Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0183 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.2625 | 0.2529 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.2866 | 0.2866 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3366 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1028 | 0.0911 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.3653 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.1031 | 0.0914 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.1031 | 0.0914 |
Echinococcus multilocularis | geminin | 0.0183 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1031 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1028 | 0.0911 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1192 | 0.3541 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.2625 | 0.2529 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1031 | 0.2209 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.1187 | 0.2673 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1479 | 0.4395 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1031 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1031 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1031 | 0.1031 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.1031 | 0.1031 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1351 | 0.4014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 19.2 % | Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) at 100 uM after 10 mins by spectrophotometry | ChEMBL. | 20153651 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.