Detailed information for compound 1093430

Basic information

Technical information
  • TDR Targets ID: 1093430
  • Name: 2-[4-[(2,3-dichlorophenyl)-phenylmethyl]piper azin-1-yl]-N,N-di(phenyl)acetamide
  • MW: 530.487 | Formula: C31H29Cl2N3O
  • H donors: 0 H acceptors: 1 LogP: 7.16 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N(c1ccccc1)c1ccccc1)CN1CCN(CC1)C(c1cccc(c1Cl)Cl)c1ccccc1
  • InChi: 1S/C31H29Cl2N3O/c32-28-18-10-17-27(30(28)33)31(24-11-4-1-5-12-24)35-21-19-34(20-22-35)23-29(37)36(25-13-6-2-7-14-25)26-15-8-3-9-16-26/h1-18,31H,19-23H2
  • InChiKey: NIMFDABOPDBIHU-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[4-[(2,3-dichlorophenyl)-phenyl-methyl]piperazin-1-yl]-N,N-di(phenyl)acetamide
  • 2-[4-[(2,3-dichlorophenyl)-phenylmethyl]-1-piperazinyl]-N,N-di(phenyl)acetamide
  • 2-[4-[(2,3-dichlorophenyl)-phenyl-methyl]piperazin-1-yl]-N,N-di(phenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.9362 0.9329
Schistosoma mansoni rab6-interacting 0.0041 0.23 0.1895
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.4977 0.3575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.05 0.05
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.05 0.05
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.4977 0.4713
Loa Loa (eye worm) hypothetical protein 0.0041 0.23 0.23
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0118 0.9362 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.05 0.05
Giardia lamblia Kinase, CMGC CLK 0.0125 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.3325 0.2974
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.2181 0.177
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.05 0.05
Loa Loa (eye worm) doublecortin family protein 0.0041 0.23 0.23
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.3325 0.1463
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.05 0.05
Brugia malayi hypothetical protein 0.0041 0.23 0.23
Loa Loa (eye worm) cytochrome P450 family protein 0.0104 0.8053 0.8053
Trypanosoma cruzi cytochrome P450, putative 0.0072 0.5119 0.3757
Brugia malayi ecdysteroid receptor 0.0021 0.05 0.05
Schistosoma mansoni polycystin 1-related 0.0041 0.23 0.1895
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3325 0.1463
Schistosoma mansoni lipoxygenase 0.0041 0.23 0.1895
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0044 0.2627 0.057
Schistosoma mansoni cytochrome P450 0.0044 0.2627 0.2239
Brugia malayi nuclear receptor NHR-88 0.0021 0.05 0.05
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.05 0.05
Echinococcus multilocularis lamin dm0 0.0029 0.1212 0.075
Onchocerca volvulus 0.0029 0.1212 0.3958
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.3325 0.2974
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.05 0.05
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.23 0.1895
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3325 0.1463
Loa Loa (eye worm) hypothetical protein 0.0021 0.05 0.05
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.1212 0.1212
Echinococcus multilocularis transcription factor Dp 1 0.004 0.2292 0.1886
Schistosoma mansoni lamin 0.0029 0.1212 0.075
Echinococcus multilocularis 0.0124 0.9871 0.9865
Echinococcus granulosus RUN 0.0041 0.23 0.1895
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.05 0.05
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.3325 0.1463
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0044 0.2627 0.057
Schistosoma mansoni intermediate filament proteins 0.0029 0.1212 0.075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.05 0.05
Schistosoma mansoni loxhd1 0.0041 0.23 0.1895
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.2181 0.177
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.4977 0.4713
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0044 0.2627 0.057
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.23 0.1895
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.2181 0.2181
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.3325 0.2974
Brugia malayi Doublecortin family protein 0.0041 0.23 0.23
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.3325 0.1463
Mycobacterium leprae Conserved hypothetical protein 0.0044 0.2627 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0125 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0125 1 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.2181 0.177
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.05 0.05
Leishmania major protein kinase, putative 0.0125 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0072 0.5119 0.3757
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.4977 1
Schistosoma mansoni hypothetical protein 0.0041 0.23 0.1895
Echinococcus granulosus lamin 0.0029 0.1212 0.075
Brugia malayi Cytochrome P450 family protein 0.0104 0.8053 0.8053
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.9362 1
Brugia malayi Cytochrome P450 family protein 0.0072 0.5119 0.5119
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.05 0.05
Trypanosoma brucei protein kinase, putative 0.0052 0.3325 0.1463
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.4977 0.3575
Loa Loa (eye worm) hypothetical protein 0.0021 0.05 0.05
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0118 0.9362 0.9329
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.3325 0.1463
Schistosoma mansoni rab6-interacting 0.0041 0.23 0.1895
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.23 0.1895
Loa Loa (eye worm) hypothetical protein 0.0027 0.1093 0.1093
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.3325 0.1463
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.2181 0.177
Onchocerca volvulus 0.0041 0.23 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.011 0.8638 0.8638
Schistosoma mansoni hypothetical protein 0.0044 0.2627 0.2239
Loa Loa (eye worm) hypothetical protein 0.0124 0.9871 0.9871
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.23 0.1895
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0021 0.05 0.05
Loa Loa (eye worm) cytochrome P450 0.0044 0.2627 0.2627
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.05 0.05
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.3325 0.3325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0041 0.23 0.23
Trichomonas vaginalis CMGC family protein kinase 0.0125 1 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.3325 0.1463
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.05 0.05
Echinococcus granulosus dual specificity protein kinase clk2 0.0125 1 1
Brugia malayi cytochrome P450 0.0044 0.2627 0.2627
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.2181 0.177
Onchocerca volvulus 0.0029 0.1212 0.3958
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0125 1 1
Schistosoma mansoni lamin 0.0029 0.1212 0.075
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.4977 0.4977
Echinococcus multilocularis RUN 0.0041 0.23 0.1895
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0125 1 1
Schistosoma mansoni lipoxygenase 0.0114 0.8957 0.8902
Mycobacterium leprae putative cytochrome p450 0.0044 0.2627 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.05 0.05
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0125 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.4977 0.3575
Brugia malayi steroid hormone receptor 0.0021 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0021 0.05 0.05
Echinococcus granulosus lamin dm0 0.0029 0.1212 0.075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.1212 0.1212
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.05 0.05
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.3325 0.2974
Loa Loa (eye worm) CYP4Cod1 0.0072 0.5119 0.5119
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.4977 0.4713
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0125 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.3325 0.2974
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0044 0.2627 0.057
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.2181 0.177
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.4977 0.3575
Brugia malayi Cytochrome P450 family protein 0.0072 0.5119 0.5119
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.5119 0.5119
Onchocerca volvulus 0.0041 0.23 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0125 1 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.23 0.1895
Loa Loa (eye worm) hypothetical protein 0.0021 0.05 0.05
Leishmania major cytochrome p450-like protein 0.0072 0.5119 0.3757
Brugia malayi hypothetical protein 0.0041 0.23 0.23
Echinococcus granulosus hypothetical protein 0.0124 0.9871 0.9865
Echinococcus multilocularis lamin 0.0029 0.1212 0.075
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0072 0.5119 0.3699
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.05 0.05
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.3325 0.1463
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0118 0.9362 0.9362
Brugia malayi intermediate filament protein 0.0029 0.1212 0.1212
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0118 0.9362 0.9185
Echinococcus multilocularis dual specificity protein kinase clk2 0.0125 1 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0125 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.05 0.05
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.3325 0.1463
Loa Loa (eye worm) hypothetical protein 0.0028 0.1164 0.1164
Brugia malayi Cytochrome P450 family protein 0.0044 0.2627 0.2627
Brugia malayi nuclear hormone receptor 0.0021 0.05 0.05
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3325 0.1463
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.8957 0.8902
Plasmodium vivax serine/threonine kinase-1, putative 0.0125 1 1
Echinococcus granulosus intermediate filament protein 0.0029 0.1212 0.075
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.9362 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.05 0.05
Echinococcus multilocularis musashi 0.0029 0.1212 0.075
Loa Loa (eye worm) hypothetical protein 0.0021 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.0039 0.2181 0.2181
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.05 0.05
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.2181 0.177
Trypanosoma brucei cytochrome P450, putative 0.0072 0.5119 0.3757
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.23 0.1895
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0125 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0125 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.3325 0.0947
Echinococcus multilocularis 0.0044 0.2627 0.2239
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3325 0.1463
Leishmania major cytochrome p450-like protein 0.0044 0.2627 0.057
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.9362 0.9329
Leishmania major protein kinase, putative 0.0125 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.05 0.05
Leishmania major cytochrome p450-like protein 0.0044 0.2627 0.057
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.05 0.05
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.2181 0.177
Echinococcus granulosus cytochrome P450 2K1 0.0044 0.2627 0.2239
Plasmodium falciparum protein serine/threonine kinase-1 0.0125 1 1
Echinococcus granulosus transcription factor Dp 1 0.004 0.2292 0.1886
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.5119 0.5119
Brugia malayi MAP kinase sur-1 0.0052 0.3325 0.3325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.05 0.05
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.05 0.05
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.4977 0.4977
Loa Loa (eye worm) hypothetical protein 0.0029 0.1212 0.1212
Loa Loa (eye worm) hypothetical protein 0.0021 0.05 0.05
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0044 0.2627 0.057
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.8957 0.8902
Loa Loa (eye worm) intermediate filament protein 0.0029 0.1212 0.1212

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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