Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3132 | 0.3132 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3132 | 0.3132 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.3132 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3132 | 0.3132 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.3132 | 0.3132 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3132 | 0.3132 |
Trypanosoma brucei | glucosidase, putative | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.3132 | 0.3132 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0176 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3132 | 0.3132 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0176 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.821 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3132 | 0.3132 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Onchocerca volvulus | 0.0102 | 0.4581 | 0.5 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3132 | 0.3132 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0039 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3132 | 0.3132 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.3132 | 0.3132 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.3132 | 0.3815 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.821 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.