Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Polycystic kidney disease protein | 0.0115 | 0.0599 | 0.1429 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.0616 | 0.1469 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.0161 | 0.0535 |
Onchocerca volvulus | Peroxidasin homolog | 0.0461 | 0.27 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.0161 | 0.0353 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0141 | 0.0865 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0141 | 0.8598 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0482 | 0.2828 | 0.6903 |
Brugia malayi | Animal haem peroxidase family protein | 0.0461 | 0.27 | 1 |
Brugia malayi | hypothetical protein | 0.0115 | 0.0599 | 0.222 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0018 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0115 | 0.0599 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0141 | 0.046 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0101 | 0.051 | 0.1888 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.0616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0599 | 0.2169 |
Brugia malayi | Animal haem peroxidase family protein | 0.0461 | 0.27 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0141 | 0.2122 |
Brugia malayi | TAR-binding protein | 0.013 | 0.0688 | 0.2548 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0141 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0141 | 0.0865 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.0161 | 0.0144 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.0688 | 0.1647 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Brugia malayi | beta-lactamase | 0.004 | 0.0141 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0141 | 0.0303 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0055 | 0.3067 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.0616 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0461 | 0.27 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0461 | 0.27 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0141 | 0.0865 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0141 | 0.0522 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0115 | 0.0599 | 0.0583 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0161 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0141 | 0.046 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0461 | 0.27 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.0688 | 0.1647 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0152 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.0688 | 0.1647 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.0688 | 0.25 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0141 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0141 | 0.8598 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0118 | 0.0616 | 0.1469 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0141 | 0.0522 |
Brugia malayi | Animal haem peroxidase family protein | 0.0461 | 0.27 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0141 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0152 | 0.033 |
Schistosoma mansoni | peroxidasin | 0.0461 | 0.27 | 0.659 |
Brugia malayi | Animal haem peroxidase family protein | 0.0461 | 0.27 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0461 | 0.27 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0115 | 0.0599 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0141 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.069 | 0.4088 | 1 |
Schistosoma mansoni | polycystin 1-related | 0.0115 | 0.0599 | 0.1429 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.0688 | 0.25 |
Onchocerca volvulus | 0.0461 | 0.27 | 1 | |
Echinococcus granulosus | peroxidasin | 0.0461 | 0.27 | 0.659 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0461 | 0.27 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.0161 | 0.0353 |
Onchocerca volvulus | 0.0115 | 0.0599 | 0.1791 | |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.0688 | 0.1647 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.095 | 0.2291 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0118 | 0.0616 | 0.1469 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.0616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0599 | 0.2169 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0141 | 0.046 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.0688 | 0.1647 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0055 | 0.0651 |
Onchocerca volvulus | 0.0461 | 0.27 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0461 | 0.27 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0141 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0115 | 0.0599 | 0.1429 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0141 | 0.046 |
Brugia malayi | Doublecortin family protein | 0.0115 | 0.0599 | 0.222 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0141 | 0.046 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0141 | 0.8598 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0461 | 0.27 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0141 | 0.8598 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0055 | 0.3067 |
Echinococcus multilocularis | geminin | 0.0173 | 0.095 | 0.0934 |
Schistosoma mansoni | peroxidasin | 0.0461 | 0.27 | 0.659 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0055 | 0.3067 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0141 | 0.046 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0152 | 0.033 |
Brugia malayi | Peroxidasin | 0.0461 | 0.27 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0055 | 0.0651 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0141 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0055 | 0.0205 |
Brugia malayi | RNA binding protein | 0.013 | 0.0688 | 0.2548 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0161 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0055 | 0.0141 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0141 | 1 |
Brugia malayi | CHE-14 protein | 0.0043 | 0.0161 | 0.0597 |
Brugia malayi | hypothetical protein | 0.0115 | 0.0599 | 0.222 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0141 | 0.0865 |
Onchocerca volvulus | 0.0461 | 0.27 | 1 | |
Schistosoma mansoni | loxhd1 | 0.0115 | 0.0599 | 0.1429 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0101 | 0.051 | 0.1209 |
Echinococcus granulosus | geminin | 0.0173 | 0.095 | 0.2291 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0141 | 0.0865 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.0688 | 0.0672 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.0616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0141 | 0.0303 |
Brugia malayi | hypothetical protein | 0.0118 | 0.0616 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0018 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0141 | 0.0124 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0115 | 0.0599 | 0.0583 |
Echinococcus multilocularis | RUN | 0.0115 | 0.0599 | 0.0583 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.069 | 0.4088 | 0.4078 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.095 | 0.2291 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0141 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0141 | 0.046 |
Onchocerca volvulus | Dual oxidase homolog | 0.0461 | 0.27 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0141 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0141 | 0.0303 |
Echinococcus granulosus | expressed conserved protein | 0.0094 | 0.0473 | 0.1118 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0101 | 0.051 | 0.0493 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0018 | 0.0065 |
Echinococcus multilocularis | expressed conserved protein | 0.0094 | 0.0473 | 0.0456 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0161 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0115 | 0.0599 | 0.1429 |
Schistosoma mansoni | rab6-interacting | 0.0115 | 0.0599 | 0.1429 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.0161 | 0.0144 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0115 | 0.0599 | 0.1429 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0118 | 0.0616 | 0.0599 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0115 | 0.0599 | 0.0583 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0198 | 0.0181 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0055 | 0.3067 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0018 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.069 | 0.4088 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0102 | 0.0519 | 0.1233 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.022 | 0.0755 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0141 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.0688 | 0.1647 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0255 | 0.1445 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0055 | 0.3067 |
Onchocerca volvulus | 0.0115 | 0.0599 | 0.1791 | |
Loa Loa (eye worm) | doublecortin family protein | 0.0115 | 0.0599 | 0.2169 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0141 | 0.0865 |
Brugia malayi | hypothetical protein | 0.0461 | 0.27 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0101 | 0.051 | 0.8232 |
Echinococcus multilocularis | peroxidasin | 0.0461 | 0.27 | 0.2687 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.051 | 0.1835 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.0688 | 0.2548 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0144 | 0.0772 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0461 | 0.27 | 1 |
Echinococcus granulosus | RUN | 0.0115 | 0.0599 | 0.1429 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0141 | 0.8598 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0461 | 0.27 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0141 | 0.0865 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.0599 | 0.1429 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0152 | 0.033 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0141 | 0.0865 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0141 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.0688 | 0.25 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0141 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0055 | 0.0651 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0144 | 0.0772 | 0.1853 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0141 | 0.0865 |
Onchocerca volvulus | Peroxidasin homolog | 0.0461 | 0.27 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0141 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0461 | 0.27 | 1 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0141 | 0.0522 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0141 | 0.8598 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0141 | 0.046 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.27 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 30.15 uM | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay | ChEMBL. | 19804979 |
GI50 (functional) | = 31.45 uM | Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay | ChEMBL. | 19804979 |
GI50 (functional) | = 35.29 uM | Cytotoxicity against human MDA-MB-468 cells after 48 hrs by SRB assay | ChEMBL. | 19804979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.