Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.0534 | 0.0534 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.0534 | 0.0534 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.0971 | 0.2145 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.1435 | 0.3178 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0102 | 0.4727 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0042 | 0.0208 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0149 | 0.3713 | 0.3713 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.0102 | 0.0102 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0042 | 0.0208 | 0.0322 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0102 | 0.4727 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0041 | 0.0188 | 0.0188 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0102 | 0.4727 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0534 | 0.1173 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.0534 | 0.0534 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0007 | 0.0007 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0971 | 0.0971 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0007 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0971 | 0.0971 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0102 | 0.4727 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.16 | 0.16 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0465 | 0.0465 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0042 | 0.0208 | 0.0208 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0041 | 0.0188 | 0.0402 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0042 | 0.0208 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0041 | 0.0188 | 0.8988 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0102 | 0.4727 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0534 | 0.0534 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0059 | 0.0768 | 0.0768 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.0208 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0102 | 0.4727 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0242 | 0.0242 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0074 | 0.1275 | 0.1275 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0041 | 0.0188 | 0.8988 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0059 | 0.0768 | 0.1693 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0059 | 0.0768 | 0.0768 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0041 | 0.0188 | 0.0188 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0465 | 0.0465 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0124 | 0.288 | 0.288 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0465 | 0.1019 |
Schistosoma mansoni | bromodomain containing protein | 0.0131 | 0.3122 | 0.3122 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0047 | 0.0371 | 0.0371 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.0102 | 0.0211 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0042 | 0.0208 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0342 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0059 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0007 | 0.0007 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0041 | 0.0188 | 0.0188 |
Echinococcus multilocularis | zinc finger protein | 0.0041 | 0.017 | 0.017 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0041 | 0.0188 | 0.0188 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0041 | 0.0188 | 0.8988 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0042 | 0.0208 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.0208 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0041 | 0.0188 | 0.8082 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0042 | 0.0208 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.0971 | 0.0971 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0173 | 0.45 | 0.45 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0041 | 0.0188 | 0.0188 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.0102 | 0.4727 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0534 | 0.0534 |
Schistosoma mansoni | zinc finger protein | 0.0041 | 0.017 | 0.017 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0037 | 0.0041 | 0.0041 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0041 | 0.0188 | 0.0188 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0042 | 0.0208 | 0.0208 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0007 | 0.0007 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0971 | 0.0971 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0041 | 0.0188 | 0.8988 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0042 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0768 | 0.0768 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0007 | 0.0007 |
Onchocerca volvulus | 0.0052 | 0.0534 | 0.2498 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0971 | 0.0971 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0534 | 0.0534 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0042 | 0.0208 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0041 | 0.017 | 0.017 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0124 | 0.288 | 0.288 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0059 | 0.0768 | 0.0768 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0465 | 0.0465 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0465 | 0.0465 |
Toxoplasma gondii | exonuclease III APE | 0.0042 | 0.0208 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0465 | 0.0465 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.0971 | 0.2145 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0074 | 0.1275 | 0.1275 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.0102 | 0.4727 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0043 | 0.0242 | 0.0242 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | MBCTL1 | 0.0059 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0007 | 0.0007 |
Brugia malayi | Bromodomain containing protein | 0.0155 | 0.3914 | 0.8695 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.0534 | 0.0534 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.6253 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.0534 | 0.0534 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.0102 | 0.4727 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0059 | 0.0768 | 0.0768 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.0971 | 0.0971 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.0534 | 0.0534 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.0534 | 0.2498 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0465 | 0.0465 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.0102 | 0.0102 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0007 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.3625 | 0.3625 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0173 | 0.45 | 0.45 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0041 | 0.0188 | 0.0188 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.0102 | 0.4727 |
Schistosoma mansoni | alpha-glucosidase | 0.0149 | 0.3713 | 0.3713 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0173 | 0.45 | 0.45 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0007 | 0.0007 |
Echinococcus multilocularis | snurportin 1 | 0.0342 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0042 | 0.0208 | 0.0447 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0534 | 0.1173 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1729 | 0.1729 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0007 | 0.0007 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0041 | 0.0188 | 0.0188 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0465 | 0.0465 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.1819 | 0.4033 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0102 | 0.4727 |
Brugia malayi | RNA binding protein | 0.0065 | 0.0971 | 0.2145 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0102 | 0.4727 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0465 | 0.0465 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.144 | 0.144 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.0102 | 0.0102 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.0208 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0188 | 0.8988 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0042 | 0.0208 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0047 | 0.0371 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0188 | 0.0188 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0041 | 0.0188 | 0.8988 |
Onchocerca volvulus | 0.01 | 0.2117 | 1 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0102 | 0.4727 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0102 | 0.4727 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0212 | 0.5767 | 0.5767 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0212 | 0.5767 | 0.5767 |
Schistosoma mansoni | hypothetical protein | 0.0323 | 0.9373 | 0.9373 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0173 | 0.45 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.0208 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0042 | 0.0208 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0041 | 0.0188 | 0.8988 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0042 | 0.0208 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0047 | 0.0371 | 0.0371 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0173 | 0.45 | 0.45 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0007 | 0.0007 |
Brugia malayi | PHD-finger family protein | 0.0052 | 0.0531 | 0.1165 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.