Detailed information for compound 1092503

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.497 | Formula: C25H31N2O6P
  • H donors: 0 H acceptors: 1 LogP: 3.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c1cc(OC)c(cc1c1c2CN2CCN(C[C@@H]2C1)P(=O)(OC)OC)OC
  • InChi: 1S/C25H31N2O6P/c1-29-17-6-7-18-20(11-17)22-13-25(31-3)24(30-2)12-21(22)19-10-16-14-27(34(28,32-4)33-5)9-8-26(16)15-23(18)19/h6-7,11-13,16H,8-10,14-15H2,1-5H3/t16-/m0/s1
  • InChiKey: GXOLGNUMEXVEDP-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0337 0.0857
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.3672 0.5332
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0319
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0557 0.1026
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.3672 0.5402
Schistosoma mansoni alpha-glucosidase 0.0153 0.3114 0.4499
Loa Loa (eye worm) TAR-binding protein 0.0257 0.5432 0.7991
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0161 0.0724
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0557 0.068
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1286 0.5797
Toxoplasma gondii ABC1 family protein 0.0072 0.1286 0.5469
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0337 0.1518
Plasmodium falciparum importin beta, putative 0.003 0.0337 0.5915
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0928 0.1708
Echinococcus granulosus tar DNA binding protein 0.0257 0.5432 0.796
Trichomonas vaginalis inositol monophosphatase, putative 0.0114 0.2219 0.4559
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0217 0.0976
Brugia malayi Pre-SET motif family protein 0.0029 0.0324 0.0597
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0102 0.1952 0.1529
Brugia malayi RNA recognition motif domain containing protein 0.0257 0.5432 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0217 0.0272
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1286 0.1769
Brugia malayi hypothetical protein 0.0016 0.0023 0.0042
Onchocerca volvulus 0.0072 0.1286 0.2643
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0938 0.1249
Plasmodium vivax importin-beta 2, putative 0.003 0.0337 0.1985
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.1286 0.0828
Mycobacterium ulcerans beta-lactamase 0.0072 0.1286 0.2775
Mycobacterium tuberculosis Conserved protein 0.0072 0.1286 0.0828
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0557 0.1145
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0337 0.1518
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0928 0.1234
Schistosoma mansoni alpha glucosidase 0.004 0.0557 0.068
Schistosoma mansoni importin beta-1 0.003 0.0337 0.0351
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2257 0.3219
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.1286 0.2368
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0211 0.0433
Loa Loa (eye worm) hypothetical protein 0.0029 0.0324 0.0477
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0161 0.0724
Loa Loa (eye worm) inositol-1 0.0114 0.2219 0.3264
Schistosoma mansoni tar DNA-binding protein 0.0257 0.5432 0.796
Trichomonas vaginalis set domain proteins, putative 0.0231 0.4867 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0257 0.5432 0.7991
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.2219 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0938 0.138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0324 0.0332
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0557 0.1928
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2257 0.3219
Leishmania major importin beta-1 subunit, putative 0.0024 0.0211 0.0949
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1286 0.2643
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1563 0.1119
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1286 0.1769
Trichomonas vaginalis esterase, putative 0.0072 0.1286 0.2643
Brugia malayi RNA, U transporter 1 0.0085 0.1568 0.2887
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0938 0.1249
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0938 0.1928
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1161 0.1805
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0938 0.1928
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0928 0.1234
Brugia malayi MH2 domain containing protein 0.0121 0.2384 0.4389
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.2219 0.4559
Echinococcus granulosus importin subunit beta 1 0.003 0.0337 0.0351
Loa Loa (eye worm) RNA binding protein 0.0257 0.5432 0.7991
Trypanosoma brucei trypanothione reductase 0.0037 0.0499 0.225
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0557 0.1145
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.051 0.061
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0557 0.2512
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.1286 0.2775
Onchocerca volvulus 0.0072 0.1286 0.2643
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1774 0.1342
Loa Loa (eye worm) hypothetical protein 0.0072 0.1286 0.1892
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0557 0.1145
Schistosoma mansoni hypothetical protein 0.0317 0.6797 1
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0938 0.1928
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0557 0.1145
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.1286 0.1769
Plasmodium falciparum thioredoxin reductase 0.0037 0.0499 1
Onchocerca volvulus 0.0019 0.0102 0.0209
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0557 0.1145
Loa Loa (eye worm) hypothetical protein 0.0072 0.1286 0.1892
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0217 0.0976
Leishmania major hypothetical protein, conserved 0.0072 0.1286 0.5797
Schistosoma mansoni alpha-glucosidase 0.0153 0.3114 0.4499
Toxoplasma gondii thioredoxin reductase 0.0037 0.0499 0.1645
Brugia malayi beta-lactamase 0.0072 0.1286 0.2368
Schistosoma mansoni ran 0.0022 0.0161 0.0088
Leishmania major trypanothione reductase 0.0037 0.0499 0.225
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.1161 0.0696
Schistosoma mansoni lipoxygenase 0.0115 0.2257 0.3219
Plasmodium falciparum glutathione reductase 0.0037 0.0499 1
Trichomonas vaginalis ran, putative 0.0022 0.0161 0.033
Brugia malayi beta-lactamase family protein 0.0072 0.1286 0.2368
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0557 0.1145
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.1161 0.1582
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0928 0.1234
Loa Loa (eye worm) hypothetical protein 0.003 0.0337 0.0496
Brugia malayi MAP kinase sur-1 0.0057 0.0938 0.1727
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0938 0.4229
Brugia malayi hypothetical protein 0.0019 0.0102 0.0187
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0938 0.4229
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1563 0.1119
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1286 0.2643
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0324 0.0332
Mycobacterium tuberculosis Probable reductase 0.0084 0.1563 0.1119
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0557 0.1145
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.2384 0.3507
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0938 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0499 0.225
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0114 0.2219 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1161 0.1805
Schistosoma mansoni ran 0.0022 0.0161 0.0088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.1286 0.2775
Echinococcus multilocularis importin subunit beta 1 0.003 0.0337 0.0351
Brugia malayi Pre-SET motif family protein 0.0203 0.4236 0.7799
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0161 0.0296
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0217 0.2889
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0938 0.1928
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1161 0.1805
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.2219 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1286 0.1892
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0161 0.0088
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.051 0.061
Brugia malayi beta-lactamase family protein 0.0072 0.1286 0.2368
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.015
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0938 0.1249
Onchocerca volvulus 0.0019 0.0102 0.0209
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.1161 0.1582
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0324 0.0332
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.1161 0.486
Echinococcus multilocularis snurportin 1 0.0317 0.6797 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0114 0.2219 1
Brugia malayi hypothetical protein 0.0019 0.0102 0.0187
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0161 0.0724
Onchocerca volvulus 0.0231 0.4867 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1774 0.1342
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.4236 0.6232
Schistosoma mansoni tar DNA-binding protein 0.0257 0.5432 0.796
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0324 0.0332
Echinococcus granulosus snurportin 1 0.0317 0.6797 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1774 0.1342
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0211 0.0949
Trypanosoma brucei glucosidase, putative 0.004 0.0557 0.2512
Mycobacterium tuberculosis Conserved protein 0.0072 0.1286 0.0828
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.2219 0.4559
Onchocerca volvulus 0.0029 0.0324 0.0666
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0928 0.0451
Plasmodium vivax glutathione reductase, putative 0.0037 0.0499 0.3355
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0324 0.0332
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0161 0.0496
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0938 0.4229
Schistosoma mansoni inositol monophosphatase 0.0114 0.2219 0.3162
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1563 0.1119
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0928 0.4183
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0938 0.4229
Mycobacterium ulcerans hypothetical protein 0.0072 0.1286 0.2775
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0499 0.0734
Brugia malayi RNA binding protein 0.0257 0.5432 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.03 0.0296
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0557 0.1145
Schistosoma mansoni tar DNA-binding protein 0.0257 0.5432 0.796
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0161 0.0088
Loa Loa (eye worm) beta-lactamase 0.0072 0.1286 0.1892
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.1286 0.5797
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0557 0.068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.3672 0.676
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.3672 0.5332
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0161 0.1479
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0557 0.2512
Entamoeba histolytica hypothetical protein 0.0024 0.0211 0.0949
Onchocerca volvulus 0.0103 0.1984 0.4077
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0161 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0324 0.0332
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0217 0.2889
Brugia malayi Inositol-1 0.0114 0.2219 0.4085
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1161 0.1582
Brugia malayi Doublecortin family protein 0.0019 0.0102 0.0187
Mycobacterium ulcerans lipase LipD 0.0072 0.1286 0.2775
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.3672 0.5332
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1161 0.1582
Onchocerca volvulus 0.0072 0.1286 0.2643
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0557 0.1145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0324 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0257 0.5432 0.796
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0938 0.4229
Loa Loa (eye worm) hypothetical protein 0.0072 0.1286 0.1892
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0211 0.0433
Echinococcus granulosus inositol monophosphatase 1 0.0114 0.2219 0.3162
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.1563 0.4154
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1286 0.2643
Echinococcus multilocularis tar DNA binding protein 0.0257 0.5432 0.796
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0499 0.3355
Schistosoma mansoni lipoxygenase 0.0081 0.1478 0.2056
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0217 0.0976
Schistosoma mansoni inositol monophosphatase 0.0114 0.2219 0.3162
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.1286 0.0828
Plasmodium vivax hypothetical protein, conserved 0.0072 0.1286 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1286 0.5797
Entamoeba histolytica Ran family GTPase 0.0022 0.0161 0.0724
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.2219 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1563 0.1119
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.1286 0.0828
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.015
Leishmania major GTP-binding protein, putative 0.0022 0.0161 0.0724
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.1286 0.0828
Brugia malayi TAR-binding protein 0.0257 0.5432 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0217 0.0969
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.6797 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.2219 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0557 0.2512
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0557 0.2512
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0938 0.1249
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.2384 0.3507
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.1286 0.0828
Schistosoma mansoni tar DNA-binding protein 0.0257 0.5432 0.796
Echinococcus multilocularis inositol monophosphatase 1 0.0114 0.2219 0.3162
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0324 0.0795
Brugia malayi Thioredoxin reductase 0.0037 0.0499 0.0919
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0938 0.3779
Brugia malayi Importin beta-1 subunit 0.003 0.0337 0.062
Leishmania major hypothetical protein, conserved 0.0024 0.0217 0.0976
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.1286 0.1892
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.1161 0.5232
Loa Loa (eye worm) glutathione reductase 0.0037 0.0499 0.0734
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1286 0.2643
Loa Loa (eye worm) hypothetical protein 0.0072 0.1286 0.1892
Brugia malayi hypothetical protein 0.0024 0.0217 0.0399
Trypanosoma brucei protein kinase, putative 0.0057 0.0938 0.4229
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0938 0.4229
Loa Loa (eye worm) hypothetical protein 0.0072 0.1286 0.1892
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0557 0.2512
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.1286 0.1769
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0557 0.082
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1563 0.1119
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1286 0.2643
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0114 0.2219 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0938 0.1249
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0938 0.4229
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0102 0.015
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0114 0.2219 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0211 0.0433
Mycobacterium tuberculosis Conserved protein 0.0072 0.1286 0.0828
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.1286 0.0828
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.1286 0.0828
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0843 0.1241
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1774 0.733
Brugia malayi glutathione reductase 0.0037 0.0499 0.0919
Plasmodium vivax SET domain protein, putative 0.0029 0.0324 0.1878
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0102 0.1952 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 8.09 uM Anticancer activity against human KB cells after 72 hrs by sulforhodamine B assay ChEMBL. 21668000
GI50 (functional) = 12.18 uM Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay ChEMBL. 21668000
GI50 (functional) = 14.66 uM Anticancer activity against human DU145 cells after 72 hrs by sulforhodamine B assay ChEMBL. 21668000

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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