Detailed information for compound 1092271

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 302.224 | Formula: C10H15N4O5P
  • H donors: 3 H acceptors: 5 LogP: -2.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CP(=O)(O)O)OCCn1cnc2c1nc[nH]c2=O
  • InChi: 1S/C10H15N4O5P/c1-7(4-20(16,17)18)19-3-2-14-6-13-8-9(14)11-5-12-10(8)15/h5-7H,2-4H2,1H3,(H,11,12,15)(H2,16,17,18)
  • InChiKey: HPZQUAFTZVHCSN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hypoxanthine phosphoribosyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania major hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania infantum hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania mexicana xanthine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt Get druggable targets OG5_127374 All targets in OG5_127374
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Onchocerca volvulus Get druggable targets OG5_127374 All targets in OG5_127374
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Schistosoma japonicum ko:K00760 hypoxanthine phosphoribosyltransferase [EC2.4.2.8], putative Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania major xanthine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Schistosoma japonicum Hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma brucei gambiense hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Plasmodium berghei hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma congolense hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania braziliensis hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma brucei gambiense hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Giardia lamblia Guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor Get druggable targets OG5_127374 All targets in OG5_127374
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Brugia malayi Phosphoribosyl transferase domain containing protein Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania braziliensis xanthine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma congolense hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho Get druggable targets OG5_127374 All targets in OG5_127374
Neospora caninum Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8), related Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma congolense hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma brucei gambiense hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania infantum xanthine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania donovani xanthine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
Leishmania mexicana hypoxanthine-guanine phosphoribosyltransferase Get druggable targets OG5_127374 All targets in OG5_127374
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.2497 0.2959
Loa Loa (eye worm) glutathione reductase 0.0043 0.2497 1
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0026 0.1128 0.114
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0111 0.7794 0.7794
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0026 0.1128 0.114
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.2497 1
Toxoplasma gondii orotate phosphoribosyltransferase 0.0026 0.1128 0.114
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.2542 0.3262
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0026 0.1128 0.114
Giardia lamblia Guanine phosphoribosyltransferase 0.0111 0.7794 1
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0111 0.7794 1
Brugia malayi Adenine phosphoribosyltransferase 0.0026 0.1128 0.1447
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0026 0.1128 0.114
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0026 0.1128 0.114
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0111 0.7794 1
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0026 0.1128 0.114
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0026 0.1128 0.114
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0111 0.7794 1
Treponema pallidum hypothetical protein 0.0026 0.1128 1
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0111 0.7794 1
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0111 0.7794 0.7794
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.011 0.7728 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.027 0.0347
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.027 0.5
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0026 0.1128 0.1447
Treponema pallidum adenine phosphoribosyltransferase 0.0026 0.1128 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.011 0.7728 1
Echinococcus granulosus uridine 5' monophosphate synthase 0.0026 0.1128 0.1447
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0111 0.7794 1
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0026 0.1128 0.114
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0026 0.1128 0.115
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0099 0.6861 0.8837
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0026 0.1128 1
Toxoplasma gondii thioredoxin reductase 0.0043 0.2497 0.2959
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0026 0.1128 0.114
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0111 0.7794 1
Plasmodium falciparum glutathione reductase 0.0043 0.2497 0.2959
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0111 0.7794 1
Trypanosoma brucei trypanothione reductase 0.0043 0.2497 0.2959
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0111 0.7794 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0099 0.6861 0.8837
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.7728 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0099 0.6861 0.8837
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0111 0.7794 1
Mycobacterium ulcerans hypothetical protein 0.0026 0.1128 0.114
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.027 0.027
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0111 0.7794 1
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0026 0.1128 0.114
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0026 0.1128 0.114
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0026 0.1128 0.1128
Brugia malayi glutathione reductase 0.0043 0.2497 0.3203
Leishmania major xanthine phosphoribosyltransferase 0.0111 0.7794 1
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0111 0.7794 1
Brugia malayi Thioredoxin reductase 0.0043 0.2497 0.3203
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0026 0.1128 0.115
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0026 0.1128 1
Onchocerca volvulus 0.0111 0.7794 1
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0026 0.1128 0.115
Giardia lamblia Adenine phosphoribosyltransferase 0.0026 0.1128 0.114
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0085 0.5756 0.7356
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0026 0.1128 0.114
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0099 0.6861 0.8686
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0026 0.1128 0.1447
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0026 0.1128 0.4517
Plasmodium falciparum thioredoxin reductase 0.0043 0.2497 0.2959
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0026 0.1128 0.115
Mycobacterium tuberculosis Conserved protein 0.0026 0.1128 0.115
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.2542 0.3262
Brugia malayi orotate phosphoribosyltransferase family protein 0.0026 0.1128 0.1447
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0026 0.1128 0.114
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0111 0.7794 1
Mycobacterium tuberculosis Probable reductase 0.0099 0.6861 0.8837
Mycobacterium tuberculosis Conserved protein 0.0026 0.1128 0.115
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.1128 0.115
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0026 0.1128 0.114
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0111 0.7794 1
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0111 0.7794 1
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0026 0.1128 0.114
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0026 0.1128 0.4517
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0111 0.7794 1
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0111 0.7794 1
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0026 0.1128 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0099 0.6861 0.8837
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.2497 0.2959
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0026 0.1128 0.1128
Leishmania major adenine phosphoribosyltransferase 0.0026 0.1128 0.114
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0085 0.5756 0.7013
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0026 0.1128 0.114
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0026 0.1128 0.1128
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0111 0.7794 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.011 0.7728 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.027 0.0347
Schistosoma mansoni uracil phosphoribosyltransferase 0.0026 0.1128 0.1128
Echinococcus granulosus adenine phosphoribosyltransferase 0.0026 0.1128 0.1447
Leishmania major trypanothione reductase 0.0043 0.2497 0.2959
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0026 0.1128 0.1447
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0111 0.7794 1
Plasmodium vivax glutathione reductase, putative 0.0043 0.2497 0.2959
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.2497 0.2985
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0026 0.1128 0.1128
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0026 0.1128 0.1128
Plasmodium falciparum orotate phosphoribosyltransferase 0.0026 0.1128 0.114
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.027 0.0347
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0099 0.6861 0.8837
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0026 0.1128 0.114

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2 uM Inhibition of human recombinant HGPRT expressed in Escherichia coli by spectrophotometric assay ChEMBL. 19666228

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.