Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutaminase | 0.0266 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.8168 | 1 |
Onchocerca volvulus | 0.0155 | 0.5185 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5185 | 0.4939 |
Brugia malayi | hypothetical protein | 0.0155 | 0.5185 | 0.5185 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0061 | 0.1078 | 0.038 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0083 | 0.2034 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4007 | 0.4007 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.1145 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.4067 | 0.3763 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0486 | 0.1214 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.1078 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.2034 | 0.1071 |
Trichomonas vaginalis | glutaminase, putative | 0.0266 | 1 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.1145 | 0.0692 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0083 | 0.2034 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.4007 | 0.37 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0083 | 0.2034 | 0.2034 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0486 | 0.0486 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4007 | 0.4007 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4007 | 0.4007 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0486 | 0.1214 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4007 | 0.4007 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0486 | 0.1214 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0083 | 0.2034 | 0.5077 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.4007 | 0.4007 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0083 | 0.2034 | 0.5 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.1078 | 0.2691 |
Loa Loa (eye worm) | glutaminase 2 | 0.0266 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0486 | 0.1214 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0062 | 0.1145 | 0.2857 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.1078 | 0.1078 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0486 | 0.0486 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0061 | 0.1078 | 0.1078 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.2034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.4067 | 0.3763 |
Schistosoma mansoni | glutaminase | 0.0266 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.2034 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0062 | 0.1145 | 0.1145 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.2034 | 0.1071 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0054 | 0.0798 | 0.1992 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0062 | 0.1145 | 0.2857 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0486 | 0.0486 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.4007 | 0.37 |
Brugia malayi | hypothetical protein | 0.0129 | 0.4067 | 0.4067 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.2034 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4007 | 0.4007 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0486 | 0.0486 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.4007 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.2034 | 0.5 |
Brugia malayi | Probable ClpP-like protease | 0.0083 | 0.2034 | 0.2034 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0054 | 0.0798 | 0.1992 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.0901 | 0.0436 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.2034 | 0.5 |
Brugia malayi | RNA binding protein | 0.0128 | 0.4007 | 0.4007 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.1078 | 0.2691 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.1145 | 0.1145 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0083 | 0.2034 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0062 | 0.1145 | 0.1145 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.4007 | 0.4007 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.4007 | 0.37 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0062 | 0.1145 | 0.2857 |
Brugia malayi | jmjC domain containing protein | 0.0062 | 0.1145 | 0.1145 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0062 | 0.1145 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.2034 | 0.1627 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0083 | 0.2034 | 0.5077 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.4007 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 2 % | Inhibition of Yarrowia lipolytica 24-SMT assessed as cholesta-7,24-dien-3-trimethylsilyl derivative at 2 ug/mL after 48 hrs by GC-MS analysis relative to untreated control | ChEMBL. | 19833521 |
Activity (binding) | = 2.3 % | Inhibition of Yarrowia lipolytica 24-SMT assessed as 5-dehydroepisterol-3-trimethylsilyl derivative at 8 ug/mL after 48 hrs by GC-MS analysis relative to untreated control | ChEMBL. | 19833521 |
Activity (binding) | = 2.7 % | Inhibition of Yarrowia lipolytica 24-sterol C-methyltransferase assessed as ergosterol-3-trimethylsilyl derivative level at 2 ug/mL after 48 hrs by GC-MS analysis relative to untreated control | ChEMBL. | 19833521 |
Activity (binding) | = 3.3 % | Inhibition of Yarrowia lipolytica 24-SMT assessed as 5-dehydroepisterol-3-trimethylsilyl derivative at 2 ug/mL after 48 hrs by GC-MS analysis relative to untreated control | ChEMBL. | 19833521 |
Activity (binding) | = 5.1 % | Inhibition of Yarrowia lipolytica 24-SMT assessed as cholesta-7,24-dien-3-trimethylsilyl derivative at 8 ug/mL after 48 hrs by GC-MS analysis relative to untreated control | ChEMBL. | 19833521 |
Activity (binding) | = 25.6 % | Inhibition of Yarrowia lipolytica 24-SMT assessed as cholesta-5,7,24-trien-3-trimethylsilyl derivative at 2 ug/mL after 48 hrs by GC-MS analysis relative to untreated control | ChEMBL. | 19833521 |
Activity (binding) | = 27.2 % | Inhibition of Yarrowia lipolytica 24-SMT assessed as dehydroergosterol-3-trimethylsilyl derivative at 8 ug/mL after 48 hrs by GC-MS analysis relative to untreated control | ChEMBL. | 19833521 |
Activity (binding) | = 65.4 % | Inhibition of Yarrowia lipolytica 24-SMT assessed as cholesta-5,7,24-trien-3-trimethylsilyl derivative at 8 ug/mL after 48 hrs by GC-MS analysis relative to untreated control | ChEMBL. | 19833521 |
Activity (binding) | = 66.4 % | Inhibition of Yarrowia lipolytica 24-SMT assessed as dehydroergosterol-3-trimethylsilyl derivative at 2 ug/mL after 48 hrs by GC-MS analysis relative to untreated control | ChEMBL. | 19833521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.