Detailed information for compound 1091583

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.322 | Formula: C17H9NO5S
  • H donors: 0 H acceptors: 5 LogP: 2.78 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1c2ccccc2C(=O)c2c1onc2S(=O)(=O)c1ccccc1
  • InChi: 1S/C17H9NO5S/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)17(18-23-16)24(21,22)10-6-2-1-3-7-10/h1-9H
  • InChiKey: CNIUQSGPRNCEBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0871 0.083
Leishmania major DNA polymerase eta, putative 0.002 0.0093 0.0259
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0096 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0871 0.083
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0777 0.1399
Plasmodium falciparum basic transcription factor 3b, putative 0.0143 0.1898 0.4668
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0133 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0777 0.0735
Schistosoma mansoni cpg binding protein 0.003 0.0229 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0096 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0383 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0096 0.0098
Echinococcus granulosus snurportin 1 0.0335 0.4718 0.4694
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0096 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0449 0.0406
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0093 0.049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0449 0.0406
Echinococcus granulosus RUN 0.004 0.0377 0.0333
Echinococcus granulosus dna polymerase kappa 0.002 0.0093 0.0048
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0523 0.048
Trypanosoma brucei transcription factor BTF3, putative 0.0143 0.1898 1
Loa Loa (eye worm) MBCTL1 0.0057 0.0624 0.1107
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.4116 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0096 0.0092
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0871 0.1181
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0777 0.0735
Loa Loa (eye worm) hypothetical protein 0.0073 0.0871 0.1579
Loa Loa (eye worm) hypothetical protein 0.0057 0.0624 0.1107
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0383 0.034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0098
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0098
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0127 0.0082
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0383 0.1824
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1125 0.1085
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0174 0.2354 0.232
Loa Loa (eye worm) hypothetical protein 0.0031 0.0255 0.04
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Loa Loa (eye worm) hypothetical protein 0.0373 0.5277 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0752 0.3818
Toxoplasma gondii ABC1 family protein 0.0073 0.0871 0.4459
Brugia malayi mbt repeat family protein 0.005 0.0523 0.0855
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0093 0.0259
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.3219 0.6067
Schistosoma mansoni zinc finger protein 0.0081 0.0979 0.0939
Echinococcus granulosus tar DNA binding protein 0.0067 0.0777 0.0735
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0098
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0167 0.066
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0537 0.2655
Brugia malayi hypothetical protein 0.004 0.0377 0.0593
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0075 0.0053
Brugia malayi TAR-binding protein 0.0067 0.0777 0.131
Schistosoma mansoni ran 0.0023 0.0133 0.0088
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0377 0.0835
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0093 0.0048
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0669 0.3369
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0096 0.0092
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0383 0.083
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0093 0.049
Schistosoma mansoni DNA polymerase eta 0.002 0.0093 0.0048
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0871 0.2029
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0537 0.2655
Schistosoma mansoni methyl-cpg binding protein mbd 0.009 0.1116 0.1075
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0871 0.083
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.668 1
Schistosoma mansoni hypothetical protein 0.0081 0.0979 0.0939
Leishmania major cathepsin L-like protease 0.0065 0.0752 0.3818
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0096 0.0098
Echinococcus multilocularis transcription factor btf3 0.0143 0.1898 0.1861
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0133 0.0168
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0093 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0096 0.0092
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0871 0.083
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0096 0.0051
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0383 0.083
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.4718 0.8931
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.4116 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1125 0.1085
Plasmodium vivax basic transcription factor 3b, putative 0.0143 0.1898 0.4668
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0073 0.0871 0.1579
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0317 0.4447 0.4422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0096 0.0098
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0093 0.0259
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0523 0.048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4116 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0096 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0803 0.409
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0523 0.0913
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0523 0.048
Onchocerca volvulus 0.005 0.0523 0.2088
Brugia malayi mbt repeat family protein 0.005 0.0523 0.0855
Mycobacterium ulcerans beta-lactamase 0.0073 0.0871 0.1985
Schistosoma mansoni cpg binding protein 0.0041 0.0402 0.0359
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0871 0.2029
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0523 0.048
Trypanosoma cruzi ISWI complex protein 0.0081 0.0979 0.5043
Brugia malayi steroid hormone receptor 0.0021 0.0096 0.0092
Onchocerca volvulus 0.0073 0.0871 0.3609
Echinococcus multilocularis methyl CpG binding domain protein 2 0.009 0.1116 0.1075
Schistosoma mansoni microtubule-associated protein tau 0.0694 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0752 0.3818
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4116 1
Brugia malayi hypothetical protein 0.0033 0.0273 0.0409
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.2669 0.2635
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0133 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Loa Loa (eye worm) hypothetical protein 0.0073 0.0871 0.1579
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0127 0.0082
Brugia malayi Bromodomain containing protein 0.0397 0.5633 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0096 0.0051
Loa Loa (eye worm) RNA binding protein 0.0067 0.0777 0.1399
Echinococcus granulosus fetal alzheimer antigen falz 0.0121 0.1566 0.1528
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0624 0.0582
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0537 0.1239
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0377 0.0333
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0777 0.0735
Brugia malayi hypothetical protein 0.0173 0.2334 0.4096
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0096 0.0051
Brugia malayi Importin beta-1 subunit 0.0031 0.0255 0.0375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Leishmania major basic transcription factor 3a, putative 0.0143 0.1898 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0547 0.271
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0871 0.2029
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0317 0.4447 0.4422
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0777 0.1399
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0537 0.2829
Brugia malayi Bromodomain containing protein 0.0202 0.2763 0.4863
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0093 0.0259
Mycobacterium ulcerans hypothetical protein 0.0073 0.0871 0.1985
Brugia malayi nuclear hormone receptor 0.0021 0.0096 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0096 0.0092
Entamoeba histolytica hypothetical protein 0.0143 0.1898 0.4551
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0096 0.0223
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4116 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1905 0.2751
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0096 0.0051
Loa Loa (eye worm) hypothetical protein 0.0091 0.1125 0.2064
Mycobacterium ulcerans lipase LipD 0.0073 0.0871 0.1985
Echinococcus multilocularis geminin 0.0184 0.2504 0.247
Onchocerca volvulus 0.0173 0.2334 1
Onchocerca volvulus 0.0021 0.0096 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0871 0.1181
Loa Loa (eye worm) hypothetical protein 0.0073 0.0871 0.1579
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Onchocerca volvulus 0.004 0.0377 0.1448
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0096 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0093 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0096 0.0092
Schistosoma mansoni rab6-interacting 0.004 0.0377 0.0333
Plasmodium vivax importin-beta 2, putative 0.0031 0.0255 0.0528
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0096 0.0051
Schistosoma mansoni bromodomain containing protein 0.0024 0.015 0.0105
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0255 0.021
Trichomonas vaginalis esterase, putative 0.0073 0.0871 0.2029
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0537 0.2655
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0096 0.0051
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.1125 0.1085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0096 0.0092
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0449 0.0772
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0093 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0449 0.0406
Echinococcus multilocularis dna polymerase eta 0.002 0.0093 0.0048
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0624 0.0582
Schistosoma mansoni hypothetical protein 0.0184 0.2504 0.247
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0383 0.0605
Leishmania major cathepsin L-like protease 0.0065 0.0752 0.3818
Schistosoma mansoni methyl-cpg binding protein mbd 0.009 0.1116 0.1075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0449 0.0406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0449 0.0406
Brugia malayi beta-lactamase family protein 0.0073 0.0871 0.1478
Brugia malayi beta-lactamase 0.0073 0.0871 0.1478
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0096 0.0092
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0871 0.1181
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0096 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0093 0.049
Brugia malayi hypothetical protein 0.0051 0.0537 0.088
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0871 0.2082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0096 0.0051
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0383 0.2018
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0871 0.1985
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0871 0.1478
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4116 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0871 0.4459
Echinococcus multilocularis zinc finger protein 0.0105 0.1336 0.1297
Schistosoma mansoni loxhd1 0.004 0.0377 0.0333
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0287 0.4014 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0383 0.034
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0287 0.4014 0.5952
Brugia malayi PHD-finger family protein 0.0133 0.175 0.305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Mycobacterium tuberculosis Conserved protein 0.0073 0.0871 0.1181
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0871 0.2029
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.019 0.2579 0.2546
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1905 0.329
Onchocerca volvulus 0.004 0.0377 0.1448
Echinococcus granulosus zinc finger protein 0.0105 0.1336 0.1297
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0096 0.0051
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0093 0.0086
Schistosoma mansoni lipoxygenase 0.0103 0.1304 0.1265
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0718 0.0676
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.4116 1
Loa Loa (eye worm) PHD-finger family protein 0.0109 0.1393 0.2577
Loa Loa (eye worm) hypothetical protein 0.0073 0.0871 0.1579
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0096 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0096 0.0098
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0167 0.03
Loa Loa (eye worm) hypothetical protein 0.0051 0.0537 0.094
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0096 0.0051
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0377 0.0333
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0377 0.0333
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0133 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0227 0.3125 0.5887
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.1898 0.4551
Brugia malayi RNA, U transporter 1 0.0089 0.1105 0.1897
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0096 0.0092
Schistosoma mansoni lipoxygenase 0.0174 0.2354 0.232
Trypanosoma cruzi transcription factor btf3, putative 0.0143 0.1898 1
Schistosoma mansoni coup transcription factor 0.0021 0.0096 0.0051
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1905 0.4621
Schistosoma mansoni hypothetical protein 0.0302 0.4229 0.4203
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0096 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0871 0.4591
Schistosoma mansoni cpg binding protein 0.0041 0.0402 0.0359
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0871 0.1181
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0096 0.0051
Brugia malayi ecdysteroid receptor 0.0021 0.0096 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0383 0.083
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0133 0.0474
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0383 0.1824
Echinococcus multilocularis RUN 0.004 0.0377 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0098
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0096 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.015 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Trypanosoma brucei unspecified product 0.002 0.0093 0.049
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0096 0.0223
Echinococcus granulosus dna polymerase eta 0.002 0.0093 0.0048
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0383 0.1824
Entamoeba histolytica Ran family GTPase 0.0023 0.0133 0.0216
Schistosoma mansoni transcription factor btf3 0.0143 0.1898 0.1861
Schistosoma mansoni ran 0.0023 0.0133 0.0088
Loa Loa (eye worm) hypothetical protein 0.0202 0.2768 0.5205
Schistosoma mansoni zinc finger protein 0.0105 0.1336 0.1297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0098
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0871 0.1579
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0133 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0871 0.4459
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.0377 0.0634
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0133 0.0157
Brugia malayi beta-NAC-like protein 0.0143 0.1898 0.3316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0096 0.0092
Loa Loa (eye worm) doublecortin family protein 0.004 0.0377 0.0634
Mycobacterium tuberculosis Conserved protein 0.0073 0.0871 0.1181
Schistosoma mansoni hypothetical protein 0.004 0.0377 0.0333
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0133 0.07
Echinococcus multilocularis microtubule associated protein 2 0.0694 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0255 0.1341
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0871 0.1985
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0377 0.0333
Leishmania major GTP-binding protein, putative 0.0023 0.0133 0.0474
Loa Loa (eye worm) hypothetical protein 0.005 0.0523 0.0913
Brugia malayi beta-lactamase family protein 0.0073 0.0871 0.1478
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0096 0.0051
Leishmania major hypothetical protein, conserved 0.0051 0.0537 0.2655
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0096 0.0051
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0093 0.0118
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0096 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4116 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.0167 0.066
Onchocerca volvulus 0.003 0.0229 0.0805
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.2669 0.2635
Loa Loa (eye worm) hypothetical protein 0.0091 0.1128 0.207
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0777 0.0735
Echinococcus granulosus cpg binding protein 0.0041 0.0402 0.0359
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0537 0.1239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0096 0.0098
Schistosoma mansoni hypothetical protein 0.0023 0.0127 0.0082
Onchocerca volvulus 0.0073 0.0871 0.3609
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0523 0.048
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0624 0.1036
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0777 0.0735
Schistosoma mansoni hypothetical protein 0.0184 0.2504 0.247
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0093 0.0048
Entamoeba histolytica hypothetical protein 0.0025 0.0167 0.03
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0287 0.4014 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0096 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0449 0.0406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Trypanosoma cruzi transcription factor btf3, putative 0.0143 0.1898 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0096 0.0051
Loa Loa (eye worm) hypothetical protein 0.004 0.0377 0.0634
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0096 0.0051
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0093 0.0118
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0871 0.1181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0096 0.0098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4116 1
Leishmania major cathepsin L-like protease 0.0065 0.0752 0.3818
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0383 0.083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0377 0.0835
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0537 0.1239
Loa Loa (eye worm) ICD-1 protein 0.0143 0.1898 0.3542
Echinococcus multilocularis dna polymerase kappa 0.002 0.0093 0.0048
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0093 0.0086
Schistosoma mansoni importin beta-1 0.0031 0.0255 0.021
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0871 0.1181
Loa Loa (eye worm) hypothetical protein 0.0091 0.1128 0.207
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0096 0.0051
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0624 0.0582
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0121 0.1566 0.1528
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0096 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0752 0.3818
Brugia malayi follicle stimulating hormone receptor 0.0233 0.3219 0.568
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0121 0.1566 0.1528
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4116 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0096 0.0092
Schistosoma mansoni hypothetical protein 0.0109 0.1393 0.1354
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0096 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0096 0.0098
Echinococcus multilocularis snurportin 1 0.0335 0.4718 0.4694
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0624 0.0582
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0777 0.0735
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0096 0.0051
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0133 0.0474
Loa Loa (eye worm) hypothetical protein 0.004 0.0383 0.0646
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0093 0.0259
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0174 0.2354 0.232
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0255 0.1131
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0093 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Trypanosoma brucei ISWI complex protein 0.0081 0.0979 0.5161
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0229 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.1898 0.4551
Echinococcus multilocularis cpg binding protein 0.0041 0.0402 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0093 0.0118
Trypanosoma cruzi ISWI complex protein 0.0081 0.0979 0.5043
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0383 0.034
Echinococcus granulosus importin subunit beta 1 0.0031 0.0255 0.021
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0624 0.0582
Leishmania major hypothetical protein, conserved 0.0081 0.0979 0.5043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0093 0.0092
Toxoplasma gondii NAC domain-containing protein 0.0143 0.1898 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0096 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0449 0.0406
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0871 0.2029
Brugia malayi hypothetical protein 0.0091 0.1128 0.1938
Brugia malayi CXXC zinc finger family protein 0.003 0.0229 0.033
Echinococcus granulosus transcription factor btf3 0.0143 0.1898 0.1861
Loa Loa (eye worm) bromodomain containing protein 0.0093 0.1163 0.2137
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0383 0.034
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0777 0.131
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0287 0.4014 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4116 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0098
Loa Loa (eye worm) hypothetical protein 0.0173 0.2334 0.4375
Mycobacterium tuberculosis Conserved protein 0.0073 0.0871 0.1181
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0383 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0096 0.0098
Leishmania major hypothetical protein, conserved 0.0073 0.0871 0.4459
Trichomonas vaginalis ran, putative 0.0023 0.0133 0.0216
Schistosoma mansoni rab6-interacting 0.004 0.0377 0.0333
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0449 0.0723
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0167 0.03
Brugia malayi hypothetical protein 0.004 0.0377 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0093 0.049
Schistosoma mansoni polycystin 1-related 0.004 0.0377 0.0333
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0383 0.0721
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0096 0.0092
Brugia malayi RNA binding protein 0.0067 0.0777 0.131
Schistosoma mansoni bromodomain containing protein 0.0336 0.4725 0.4701
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0383 0.034
Loa Loa (eye worm) hypothetical protein 0.0073 0.0871 0.1579
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0377 0.0333
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0096 0.0051
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0523 0.048
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0133 0.0474
Onchocerca volvulus 0.0073 0.0871 0.3609
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.019 0.2579 0.2546
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0523 0.048
Echinococcus granulosus methyl CpG binding domain protein 2 0.009 0.1116 0.1075
Loa Loa (eye worm) beta-lactamase 0.0073 0.0871 0.1579
Leishmania major DNA polymerase kappa, putative 0.002 0.0093 0.0259
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0167 0.03
Echinococcus granulosus geminin 0.0184 0.2504 0.247
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.4116 1
Loa Loa (eye worm) hypothetical protein 0.0215 0.2952 0.5556
Brugia malayi Doublecortin family protein 0.004 0.0377 0.0593
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0098
Schistosoma mansoni eyes absent homolog 0.0091 0.1128 0.1088
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0752 0.3818
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0096 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0255 0.1341
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0133 0.0221
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0383 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.1898 0.4551
Plasmodium falciparum importin beta, putative 0.0031 0.0255 0.0528
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0752 0.3965
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0096 0.0092
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0871 0.1181
Entamoeba histolytica transcription factor BTF3, putative 0.0143 0.1898 0.4551
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0096 0.0051
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0287 0.4014 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0093 0.049
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0523 0.2088
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.1125 0.1085
Schistosoma mansoni hypothetical protein 0.0335 0.4718 0.4694
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0377 0.0333

Activities

Activity type Activity value Assay description Source Reference
MIC50 (functional) = 2.5 uM Antifungal activity against Candida albicans PYCC 3436 after 48 hrs ChEMBL. 19926280
MIC50 (functional) = 56.7 uM Antifungal activity against Candida albicans ATCC 90028 after 48 hrs ChEMBL. 19926280

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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