Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.00761339 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.00761339 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00263827 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.00761339 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.00263827 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.00263827 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.00761339 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.00263827 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.00761339 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.00761339 | 1 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.00263827 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.00263827 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00263827 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.00761339 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.00263827 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.00263827 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.00263827 | 0 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.00263827 | 0 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.00761339 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.00761339 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.00761339 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.00761339 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.00761339 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.00761339 | 1 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.00761339 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.00761339 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.55 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense | ChEMBL. | 19781948 |
IC50 (functional) | = 0.57 uM | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay | ChEMBL. | 19781948 |
IC50 (functional) | = 1.53 uM | Antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 19781948 |
IC50 (functional) | = 16.8 uM | Antileishmanial activity against Leishmania donovani axenic amastigotes | ChEMBL. | 19781948 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 19781948 | ||
Leishmania donovani | ChEMBL23 | 19781948 | |
Trypanosoma cruzi | ChEMBL23 | 19781948 | |
Plasmodium falciparum | 19781948 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.