TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 413.13 | Formula: C14H11Br2N3S
H donors: 2 H acceptors: 0 LogP: 4.46 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=S)N/N=C(\c1ccccc1Br)/c1ccc(cc1)Br
InChi: 1S/C14H11Br2N3S/c15-10-7-5-9(6-8-10)13(18-19-14(17)20)11-3-1-2-4-12(11)16/h1-8H,(H3,17,19,20)/b18-13-
InChiKey: WWVHUIPWMFUTBQ-AQTBWJFISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0475	0.0612
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0307	0.0746
Brugia malayi	Pre-SET motif family protein	0.0204	0.4387	1
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0475	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1354	0.1772
Echinococcus granulosus	cathepsin b	0.0171	0.3629	0.5491
Onchocerca volvulus		0.0032	0.0475	0.0426
Echinococcus multilocularis	cathepsin b	0.0171	0.3629	0.5491
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0475	0.0612
Leishmania major	cathepsin L-like protease	0.0032	0.0475	0.223
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1354	0.1772
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0415	0.0628
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0475	0.0854
Giardia lamblia	Cathepsin B precursor	0.006	0.1106	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0307	0.0374
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.0475	0.0719
Echinococcus granulosus	cathepsin L	0.0019	0.0178	0.027
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.0475	0.0395
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0475	0.0854
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.3629	0.5491
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.1354	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0307	0.0746
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0475	0.0426
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1354	0.3409
Leishmania major	cathepsin L-like protease	0.0032	0.0475	0.223
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.0475	0.223
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0475	0.0854
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Loa Loa (eye worm)	beta-lactamase	0.0071	0.1354	0.1772
Onchocerca volvulus		0.0032	0.0475	0.0426
Echinococcus multilocularis	cathepsin L	0.0019	0.0178	0.027
Plasmodium falciparum	importin beta, putative	0.0028	0.0392	0.7213
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.0475	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0273	0.0078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0273	0.0195
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.1354	0.2425
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3629	0.5334
Onchocerca volvulus		0.0071	0.1354	0.2275
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0391	0.0591
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0475	0.0612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1354	0.1772
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0475	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	0.3629	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.4387	0.6521
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0415	0.0628
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0475	0.0719
Echinococcus granulosus	snurportin 1	0.0302	0.6608	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0307	0.0132
Toxoplasma gondii	ABC1 family protein	0.0071	0.1354	1
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0392	0.182
Echinococcus multilocularis	cathepsin b	0.0171	0.3629	0.5491
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0475	0.0395
Onchocerca volvulus		0.0032	0.0475	0.0426
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0392	0.0594
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0223	0.0129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0223	0.0378
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.1106	0.7802
Leishmania major	cathepsin L-like protease	0.0032	0.0475	0.223
Brugia malayi	beta-lactamase	0.0071	0.1354	0.291
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0302	0.6608	1
Toxoplasma gondii	cathepsin B	0.006	0.1106	0.7802
Plasmodium vivax	vivapain-2	0.0032	0.0475	0.2524
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0271	0.0191
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0475	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.0475	0.086
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.1354	0.205
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0415	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0415	0.0301
Mycobacterium ulcerans	hypothetical protein	0.0071	0.1354	0.5
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.1106	0.7885
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0307	0.4343
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0223	0.0129
Brugia malayi	beta-lactamase family protein	0.0071	0.1354	0.291
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.0178	0.027
Brugia malayi	Pre-SET motif family protein	0.0029	0.0415	0.0714
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0475	0.0612
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0475	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0475	0.0719
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0178	0.027
Brugia malayi	cathepsin L-like precursor	0.0023	0.0273	0.0381
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.1354	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0178	0.027
Onchocerca volvulus		0.0032	0.0475	0.0426
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0307	0.1096
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0475	0.0612
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0475	0.0719
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.5027	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.1354	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.1106	0.1673
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0475	0.086
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0392	0.0266
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0415	0.0628
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1354	0.3409
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0475	0.0612
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0223	0.0337
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.1354	0.2425
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0415	0.1699
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0273	0.0274
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0392	0.0594
Echinococcus multilocularis	cysteine protease	0.0032	0.0475	0.0719
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0178	0.016
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0307	0.0374
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0307	0.1096
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0392	0.182
Leishmania major	cathepsin L-like protease	0.0032	0.0475	0.223
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0273	0.0381
Entamoeba histolytica	hypothetical protein	0.0023	0.0271	0.312
Schistosoma mansoni	ran	0.0021	0.0223	0.0337
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1354	0.2425
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.1354	0.291
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0475	0.0854
Echinococcus multilocularis	snurportin 1	0.0302	0.6608	1
Onchocerca volvulus		0.0032	0.0475	0.0426
Brugia malayi	Cytochrome P450 family protein	0.0045	0.0766	0.1534
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.3629	0.5491
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.1354	0.205
Onchocerca volvulus		0.0032	0.0475	0.0426
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0307	0.4343
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0223	0.0264
Loa Loa (eye worm)	cytochrome P450 family protein	0.0045	0.0766	0.085
Echinococcus granulosus	cysteine protease	0.0019	0.0178	0.027
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.1354	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0475	0.086
Leishmania major	hypothetical protein, conserved	0.0071	0.1354	1
Echinococcus granulosus	cathepsin b	0.0171	0.3629	0.5491
Loa Loa (eye worm)	fibroinase	0.0032	0.0475	0.0395
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0223	0.0378
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0271	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1354	0.1772
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0475	0.0612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0273	0.0195
Brugia malayi	cathepsin B-like cysteine proteinase	0.0171	0.3629	0.8227
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0273	0.0381
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0271	0.0191
Echinococcus multilocularis	cysteine protease	0.0032	0.0475	0.0719
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0415	0.0628
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.3629	0.5491
Brugia malayi	hypothetical protein	0.0025	0.0307	0.0462
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0392	0.182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0475	0.0612
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0475	0.0612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0475	0.0426
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Echinococcus granulosus	cathepsin l1	0.0032	0.0475	0.0719
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0273	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1354	0.1772
Giardia lamblia	Cathepsin B precursor	0.006	0.1106	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1354	0.2425
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0475	0.0719
Onchocerca volvulus		0.0071	0.1354	0.2275
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0415	0.0628
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0178	0.027
Plasmodium vivax	vivapain-2	0.0032	0.0475	0.2524
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1354	0.1772
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.0475	1
Leishmania major	cathepsin L-like protease	0.0032	0.0475	0.223
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0273	0.0078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0273	0.0078
Mycobacterium leprae	Probable lipase LipE	0.0071	0.1354	0.5
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.1354	0.1772
Brugia malayi	RNA, U transporter 1	0.008	0.1577	0.343
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0415	0.0628
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0475	0.086
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0475	0.086
Leishmania major	cathepsin L-like protease	0.0032	0.0475	0.223
Loa Loa (eye worm)	ctsf protein	0.0032	0.0475	0.0395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Mycobacterium ulcerans	beta-lactamase	0.0071	0.1354	0.5
Echinococcus granulosus	cathepsin l1	0.0023	0.0273	0.0413
Schistosoma mansoni	ran	0.0021	0.0223	0.0337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Plasmodium vivax	SET domain protein, putative	0.0029	0.0415	0.2013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Onchocerca volvulus		0.0071	0.1354	0.2275
Onchocerca volvulus		0.0032	0.0475	0.0426
Schistosoma mansoni	importin beta-1	0.0028	0.0392	0.0594
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.0475	1
Entamoeba histolytica	Ran family GTPase	0.0021	0.0223	0.1499
Brugia malayi	beta-lactamase family protein	0.0071	0.1354	0.291
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1354	0.2425
Toxoplasma gondii	cathepsin CPL	0.0032	0.0475	0.223
Brugia malayi	Importin beta-1 subunit	0.0028	0.0392	0.0661
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0273	0.0381
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.1106	0.1912
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.0475	0.0719
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0271	0.0268
Mycobacterium ulcerans	lipase LipD	0.0071	0.1354	0.5
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0475	0.0854
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0475	0.0719
Onchocerca volvulus		0.0232	0.5027	1
Leishmania major	cathepsin L-like protease	0.0032	0.0475	0.223
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0475	0.0612
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0475	0.0719
Loa Loa (eye worm)	cathepsin B	0.006	0.1106	0.1383
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.0475	0.0395
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0178	0.016
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0475	0.0854
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0475	0.0612
Leishmania major	cathepsin L-like protease	0.0032	0.0475	0.223
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0475	0.0612
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0223	0.1499
Trichomonas vaginalis	esterase, putative	0.0071	0.1354	0.2425
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Trichomonas vaginalis	ran, putative	0.0021	0.0223	0.0092
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0223	0.0337
Loa Loa (eye worm)	cysteine protease	0.0032	0.0475	0.0395
Giardia lamblia	Cathepsin B precursor	0.006	0.1106	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.1354	0.205
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0273	0.3182
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.1354	0.5
Onchocerca volvulus		0.0029	0.0415	0.0299
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0271	0.0191
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.1106	0.2688
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0392	0.1499
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0475	0.2524
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.1354	0.205
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	0.3629	0.5491
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.0475	0.0426
Schistosoma mansoni	hypothetical protein	0.0302	0.6608	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10000 nM	Inhibition of human liver cathepsin L	ChEMBL.	20089402
IC50 (binding)	> 10000 nM	Inhibition of human liver cathepsin B	ChEMBL.	20089402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL598630

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1093373