Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1424 | 0.4395 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1072 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1301 | 0.4014 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1072 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1624 | 0.4159 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1072 | 0.1072 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1624 | 0.1624 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1072 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.1143 | 0.2673 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1624 | 0.152 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1072 | 0.1072 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1072 | 0.096 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.099 | 0.0877 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1072 | 0.2454 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.324 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1147 | 0.3541 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1624 | 0.5013 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2527 | 0.2434 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.2759 | 0.2759 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2527 | 0.2434 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.3517 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.099 | 0.0877 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1624 | 0.152 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1624 | 0.1624 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1072 | 0.096 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1624 | 0.152 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1072 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1624 | 0.1624 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0124 | 0.0124 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1624 | 0.152 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 60 uM | Inhibition of human recombinant FTase by fluorescent-based assay | ChEMBL. | 20036564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.