Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0339 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.1002 | 0.1604 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0584 | 0.0563 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.1265 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4598 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0339 | 0.261 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.1002 | 0.1558 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0339 | 0.261 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1265 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.1265 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.5539 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4598 | 0.7362 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0339 | 0.261 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0407 | 0.016 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.1265 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0407 | 0.016 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0339 | 0.0316 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0339 | 0.261 |
Schistosoma mansoni | smad | 0.0008 | 0.0339 | 0.0542 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0597 | 0.0606 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2592 | 0.415 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.1265 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0339 | 0.0316 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0339 | 0.261 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0339 | 0.261 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0339 | 0.261 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.1265 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.1002 | 0.1604 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.2928 | 0.6079 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1002 | 0.0981 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0339 | 0.0542 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1265 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.1265 | 0.2176 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.1265 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0339 | 0.261 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0339 | 0.261 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0597 | 0.0575 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0339 | 0.261 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1265 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.1265 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0339 | 0.261 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.2928 | 0.4688 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0339 | 0.261 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.3961 | 0.3948 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0339 | 0.0542 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1265 | 0.2026 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0339 | 0.261 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0339 | 0.261 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0597 | 0.0606 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0339 | 0.0542 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.1265 | 0.1245 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0339 | 0.261 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.3961 | 0.3948 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.1002 | 0.0981 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.3961 | 0.3948 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.1002 | 0.1558 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.1002 | 0.1558 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0339 | 0.0316 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.1002 | 0.1558 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.4598 | 0.4585 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0339 | 0.261 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0339 | 0.261 |
Onchocerca volvulus | 0.0035 | 0.275 | 0.5 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.1002 | 0.1558 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.275 | 0.4403 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4598 | 0.7362 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2592 | 0.2575 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4598 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0339 | 0.0542 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.2928 | 0.6079 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.1002 | 0.1604 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0079 | 0.0127 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0339 | 0.261 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0407 | 0.0651 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.1002 | 0.1558 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1265 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.6245 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4598 | 0.7362 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0407 | 0.016 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0339 | 0.0542 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0407 | 0.016 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.1265 | 0.1245 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0339 | 0.0316 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.275 | 0.2733 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3961 | 0.3948 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4598 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0339 | 0.0316 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.1002 | 0.0981 |
Brugia malayi | Smad1 | 0.0008 | 0.0339 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.1002 | 0.1604 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.1002 | 0.0981 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.1265 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.1265 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.1265 | 0.2176 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1265 | 0.2026 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4598 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.2928 | 0.4688 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.1265 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.4598 | 0.4585 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.275 | 0.2733 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0339 | 0.0316 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.2592 | 0.2575 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.