Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0088 | 0.0343 | 0.1719 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0112 | 0.0459 | 0.0459 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.2097 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0148 | 0.0403 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0167 | 0.0721 | 0.0721 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0088 | 0.0343 | 0.7442 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0075 | 0.0281 | 0.0789 |
Brugia malayi | hypothetical protein | 0.0245 | 0.1099 | 0.3509 |
Loa Loa (eye worm) | beta-lactamase | 0.0112 | 0.0459 | 0.1457 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0112 | 0.0459 | 0.1304 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0066 | 0.0235 | 0.0727 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0235 | 0.0235 |
Plasmodium vivax | SET domain protein, putative | 0.0093 | 0.0366 | 0.7688 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0047 | 0.0145 | 0.0201 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.003 | 0.0062 | 0.1215 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0149 | 0.0404 |
Mycobacterium tuberculosis | Conserved protein | 0.0112 | 0.0459 | 0.1158 |
Schistosoma mansoni | bromodomain containing protein | 0.0079 | 0.0299 | 0.0299 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0049 | 0.0153 | 0.3233 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0459 | 0.1457 |
Brugia malayi | Bromodomain containing protein | 0.0093 | 0.0366 | 0.1148 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0235 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0154 | 0.0475 |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.0031 | 0.0069 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.011 | 0.01 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.017 | 0.0468 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0217 | 0.4639 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0235 | 0.0235 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0047 | 0.0145 | 0.3043 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0182 | 0.0566 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0035 | 0.0088 | 0.0028 |
Leishmania major | hypothetical protein, conserved | 0.0112 | 0.0459 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0035 | 0.0088 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0143 | 0.0609 | 0.06 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.0367 | 0.0357 |
Mycobacterium ulcerans | beta-lactamase | 0.0112 | 0.0459 | 1 |
Echinococcus multilocularis | peregrin | 0.0035 | 0.0089 | 0.0079 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0299 | 0.1359 | 0.1351 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0035 | 0.0088 | 0.0781 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.003 | 0.0062 | 0.0179 |
Onchocerca volvulus | 0.005 | 0.016 | 0.0437 | |
Echinococcus granulosus | tar DNA binding protein | 0.0664 | 0.3113 | 0.3106 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Schistosoma mansoni | smad | 0.0019 | 0.001 | 0.001 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0121 | 0.0358 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0047 | 0.0145 | 0.3043 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.0165 | 0.0452 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0112 | 0.0459 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0088 | 0.0343 | 0.7442 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0088 | 0.0343 | 0.0334 |
Onchocerca volvulus | 0.0093 | 0.0366 | 0.1032 | |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.0601 | 0.0601 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0142 | 0.0601 | 0.1906 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0056 | 0.0056 |
Schistosoma mansoni | thyroid hormone receptor | 0.0155 | 0.0665 | 0.0665 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0145 | 0.0445 |
Brugia malayi | MH2 domain containing protein | 0.0614 | 0.2871 | 0.9221 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0112 | 0.0459 | 0.1158 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0056 | 0.0191 | 0.4069 |
Brugia malayi | Bromodomain containing protein | 0.0049 | 0.0157 | 0.0475 |
Echinococcus multilocularis | zinc finger protein | 0.0027 | 0.0051 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0262 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0075 | 0.0279 | 0.0269 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0262 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0614 | 0.2871 | 0.9222 |
Echinococcus granulosus | GPCR family 2 | 0.0066 | 0.0235 | 0.0226 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0135 | 0.0414 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0156 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0145 | 0.0445 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0075 | 0.0279 | 0.0269 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0148 | 0.0403 |
Entamoeba histolytica | hypothetical protein | 0.0299 | 0.1359 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0047 | 0.0145 | 0.153 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0112 | 0.0459 | 0.1158 |
Onchocerca volvulus | 0.0112 | 0.0459 | 0.1302 | |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0113 | 0.0463 | 0.0453 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0217 | 0.4639 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0017 | 0.0017 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0056 | 0.1048 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0062 | 0.0153 |
Echinococcus granulosus | smad | 0.0042 | 0.0121 | 0.0111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.017 | 0.0468 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0096 | 0.0096 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0167 | 0.0721 | 0.0712 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0112 | 0.0459 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0149 | 0.0404 |
Echinococcus granulosus | zinc finger protein | 0.0027 | 0.0051 | 0.0041 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0044 | 0.0132 | 0.2651 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0121 | 0.0358 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0088 | 0.0343 | 0.7442 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.003 | 0.0062 | 0.0062 |
Entamoeba histolytica | hypothetical protein | 0.0299 | 0.1359 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0135 | 0.0125 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.0367 | 0.0357 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0042 | 0.0121 | 0.0111 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0093 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.001 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.0173 | 0.0475 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0048 | 0.0048 |
Echinococcus multilocularis | smad | 0.0042 | 0.0121 | 0.0111 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0647 | 0.3029 | 0.9729 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0257 | 0.0718 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0088 | 0.0343 | 0.0343 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0124 | 0.0115 |
Mycobacterium ulcerans | lipase LipD | 0.0112 | 0.0459 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0113 | 0.0463 | 0.0463 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 0.0217 | 0.4639 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0007 | 0.0007 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.0165 | 0.2704 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0235 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0056 | 0.0161 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0028 | 0.0056 | 0.0161 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.0173 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0262 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.016 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0171 | 0.0531 |
Trichomonas vaginalis | set domain proteins, putative | 0.0736 | 0.3458 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.1064 | 0.5034 | 0.5029 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0145 | 0.153 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.002 | 0.0017 | 0.0007 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0124 | 0.0115 |
Mycobacterium tuberculosis | Conserved protein | 0.0112 | 0.0459 | 0.1158 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0042 | 0.0121 | 0.0111 |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.0031 | 0.0069 |
Brugia malayi | beta-lactamase family protein | 0.0112 | 0.0459 | 0.1447 |
Giardia lamblia | GTOR | 0.0088 | 0.0343 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0201 | 0.0629 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0096 | 0.0289 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0112 | 0.0459 | 0.1304 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0047 | 0.0145 | 0.0099 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0121 | 0.0358 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0135 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.016 | 0.016 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.003 | 0.0062 | 0.1215 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0113 | 0.0463 | 0.0453 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.002 | 0.0017 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0037 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0066 | 0.0235 | 0.0737 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0257 | 0.0718 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0047 | 0.0145 | 0.153 |
Loa Loa (eye worm) | nuclear factor I | 0.0023 | 0.0031 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0235 | 0.0235 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.1359 | 0.1359 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0664 | 0.3113 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Plasmodium vivax | hypothetical protein, conserved | 0.0112 | 0.0459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0601 | 0.1915 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0112 | 0.0459 | 0.0459 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.0217 | 0.4639 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0135 | 0.0125 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0145 | 0.0434 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0235 | 0.0654 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0217 | 0.4639 |
Onchocerca volvulus | 0.0156 | 0.0669 | 0.191 | |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0088 | 0.0343 | 0.7442 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0112 | 0.0459 | 1 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.007 | 0.0257 | 0.5533 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0235 | 0.0654 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0148 | 0.0403 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0042 | 0.0121 | 0.0121 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0042 | 0.012 | 0.2504 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.1099 | 0.109 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0135 | 0.0125 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0143 | 0.0609 | 0.06 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0062 | 0.0153 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0155 | 0.0665 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0235 | 0.0737 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0042 | 0.0121 | 0.037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0257 | 0.0718 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0463 | 0.147 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0299 | 0.1359 | 0.1351 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0145 | 0.0434 |
Onchocerca volvulus | 0.0047 | 0.0145 | 0.0391 | |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.0275 | 0.0275 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0093 | 0.0366 | 0.0366 |
Brugia malayi | Pre-SET motif family protein | 0.0093 | 0.0366 | 0.1147 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0112 | 0.0459 | 0.1304 |
Loa Loa (eye worm) | Smad1 | 0.0042 | 0.0121 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0009 | 0.0009 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0145 | 0.0434 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0121 | 0.0358 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0664 | 0.3113 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0048 | 0.0038 |
Echinococcus multilocularis | Smad4 | 0.0042 | 0.0121 | 0.0111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0235 | 0.0654 |
Brugia malayi | TAR-binding protein | 0.0664 | 0.3113 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0262 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0112 | 0.0459 | 0.045 |
Brugia malayi | beta-lactamase | 0.0112 | 0.0459 | 0.1447 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0096 | 0.0086 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0112 | 0.0459 | 0.1158 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0112 | 0.0459 | 0.1457 |
Mycobacterium tuberculosis | Conserved protein | 0.0112 | 0.0459 | 0.1158 |
Schistosoma mansoni | smad | 0.0042 | 0.0121 | 0.0121 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.007 | 0.0257 | 0.5533 |
Schistosoma mansoni | tar DNA-binding protein | 0.0664 | 0.3113 | 0.3113 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0088 | 0.0343 | 0.0334 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0235 | 0.0654 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0042 | 0.0121 | 0.037 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.0609 | 0.0609 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.011 | 0.01 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.0165 | 0.3469 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0121 | 0.0121 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.1099 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0262 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0257 | 0.0718 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0112 | 0.0459 | 0.1158 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0149 | 0.0404 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0159 | 0.0686 | 0.0677 |
Echinococcus granulosus | Smad4 | 0.0042 | 0.0121 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0322 | 0.1018 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0047 | 0.0145 | 0.0201 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0235 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0459 | 0.1457 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0343 | 0.0969 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0121 | 0.0121 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0034 | 0.0071 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0088 | 0.0343 | 0.7442 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0047 | 0.0145 | 0.3043 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0028 | 0.0056 | 0.0047 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0135 | 0.0403 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0235 | 0.0226 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0088 | 0.0343 | 0.1085 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0062 | 0.0153 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0019 | 0.001 | 0.0012 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.003 | 0.0062 | 0.1215 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0028 | 0.0056 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1099 | 0.3517 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0093 | 0.0366 | 0.7931 |
Schistosoma mansoni | Smad4 | 0.0019 | 0.001 | 0.001 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0088 | 0.0343 | 0.7442 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0235 | 0.0226 |
Onchocerca volvulus | Alhambra homolog | 0.0028 | 0.0056 | 0.0135 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0037 | 0.0096 | 0.1965 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.003 | 0.0062 | 0.1215 |
Entamoeba histolytica | hypothetical protein | 0.0299 | 0.1359 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0343 | 0.0969 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.003 | 0.0062 | 0.1215 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0081 | 0.0229 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.003 | 0.0062 | 0.1215 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0066 | 0.0235 | 0.5018 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.0217 | 0.4639 |
Schistosoma mansoni | microtubule-associated protein tau | 0.2097 | 1 | 1 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0088 | 0.0343 | 0.1719 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.0165 | 0.3469 |
Loa Loa (eye worm) | acetyltransferase | 0.0167 | 0.0721 | 0.2302 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0112 | 0.0459 | 0.1447 |
Mycobacterium leprae | conserved hypothetical protein | 0.0112 | 0.0459 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0019 | 0.001 | 0.0012 |
Onchocerca volvulus | 0.0112 | 0.0459 | 0.1302 | |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0112 | 0.0459 | 0.1158 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0042 | 0.0121 | 0.0111 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0167 | 0.0721 | 0.2294 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0066 | 0.0235 | 0.0727 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0062 | 0.0153 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0112 | 0.0459 | 0.045 |
Schistosoma mansoni | Smad4 | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0459 | 0.1457 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0035 | 0.0088 | 0.4134 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0047 | 0.0145 | 0.153 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0207 | 0.0917 | 0.2922 |
Brugia malayi | Pre-SET motif family protein | 0.0647 | 0.3029 | 0.9729 |
Brugia malayi | Smad1 | 0.0042 | 0.0121 | 0.0358 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.003 | 0.0062 | 0.0052 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0048 | 0.0038 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0047 | 0.0145 | 0.153 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0007 | 0.0007 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0017 | 0.0017 |
Trichomonas vaginalis | esterase, putative | 0.0112 | 0.0459 | 0.1304 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.0173 | 0.0475 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0459 | 0.1457 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.007 | 0.0257 | 0.5533 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0149 | 0.0404 |
Mycobacterium leprae | Probable lipase LipE | 0.0112 | 0.0459 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0299 | 0.1359 | 0.1359 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0614 | 0.2871 | 0.9222 |
Echinococcus multilocularis | GPCR, family 2 | 0.0066 | 0.0235 | 0.0226 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0343 | 0.0969 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0716 | 0.3363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0138 | 0.0425 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0056 | 0.1048 |
Schistosoma mansoni | tar DNA-binding protein | 0.0664 | 0.3113 | 0.3113 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0057 | 0.0195 | 0.0538 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0031 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0459 | 0.1457 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0145 | 0.0445 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0112 | 0.0459 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0664 | 0.3113 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0028 | 0.0056 | 0.0056 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0088 | 0.0343 | 0.1075 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.0217 | 0.4639 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0112 | 0.0459 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0135 | 0.0125 |
Brugia malayi | beta-lactamase family protein | 0.0112 | 0.0459 | 0.1447 |
Schistosoma mansoni | tar DNA-binding protein | 0.0664 | 0.3113 | 0.3113 |
Echinococcus granulosus | peregrin | 0.0035 | 0.0089 | 0.0079 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.0132 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0257 | 0.0718 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.0217 | 0.4639 |
Mycobacterium ulcerans | hypothetical protein | 0.0112 | 0.0459 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0135 | 0.0135 |
Toxoplasma gondii | ABC1 family protein | 0.0112 | 0.0459 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0062 | 0.0153 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0042 | 0.0121 | 0.0111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0059 | 0.0204 | 0.0565 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0113 | 0.0463 | 0.0463 |
Brugia malayi | Bromodomain containing protein | 0.0035 | 0.0089 | 0.0255 |
Mycobacterium ulcerans | hypothetical protein | 0.0047 | 0.0145 | 0.153 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.003 | 0.0062 | 0.0052 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0207 | 0.0917 | 0.293 |
Entamoeba histolytica | hypothetical protein | 0.0299 | 0.1359 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0093 | 0.0366 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0669 | 0.2132 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0047 | 0.0145 | 0.0099 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0112 | 0.0459 | 0.1304 |
Onchocerca volvulus | 0.0112 | 0.0459 | 0.1302 | |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0085 | 0.0075 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0037 | 0.01 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.003 | 0.0062 | 0.0168 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0096 | 0.0096 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.0165 | 0.0452 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0112 | 0.0459 | 0.1304 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0235 | 0.0654 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0235 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.0917 | 0.293 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.0165 | 0.0156 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.016 | 0.016 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0145 | 0.153 |
Schistosoma mansoni | tar DNA-binding protein | 0.0664 | 0.3113 | 0.3113 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0056 | 0.015 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0145 | 0.153 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0025 | 0.004 | 0.0108 |
Onchocerca volvulus | 0.0736 | 0.3458 | 1 | |
Schistosoma mansoni | zinc finger protein | 0.0027 | 0.0051 | 0.0051 |
Schistosoma mansoni | thyroid hormone receptor | 0.0155 | 0.0665 | 0.0665 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.0367 | 0.115 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0207 | 0.0917 | 0.2922 |
Schistosoma mansoni | tar DNA-binding protein | 0.0664 | 0.3113 | 0.3113 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0112 | 0.0459 | 0.1158 |
Brugia malayi | hypothetical protein | 0.0299 | 0.1359 | 0.4349 |
Echinococcus multilocularis | tumor protein p63 | 0.1064 | 0.5034 | 0.5029 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0112 | 0.0459 | 0.1158 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0047 | 0.0145 | 0.0099 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0089 | 0.0349 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0459 | 0.1457 |
Loa Loa (eye worm) | TAR-binding protein | 0.0664 | 0.3113 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0096 | 0.0277 |
Echinococcus multilocularis | tar DNA binding protein | 0.0664 | 0.3113 | 0.3106 |
Brugia malayi | RNA binding protein | 0.0664 | 0.3113 | 1 |
Schistosoma mansoni | Smad4 | 0.0042 | 0.0121 | 0.0121 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 71.5 % | Antileishmanial activity against Leishmania infantum MCAN/ES/92/BCN 83 promastigotes at 100 ug/ml after 48 hrs by resazurin method | ChEMBL. | 19811921 |
IC50 (functional) | = 164 uM | Antileishmanial activity against Leishmania infantum MCAN/ES/92/BCN 83 promastigotes after 48 hrs by resazurin method | ChEMBL. | 19811921 |
IC50 (ADMET) | > 256 uM | Cytotoxicity against mouse J774 cells after 24 hrs by by resazurin reduction test | ChEMBL. | 19811921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.