Detailed information for compound 1091584

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 569.757 | Formula: C34H39N3O3S
  • H donors: 1 H acceptors: 3 LogP: 5.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N1CCC(CC1)N1CCCC1)Cn1c2cc(ccc2c(c1c1cc2c(s1)cccc2)C1CCCCC1)C(=O)O
  • InChi: 1S/C34H39N3O3S/c38-31(36-18-14-26(15-19-36)35-16-6-7-17-35)22-37-28-20-25(34(39)40)12-13-27(28)32(23-8-2-1-3-9-23)33(37)30-21-24-10-4-5-11-29(24)41-30/h4-5,10-13,20-21,23,26H,1-3,6-9,14-19,22H2,(H,39,40)
  • InChiKey: OHMZPKKXMJHXPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0051 0.0412 0.3526
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0055 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.0204 0.0372
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.007 0.0128
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0368 1
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.3375 0.3361
Schistosoma mansoni hypothetical protein 0.0113 0.1441 0.1404
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0177 0.0978
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0055 0.0034
Schistosoma mansoni ran 0.0044 0.0295 0.0252
Echinococcus granulosus neuropeptide s receptor 0.0471 0.7317 0.7312
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0295 0.0539
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.106 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0177 0.0978
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0156 0.4242
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1519 0.1519
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0089 0.0845
Schistosoma mansoni tar DNA-binding protein 0.0196 0.2795 0.2764
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0061 0.0576
Echinococcus multilocularis PHD finger protein rhinoceros 0.009 0.106 0.1041
Leishmania major importin beta-1 subunit, putative 0.0048 0.0368 1
Plasmodium falciparum importin beta, putative 0.0059 0.0553 0.5215
Onchocerca volvulus 0.0037 0.0177 0.1277
Schistosoma mansoni hypothetical protein 0.0405 0.6232 0.6216
Mycobacterium ulcerans beta-lactamase 0.0037 0.0177 0.5
Leishmania major hypothetical protein, conserved 0.0029 0.0055 0.1494
Brugia malayi beta-lactamase family protein 0.0037 0.0177 0.0323
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0177 0.3199
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0177 0.0978
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.181 0.1775
Echinococcus granulosus geminin 0.0341 0.5191 0.518
Entamoeba histolytica hypothetical protein 0.0048 0.0368 0.0718
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.219 0.2173
Loa Loa (eye worm) hypothetical protein 0.0055 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0021
Schistosoma mansoni cpg binding protein 0.003 0.007 0.0027
Plasmodium falciparum phd finger protein, putative 0.009 0.106 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.009 0.106 0.1021
Schistosoma mansoni hypothetical protein 0.0113 0.1441 0.1404
Echinococcus multilocularis lysine specific demethylase 5A 0.0109 0.1372 0.1353
Schistosoma mansoni hypothetical protein 0.0634 1 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0295 0.0274
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0055 0.0519
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0295 0.4435 0.4423
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0156 0.1473
Brugia malayi beta-lactamase 0.0037 0.0177 0.0323
Onchocerca volvulus 0.0056 0.0499 0.4358
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0177 0.0978
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0499 0.0499
Schistosoma mansoni hypothetical protein 0.0113 0.1441 0.1404
Schistosoma mansoni intermediate filament proteins 0.0056 0.0499 0.0457
Mycobacterium ulcerans hypothetical protein 0.0037 0.0177 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0177 0.0134
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0177 0.0323
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0177 0.0978
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0358 0.547 0.547
Loa Loa (eye worm) hypothetical protein 0.0245 0.3605 0.3605
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0055 0.0034
Echinococcus multilocularis tumor protein p63 0.0347 0.5285 0.5275
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.6232 0.6224
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0113 0.1441 0.1423
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.219 0.4003
Loa Loa (eye worm) hypothetical protein 0.0059 0.0553 0.0553
Brugia malayi RNA, U transporter 1 0.0169 0.2353 0.4301
Onchocerca volvulus Alhambra homolog 0.009 0.106 0.9731
Echinococcus multilocularis GPCR, family 2 0.0113 0.1441 0.1423
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0295 0.2782
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0553 0.5215
Loa Loa (eye worm) latrophilin receptor protein 2 0.0113 0.1441 0.1441
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0177 0.5
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0634 1 1
Echinococcus multilocularis peregrin 0.009 0.106 0.1041
Echinococcus granulosus phd:f box containing protein 0.0029 0.0055 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0177 0.0177
Echinococcus granulosus lamin 0.0056 0.0499 0.0478
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0055 0.0519
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0055 0.0519
Brugia malayi AF-10 protein 0.0029 0.0061 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0196 0.2795 0.2764
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.106 1
Schistosoma mansoni hypothetical protein 0.0122 0.1587 0.155
Schistosoma mansoni transcription factor LCR-F1 0.0215 0.3105 0.3075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0567 0.0526
Brugia malayi jmjC domain containing protein 0.0111 0.1398 0.2556
Schistosoma mansoni hypothetical protein 0.0245 0.3605 0.3577
Schistosoma mansoni tar DNA-binding protein 0.0196 0.2795 0.2764
Brugia malayi Importin beta-1 subunit 0.0059 0.0553 0.101
Loa Loa (eye worm) hypothetical protein 0.0037 0.0177 0.0177
Echinococcus granulosus lamin dm0 0.0056 0.0499 0.0478
Loa Loa (eye worm) hypothetical protein 0.0358 0.547 0.547
Entamoeba histolytica hypothetical protein 0.0215 0.3105 1
Schistosoma mansoni lamin 0.0056 0.0499 0.0457
Schistosoma mansoni thyroid hormone receptor 0.0142 0.1909 0.1873
Loa Loa (eye worm) RNA binding protein 0.0196 0.2795 0.2795
Onchocerca volvulus 0.0047 0.0351 0.2945
Schistosoma mansoni alpha-glucosidase 0.0137 0.1826 0.179
Schistosoma mansoni hypothetical protein 0.0029 0.0061 0.0018
Brugia malayi beta-lactamase family protein 0.0037 0.0177 0.0323
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.7317 0.7312
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0368 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.181 0.1793
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0177 0.4805
Loa Loa (eye worm) hypothetical protein 0.0037 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0051 0.0412 0.0412
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0156 0.4242
Schistosoma mansoni hypothetical protein 0.0215 0.3105 0.3075
Echinococcus granulosus importin subunit beta 1 0.0059 0.0553 0.0532
Brugia malayi follicle stimulating hormone receptor 0.0237 0.348 0.6361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.181 0.1775
Loa Loa (eye worm) hypothetical protein 0.009 0.106 0.106
Leishmania major GTP-binding protein, putative 0.0044 0.0295 0.8012
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0553 1
Brugia malayi hypothetical protein 0.0215 0.3105 0.5675
Schistosoma mansoni tar DNA-binding protein 0.0196 0.2795 0.2764
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0055 0.0055
Brugia malayi latrophilin 2 splice variant baaae 0.0245 0.3605 0.6591
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0055 0.0995
Schistosoma mansoni hypothetical protein 0.0341 0.5191 0.517
Echinococcus granulosus lysine specific demethylase 5A 0.0111 0.1398 0.138
Brugia malayi intermediate filament protein 0.0056 0.0499 0.0911
Echinococcus multilocularis jumonji domain containing protein 0.0126 0.1641 0.1623
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0177 0.0134
Giardia lamblia PHD finger protein 15 0.009 0.106 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0055 0.0055
Schistosoma mansoni lamin 0.0056 0.0499 0.0457
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0351 0.0642
Plasmodium vivax hypothetical protein, conserved 0.009 0.106 1
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0553 0.0532
Echinococcus granulosus PHD finger protein rhinoceros 0.009 0.106 0.1041
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0177 0.0177
Echinococcus multilocularis tar DNA binding protein 0.0196 0.2795 0.278
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0295 0.0274
Brugia malayi jmjC domain containing protein 0.0029 0.0055 0.01
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0113 0.1441 0.1423
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0177 0.5
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0177 0.5
Trichomonas vaginalis esterase, putative 0.0037 0.0177 0.0978
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0156 0.0135
Schistosoma mansoni hypothetical protein 0.0113 0.1441 0.1404
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.219 0.2173
Entamoeba histolytica hypothetical protein 0.0215 0.3105 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0295 0.8012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.181 0.1793
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0499 0.0911
Trichomonas vaginalis ran, putative 0.0044 0.0295 0.6548
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0089 0.0845
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.007 0.007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.0082 0.006
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0055 0.0012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.2795 0.2795
Brugia malayi Calcitonin receptor-like protein seb-1 0.0358 0.547 1
Brugia malayi PHD-finger family protein 0.009 0.106 0.1937
Schistosoma mansoni alpha glucosidase 0.0035 0.0156 0.0113
Brugia malayi Bromodomain containing protein 0.009 0.106 0.1937
Brugia malayi hypothetical protein 0.0231 0.3375 0.617
Schistosoma mansoni alpha-glucosidase 0.0137 0.1826 0.179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0113 0.1441 0.1423
Brugia malayi TAR-binding protein 0.0196 0.2795 0.511
Echinococcus multilocularis thyroid hormone receptor alpha 0.0142 0.1909 0.1891
Brugia malayi jmjC domain containing protein 0.0029 0.0055 0.01
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0055 0.0034
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0295 0.2782
Schistosoma mansoni hypothetical protein 0.0341 0.5191 0.517
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.181 0.3309
Schistosoma mansoni importin beta-1 0.0059 0.0553 0.0511
Onchocerca volvulus 0.0037 0.0177 0.1277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.181 0.1793
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0055 0.0034
Echinococcus granulosus jumonji domain containing protein 0.0126 0.1641 0.1623
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0055 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0177 0.0177
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.219 0.219
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0055 0.0034
Echinococcus granulosus intermediate filament protein 0.0056 0.0499 0.0478
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1519 0.1519
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.1398 0.1361
Brugia malayi jmjC domain containing protein 0.0295 0.4435 0.8107
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0047 0.0351 0.0309
Entamoeba histolytica Ran family GTPase 0.0044 0.0295 0.047
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.2795 0.511
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0295 0.8012
Mycobacterium leprae Probable lipase LipE 0.0037 0.0177 0.5
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0156 0.0285
Onchocerca volvulus 0.0092 0.1088 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0177 0.1668
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0177 0.4805
Loa Loa (eye worm) hypothetical protein 0.0056 0.0499 0.0499
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0215 0.3105 0.309
Schistosoma mansoni jumonji domain containing protein 0.0235 0.3436 0.3408
Brugia malayi CXXC zinc finger family protein 0.0028 0.0043 0.0079
Entamoeba histolytica hypothetical protein 0.0215 0.3105 1
Brugia malayi MH2 domain containing protein 0.0118 0.1519 0.2776
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0368 1
Leishmania major hypothetical protein, conserved 0.0037 0.0177 0.4805
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0156 0.4242
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0499 0.0499
Echinococcus granulosus cpg binding protein 0.003 0.007 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0177 0.0134
Plasmodium vivax importin-beta 2, putative 0.0059 0.0553 0.5215
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0177 0.0156
Echinococcus multilocularis geminin 0.0341 0.5191 0.518
Brugia malayi PHD-finger family protein 0.0031 0.0088 0.016
Loa Loa (eye worm) PHD-finger family protein 0.009 0.106 0.106
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0055 0.1494
Echinococcus multilocularis snurportin 1 0.0634 1 1
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0055 0.0012
Echinococcus multilocularis musashi 0.0056 0.0499 0.0478
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0156 0.0156
Brugia malayi RNA binding protein 0.0196 0.2795 0.511
Loa Loa (eye worm) TAR-binding protein 0.0196 0.2795 0.2795
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0055 0.0012
Schistosoma mansoni hypothetical protein 0.009 0.106 0.1021
Echinococcus multilocularis lamin dm0 0.0056 0.0499 0.0478
Mycobacterium ulcerans lipase LipD 0.0037 0.0177 0.5
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0061 0.1104
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0358 0.547 1
Trypanosoma brucei glucosidase, putative 0.0035 0.0156 0.2824
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0553 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Echinococcus granulosus GPCR family 2 0.0113 0.1441 0.1423
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1587 0.1569
Schistosoma mansoni thyroid hormone receptor 0.0142 0.1909 0.1873
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0412 0.037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0055
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.348 0.348
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.1398 0.1361
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0055 0.0012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0113 0.1441 0.1441
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0295 0.5334
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.219 0.2173
Schistosoma mansoni survival motor neuron protein 0.0047 0.0351 0.0309
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0113 0.1441 0.1423
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0186 0.2639 0.2639
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0156 0.0135
Echinococcus multilocularis cpg binding protein 0.003 0.007 0.0049
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0055 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0196 0.2795 0.2764
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.181 0.181
Echinococcus granulosus dnaJ subfamily B 0.0405 0.6232 0.6224
Onchocerca volvulus 0.0037 0.0177 0.1277
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0462 0.4355
Loa Loa (eye worm) hypothetical protein 0.0037 0.0177 0.0177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.181 0.1793
Loa Loa (eye worm) hypothetical protein 0.0231 0.3375 0.3375
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0295 0.0295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.181 0.1775
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0295 0.4435 0.4423
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.3414 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0177 0.0177
Brugia malayi Latrophilin receptor protein 2 0.0113 0.1441 0.2634
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.7317 0.7312
Schistosoma mansoni cpg binding protein 0.003 0.007 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.1398 0.1398
Loa Loa (eye worm) hypothetical protein 0.0155 0.2119 0.2119
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.0082 0.006
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0295 0.2782
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1587 0.1569
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0043 0.0043
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0061 0.0576
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0055 0.0055
Schistosoma mansoni ran 0.0044 0.0295 0.0252
Echinococcus granulosus tar DNA binding protein 0.0196 0.2795 0.278
Echinococcus granulosus tumor protein p63 0.0347 0.5285 0.5275
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.3375 0.3361
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0113 0.1441 0.2634
Echinococcus multilocularis lamin 0.0056 0.0499 0.0478
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0215 0.3105 0.309
Echinococcus granulosus peregrin 0.009 0.106 0.1041
Entamoeba histolytica hypothetical protein 0.0215 0.3105 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0177 0.0156
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.7317 0.7312
Brugia malayi jmjC domain containing protein 0.0029 0.0055 0.01
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0055 0.1494
Onchocerca volvulus 0.0056 0.0499 0.4358
Toxoplasma gondii ABC1 family protein 0.0037 0.0177 0.1668
Plasmodium vivax JmjC domain containing protein 0.0029 0.0055 0.0519
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0061 0.1104
Brugia malayi jmjC domain containing protein 0.0029 0.0055 0.01
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0368 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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