Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0146 | 0.3019 | 0.3871 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0257 | 0.6268 | 0.6133 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0055 | 0.0349 | 0.0646 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0055 | 0.0349 | 0.0448 |
Brugia malayi | hypothetical protein | 0.0257 | 0.6268 | 0.6794 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.0349 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0383 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0053 | 0.0279 | 0.0358 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.1785 | 0.1722 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0163 | 0.3504 | 0.3369 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.0671 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0816 | 0.0626 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.0349 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0146 | 0.3019 | 0.3871 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2692 | 0.3451 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.0349 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.1785 | 0.1722 |
Mycobacterium ulcerans | hypothetical protein | 0.0163 | 0.3504 | 0.3369 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0353 | 0.9102 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0353 | 0.9102 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0353 | 0.9102 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0353 | 0.9102 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0353 | 0.9102 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.0671 | 0.0861 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2692 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.0349 | 0.0098 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0661 | 0.0451 |
Trypanosoma brucei | protein kinase, putative | 0.0055 | 0.0349 | 0.0448 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0353 | 0.9102 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.0671 | 0.0462 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0257 | 0.6268 | 0.6133 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0374 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1785 | 0.164 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0661 | 0.0418 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.2708 | 0.2766 |
Onchocerca volvulus | 0.0056 | 0.0374 | 1 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0135 | 0.2692 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.0349 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0055 | 0.0349 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0066 | 0.0671 | 0.0432 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.0349 | 0.0448 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0309 | 0.78 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0816 | 0.0626 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2692 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0056 | 0.0374 | 0.0126 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0661 | 0.0323 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.0671 | 0.0462 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.1785 | 0.164 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0309 | 0.78 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2692 | 0.3144 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0146 | 0.3019 | 0.3583 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0661 | 0.189 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0353 | 0.9102 | 0.9069 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0055 | 0.0349 | 0.0448 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.0671 | 0.0333 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.0671 | 0.0861 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.0671 | 0.0861 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0816 | 0.0533 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.0671 | 0.0368 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.0349 | 0.0448 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0661 | 0.0451 |
Echinococcus granulosus | dihydrofolate reductase | 0.0353 | 0.9102 | 0.9069 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.6268 | 0.6762 |
Brugia malayi | MAP kinase sur-1 | 0.0055 | 0.0349 | 0.0098 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0309 | 0.78 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.2708 | 0.2695 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0309 | 0.78 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0353 | 0.9102 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2692 | 0.3451 |
Brugia malayi | dihydrofolate reductase family protein | 0.0353 | 0.9102 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.2708 | 0.2695 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.0671 | 0.0333 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0055 | 0.0349 | 0.0448 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0661 | 0.0323 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23 uM | Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells | ChEMBL. | 20117004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.