.0938	0.0938
Toxoplasma gondii	hypothetical protein	0.0047	0.0631	0.2476
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.029	0.0246
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0106	0.2486	0.32
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0227	0.6256	0.8176
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0057	0.0938	0.1226
Schistosoma mansoni	lamin	0.0055	0.0887	0.0887
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0101	0.2312	0.3021
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0251	0.0872
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0229	0.0229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0057	0.0938	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0251	0.0328
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0255	0.0334
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0229	0.0229
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0106	0.2486	0.2486
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0029	0.0059	0.0066
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0047	0.0631	0.0531
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0057	0.0938	0.0938
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.061	0.0586
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0255	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0938	0.1226
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0036	0.029	0.038
Schistosoma mansoni	hypothetical protein	0.0038	0.0341	0.0341
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0057	0.0938	0.1226
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0229	0.0299
Brugia malayi	Steroid receptor seven-up type 2	0.0057	0.0938	0.1226
Echinococcus granulosus	lysosomal alpha glucosidase	0.0157	0.4088	0.4088
Loa Loa (eye worm)	intermediate filament protein	0.0055	0.0887	0.1159
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0251	0.0328
Schistosoma mansoni	coup transcription factor	0.0057	0.0938	0.0938
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.3524	0.3524
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0057	0.0938	0.0938
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0251	0.0204
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.029	0.0246
Echinococcus granulosus	tar DNA binding protein	0.0139	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0887	0.1159
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1919	0.2389
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0044	0.0057
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0255	0.0006
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.01	0.0131
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0101	0.2312	0.2312
Trypanosoma brucei	PAB1-binding protein , putative	0.0084	0.179	0.1842
Trypanosoma brucei	glucosidase, putative	0.0035	0.0255	0.0208
Echinococcus granulosus	intermediate filament protein	0.0055	0.0887	0.0887
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0251	0.0251
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.018	0.018
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.3524	0.3524
Brugia malayi	beta-lactamase family protein	0.0035	0.0251	0.0328
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0255	0.0208
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0106	0.2486	0.2582
Loa Loa (eye worm)	thioredoxin reductase	0.0104	0.2418	0.316
Brugia malayi	Intermediate filament tail domain containing protein	0.0055	0.0887	0.1159
Plasmodium falciparum	glutathione reductase	0.0036	0.029	0.1039
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0036	0.029	0.1039
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0251	0.0328
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0229	0.0229
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0255	0.0006
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.018	0.018
Schistosoma mansoni	intermediate filament proteins	0.0055	0.0887	0.0887
Loa Loa (eye worm)	hypothetical protein	0.003	0.01	0.0131
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0057	0.0938	0.0938
Brugia malayi	jmjC domain containing protein	0.0092	0.2049	0.2678
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0982	0.1284
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0065	0.1198	0.1198
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0065	0.1198	0.1566
Loa Loa (eye worm)	hypothetical protein	0.003	0.01	0.0131
Mycobacterium ulcerans	putative regulatory protein	0.0047	0.0631	0.0878
Brugia malayi	photoreceptor-specific nuclear receptor	0.0057	0.0938	0.1226
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0106	0.2486	0.32
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.0255	0.0006
Loa Loa (eye worm)	hypothetical protein	0.003	0.01	0.0131
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0229	0.0229
Echinococcus granulosus	lamin dm0	0.0055	0.0887	0.0887
Brugia malayi	Pre-SET motif family protein	0.0227	0.6256	0.8176
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0059	0.0078
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0044	0.0044
Schistosoma mansoni	thyroid hormone receptor	0.0057	0.0938	0.0938
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.061	0.0586
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.029	0.0246
Echinococcus multilocularis	lamin dm0	0.0055	0.0887	0.0887
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0255	0.0006
Giardia lamblia	ABC transporter, putative	0.0029	0.0059	0.0639
Schistosoma mansoni	thyroid hormone receptor	0.0057	0.0938	0.0938
Onchocerca volvulus		0.0035	0.0251	0.0347
Mycobacterium tuberculosis	Probable reductase	0.0237	0.6589	0.8844
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1919	0.2389
Trypanosoma cruzi	trypanothione reductase, putative	0.0036	0.029	0.0246
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0101	0.2312	0.3021
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0057	0.0938	0.1226
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0264	0.7417	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0052	0.0068
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0065	0.1198	0.1566
Brugia malayi	RNA recognition motif domain containing protein	0.0139	0.3524	0.4605
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0106	0.2486	0.32
Brugia malayi	beta-lactamase	0.0035	0.0251	0.0328
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0044	0.0044
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0036	0.029	0.0246
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0036	0.029	0.1039
Plasmodium vivax	SET domain protein, putative	0.0033	0.018	0.0573
Brugia malayi	Pre-SET motif family protein	0.0033	0.018	0.0235
Echinococcus granulosus	multidrug resistance associated protein 7	0.0029	0.0059	0.0059
Echinococcus multilocularis	geminin	0.0346	1	1
Echinococcus granulosus	lamin	0.0055	0.0887	0.0887
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Brugia malayi	glutathione reductase	0.0104	0.2418	0.316
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0057	0.0938	0.1226
Onchocerca volvulus	Alhambra homolog	0.0028	0.0044	0.006
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.3524	0.3524
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Brugia malayi	hypothetical protein	0.003	0.01	0.0131
Onchocerca volvulus		0.0057	0.0938	0.1297
Schistosoma mansoni	lipoxygenase	0.0061	0.1082	0.1082
Brugia malayi	Nuclear hormone receptor-like 1	0.0057	0.0938	0.1226
Brugia malayi	hypothetical protein	0.0054	0.0859	0.1122
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.018	0.018
Mycobacterium tuberculosis	Probable dehydrogenase	0.0237	0.6589	0.8844
Onchocerca volvulus		0.0035	0.0251	0.0347
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0255	0.0255
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Toxoplasma gondii	LsmAD domain-containing protein	0.0084	0.179	0.7356
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0057	0.0938	0.0938
Brugia malayi	hypothetical protein	0.003	0.01	0.0131
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0104	0.2418	0.2418
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0065	0.1198	0.1357
Leishmania major	hypothetical protein, conserved	0.0035	0.0251	0.0204
Brugia malayi	nuclear hormone receptor	0.0057	0.0938	0.1226
Toxoplasma gondii	thioredoxin reductase	0.0104	0.2418	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0092	0.2049	0.2049
Toxoplasma gondii	GAF domain-containing protein	0.0047	0.0631	0.2476
Treponema pallidum	NADH oxidase	0.0036	0.029	0.5
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0106	0.2486	0.2582
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.018	0.0573
Trypanosoma cruzi	PAB1-binding protein , putative	0.0084	0.179	0.1842
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.2486	0.32
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0036	0.029	0.0246
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0057	0.0938	0.0938
Plasmodium falciparum	glutathione reductase	0.0104	0.2418	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0106	0.2486	0.32
Echinococcus multilocularis	musashi	0.0055	0.0887	0.0887
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.2486	0.32
Loa Loa (eye worm)	RNA binding protein	0.0139	0.3524	0.4605
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.018	0.018
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.018	0.018
Plasmodium vivax	hypothetical protein, conserved	0.0047	0.0631	0.2476
Onchocerca volvulus		0.0055	0.0887	0.1226
Brugia malayi	nuclear receptor RXR	0.003	0.01	0.0131
Echinococcus multilocularis	peregrin	0.0028	0.0044	0.0044
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0036	0.029	0.5
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0036	0.029	0.029
Brugia malayi	MH2 domain containing protein	0.0271	0.7652	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0139	0.3524	0.4605
Plasmodium vivax	thioredoxin reductase, putative	0.0104	0.2418	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0271	0.7652	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0251	0.0328
Echinococcus granulosus	ecdysone induced protein 78C	0.0057	0.0938	0.0938
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0057	0.0938	0.0938
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0255	0.0891
Brugia malayi	steroid hormone receptor	0.0057	0.0938	0.1226
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0251	0.0204
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0057	0.0938	0.1226
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0251	0.0204
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.029	0.0246
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0061	0.1082	0.1082
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0057	0.0938	0.0938
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0036	0.029	0.0246

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of human recombinant PDE11	ChEMBL.	19906530
IC50 (binding)	= 0.001 uM	Inhibition of bovine platelet PDE5	ChEMBL.	19906530
IC50 (binding)	= 0.34 uM	Inhibition of bovine retina PDE6	ChEMBL.	19906530

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL595104

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1090942