Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.00582983 | 0.0256209 | 0.0287329 |
Echinococcus granulosus | acetylcholinesterase | 0.0345031 | 0.63857 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00582983 | 0.0256209 | 0.0287329 |
Plasmodium vivax | polyprenol reductase, putative | 0.00463131 | 0 | 0.5 |
Onchocerca volvulus | 0.00582983 | 0.0256209 | 1 | |
Onchocerca volvulus | 0.00582983 | 0.0256209 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.00582983 | 0.0256209 | 0.0401223 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.046344 | 0.891692 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.046344 | 0.891692 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00582983 | 0.0256209 | 0.0401223 |
Loa Loa (eye worm) | hypothetical protein | 0.00582983 | 0.0256209 | 0.0287329 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.046344 | 0.891692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00582983 | 0.0256209 | 0.0287329 |
Echinococcus granulosus | neuroligin | 0.00582983 | 0.0256209 | 0.0401223 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0345031 | 0.63857 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.00582983 | 0.0256209 | 0.0401223 |
Loa Loa (eye worm) | carboxylesterase | 0.00582983 | 0.0256209 | 0.0287329 |
Echinococcus granulosus | BC026374 protein S09 family | 0.00582983 | 0.0256209 | 0.0401223 |
Onchocerca volvulus | 0.00582983 | 0.0256209 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00582983 | 0.0256209 | 0.0287329 |
Schistosoma mansoni | gliotactin | 0.00582983 | 0.0256209 | 0.0401223 |
Onchocerca volvulus | 0.00582983 | 0.0256209 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00582983 | 0.0256209 | 0.0287329 |
Echinococcus granulosus | carboxylesterase 5A | 0.0345031 | 0.63857 | 1 |
Brugia malayi | hypothetical protein | 0.00582983 | 0.0256209 | 0.0287329 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0514105 | 1 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.046344 | 0.891692 | 1 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0161337 | 0.245886 | 0.226057 |
Mycobacterium ulcerans | hypothetical protein | 0.046344 | 0.891692 | 0.888844 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0345031 | 0.63857 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00582983 | 0.0256209 | 0.0401223 |
Echinococcus multilocularis | acetylcholinesterase | 0.0345031 | 0.63857 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0345031 | 0.63857 | 0.716132 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00582983 | 0.0256209 | 0.0401223 |
Brugia malayi | Carboxylesterase family protein | 0.00582983 | 0.0256209 | 0.0287329 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.046344 | 0.891692 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.00582983 | 0.0256209 | 0.0401223 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0514105 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.00582983 | 0.0256209 | 0.0287329 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.046344 | 0.891692 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0345031 | 0.63857 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.00463131 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.00582983 | 0.0256209 | 0.0287329 |
Loa Loa (eye worm) | hypothetical protein | 0.00582983 | 0.0256209 | 0.0287329 |
Loa Loa (eye worm) | hypothetical protein | 0.0345031 | 0.63857 | 0.716132 |
Brugia malayi | Carboxylesterase family protein | 0.0345031 | 0.63857 | 0.716132 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0345031 | 0.63857 | 0.716132 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.046344 | 0.891692 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00582983 | 0.0256209 | 0.0287329 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.00582983 | 0.0256209 | 0.0401223 |
Onchocerca volvulus | 0.00582983 | 0.0256209 | 1 | |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.046344 | 0.891692 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0345031 | 0.63857 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.00582983 | 0.0256209 | 0.0401223 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0161337 | 0.245886 | 0.226057 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.00582983 | 0.0256209 | 0.0401223 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.00582983 | 0.0256209 | 0.0287329 |
Brugia malayi | Carboxylesterase family protein | 0.00582983 | 0.0256209 | 0.0287329 |
Loa Loa (eye worm) | carboxylesterase | 0.0345031 | 0.63857 | 0.716132 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.046344 | 0.891692 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.00582983 | 0.0256209 | 0.0401223 |
Brugia malayi | Carboxylesterase family protein | 0.0345031 | 0.63857 | 0.716132 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.046344 | 0.891692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.046344 | 0.891692 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.00463131 | 0 | 0.5 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.00463131 | 0 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.00582983 | 0.0256209 | 0.0401223 |
Plasmodium falciparum | polyprenol reductase, putative | 0.00463131 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.00582983 | 0.0256209 | 0.0287329 |
Echinococcus multilocularis | neuroligin | 0.00582983 | 0.0256209 | 0.0401223 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 | > 100 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 0.964 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 2.474 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.