Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.3527 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.3527 | 0.8706 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1086 | 0.2612 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0101 | 0.3915 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1086 | 0.2612 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1086 | 0.2612 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.3527 | 0.8706 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.3915 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0094 | 0.3527 | 0.5 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3461 | 0.98 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0094 | 0.3527 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0211 | 1 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0093 | 0.3461 | 0.3461 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1086 | 0.2612 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0211 | 1 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0101 | 0.3915 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.3915 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0101 | 0.3915 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.3527 | 0.8706 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.3527 | 0.8706 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3461 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.3527 | 0.8706 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 0.3527 | 0.0101 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0094 | 0.3527 | 0.5 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0093 | 0.3461 | 0.98 |
Schistosoma mansoni | kinase | 0.0048 | 0.0985 | 0.2307 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0101 | 0.3915 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0211 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.3527 | 0.3527 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3461 | 0.5 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0093 | 0.3461 | 0.98 |
Trypanosoma brucei | polo-like protein kinase | 0.0094 | 0.3527 | 0.0101 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3461 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.3527 | 0.8706 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 0.3527 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0094 | 0.3527 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0031 | 0.0049 | 0.0049 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0094 | 0.3527 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.3527 | 0.3527 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0101 | 0.3915 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.3527 | 0.8706 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0032 | 0.0128 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Cytotoxicity against human MCF7 cells after 18 hrs by MTT assay | ChEMBL. | 19932024 |
IC50 (functional) | > 50 uM | Cytotoxicity against human MDA-MB-231 cells after 18 hrs by MTT assay | ChEMBL. | 19932024 |
IC50 (functional) | > 50 uM | Cytotoxicity against human Ishikawa cells after 18 hrs by MTT assay | ChEMBL. | 19932024 |
IC50 (functional) | > 50 uM | Cytotoxicity against human DU145 cells after 18 hrs by MTT assay | ChEMBL. | 19932024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.